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PDE4 inhibitors: a review of current developments (2005 – 2009)

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Pages 1501-1519 | Published online: 16 Oct 2009

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Zhihao Liu, Mingjian Liu, Zhenqing Cao, Pengsen Qiu & Gaopeng Song. (2022) Phosphodiesterase‑4 inhibitors: a review of current developments (2013–2021). Expert Opinion on Therapeutic Patents 32:3, pages 261-278.
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Fuminori Ohba, Shunji Matsuki, Shuhei Imayama, Kyoko Matsuguma, Seiichiro Hojo, Maiko Nomoto & Hideto Akama. (2016) Efficacy of a novel phosphodiesterase inhibitor, E6005, in patients with atopic dermatitis: An investigator-blinded, vehicle-controlled study. Journal of Dermatological Treatment 27:5, pages 467-472.
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Fuminori Ohba, Maiko Nomoto, Seiichiro Hojo & Hideto Akama. (2016) Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis. Journal of Dermatological Treatment 27:3, pages 241-246.
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Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
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Jerry J Flores, Yang Zhang, Damon W Klebe, Tim Lekic, Weiling Fu & John H Zhang. (2014) Small molecule inhibitors in the treatment of cerebral ischemia. Expert Opinion on Pharmacotherapy 15:5, pages 659-680.
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Mary Gregory & Daniel G Cyr. (2014) The blood-epididymis barrier and inflammation. Spermatogenesis 4:2.
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Amadeu Gavaldà & Richard S Roberts. (2013) Phosphodiesterase-4 inhibitors: a review of current developments (2010 – 2012). Expert Opinion on Therapeutic Patents 23:8, pages 997-1016.
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Jay H. Chung. (2012) Metabolic benefits of inhibiting cAMP-PDEs with resveratrol. Adipocyte 1:4, pages 256-258.
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Mark A Giembycz & Stephen K Field. (2010) Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Design, Development and Therapy 4, pages 147-158.
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Daniela Bianchi, Pasquale De Michele, Cristina Marchetti, Brunello Tirozzi, Salvatore Cuomo, Hélène Marie & Michele Migliore. (2014) Effects of increasing CREB-dependent transcription on the storage and recall processes in a hippocampal CA1 microcircuit. Hippocampus 24:2, pages 165-177.
Crossref
Ling Huang, Wenjun Shan, Qi Zhou, Jiaxing Xie, Kefang Lai & Xingshu Li. (2014) Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 24:1, pages 249-253.
Crossref
Taiji Goto, Akiko Shiina, Toshiharu Yoshino, Kiyoshi Mizukami, Kazuki Hirahara, Osamu Suzuki, Yoshitaka Sogawa, Tomoko Takahashi, Tsuyoshi Mikkaichi, Naoki Nakao, Mizuki Takahashi, Masashi Hasegawa & Shigeki Sasaki. (2013) Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorganic & Medicinal Chemistry 21:22, pages 7025-7037.
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Crossref
Manel Ferrer, Richard S. Roberts & Sara Sevilla. (2013) A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as PDE4 inhibitors. Tetrahedron Letters 54:36, pages 4821-4825.
Crossref
Peter Kraft, Tobias Schwarz, Eva Göb, Nadine Heydenreich, Marc Brede, Sven G. Meuth & Christoph Kleinschnitz. (2013) The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood–brain-barrier damage, inflammation and thrombosis. Experimental Neurology 247, pages 80-90.
Crossref
Rainer Gewald, Christian Grunwald & Ute Egerland. (2013) Discovery of triazines as potent, selective and orally active PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:15, pages 4308-4314.
Crossref
Naoto Ishii, Manabu Shirato, Hisashi Wakita, Kazuki Miyazaki, Yasutaka Takase, Osamu Asano, Kazutomi Kusano, Eiichi Yamamoto, Chiharu Inoue & Ieharu Hishinuma. (2013) Antipruritic Effect of the Topical Phosphodiesterase 4 Inhibitor E6005 Ameliorates Skin Lesions in a Mouse Atopic Dermatitis Model. Journal of Pharmacology and Experimental Therapeutics 346:1, pages 105-112.
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Anke Heuser, Lars Mecklenburg, Deborah Ockert, Manfred Kohler & Jörg Kemkowski. (2012) Selective Inhibition of PDE4 in Wistar Rats Can Lead to Dilatation in Testis, Efferent Ducts, and Epididymis and Subsequent Formation of Sperm Granulomas. Toxicologic Pathology 41:4, pages 615-627.
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Taiji Goto, Akiko Shiina, Toshiharu Yoshino, Kiyoshi Mizukami, Kazuki Hirahara, Osamu Suzuki, Yoshitaka Sogawa, Tomoko Takahashi, Tsuyoshi Mikkaichi, Naoki Nakao, Mizuki Takahashi, Masashi Hasegawa & Shigeki Sasaki. (2013) Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3325-3328.
Crossref
Mario Thevis, Oliver Krug & Wilhelm Schänzer. (2013) Monitoring phosphodiesterase-4 inhibitors using liquid chromatography/(tandem) mass spectrometry in sports drug testing. Rapid Communications in Mass Spectrometry 27:9, pages 993-1004.
Crossref
Pierre Voisin & Marianne Bernard. (2013) Cyclic AMP-dependent regulation of tyrosine hydroxylase mRNA and immunofluorescence levels in rat retinal precursor cells. Cell and Tissue Research 352:2, pages 207-216.
Crossref
Joseph D. Panarese & Craig W. Lindsley. (2012) Biomimetic Synthesis and Biological Evaluation of Aplidiopsamine A. Organic Letters 14:22, pages 5808-5810.
Crossref
Georg Schett, Jurgen Wollenhaupt, Kim Papp, Rik Joos, Jude F. Rodrigues, Adele R. Vessey, ChiaChi Hu, Randall Stevens & Kurt L. de Vlam. (2012) Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double‐blind, placebo‐controlled study. Arthritis & Rheumatism 64:10, pages 3156-3167.
Crossref
Arthur E. Kümmerle, Martine Schmitt, Suzana V. S. Cardozo, Claire Lugnier, Pascal Villa, Alexandra B. Lopes, Nelilma C. Romeiro, Hélène Justiniano, Marco A. Martins, Carlos A. M. Fraga, Jean-Jacques Bourguignon & Eliezer J. Barreiro. (2012) Design, Synthesis, and Pharmacological Evaluation of N -Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors . Journal of Medicinal Chemistry 55:17, pages 7525-7545.
Crossref
Debra J Reid & Nga T Pham. (2012) Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary Disease. Annals of Pharmacotherapy 46:4, pages 521-529.
Crossref
Thérèse Keravis & Claire Lugnier. (2012) Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. British Journal of Pharmacology 165:5, pages 1288-1305.
Crossref
Jan Lötvall & Bo Lundbäck. 2012. Advances in Combination Therapy for Asthma and COPD. Advances in Combination Therapy for Asthma and COPD 296 310 .
Chung-Hung Shih, Ling-Hung Lin, Hsin-Te Hsu, Kuo-Hsien Wang, Chi-Yin Lai, Chien-Ming Chen & Wun-Chang Ko. (2012) Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-10.
Crossref
Nicholas D. Bland, Cuihua Wang, Craig Tallman, Alden E. Gustafson, Zhouxi Wang, Trent D. Ashton, Stefan O. Ochiana, Gregory McAllister, Kristina Cotter, Anna P. Fang, Lara Gechijian, Norman Garceau, Rajiv Gangurde, Ron Ortenberg, Mary Jo Ondrechen, Robert K. Campbell & Michael P. Pollastri. (2011) Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness. Journal of Medicinal Chemistry 54:23, pages 8188-8194.
Crossref
You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han, Chien-Ming Chen, Chi-Ming Chen & Wun-Chang Ko. (2011) Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. Journal of Biomedical Science 18:1.
Crossref
SANG-DO LEE, DAVID S. C. HUI, AZIAH A. MAHAYIDDIN, CAMILO C. ROA JR, KHENG HOE KWA, UDO-MICHAEL GOEHRING, DIRK BREDENBRÖKER & HAN-PIN KUO. (2011) Roflumilast in Asian patients with COPD: A randomized placebo-controlled trial. Respirology 16:8, pages 1249-1257.
Crossref
S.H. Christiansen, J. Selige, T. Dunkern, A. Rassov & M. Leist. (2011) Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP. Neurochemistry International 59:6, pages 837-846.
Crossref
Frédéric J.J. Bihel, Hélène Justiniano, Martine Schmitt, Malik Hellal, Mohamed A. Ibrahim, Claire Lugnier & Jean-Jacques Bourguignon. (2011) New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam. Bioorganic & Medicinal Chemistry Letters 21:21, pages 6567-6572.
Crossref
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Mònica Córdoba, Elena Calama, José Luis Montero, Míriam Andrés, Montserrat Miralpeix, Dolors Vilella, Begoña Hernández, Jorge Beleta, Hamish Ryder & Lluís Pagès. (2011) Synthesis and biological activity of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors. European Journal of Medicinal Chemistry 46:10, pages 4946-4956.
Crossref
Klaus F. Rabe. (2011) Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. British Journal of Pharmacology 163:1, pages 53-67.
Crossref
Wun-Chang Ko, Ling-Hung Lin, Hsin-Yi Shen, Chi-Yin Lai, Chien-Ming Chen & Chung-Hung Shih. (2011) Biochanin A, a Phytoestrogenic Isoflavone with Selective Inhibition of Phosphodiesterase 4, Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-13.
Crossref
Hermann Tenor, Armin Hatzelmann, Rolf Beume, Gezim Lahu, Karl Zech & Thomas D. Bethke. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 85 119 .
Mark A. Giembycz & Robert Newton. 2011. Phosphodiesterases as Drug Targets. Phosphodiesterases as Drug Targets 415 446 .
Michel Gallant, Renee Aspiotis, Stephen Day, Rebecca Dias, Daniel Dubé, Laurence Dubé, Richard W. Friesen, Mario Girard, Daniel Guay, Pierre Hamel, Zheng Huang, Patrick Lacombe, Sebastien Laliberté, Jean-François Lévesque, Susana Liu, Dwight Macdonald, Joseph Mancini, Donald W. Nicholson, Angela Styhler, Karen Townson, Kerry Waters, Robert N. Young & Yves Girard. (2010) Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6387-6393.
Crossref
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Míriam Andrés, Mònica Córdoba, Montserrat Miralpeix, Dolors Vilella, Jorge Beleta, Hamish Ryder & Lluís Pagès. (2010) Synthesis and Biological Activity of Pyrido[3′,2′:4,5]thieno[3,2- d ]pyrimidines as Phosphodiesterase Type 4 Inhibitors . Journal of Medicinal Chemistry 53:19, pages 6912-6922.
Crossref
Chung-Hong Shih, Ling-Hung Lin, Ya-Hsin Lai, Chi-Yin Lai, Cheng-Ying Han, Chien-Ming Chen & Wun-Chang Ko. (2010) Genistein, a competitive PDE1–4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects. European Journal of Pharmacology 643:1, pages 113-120.
Crossref
Fei-Peng Lee, Chwen-Ming Shih, Hsin-Yi Shen, Chien-Ming Chen, Chi-Ming Chen & Wun-Chang Ko. (2010) Ayanin, a non-selective phosphodiesterase 1–4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia. European Journal of Pharmacology 635:1-3, pages 198-203.
Crossref
Zhi Chen, Guanghui Tian, Zhen Wang, Hualiang Jiang, Jingshan Shen & Weiliang Zhu. (2010) Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity. Journal of Chemical Information and Modeling 50:4, pages 615-625.
Crossref
Mousumi Ghosh & Damien Pearse. (2010) Cyclic AMP-specific PDEs: A promising therapeutic target for CNS repair. Translational Neuroscience 1:2.
Crossref
Philipp Skroblin, Solveig Grossmann, Gesa Schäfer, Walter Rosenthal & Enno Klussmann. 2010. 235 330 .
Julio Cortijo Gimeno. (2010) Inhibidores de fosfodiesterasa 4: un nuevo grupo farmacológico en el tratamiento de la inflamación crónica de las vías aéreas. Archivos de Bronconeumología 46, pages 3-7.
Crossref

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