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Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents

Pages 1485-1499 | Published online: 26 Oct 2009

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Jean M Whaley, Mark Tirmenstein, Timothy P Reilly, Simon M Poucher, JoAnne Saye, Shamik Parikh & James F List. (2012) Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity 5, pages 135-148.
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William N Washburn. (2012) Sodium glucose co-transporter 2 (SGLT2) inhibitors: novel antidiabetic agents. Expert Opinion on Therapeutic Patents 22:5, pages 483-494.
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Philip A Carpino & Bryan Goodwin. (2010) Diabetes area participation analysis: a review of companies and targets described in the 2008 – 2010 patent literature. Expert Opinion on Therapeutic Patents 20:12, pages 1627-1651.
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Thomas D Aicher, Steven A Boyd, Maralee McVean & Anthony Celeste. (2010) Novel therapeutics and targets for the treatment of diabetes. Expert Review of Clinical Pharmacology 3:2, pages 209-229.
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琪 张. (2022) Study on the Pharmacological Effects of the Main Active Ingredients in the Seeds of “Guiyou No. 1” Pomelo on Diabetes. Botanical Research 11:03, pages 229-238.
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Dana El Masri, Yasser Jamil & Jocelyne Eid Fares. (2022) Sodium-Glucose Co-Transporter Protein 2 Inhibitors Induced Hypercalcemia: A Case Series and Literature Review. AACE Clinical Case Reports 8:1, pages 30-33.
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L.M. Kalynska & O.I. Kovzun. (2021) Вплив дапагліфлозину на активність ангіотензин-перетворюючого ферменту в структурах гіпоталамо-гіпофізарно- адренокортикальної системи та функцію кори надниркових залоз у щурів із цукровим діабетом 2-го типу. Endokrynologia 26:4, pages 357-365.
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Мaryana М. Rоsul, Мiroslava М. Bletskan, Nataliya V. Ivano, Marina O. Korabelschykova & Yelyzaveta І. Rubtsova. (2020) PRIORITIES OF ANTI-HYPERGLYCAEMIC DRUG THERAPY IN PATIENTS WITH TYPE 2 DIABETES AND HEART FAILURE. Wiadomości Lekarskie 73:3, pages 609-613.
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Stefan D. Anker & Javed Butler. (2018) Empagliflozin, calcium, and SGLT1/2 receptor affinity: another piece of the puzzle. ESC Heart Failure 5:4, pages 549-551.
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Anderson R. Aguillón, Alessandra Mascarello, Natanael D. Segretti, Hatylas F. Z de Azevedo, Cristiano R. W. Guimaraes, Leandro S. M. Miranda & Rodrigo O. M. A. de Souza. (2018) Synthetic Strategies toward SGLT2 Inhibitors. Organic Process Research & Development 22:4, pages 467-488.
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Anna Sadurní, Gerald Kehr, Marie Ahlqvist, Johan Wernevik, Helena Peilot Sjögren, Cecilia Kankkonen, Laurent Knerr & Ryan Gilmour. (2018) Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes. Chemistry - A European Journal 24:12, pages 2832-2836.
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Yao Li, Zongjun Shi, Lei Chen, Suxin Zheng, Sheng Li, Bo Xu, Zhenhong Liu, Jianyu Liu, Chongyang Deng & Fei Ye. (2017) Discovery of a Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor (HSK0935) for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry 60:10, pages 4173-4184.
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Nicole C. Goodwin, Zhi-Ming Ding, Bryce A. Harrison, Eric D. Strobel, Angela L. Harris, Melinda Smith, Andrea Y. Thompson, Wendy Xiong, Faika Mseeh, Debra J. Bruce, Damaris Diaz, Suma Gopinathan, Ling Li, Emily O’Neill, Mary Thiel, Alan G. E. Wilson, Kenneth G. Carson, David R. Powell & David B. Rawlins. (2017) Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes. Journal of Medicinal Chemistry 60:2, pages 710-721.
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S. Mishra, A.S. Singh, N. Mishra, H. Pandey & V.K. Tiwari. 2017. Discovery and Development of Antidiabetic Agents from Natural Products. Discovery and Development of Antidiabetic Agents from Natural Products 147 183 .
Yukihiro Bando, Hitomi Tohyama, Keiko Aoki, Hideo Kanehara, Azusa Hisada, Kazuhiro Okafuji & Daisyu Toya. (2016) Ipragliflozin lowers small, dense low-density lipoprotein cholesterol levels in Japanese patients with type 2 diabetes mellitus. Journal of Clinical & Translational Endocrinology 6, pages 1-7.
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Prachi Gupta, Manju Bala, Sanjeev Gupta, Anita Dua, Rajesh Dabur, Elisha Injeti & Ashwani Mittal. (2016) Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs—A mechanistic revisit to understand their mode of action. Pharmacological Research 113, pages 636-674.
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Preeti Arora, Rakesh Narang, Surendra Kumar Nayak, Sachin Kumar Singh & Vikramjeet Judge. (2016) 2,4-Disubstituted thiazoles as multitargated bioactive molecules. Medicinal Chemistry Research 25:9, pages 1717-1743.
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Qi Yan, Ning Ding & Yingxia Li. (2016) Synthesis and biological evaluation of novel dioxa-bicycle C-aryl glucosides as SGLT2 inhibitors. Carbohydrate Research 421, pages 1-8.
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Chiho Yamamoto, Hideaki Miyoshi, Kota Ono, Hajime Sugawara, Reina Kameda, Mei Ichiyama, Kohei Yamamoto, Hiroshi Nomoto, Akinobu Nakamura & Tatsuya Atsumi. (2016) Ipragliflozin effectively reduced visceral fat in Japanese patients with type 2 diabetes under adequate diet therapy. Endocrine Journal 63:6, pages 589-596.
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Toshiyuki Takasu, Shoji Takakura & Kaori Hamada. (2016) Visualization of mechanism of action, and a further therapeutic potential of ipragliflozin, a selective SGLT2 inhibitor. Folia Pharmacologica Japonica 148:5, pages 266-271.
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Madhu Babu Tatina, Anil Kumar Kusunuru & Debaraj Mukherjee. (2015) Organo-zinc Promoted Diastereoselective C -Arylation of 1,2-Anhydrosugars from Arylboronic Acids . Organic Letters 17:18, pages 4624-4627.
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Yuyang Ding, Liufeng Mao, Dengfeng Xu, Hui Xie, Ling Yang, Hongjiang Xu, Wenjun Geng, Yong Gao, Chunguang Xia, Xiquan Zhang, Qingyi Meng, Donghai Wu, Junling Zhao & Wenhui Hu. (2015) C-Aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents. Bioorganic & Medicinal Chemistry Letters 25:14, pages 2744-2748.
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Julian P. Henschke, Chen-Wei Lin, Ping-Yu Wu, Wen-Shing Tsao, Jyh-Hsiung Liao & Pei-Chen Chiang. (2015) β-Selective C -Arylation of Diisobutylaluminum Hydride Modified 1,6-Anhydroglucose: Synthesis of Canagliflozin without Recourse to Conventional Protecting Groups . The Journal of Organic Chemistry 80:10, pages 5189-5195.
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John R. WhiteJrJr. (2015) Empagliflozin, an SGLT2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. Annals of Pharmacotherapy 49:5, pages 582-598.
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Julian P. Henschke, Ping-Yu Wu, Chen-Wei Lin, Shi-Feng Chen, Pei-Chen Chiang & Chi-Nung Hsiao. (2015) β-Selective C -Arylation of Silyl Protected 1,6-Anhydroglucose with Arylalanes: The Synthesis of SGLT2 Inhibitors . The Journal of Organic Chemistry 80:4, pages 2295-2309.
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Toshiyuki Takasu, Shoji Takakura & Seiji Kaku. (2015) Pharmacological and clinical profile of ipragliflozin (Suglat®): a new therapeutic agent for type 2 diabetes. Folia Pharmacologica Japonica 145:1, pages 36-42.
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Priyanka Malla, Rajnish Kumar, Manoj K. Mahapatra & Manoj Kumar. (2014) Ramping Glucosuria for Management of Type 2 Diabetes Mellitus: An Emerging Cynosure. Medicinal Research Reviews 34:6, pages 1146-1167.
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Atsunori Kashiwagi, Kenichi Kazuta, Satoshi Yoshida & Itsuro Nagase. (2013) Randomized, placebo‐controlled, double‐blind glycemic control trial of novel sodium‐dependent glucose cotransporter 2 inhibitor ipragliflozin in Japanese patients with type 2 diabetes mellitus. Journal of Diabetes Investigation 5:4, pages 382-391.
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Timothy P. Reilly, Michael J. Graziano, Evan B. Janovitz, Thomas E. Dorr, Craig Fairchild, Francis Lee, Jian Chen, Tai Wong, Jean M. Whaley & Mark Tirmenstein. (2014) Carcinogenicity Risk Assessment Supports the Chronic Safety of Dapagliflozin, an Inhibitor of Sodium–Glucose Co-Transporter 2, in the Treatment of Type 2 Diabetes Mellitus. Diabetes Therapy 5:1, pages 73-96.
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Janet C. Gould, Sreeneeranj Kasichayanula, David C. Shepperly & David W. Boulton. (2013) Use of low-dose clinical pharmacodynamic and pharmacokinetic data to establish an occupational exposure limit for dapagliflozin, a potent inhibitor of the renal sodium glucose co-transporter 2. Regulatory Toxicology and Pharmacology 67:1, pages 89-97.
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Shawn Riser Taylor & Kira B. Harris. (2013) The Clinical Efficacy and Safety of Sodium Glucose Cotransporter-2 Inhibitors in Adults with Type 2 Diabetes Mellitus. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 33:9, pages 984-999.
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Eiji Kurosaki & Hideaki Ogasawara. (2013) Ipragliflozin and other sodium–glucose cotransporter-2 (SGLT2) inhibitors in the treatment of type 2 diabetes: Preclinical and clinical data. Pharmacology & Therapeutics 139:1, pages 51-59.
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Debbie Hinnen. (2013) The Role of the Kidney in Hyperglycemia. Journal of Cardiovascular Nursing 28:2, pages 157-165.
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Brian Zambrowicz, Zhi-Ming Ding, Ike Ogbaa, Kenny Frazier, Phillip Banks, Anne Turnage, Joel Freiman, Melinda Smith, Dennis Ruff, Arthur Sands & David Powell. (2013) Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes. Clinical Therapeutics 35:3, pages 273-285.e7.
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Vincent Mascitti, Benjamin A. Thuma, Aaron C. Smith, Ralph P. Robinson, Thomas Brandt, Amit S. Kalgutkar, Tristan S. Maurer, Brian Samas & Raman Sharma. (2013) On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin. MedChemComm 4:1, pages 101-111.
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Chun-Hsu Yao, Jen-Shin Song, Chiung-Tong Chen, Teng-Kuang Yeh, Tsung-Chih Hsieh, Szu-Huei Wu, Chung-Yu Huang, Yu-Lin Huang, Min-Hsien Wang, Yu-Wei Liu, Chi-Hui Tsai, Chidambaram Ramesh Kumar & Jinq-Chyi Lee. (2012) Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors. European Journal of Medicinal Chemistry 55, pages 32-38.
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G. Luippold, T. Klein, M. Mark & R. Grempler. (2012) Empagliflozin, a novel potent and selective SGLT‐2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin‐induced diabetic rats, a model of type 1 diabetes mellitus. Diabetes, Obesity and Metabolism 14:7, pages 601-607.
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Chunlei Tang, Xiaoyun Zhu, Dandan Huang, Xin Zan, Baowei Yang, Ying Li, Xiaoyong Du, Hai Qian & Wenlong Huang. (2011) A specific pharmacophore model of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Journal of Molecular Modeling 18:6, pages 2795-2804.
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Shinji Sakuma, Shun Kanamitsu, Yumi Teraoka, Yoshie Masaoka, Makoto Kataoka, Shinji Yamashita, Yoshiyuki Shirasaka, Ikumi Tamai, Masahiro Muraoka, Yohji Nakatsuji, Toshiyuki Kida & Mitsuru Akashi. (2012) Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na + /Glucose Cotransporter 1 (SGLT1)-Mediated d -Glucose Uptake . Molecular Pharmaceutics 9:4, pages 922-929.
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