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Patent Evaluations

mGluR4 positive allosteric modulators with potential for the treatment of Parkinson's disease: WO09010455

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Pages 441-445 | Published online: 24 Feb 2010

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Anna Stankiewicz, Katarzyna Kaczorowska, Ryszard Bugno, Aneta Kozioł, Maria H. Paluchowska, Grzegorz Burnat, Barbara Chruścicka, Paulina Chorobik, Piotr Brański, Joanna M. Wierońska, Beata Duszyńska, Andrzej Pilc & Andrzej J. Bojarski. (2022) New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 211-225.
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Dario Doller, Anton Bespalov, Rob Miller, Malgorzata Pietraszek & Mikhail Kalinichev. (2020) A case study of foliglurax, the first clinical mGluR4 PAM for symptomatic treatment of Parkinson’s disease: translational gaps or a failing industry innovation model?. Expert Opinion on Investigational Drugs 29:12, pages 1323-1338.
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Mojgan Oshaghi, Masoumeh Kourosh-Arami & Maryam Roozbehkia. (2022) Role of neurotransmitters in immune-mediated inflammatory disorders: a crosstalk between the nervous and immune systems. Neurological Sciences 44:1, pages 99-113.
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Karen J. Gregory & Cyril Goudet. (2020) International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors. Pharmacological Reviews 73:1, pages 521-569.
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Dario Doller & Xinyan Huang. 2016. Allosterism in Drug Discovery. Allosterism in Drug Discovery 1 23 .
Lucyna Pomierny-Chamioło, Kinga Rup, Bartosz Pomierny, Ewa Niedzielska, Peter W. Kalivas & Małgorzata Filip. (2014) Metabotropic glutamatergic receptors and their ligands in drug addiction. Pharmacology & Therapeutics 142:3, pages 281-305.
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James Bogenpohl, Adriana Galvan, Xing Hu, Thomas Wichmann & Yoland Smith. (2013) Metabotropic glutamate receptor 4 in the basal ganglia of parkinsonian monkeys: Ultrastructural localization and electrophysiological effects of activation in the striatopallidal complex. Neuropharmacology 66, pages 242-252.
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Karen J. Gregory, Meredith J. Noetzel & Colleen M. Niswender. 2013. Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors. Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors 61 121 .
Emmanuel Le Poul, Christelle Boléa, Francoise Girard, Sonia Poli, Delphine Charvin, Brice Campo, Julien Bortoli, Abdhelak Bessif, Bin Luo, Amy Jo Koser, Lisa M. Hodge, Karen M. Smith, Anthony G. DiLella, Nigel Liverton, Fred Hess, Susan E. Browne & Ian J. Reynolds. (2012) A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease. Journal of Pharmacology and Experimental Therapeutics 343:1, pages 167-177.
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Albert J. Robichaud, Darren W. Engers, Craig W. Lindsley & Corey R. Hopkins. (2011) Recent Progress on the Identification of Metabotropic Glutamate 4 Receptor Ligands and Their Potential Utility as CNS Therapeutics. ACS Chemical Neuroscience 2:8, pages 433-449.
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Stephan Urwyler. (2011) Allosteric Modulation of Family C G-Protein-Coupled Receptors: from Molecular Insights to Therapeutic Perspectives. Pharmacological Reviews 63:1, pages 59-126.
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Anna M Hansen & Rachel R Caspi. (2010) Glutamate joins the ranks of immunomodulators. Nature Medicine 16:8, pages 856-858.
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Stephen P. East, Samantha Bamford, Matthias G.A. Dietz, Christian Eickmeier, Adam Flegg, Boris Ferger, Mark J. Gemkow, Ralf Heilker, Bastian Hengerer, Adrian Kotey, Pui Loke, Gerhard Schänzle, Hans-Dieter Schubert, John Scott, Mark Whittaker, Mildred Williams, Przemyslaw Zawadzki & Kai Gerlach. (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorganic & Medicinal Chemistry Letters 20:16, pages 4901-4905.
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