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Inhibitors of cathepsin C (dipeptidyl peptidase I)

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Pages 497-506 | Published online: 08 Mar 2010

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Holly R Keir, Christopher J Fong, Alison J Dicker & James D Chalmers. (2017) Profile of the ProAxsis active neutrophil elastase immunoassay for precision medicine in chronic respiratory disease. Expert Review of Molecular Diagnostics 17:10, pages 875-884.
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Melisa Bunderson-Schelvan, Andrij Holian & Raymond F. Hamilton$suffix/text()$suffix/text(). (2017) Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. Journal of Toxicology and Environmental Health, Part B 20:4, pages 230-248.
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Articles from other publishers (35)

Jonathan Maurer, Eric Grouzmann & Philippe J. Eugster. (2023) Tutorial review for peptide assays: An ounce of pre-analytics is worth a pound of cure. Journal of Chromatography B 1229, pages 123904.
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Isma Gul, Muhammad Nadeem Abbas, Saima Kausar, Jili Luo, Xinyue Gao, Yuhang Mu, Wenhui Fan & Honghuan Cui. (2023) Insight into crustacean cathepsins: Structure-evolutionary relationships and functional roles in physiological processes. Fish & Shellfish Immunology 139, pages 108852.
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Milena Stojkovska Docevska & Marko Novinec. (2023) Cathepsin C: structure, function, and pharmacological targeting. Rare Disease and Orphan Drugs Journal 2:3.
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Nora Tromsdorf, Fabian T. H. Ullrich, Markus Rethmeier, Christian P. Sommerhoff & Norbert Schaschke. (2023) E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area. ChemMedChem.
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Jessica Basso, Kuan-Ju Chen, Yuchen Zhou, Lilly Mark, Daniel LaSala, Arielle Dorfman, Mary Atalla, Donald Chun, Veronica Viramontes, Christina Chang, Franziska Leifer, Patrick P. McDonald & David C. Cipolla. (2023) The pharmacokinetic profile of brensocatib and its effect on pharmacodynamic biomarkers including NE, PR3, and CatG in various rodent species. Frontiers in Pharmacology 14.
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Abhisek Banerjee, Ranganadh Velagaleti, Sandip Patil, Mahesh Pawar, Pravin Yadav, Pradip Kadam, Mohammad Mohsin Qadri, Samitabh Chakraborti, Jagmohan S. Saini, Dayanidhi B. Behera, Keya Karanjai, Pravin S. Iyer, Laxmikant A. Gharat & Sanjib Das. (2021) Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy. Bioorganic & Medicinal Chemistry Letters 47, pages 128202.
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Brice Korkmaz, Adam Lesner, Sylvain Marchand-Adam, Celia MossDieter E. Jenne. (2020) Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?. Journal of Medicinal Chemistry 63:22, pages 13258-13265.
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Mateja Rebernik, Tina Snoj, Marina Klemenčič & Marko Novinec. (2019) Interplay between tetrameric structure, enzymatic activity and allosteric regulation of human dipeptidyl-peptidase I. Archives of Biochemistry and Biophysics 675, pages 108121.
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Helena Käck, Kevin DoyleSamantha J. HughesMichael S. Bodnarchuk, Hans Lönn, Amanda Van De PoëlNicholas Palmer. (2019) DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines. ACS Medicinal Chemistry Letters 10:8, pages 1222-1227.
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Weijie Hou, Huan Sun, Yongfen Ma, Chunyan Liu & Zhiyuan Zhang. (2019) Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors. Journal of Medicinal Chemistry 62:12, pages 5901-5919.
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Tejinder Pal Khaket, Taeg Kyu Kwon & Sun Chul Kang. (2019) Cathepsins: Potent regulators in carcinogenesis. Pharmacology & Therapeutics 198, pages 1-19.
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Brice Korkmaz, Adam Lesner, Magdalena Wysocka, Artur Gieldon, Maria Håkansson, Francis Gauthier, Derek T. Logan, Dieter E. Jenne, Conni Lauritzen & John Pedersen. (2019) Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C. Biochemical Pharmacology 164, pages 349-367.
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Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren & Nalin S. Thakker. (2018) Therapeutic targeting of cathepsin C: from pathophysiology to treatment. Pharmacology & Therapeutics 190, pages 202-236.
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Natasja Stæhr Gudmann, Tina Manon-Jensen, Jannie Marie Bülow Sand, Claudia Diefenbach, Shu Sun, Annette Danielsen, Morten Asser Karsdal & Diana Julie Leeming. (2018) Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease. Biochemical and Biophysical Research Communications 503:3, pages 1284-1290.
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Vladimir V. Kouznetsov & Carlos E. Puerto Galvis. (2018) Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties. Tetrahedron 74:8, pages 773-810.
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Louis J. Dell’ItaliaJames F. CollawnCarlos M. Ferrario. (2018) Multifunctional Role of Chymase in Acute and Chronic Tissue Injury and Remodeling. Circulation Research 122:2, pages 319-336.
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Paweł Lenartowicz, Maciej Makowski, Bartosz Oszywa, Kinga Haremza, Rafał Latajka, Małgorzata Pawełczak & Paweł Kafarski. (2017) Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C. Biochimie 139, pages 46-55.
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Chun-Jun Guo, Fang-Yuan Chang, Thomas P. Wyche, Keriann M. Backus, Timothy M. Acker, Masanori Funabashi, Mao Taketani, Mohamed S. Donia, Stephen Nayfach, Katherine S. Pollard, Charles S. Craik, Benjamin F. Cravatt, Jon Clardy, Christopher A. Voigt & Michael A. Fischbach. (2017) Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell 168:3, pages 517-526.e18.
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Kevin DoyleHans Lönn, Helena Käck, Amanda Van de PoëlSteve SwallowPhilip Gardiner, Stephen Connolly, James Root, Cecilia Wikell, Göran Dahl, Kristina Stenvall & Petra Johannesson. (2016) Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). Journal of Medicinal Chemistry 59:20, pages 9457-9472.
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Tejinder Pal Khaket, Suman Dhanda, Drukshakshi Jodha & Jasbir Singh. (2016) Biochemical studies on dipeptidyl peptidase I (cathepsin C) from germinated Vigna radiata seeds. Process Biochemistry 51:8, pages 1015-1027.
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Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier & Brice Korkmaz. (2016) Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases. Journal of Biological Chemistry 291:16, pages 8486-8499.
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Piotr Szcześniak, Michał Pieczykolan & Sebastian Stecko. (2016) The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. The Journal of Organic Chemistry 81:3, pages 1057-1074.
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Huan SunYan Ren, Weijie HouLin Li, Fanqi Zeng, Sisi Li, Yongfen Ma, Xiao Liu, She Chen & Zhiyuan Zhang. (2016) Focusing on probe-modified peptides: a quick and effective method for target identification. Chemical Communications 52:67, pages 10225-10228.
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Maciej Makowski, Paweł Lenartowicz, Bartosz Oszywa, Michał Jewgiński, Małgorzata Pawełczak & Paweł Kafarski. (2015) Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C. Medicinal Chemistry Research 24:8, pages 3157-3165.
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Wilko Duprez, Lakshmanane Premkumar, Maria A. Halili, Fredrik Lindahl, Robert C. Reid, David P. Fairlie & Jennifer L. Martin. (2014) Peptide Inhibitors of the Escherichia coli DsbA Oxidative Machinery Essential for Bacterial Virulence . Journal of Medicinal Chemistry 58:2, pages 577-587.
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Mark Furber, Anna-Karin Tiden, Philip Gardiner, Antonio Mete, Rhonan Ford, Ian Millichip, Linda Stein, Andrew Mather, Elizabeth Kinchin, Christopher Luckhurst, Simon Barber, Peter Cage, Hitesh Sanganee, Rupert Austin, Kamaldeep Chohan, Raj Beri, Bob Thong, Alan Wallace, Victor Oreffo, Ray Hutchinson, Steve Harper, Judit Debreczeni, Jason Breed, Lisa Wissler & Karl Edman. (2014) Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate. Journal of Medicinal Chemistry 57:6, pages 2357-2367.
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Alejandro A. Schäffer & Christoph Klein. (2013) Animal Models of Human Granulocyte Diseases. Hematology/Oncology Clinics of North America 27:1, pages 129-148.
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Boris Turk, Dusan Turk, Iztok Dolenc & Vito Turk. 2013. Handbook of Proteolytic Enzymes. Handbook of Proteolytic Enzymes 1968 1974 .
Jon K. Rubach, Guanglei Cui, Jessica L. Schneck, Amy N. Taylor, Baoguang Zhao, Angela Smallwood, Neysa Nevins, David Wisnoski, Sara H. Thrall & Thomas D. Meek. (2012) The Amino-Acid Substituents of Dipeptide Substrates of Cathepsin C Can Determine the Rate-Limiting Steps of Catalysis. Biochemistry 51:38, pages 7551-7568.
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Mark C. Noe & Adam M. Gilbert. 2012. Annual Reports in Medicinal Chemistry Volume 47. Annual Reports in Medicinal Chemistry Volume 47 413 439 .
Stephen Foreman, Joseph Kilsdonk, Kelly Boggs, Wendy E. Mouradian, Suzanne Boulter, Paul Casamassimo, Valerie J. H. Powell, Beth Piraino, Wells Shoemaker, Jessica Kovarik, Evan(Jake) Waxman, Biju Cheriyan, Henry Hood, Allan G. Farman, Matthew Holder, Miguel Humberto Torres-Urquidy, Muhammad F. Walji, Amit Acharya, Andrea Mahnke, Po-Huang Chyou, Franklin M. Din & Steven J. Schrodi. 2012. Integration of Medical and Dental Care and Patient Data. Integration of Medical and Dental Care and Patient Data 167 298 .
Wei Yang, Wenjuan Xia, Jingjing Mao, Daqi Xu, Jianhe Chen, Shan Feng, Jianhua Wang, Hua Li, Claus Friis Theisen, Jørn Meidahl Petersen, Matthías Thórólfsson, Hanne Benedicte Rasmussen, Flemming Junker, Esper Boel & Jing Su. (2011) High level expression, purification and activation of human dipeptidyl peptidase I from mammalian cells. Protein Expression and Purification 76:1, pages 59-64.
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Dramane Lainé, Michael Palovich, Brent McCleland, Emilie Petitjean, Isabelle Delhom, Haibo Xie, Jianghe Deng, Guoliang Lin, Roderick Davis, Anais Jolit, Neysa Nevins, Baoguang Zhao, Jim Villa, Jessica Schneck, Patrick McDevitt, Robert Midgett, Casey Kmett, Sandra Umbrecht, Brian Peck, Alicia Bacon Davis & David Bettoun. (2010) Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C. ACS Medicinal Chemistry Letters 2:2, pages 142-147.
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Bob Thong, James Pilling, Edward Ainscow, Raj Beri & John Unitt. (2011) Development and Validation of a Simple Cell-Based Fluorescence Assay for Dipeptidyl Peptidase 1 (DPP1) Activity. SLAS Discovery 16:1, pages 36-43.
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Jun ZhongSarah A. KrawczykRaghothama ChaerkadyHailiang HuangRenu GoelJoel S. BaderG. William WongBarbara E. CorkeyAkhilesh Pandey. (2010) Temporal Profiling of the Secretome during Adipogenesis in Humans. Journal of Proteome Research 9:10, pages 5228-5238.
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