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P2X purinergic receptor ligands: recently patented compounds

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Pages 625-646 | Published online: 08 Mar 2010

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Praveen PN Rao & Tarek Mohamed. (2011) Current and emerging “at-site” pain medications: a review. Journal of Pain Research 4, pages 279-286.
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Shi-qi Hu, Jia-ling Hu, Fei-long Zou, Ji-peng Liu, Hong-liang Luo, Dong-xia Hu, Li-dong Wu & Wen-jun Zhang. (2022) P2X7 receptor in inflammation and pain. Brain Research Bulletin 187, pages 199-209.
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Abid Mahmood & Jamshed Iqbal. (2022) Purinergic receptors modulators: An emerging pharmacological tool for disease management. Medicinal Research Reviews 42:4, pages 1661-1703.
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Abtar Mishra, Assirbad Behura, Ashish Kumar, Lincoln Naik, Ashapoorna Swain, Mousumi Das, Suman Sudha Sarangi, Puja Dokania, Vijaya R. Dirisala, Sujit K. Bhutia, Amit Mishra, Ramandeep Singh & Rohan Dhiman. (2021) P2X7 receptor in multifaceted cellular signalling and its relevance as a potential therapeutic target in different diseases. European Journal of Pharmacology 906, pages 174235.
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Zihao Li, Ziyu Huang & Lunhao Bai. (2021) The P2X7 Receptor in Osteoarthritis. Frontiers in Cell and Developmental Biology 9.
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Mitch Mathiew, Belinda M Dennis, Felix Bennetts, N N Eunice Su, Nghi Nguyen, Antony Botteon, Jonathan B Baell & Sabatino Ventura. (2020) Synthesis of 2-phenyl-5,6,7,8-tetrahydroquinoxaline derivatives and screening for P2X1-purinoceptor antagonist activity in isolated preparations of rat vas deferens, for translation into a male contraceptive†. Biology of Reproduction 103:2, pages 323-332.
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Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio & Shaun McNulty. (2020) P2X7 in Cancer: From Molecular Mechanisms to Therapeutics. Frontiers in Pharmacology 11.
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Wen-jun Zhang, Zheng-ming Zhu & Zeng-xu Liu. (2020) The role and pharmacological properties of the P2X7 receptor in neuropathic pain. Brain Research Bulletin 155, pages 19-28.
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Giorgia Scarpellino, Tullio Genova & Luca Munaron. (2019) Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment. Recent Patents on Anti-Cancer Drug Discovery 14:1, pages 32-38.
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Yu. A. Palikova, L. A. Skobtsova, T. Yu. Zharmukhamedova, V. A. Palikov, V. B. Rudenko, O. N. Khokhlova, A. V. Lobanov, D. I. Rzhevskii, G. A. Slashcheva, E. V. D’yachenko, G. I. Belous, Ya. A. Andreev, Yu. A. Logashina, S. A. Kozlov, A. N. Yavorskii, E. G. Elyakova & I. A. D’yachenko. (2018) Influence of New Promising Analgesic Compounds on Locomotor Activity of Mice. Pharmaceutical Chemistry Journal 52:8, pages 700-703.
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Yu. A. Palikova, L. A. Skobtsova, V. A. Palikov, G. I. Belous, O. N. Khokhlova, A. V. Lobanov, G. A. Slashcheva, D. I. Rzhevskii, V. B. Rudenko, E. A. Kalabina, G. A. Osipova, Ya. A. Andreev, Yu. A. Logashina, S. A. Kozlov, A. N. Yavorskii, G. Elyakova & I. A. D’yachenko. (2018) Effects of Novel Potential Analgesic Compounds on the Cardiovascular and Respiratory Systems. Pharmaceutical Chemistry Journal 52:7, pages 593-595.
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Francesco Di Virgilio, Diego Dal Ben, Alba Clara Sarti, Anna Lisa Giuliani & Simonetta Falzoni. (2017) The P2X7 Receptor in Infection and Inflammation. Immunity 47:1, pages 15-31.
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Wei Wang, Xiaosong Yi, Yanfang Ren & Qiufei Xie. (2016) Effects of Adenosine Triphosphate on Proliferation and Odontoblastic Differentiation of Human Dental Pulp Cells. Journal of Endodontics 42:10, pages 1483-1489.
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Kenneth A. Jacobson & Christa E. Müller. (2016) Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology 104, pages 31-49.
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Manju Tewari & Pankaj Seth. (2015) Emerging role of P2X7 receptors in CNS health and disease. Ageing Research Reviews 24, pages 328-342.
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Charline Giroud, Mariana Marin, Jason Hammonds, Paul Spearman & Gregory B. Melikyan. (2015) P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. Journal of Virology 89:18, pages 9368-9382.
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Francesca GrazianoMarion DesdouitsLivia GarzettiPaola PodiniMassimo AlfanoAnna RubartelliRoberto FurlanPhilippe BenarochGuido Poli. (2015) Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proceedings of the National Academy of Sciences 112:25.
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Rômulo José Soares-Bezerra, Natiele Carla da Silva Ferreira, Anael Viana Pinto Alberto, André Gustavo Bonavita, Antônio Augusto Fidalgo-Neto, Andrea Surrage Calheiros, Valber da Silva Frutuoso & Luiz Anastacio Alves. (2015) An Improved Method for P2X7R Antagonist Screening. PLOS ONE 10:5, pages e0123089.
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Yanli Yan, Jianwen BaiXiaoxu Zhou, Jinhua Tang, Chunming Jiang, Evelyn Tolbert, George Bayliss, Rujun Gong, Ting C. Zhao & Shougang Zhuang. (2015) P2X7 receptor inhibition protects against ischemic acute kidney injury in mice. American Journal of Physiology-Cell Physiology 308:6, pages C463-C472.
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Robin Ortiz, Henning Ulrich, Carlos A. ZarateJr.Jr. & Rodrigo Machado-Vieira. (2015) Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics. Progress in Neuro-Psychopharmacology and Biological Psychiatry 57, pages 117-131.
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Vaskar Das. 2015. Molecular and Cell Biology of Pain. Molecular and Cell Biology of Pain 1 30 .
Talia H. Swartz, Anthony M. Esposito, Natasha D. Durham, Boris M. Hartmann & Benjamin K. Chen. (2014) P2X-Selective Purinergic Antagonists Are Strong Inhibitors of HIV-1 Fusion during both Cell-to-Cell and Cell-Free Infection. Journal of Virology 88:19, pages 11504-11515.
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Rachael Bartlett, Leanne Stokes & Ronald Sluyter. (2014) The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews 66:3, pages 638-675.
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Fernando Ochoa-Cortes, Andromeda Liñán-Rico, Kenneth A. Jacobson & Fievos L. Christofi. (2014) Potential for Developing Purinergic Drugs for Gastrointestinal Diseases. Inflammatory Bowel Diseases 20:7, pages 1259-1287.
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Bieneke Janssen, Danielle J. Vugts, Uta Funke, Arnold Spaans, Robert C. Schuit, Esther Kooijman, Marissa Rongen, Lars R. Perk, Adriaan A. Lammertsma & Albert D. Windhorst. (2014) Synthesis and initial preclinical evaluation of the P2X 7 receptor antagonist [ 11 C]A-740003 as a novel tracer of neuroinflammation . Journal of Labelled Compounds and Radiopharmaceuticals 57:8, pages 509-516.
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Wolfgang Fischer, Nicole Urban, Kerstin Immig, Heike Franke & Michael Schaefer. (2013) Natural compounds with P2X7 receptor-modulating properties. Purinergic Signalling 10:2, pages 313-326.
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Maoqun Tian, Aliaa Abdelrahman, Stephanie Weinhausen, Sonja Hinz, Stefanie Weyer, Stefan Dosa, Ali El-Tayeb & Christa E. Müller. (2014) Carbamazepine derivatives with P2X4 receptor-blocking activity. Bioorganic & Medicinal Chemistry 22:3, pages 1077-1088.
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Lisa E. Wickert, Joshua B. Blanchette, Noelle V. Waldschmidt, Paul J. Bertics, John M. Denu, Loren C. Denlinger & Lisa Y. Lenertz. (2013) The C-Terminus of Human Nucleotide Receptor P2X7 Is Critical for Receptor Oligomerization and N-Linked Glycosylation. PLoS ONE 8:5, pages e63789.
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Rômulo Soares-Bezerra, Andrea Calheiros, Natiele da Silva Ferreira, Valber da Silva Frutuoso & Luiz Alves. (2013) Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors. Pharmaceuticals 6:5, pages 650-658.
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