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Patent Evaluation

Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase

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Pages 849-853 | Published online: 07 Mar 2010

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David A Powell. (2014) An overview of patented small molecule stearoyl coenzyme-A desaturase inhibitors (2009 – 2013). Expert Opinion on Therapeutic Patents 24:2, pages 155-175.
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Articles from other publishers (7)

Adriana Mika, Lukasz Kaska, Justyna Korczynska, Agnieszka Mirowska, Piotr Stepnowski, Monika Proczko, Krzysztof Ratnicki‐Sklucki, Elzbieta Goyke & Tomasz Sledzinski. (2015) Visceral and subcutaneous adipose tissue stearoyl‐CoA desaturase‐1 mRNA levels and fatty acid desaturation index positively correlate with BMI in morbidly obese women. European Journal of Lipid Science and Technology 117:7, pages 926-932.
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Hans Matter, Gerhard Zoller, Andreas W. Herling, Juan-Antonio Sanchez-Arias, Christophe Philippo, Claudie Namane, Markus Kohlmann, Anja Pfenninger & Marc D. Voss. (2013) Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization. Bioorganic & Medicinal Chemistry Letters 23:6, pages 1817-1822.
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Nicolas Lachance, Yves Gareau, Sébastien Guiral, Zheng Huang, Elise Isabel, Jean-Philippe Leclerc, Serge Léger, Evelyn Martins, Christian Nadeau, Renata M. Oballa, Stéphane G. Ouellet, David A. Powell, Yeeman K. Ramtohul, Geoffrey K. Tranmer, Thao Trinh, Hao Wang & Lei Zhang. (2012) Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorganic & Medicinal Chemistry Letters 22:2, pages 980-984.
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Nicolas Lachance, Sébastien Guiral, Zheng Huang, Jean-Philippe Leclerc, Chun Sing Li, Renata M. Oballa, Yeeman K. Ramtohul, Hao Wang, Jin Wu & Lei Zhang. (2012) Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorganic & Medicinal Chemistry Letters 22:1, pages 623-627.
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David A. Powell, W. Cameron Black, Kelly Bleasby, Chi-Chung Chan, Denis Deschenes, Marc Gagnon, Rob Gordon, Jocelyne Guay, Sebastien Guiral, Michael J. Hafey, Zheng Huang, Elise Isabel, Yves Leblanc, Angela Styhler, Li-Jing Xu, Lei Zhang & Renata M. Oballa. (2011) Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy. Bioorganic & Medicinal Chemistry Letters 21:24, pages 7281-7286.
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Jean-Philippe Leclerc, Jean-Pierre Falgueyret, Mélina Girardin, Jocelyne Guay, Sébastien Guiral, Zheng Huang, Chun Sing Li, Renata Oballa, Yeeman K. Ramtohul, Kathryn Skorey, Paul Tawa, Hao Wang & Lei Zhang. (2011) Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors. Bioorganic & Medicinal Chemistry Letters 21:21, pages 6505-6509.
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David A. Powell, Yeeman Ramtohul, Marie-Eve Lebrun, Renata Oballa, Sathesh Bhat, Jean-Pierre Falgueyret, Sebastien Guiral, Zheng Huang, Kathryn Skorey, Paul Tawa & Lei Zhang. (2010) 2-Aryl benzimidazoles: Human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorganic & Medicinal Chemistry Letters 20:22, pages 6366-6369.
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