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Review

New inhibitors of p38 kinase

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Pages 25-37 | Published online: 25 Feb 2005

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P. Singh & B. K. Sharma. (2007) Quantitative structure-activity relationship study of benzylsulfanyl imidazoles as cytokine release inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 22:1, pages 15-21.
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Peter Norman. (2006) Allosteric p38 kinase inhibitors. Expert Opinion on Therapeutic Patents 16:10, pages 1443-1448.
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Jeffrey Boehm. (2005) 5-Amino-2-carbonylthiophene derivatives for use as p38 MAPK inhibitors in the treatment of inflammatory diseases. Expert Opinion on Therapeutic Patents 15:10, pages 1471-1476.
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Celia Dominguez, Nuria Tamayo & Dawei Zhang. (2005) p38 Inhibitors: beyond pyridinylimidazoles. Expert Opinion on Therapeutic Patents 15:7, pages 801-816.
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. (2003) Novel 8-benzoylimidazo[1,2-a] pyridin-5-one mitogen-activated protein kinase inhibitors. Expert Opinion on Therapeutic Patents 13:10, pages 1663-1666.
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. (2001) Amide derivatives useful for the treatment of diseases mediated by cytokines. Expert Opinion on Therapeutic Patents 11:9, pages 1471-1473.
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Jacques Dumas. (2001) Protein kinase inhibitors: emerging pharmacophores 1997 - 2000. Expert Opinion on Therapeutic Patents 11:3, pages 405-429.
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Peter Norman. (2001) Therapeutic approaches to respiratory diseases excluding asthma:Trends from the patent literature 1997 - 2000. Expert Opinion on Therapeutic Patents 11:2, pages 307-322.
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. (2000) Amide derivatives as cytokine inhibitors. Expert Opinion on Therapeutic Patents 10:9, pages 1451-1454.
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. (2000) A novel adenosine receptor pharmacophore. Expert Opinion on Therapeutic Patents 10:5, pages 729-732.
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Sana Tariq, Ozair Alam & Mohammad Amir. (2018) Synthesis, p38α MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines. Archiv der Pharmazie 351:3-4, pages 1700304.
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Dijana Pešić, Ivana Ozimec Landek, Ana Čikoš, Biserka Metelko, Vesna Gabelica, Barbara Stanić, Mladen Merćep & Milan Mesić. (2009) Synthesis of 2‐formyl‐1‐aza‐dibenzo[ e , h ]azulenes . Journal of Heterocyclic Chemistry 44:5, pages 1129-1133.
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Robert SolivaJosep Lluis GelpíCarmen AlmansaMarina VirgiliModesto Orozco. (2006) Dissection of the Recognition Properties of p38 MAP Kinase. Determination of the Binding Mode of a New Pyridinyl−Heterocycle Inhibitor Family. Journal of Medicinal Chemistry 50:2, pages 283-293.
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M.J. Elices & T. Arrhenius. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 969 985 .
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Pooja Sharma & Nanda Ghoshal. (2006) Exploration of a Binding Mode of Benzothiazol-2-yl Acetonitrile Pyrimidine Core Based Derivatives as Potent c-Jun N-Terminal Kinase-3 Inhibitors and 3D-QSAR Analyses. Journal of Chemical Information and Modeling 46:4, pages 1763-1774.
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Alfonso de Dios, Chuan Shih, Beatriz López de Uralde, Concepción Sánchez, Miriam del Prado, Luisa M. Martín Cabrejas, Sehila Pleite, Jaime Blanco-Urgoiti, María José Lorite, C. Richard Nevill, Rosanne Bonjouklian, Jeremy York, Michal Vieth, Yong Wang, Nicholas Magnus, Robert M. Campbell, Bryan D. Anderson, Denis J. McCann, Deborah D. Giera, Paul A. Lee, Richard M. Schultz, Li, Lea M. Johnson & Jeffrey A. Wolos. (2005) Design of Potent and Selective 2-Aminobenzimidazole-Based p38α MAP Kinase Inhibitors with Excellent in Vivo Efficacy. Journal of Medicinal Chemistry 48:7, pages 2270-2273.
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Stefan A. Laufer, David M. Domeyer, Thomas R. F. Scior, Wolfgang Albrecht & Dominik R. J. Hauser. (2005) Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors. Journal of Medicinal Chemistry 48:3, pages 710-722.
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Stefan A. Laufer, Werner Zimmermann & Kathrin J. Ruff. (2004) Tetrasubstituted Imidazole Inhibitors of Cytokine Release:  Probing Substituents in the N-1 Position. Journal of Medicinal Chemistry 47:25, pages 6311-6325.
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John G. Cumming, Caroline L. McKenzie, Stuart G. Bowden, Douglas Campbell, David J. Masters, Jason Breed & Philip J. Jewsbury. (2004) Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase. Bioorganic & Medicinal Chemistry Letters 14:21, pages 5389-5394.
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Donnie E. Shifflett, Samuel L. Jones, Adam J. Moeser & Anthony T. Blikslager. (2004) Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum. American Journal of Physiology-Gastrointestinal and Liver Physiology 286:6, pages G906-G913.
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Gilberto M. Sperandio da Silva, Carlos M.R. Sant'Anna & Eliezer J. Barreiro. (2004) A novel 3D-QSAR comparative molecular field analysis (CoMFA) model of imidazole and quinazolinone functionalized p38 MAP kinase inhibitors. Bioorganic & Medicinal Chemistry 12:12, pages 3159-3166.
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Erik Rytter Ottosen, Morten Dahl Sørensen, Fredrik Björkling, Tine Skak-Nielsen, Marianne Scheel Fjording, Helle Aaes & Lise Binderup. (2003) Synthesis and Structure−Activity Relationship of Aminobenzophenones. A Novel Class of p38 MAP Kinase Inhibitors with High Antiinflammatory Activity. Journal of Medicinal Chemistry 46:26, pages 5651-5662.
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Catherine E Fitzgerald, Sangita B Patel, Joseph W Becker, Patricia M Cameron, Dennis Zaller, Vasilis Bill Pikounis, Stephen J O'Keefe & Giovanna Scapin. (2003) Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Nature Structural & Molecular Biology 10:9, pages 764-769.
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Zehong Wan, Jeffrey C. Boehm, Michael J. Bower, Shouki Kassis, John C. Lee, Baoguang Zhao & Jerry L. Adams. (2003) N-Phenyl-N-purin-6-yl ureas: The design and synthesis of p38α MAP kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1191-1194.
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Steven L. Colletti, Jessica L. Frie, Elizabeth C. Dixon, Suresh B. Singh, Bernard K. Choi, Giovanna Scapin, Catherine E. Fitzgerald, Sanjeev Kumar, Elizabeth A. Nichols, Stephen J. O'Keefe, Edward A. O'Neill, Gene Porter, Koppara Samuel, Dennis M. Schmatz, Cheryl D. Schwartz, Wesley L. Shoop, Chris M. Thompson, James E. Thompson, Ruixiu Wang, Andrea Woods, Dennis M. Zaller & James B. Doherty. (2002) Hybrid-Designed Inhibitors of p38 MAP Kinase Utilizing N -Arylpyridazinones . Journal of Medicinal Chemistry 46:3, pages 349-352.
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Swaminathan R. Natarajan, David D. Wisnoski, Suresh B. Singh, John E. Stelmach, Edward A. O'Neill, Cheryl D. Schwartz, Chris M. Thompson, Catherine E. Fitzgerald, Stephen J. O'Keefe, Sanjeev Kumar, Cornelis E.C.A. Hop, Dennis M. Zaller, Dennis M. Schmatz & James B. Doherty. (2003) p38MAP kinase inhibitors. part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold. Bioorganic & Medicinal Chemistry Letters 13:2, pages 273-276.
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John E. Stelmach, Luping Liu, Sangita B. Patel, James V. Pivnichny, Giovanna Scapin, Suresh Singh, Cornelis E.C.A. Hop, Zhen Wang, John R. Strauss, Patricia M. Cameron, Elizabeth A. Nichols, Stephen J. O'Keefe, Edward A. O'Neill, Dennis M. Schmatz, Cheryl D. Schwartz, Chris M. Thompson, Dennis M. Zaller & James B. Doherty. (2003) Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorganic & Medicinal Chemistry Letters 13:2, pages 277-280.
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Stefan A. Laufer, Hans-Günther Striegel & Gerd K. Wagner. (2002) Imidazole Inhibitors of Cytokine Release:  Probing Substituents in the 2 Position. Journal of Medicinal Chemistry 45:21, pages 4695-4705.
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John Regan, Steffen Breitfelder, Pier Cirillo, Thomas Gilmore, Anne G. Graham, Eugene Hickey, Bernhard Klaus, Jeffrey Madwed, Monica Moriak, Neil Moss, Chris Pargellis, Sue Pav, Alfred Proto, Alan Swinamer, Liang Tong & Carol Torcellini. (2002) Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate. Journal of Medicinal Chemistry 45:14, pages 2994-3008.
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Elaine A. IrvingMark Bamford. (2016) Role of Mitogen- and Stress-Activated Kinases in Ischemic Injury. Journal of Cerebral Blood Flow & Metabolism 22:6, pages 631-647.
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Jeffrey M. McKenna, Frank Halley, John E. Souness, Iain M. McLay, Stephen D. Pickett, Alan J. Collis, Kenneth Page & Imtiaz Ahmed. (2002) An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors. Journal of Medicinal Chemistry 45:11, pages 2173-2184.
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James F. Callahan, Joelle L. Burgess, James A. Fornwald, Laramie M. Gaster, John D. Harling, Frank P. Harrington, Jag Heer, Chet Kwon, Ruth Lehr, A. Mathur, Barbara A. Olson, Joseph Weinstock & Nicholas J. Laping. (2002) Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5). Journal of Medicinal Chemistry 45:5, pages 999-1001.
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Charles J McIntyre, Gerald S Ponticello, Nigel J Liverton, Stephen J O’Keefe, Edward A O’Neill, Margaret Pang, Cheryl D Schwartz & David A Claremon. (2002) Pyridazine based inhibitors of p38 MAPK. Bioorganic & Medicinal Chemistry Letters 12:4, pages 689-692.
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Iain M. McLay, Frank Halley, John E. Souness, Jeffrey McKenna, Veronique Benning, Mark Birrell, Brenda Burton, Maria Belvisi, Alan Collis, Alex Constan, Martyn Foster, David Hele, Zaid Jayyosi, Mike Kelley, Chris Maslen, Glen Miller, Marie-Claude Ouldelhkim, Kenneth Page, Simon Phipps, Kenneth Pollock, Barry Porter, Andrew J. Ratcliffe, Elisabeth J. Redford, Stephen Webber, Bryan Slater, Veronique Thybaud & Nicola Wilsher. (2001) The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy. Bioorganic & Medicinal Chemistry 9:2, pages 537-554.
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