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Review

Inhibitors of protein prenylation 2000

Pages 1813-1831 | Published online: 25 Feb 2005

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N. S. Hari Narayana Moorthy, Sergio F. Sousa, Maria J. Ramos & Pedro A. Fernandes. (2011) Structural feature study of benzofuran derivatives as farnesyltransferase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 26:6, pages 777-791.
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Dario Cattaneo, Sara Baldelli, Simona Merlini, Stefania Zenoni, Norberto Perico & Giuseppe Remuzzi. (2004) Therapeutic use of HMG-CoA reductase inhibitors: current practice and future perspectives. Expert Opinion on Therapeutic Patents 14:11, pages 1553-1566.
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Articles from other publishers (24)

Steven Fletcher, Erin Pusateri Keaney, Christopher G. Cummings, Michelle A. Blaskovich, Michael A. Hast, Matthew P. Glenn, Sung-Youn Chang, Cynthia J. Bucher, Ryan J. Floyd, William P. Katt, Michael H. Gelb, Wesley C. Van Voorhis, Lorena S. Beese, Said M. Sebti & Andrew D. Hamilton. (2010) Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents. Journal of Medicinal Chemistry 53:19, pages 6867-6888.
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Aijun Lu, Jian Zhang, Xiaojin Yin, Xiaomin Luo & Hualiang Jiang. (2007) Farnesyltransferase pharmacophore model derived from diverse classes of inhibitors. Bioorganic & Medicinal Chemistry Letters 17:1, pages 243-249.
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Wayne C. Guida, Andrew D. Hamilton, Justin W. Crotty & Saïd M. Sebti. (2006) Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling. Journal of Computer-Aided Molecular Design 19:12, pages 871-885.
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Laurence Goossens, Sophie Deweer, Jean Pommery, Jean-Pierre Hénichart & Jean-François Goossens. (2005) Spectroscopic study of fluorescent peptides for prenyl transferase assays. Journal of Pharmaceutical and Biomedical Analysis 37:3, pages 417-422.
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Katja Kettler, Jochen Wiesner, Katrin Silber, Peter Haebel, Regina Ortmann, Isabel Sattler, Hans-Martin Dahse, Hassan Jomaa, Gerhard Klebe & Martin Schlitzer. (2005) Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity. European Journal of Medicinal Chemistry 40:1, pages 93-101.
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Andreas Mitsch, Mirko Altenkämper, Isabel Sattler & Martin Schlitzer. (2005) Non‐Thiol Farnesyltransferase Inhibitors: Utilization of the Far Aryl Binding Site by Arylthienylacryloylaminobenzophenones. Archiv der Pharmazie 338:1, pages 9-17.
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Andreas Mitsch, Pia Wißner, Katrin Silber, Peter Haebel, Isabel Sattler, Gerhard Klebe & Martin Schlitzer. (2004) Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides. Bioorganic & Medicinal Chemistry 12:17, pages 4585-4600.
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Andreas Mitsch, Pia Wißner, Markus Böhm, Katrin Silber, Gerhard Klebe, Isabel Sattler & Martin Schlitzer. (2004) Non‐thiol Farnesyltransferase Inhibitors: Utilization of the Far Aryl Binding Site by 5‐Cinnamoylaminobenzophenones. Archiv der Pharmazie 337:9, pages 493-501.
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Xiao-hui Liu & Glenn D. Prestwich. (2004) Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase. Bioorganic & Medicinal Chemistry Letters 14:9, pages 2137-2140.
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Andreas Mitsch, Markus Böhm, Isabel Sattler & Martin Schlitzer. (2004) Non‐Thiol Farnesyltransferase Inhibitors: Utilization of the Near Aryl Binding Site by 5‐Arylacetylaminobenzophenones. Archiv der Pharmazie 337:4, pages 213-218.
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Nancy E. Kohl. 2004. Cancer Chemoprevention. Cancer Chemoprevention 303 316 .
Jochen Wiesner, Katja Kettler, Jacek Sakowski, Regina Ortmann, Alejandro M. Katzin, Emília A. Kimura, Katrin Silber, Gerhard Klebe, Hassan Jomaa & Martin Schlitzer. (2003) Farnesyltransferase Inhibitors Inhibit the Growth of Malaria Parasites In Vitro and In Vivo. Angewandte Chemie International Edition 43:2, pages 251-254.
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Jochen Wiesner, Katja Kettler, Jacek Sakowski, Regina Ortmann, Alejandro M. Katzin, Emília A. Kimura, Katrin Silber, Gerhard Klebe, Hassan Jomaa & Martin Schlitzer. (2003) Farnesyltransferase‐Inhibitoren hemmen das Wachstum von Malaria‐Erregern in vitro und in vivo. Angewandte Chemie 116:2, pages 254-257.
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Katsuhiko Iwasaki, Mari Nakatani, Munenori Inoue & Tadashi Katoh. (2003) Synthetic studies of kampanols, novel p21ras farnesyltransferase inhibitors: an efficient synthesis of the tetracyclic ABCD ring system of kampanols. Tetrahedron 59:44, pages 8763-8773.
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Robert B. Lobell, Joseph P. Davide, Nancy E. Kohl, H. Donald Burns, Wai-Si Eng & Raymond E. Gibson. (2003) A Cell-Based Radioligand Binding Assay for Farnesyl: Protein Transferase Inhibitors. SLAS Discovery 8:4, pages 430-438.
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Michael Thutewohl, Lars Kissau, Boriana Popkirova, Ionna-Maria Karaguni, Thorsten Nowak, Michael Bate, Jürgen Kuhlmann, Oliver Müller & Herbert Waldmann. (2003) Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library. Bioorganic & Medicinal Chemistry 11:12, pages 2617-2626.
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Katja Kettler, Jacek Sakowski, Katrin Silber, Isabel Sattler, Gerhard Klebe & Martin Schlitzer. (2003) Non-thiol farnesyltransferase inhibitors: n -(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. Bioorganic & Medicinal Chemistry 11:7, pages 1521-1530.
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Stephen L. GwaltneyIIII, Stephen J. O'Connor, Lissa T.J. Nelson, Gerard M. Sullivan, Hovis Imade, Weibo Wang, Lisa Hasvold, Qun Li, Jerome Cohen, Wen-Zhen Gu, Stephen K. Tahir, Joy Bauch, Kennan Marsh, Shi-Chung Ng, David J. Frost, Haiying Zhang, Steve Muchmore, Clarissa G. Jakob, Vincent Stoll, Charles Hutchins, Saul H. Rosenberg & Hing L. Sham. (2003) Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorganic & Medicinal Chemistry Letters 13:7, pages 1359-1362.
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M.E DePuy, D.G Musson, S Yu & A.L Fisher. (2002) LC-MS/MS determination of a farnesyl transferase inhibitor in human plasma and urine. Journal of Pharmaceutical and Biomedical Analysis 30:4, pages 1157-1171.
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Andreas Mitsch, Markus Böhm, Pia Wißner, Isabel Sattler & Martin Schlitzer. (2002) Non-Thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones. Bioorganic & Medicinal Chemistry 10:8, pages 2657-2662.
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Diem N. Nguyen, Craig A. Stump, Eileen S. Walsh, Christine Fernandes, Joseph P. Davide, Michelle Ellis-Hutchings, Ronald G. Robinson, Theresa M. Williams, Robert B. Lobell, Hans E. Huber & Carolyn A. Buser. (2002) Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I. Bioorganic & Medicinal Chemistry Letters 12:9, pages 1269-1273.
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Douglas C. Beshore & Christopher J. Dinsmore. (2002) Preparation of Substituted Piperazinones via Tandem Reductive Amination−( N , N ‘-Acyl Transfer)−Cyclization . Organic Letters 4:7, pages 1201-1204.
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Douglas C Beshore, Ian M Bell, Christopher J Dinsmore, Carl F Homnick, J.Christopher Culberson, Ronald G Robinson, Christine Fernandes, Eileen S Walsh, Marc T Abrams, Hema G Bhimnathwala, Joseph P Davide, Michelle S Ellis-Hutchings, Hans A Huber, Kenneth S Koblan, Carolyn A Buser, Nancy E Kohl, Robert B Lobell, I-Wu Chen, Debra A McLoughlin, Timothy V Olah, Samuel L Graham, George D Hartman & Theresa M Williams. (2001) Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase. Bioorganic & Medicinal Chemistry Letters 11:14, pages 1817-1821.
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Jeffrey M Bergman, Marc T Abrams, Joseph P Davide, Ian B Greenberg, Ronald G Robinson, Carolyn A Buser, Hans E Huber, Kenneth S Koblan, Nancy E Kohl, Robert B Lobell, Samuel L Graham, George D Hartman, Theresa M Williams & Christopher J Dinsmore. (2001) Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. Bioorganic & Medicinal Chemistry Letters 11:11, pages 1411-1415.
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