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Review

Protein kinase inhibitors: emerging pharmacophores 1997 - 2000

Pages 405-429 | Published online: 25 Feb 2005

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Mohammad M. Al-Sanea, Tamer M. Nasr, Samir Bondock, Aya Y. Gawish & Nada M. Mohamed. (2023) Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Jian Wang, Ya-Dong Chen, Hai-Chun Liu, Guo-Wu Lin, Tao-Tao Yang, Hao-Liang Yuan, Ting Ran, Shuai Lu, Wei-Wei Zhang, Ying Leng & Tao Lu. (2011) De novo design of quinazoline derivatives as CDK2 inhibitors: 3D-QSAR, molecular fragment replacement and Volsurf predictions. Molecular Simulation 37:10, pages 824-836.
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Richard D Connell. (2003) The 2-oxindole chemotype and patent activity inspired by the SU5416 franchise. Expert Opinion on Therapeutic Patents 13:6, pages 737-749.
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Richard D Connell & Jean S Beebe. (2001) Patent focus on cancer chemotherapeutics. III Angiogenesis agents: October 2000 – March 2001. Expert Opinion on Therapeutic Patents 11:7, pages 1171-1203.
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Thanh-Diep Ly, Ricarda Plümers, Bastian Fischer, Vanessa Schmidt, Doris Hendig, Joachim Kuhn, Cornelius Knabbe & Isabel Faust. (2020) Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts. Biomolecules 10:4, pages 609.
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Shang Gao, Chi Yang, Yue Huang, Lei Zhao, Xiaoming Wu, Hequan Yao & Aijun Lin. (2016) Pd( ii )-catalyzed intramolecular oxidative Heck dearomative reaction: approach to thiazole-fused pyrrolidinones with a C2-azaquarternary center . Organic & Biomolecular Chemistry 14:3, pages 840-843.
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T.K. Sawyer. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 959 992 .
Tomi K. Sawyer. 2007. Cancer. Cancer 383 405 .
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Crossref
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Crossref
Rachel R. KroeJohn ReganAl ProtoGregory W. PeetTapon RoyLaura D. LandroNatalie G. FuschettoChristopher A. PargellisRichard H. Ingraham. (2003) Thermal Denaturation:  A Method to Rank Slow Binding, High-Affinity P38α MAP Kinase Inhibitors. Journal of Medicinal Chemistry 46:22, pages 4669-4675.
Crossref
Giovanna Scapin, Sangita B. Patel, JeanMarie Lisnock, Joseph W. Becker & Philip V. LoGrasso. (2003) The Structure of JNK3 in Complex with Small Molecule Inhibitors. Chemistry & Biology 10:8, pages 705-712.
Crossref
Anthony M. Manning & Roger J. Davis. (2003) Targeting JNK for therapeutic benefit: from junk to gold?. Nature Reviews Drug Discovery 2:7, pages 554-565.
Crossref
Yvette Mettey, Marie Gompel, Virginie Thomas, Matthieu Garnier, Maryse Leost, Irène Ceballos-Picot, Martin Noble, Jane Endicott, Jean-michel Vierfond & Laurent Meijer. (2002) Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects. Journal of Medicinal Chemistry 46:2, pages 222-236.
Crossref
A. L. Hopkins & C. R. Groom. 2003. Small Molecule — Protein Interactions. Small Molecule — Protein Interactions 11 17 .
Colin R Groom & Andrew L Hopkins. (2002) Protein kinase drugs – optimism doesn't wait on facts ▾. Drug Discovery Today 7:15, pages 801-802.
Crossref
Marie Knockaert, Karen Wieking, Sophie Schmitt, Maryse Leost, Karen M. Grant, Jeremy C. Mottram, Conrad Kunick & Laurent Meijer. (2002) Intracellular Targets of Paullones. Journal of Biological Chemistry 277:28, pages 25493-25501.
Crossref
John Regan, Steffen Breitfelder, Pier Cirillo, Thomas Gilmore, Anne G. Graham, Eugene Hickey, Bernhard Klaus, Jeffrey Madwed, Monica Moriak, Neil Moss, Chris Pargellis, Sue Pav, Alfred Proto, Alan Swinamer, Liang Tong & Carol Torcellini. (2002) Pyrazole Urea-Based Inhibitors of p38 MAP Kinase:  From Lead Compound to Clinical Candidate. Journal of Medicinal Chemistry 45:14, pages 2994-3008.
Crossref
Giovanna Scapin. (2002) Structural biology in drug design: selective protein kinase inhibitors. Drug Discovery Today 7:11, pages 601-611.
Crossref
Yadagiri Bathini, Inderjit Sidhu, Rajeshwar Singh, Ronald G. Micetich & Peter L. Toogood. (2002) Synthesis of substituted quinazolines. Tetrahedron Letters 43:18, pages 3295-3296.
Crossref
Roger A Smith, James Barbosa, Cheri L Blum, Mark A Bobko, Yolanda V Caringal, Robert Dally, Jeffrey S Johnson, Michael E Katz, Nancy Kennure, Jill Kingery-Wood, Wendy Lee, Timothy B Lowinger, John Lyons, Vivienne Marsh, Daniel H Rogers, Stephen Swartz, Tracy Walling & Hanno Wild. (2001) Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach. Bioorganic & Medicinal Chemistry Letters 11:20, pages 2775-2778.
Crossref
Alexander J. Bridges. (2001) Chemical Inhibitors of Protein Kinases. Chemical Reviews 101:8, pages 2541-2572.
Crossref
S.David Kimball & Kevin R. Webster. 2001. 139 148 .

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