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Expert Opinion on Therapeutic Patents Volume 11, 2001 - Issue 3
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Review

CCK2 receptor antagonists

Iain M McDonald James Black Foundation, 68 Half Moon Lane, Dulwich, London, SE24 9JE, UK. [email protected]
Pages 445-462 | Published online: 25 Feb 2005

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Sean D Hood, Spilios V Argyropoulos & David J Nutt. (2003) New directions in the treatment of anxiety disorders. Expert Opinion on Therapeutic Patents 13:4, pages 401-423.
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Duan Chen, Susan J. Hagen, Malcolm Boyce & Chun‐Mei Zhao. (2023) Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology. Journal of Neuroendocrinology 35:11.
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Doroteja Novak, Marko Anderluh & Petra Kolenc Peitl. (2020) CCK2R antagonists: from SAR to clinical trials. Drug Discovery Today 25:8, pages 1322-1336.
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Sisir Nandi, Mridula Saxena & Anil Kumar Saxena. (2019) QSAR Modeling of CCK2 Receptor Antagonists Utilizing Computed Structural Indices. International Journal of Quantitative Structure-Property Relationships 4:3, pages 20-33.
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Eric Lattmann. (2018) N‒substituted 5‒hydroxy‒pyrrol‒2‒ones based cholecystokinin‒2 antagonists as experimental anticancer agents for the treatment of lung cancer. MOJ Drug Design Development & Therapy 2:4.
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Eric Lattmann, Ramesh Narayanan, Steven T Russell, Wayne A Fleary, Mankaran Singh, PN Balaram & Pornthip Lattmann. (2018) Cholecystokinin Antagonists: Fluorinated 5-Hydroxy-5-Aryl-Pyrrol-2-Ones as Experimental Agents for Brain, Colon and Pancreatic Cancer. Journal of Cancer Prevention & Current Research 9:1.
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E. Lattmann, J. Sattayasai, R. Narayanan, N. Ngoc, D. Burrell, P. N. Balaram, T. Palizdar & P. Lattmann. (2017) Cholecystokinin-2/gastrin antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anti-inflammatory analgesics for the treatment of inflammatory bowel disease. MedChemComm 8:3, pages 680-685.
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Eric Lattmann, Jintana Sattayasai, Carl H. Schwalbe, Yodchai Boonprakob, Simon Dunn, Feyisayo Fajana & Pornthip Lattmann. (2016) Analgesic Effects of 5-Alkyloxy-4-amino-2(5 H )-furanones as Cholecystokinin-2 Antagonists . Archiv der Pharmazie 349:6, pages 456-465.
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E. Lattmann, S. T. Russell, C. H. Schwalbe, A. Shortt, P. N. Balaram, E. Theochari, M. Alharbi, R. Narayanan & P. Lattmann. (2016) Cholecystokinin-1 receptor antagonists: 5-hydroxy-5-aryl-pyrrol-2-ones as anticancer agents. Med. Chem. Commun. 7:6, pages 1138-1145.
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Malcolm Boyce, Steve Warrington & James Black. (2013) Netazepide, a gastrin/CCK 2 receptor antagonist, causes dose-dependent, persistent inhibition of the responses to pentagastrin in healthy subjects . British Journal of Clinical Pharmacology 76:5, pages 689-698.
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Amit K. Gupta, Kanika Varshney, Neetu Singh, Vaibhav Mishra, Mridula Saxena, Gautam Palit & Anil K. Saxena. (2013) Identification of Novel Amino Acid Derived CCK-2R Antagonists As Potential Antiulcer Agent: Homology Modeling, Design, Synthesis, and Pharmacology. Journal of Chemical Information and Modeling 53:1, pages 176-187.
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M. Boyce, O. David, K. Darwin, T. Mitchell, A. Johnston & S. Warrington. (2012) Single oral doses of netazepide ( YF 476), a gastrin receptor antagonist, cause dose‐dependent, sustained increases in gastric pH compared with placebo and ranitidine in healthy subjects . Alimentary Pharmacology & Therapeutics 36:2, pages 181-189.
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Amit K. Gupta, Kanika Varshney & Anil K. Saxena. (2012) Toward the Identification of a Reliable 3D QSAR Pharmacophore Model for the CCK2 Receptor Antagonism. Journal of Chemical Information and Modeling 52:5, pages 1376-1390.
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John Spencer, Rajendra P Rathnam & Babur Z Chowdhry. (2010) 1,4-benzodiazepin-2-ones in medicinal chemistry. Future Medicinal Chemistry 2:9, pages 1441-1449.
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T. Salum, S. Kõks, C. Kairane, R. Mahlapuu, M. Zilmer & E. Vasar. (2010) Temperature Dependence of the Sodium Pump is Altered in the Cerebral Cortex of CCK2 Receptor-Deficient Mice. Neurochemical Research 35:5, pages 688-692.
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Eric Lattmann, Harjit Singh, Pornthip Lattmann, Yodchai Boonprakob & Jintana Sattayasai. (2006) Synthesis and evaluation of N-(3-oxo-2,3-dihydro-1 H -pyrazol-4-yl)-1 H -indole-carboxamides as cholecystokinin antagonists . Journal of Pharmacy and Pharmacology 58:3, pages 393-401.
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John Spencer. (2010) Research Spotlight: Microwave chemistry enabling the synthesis of biologically relevant amines. Future Medicinal Chemistry 2:2, pages 161-168.
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Kirandeep Kaur & Tanaji T. Talele. (2008) 3D QSAR studies of 1,3,4-benzotriazepine derivatives as CCK2 receptor antagonists. Journal of Molecular Graphics and Modelling 27:4, pages 409-420.
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Craig R. Woods, Michael D. Hack, Brett D. Allison, Victor K. Phuong, Mark D. Rosen, Magda F. Morton, Clodagh E. Prendergast, Terrance D. Barrett, Nigel P. Shankley & Michael H. Rabinowitz. (2007) Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands. Bioorganic & Medicinal Chemistry Letters 17:24, pages 6905-6909.
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E A Harper, S P Roberts & S B Kalindjian. (2007) Thermodynamic analysis of ligands at cholecystokinin CCK 2 receptors in rat cerebral cortex . British Journal of Pharmacology 151:8, pages 1352-1367.
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Iain M. McDonald, James W. Black, Ildiko M. Buck, David J. Dunstone, Eric P. Griffin, Elaine A. Harper, Robert A. D. Hull, S. Barret Kalindjian, Elliot J. Lilley, Ian D. Linney, Michael J. Pether, Sonia P. Roberts, Mark E. Shaxted, John Spencer, Katherine I. M. Steel, David A. Sykes, Martin K. Walker, Gillian F. Watt, Laurence Wright, Paul T. Wright & Wei Xun. (2007) Optimization of 1,3,4-Benzotriazepine-Based CCK 2 Antagonists to Obtain Potent, Orally Active Inhibitors of Gastrin-Mediated Gastric Acid Secretion . Journal of Medicinal Chemistry 50:13, pages 3101-3112.
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Brett D. Allison, Victor K. Phuong, Laura C. McAtee, Mark Rosen, Magda Morton, Clodagh Prendergast, Terry Barrett, Guy Lagaud, Jamie Freedman, Lina Li, Xiaodong Wu, Hariharan Venkatesan, Marna Pippel, Craig Woods, Michèle C. Rizzolio, Michael Hack, Kenway Hoey, Xiaohu Deng, Christopher King, Nigel P. Shankley & Michael H. Rabinowitz. (2006) Identification and Optimization of Anthranilic Sulfonamides as Novel, Selective Cholecystokinin-2 Receptor Antagonists. Journal of Medicinal Chemistry 49:21, pages 6371-6390.
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Michael Offel, Pornthip Lattmann, Harjit Singh, D. C. Billington, Yodchai Bunprakob, Jintana Sattayasai & Eric Lattmann. (2006) Synthesis of Substituted 3‐Anilino‐5‐phenyl‐1,3‐dihydro‐ 2 H ‐1,4‐benzodiazepine‐2‐ones and their Evaluation as Cholecystokinin‐Ligands . Archiv der Pharmazie 339:4, pages 163-173.
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Caroline M. R. LowIldiko M. BuckTracey CookeJulia R. CushnirS. Barret KalindjianAtul KotechaMichael J. PetherNigel P. ShankleyJ. G. VinterLaurence Wright. (2005) Scaffold Hopping with Molecular Field Points:  Identification of a Cholecystokinin-2 (CCK 2 ) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of Pyrrole- and Imidazole-Based CCK 2 Antagonists . Journal of Medicinal Chemistry 48:22, pages 6790-6802.
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Ildiko M. BuckJames W. BlackTracey CookeDavid J. DunstoneJohn D. GaffenEric P. GriffinElaine A. HarperRobert A. D. HullS. Barret KalindjianElliot J. LilleyIan D. LinneyCaroline M. R. LowIain M. McDonaldMichael J. PetherSonia P. RobertsNigel P. ShankleyMark E. ShaxtedKatherine I. M. SteelDavid A. SykesMatthew J. TozerGillian F. WattMartin K. WalkerLaurence WrightPaul T. Wright. (2005) Optimization of the in Vitro and in Vivo Properties of a Novel Series of 2,4,5-Trisubstituted Imidazoles as Potent Cholecystokinin-2 (CCK 2 ) Antagonists . Journal of Medicinal Chemistry 48:22, pages 6803-6812.
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S. Yu. Makan, N. A. Tkachuk, V. M. Korkhov, S. V. Kostenko, I. A. Boiko, S. P. Smul'skii, K. S. Andronati, E. A. Kostenko, T. L. Karaseva & S. A. Andronati. (2005) Molecular Targets of New 1,4-Benzodiazepin-2-one Derivatives Influencing the Appetite of Experimental Animals. Pharmaceutical Chemistry Journal 39:6, pages 300-302.
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Pilar Muñoz-Ruiz, M. Teresa García-López, Edurne Cenarruzabeitia, Joaquín Del Río, Marlene Dufresne, Magali Foucaud, Daniel Fourmy & Rosario Herranz. (2004) 5-(Tryptophylamino)-1,3-dioxoperhydropyrido[1,2- c ]pyrimidine-Based Cholecystokinin Receptor Antagonists:  Reversal of CCK 1 Receptor Subtype Selectivity toward CCK 2 Receptors . Journal of Medicinal Chemistry 47:21, pages 5318-5329.
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Rosario Herranz. (2003) Cholecystokinin antagonists: Pharmacological and therapeutic potential. Medicinal Research Reviews 23:5, pages 559-605.
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Donald J. AbrahamSonia Roberts & Iain M. McDonald. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 75 117 .
Donald J. AbrahamA. D. Buss, B. Cox & R. D. Waigh. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 847 900 .
James W. Black & S. Barret Kalindjian. (2003) Gastrin Agonists and Antagonists. Pharmacology & Toxicology 91:6, pages 275-281.
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