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Review

p53 as a drug target in cancer therapy

Pages 923-935 | Published online: 25 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Jinxia Deng, Raveendra Dayam & Nouri Neamati. (2006) Patented small molecule inhibitors of p53–MDM2 interaction. Expert Opinion on Therapeutic Patents 16:2, pages 165-188.
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Heng-Yin Yang, Yu-Ye Wen, Chih-Hsin Chen, Guillermina Lozano & Mong-Hong Lee. (2003) 14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth. Molecular and Cellular Biology 23:20, pages 7096-7107.
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Mong-Hong Lee & Heng-Yin Yang. (2003) Molecular targets for cell cycle inhibition and cancer therapy. Expert Opinion on Therapeutic Patents 13:3, pages 329-346.
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Dafydd A Dart, Maqsood S Mansoor, Paul M Loadman & Steven M Picksley. (2001) Current advances in the inhibition of the auto-regulatory interaction between the p53 tumour suppressor protein and MDM2 protein. Expert Opinion on Therapeutic Patents 11:12, pages 1825-1835.
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Articles from other publishers (9)

Vishakha Singh, Amit Khurana, Umashanker Navik, Prince Allawadhi, Kala Kumar Bharani & Ralf Weiskirchen. (2022) Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics. Sci 4:2, pages 15.
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Amir Khodavirdipour, Motahareh Piri, Sarvin Jabbari, Shiva Keshavarzi, Reza Safaralizadeh & Mohammad Yousef Alikhani. (2021) Apoptosis Detection Methods in Diagnosis of Cancer and Their Potential Role in Treatment: Advantages and Disadvantages: a Review. Journal of Gastrointestinal Cancer 52:2, pages 422-430.
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Rebecca SY Wong. (2011) Apoptosis in cancer: from pathogenesis to treatment. Journal of Experimental & Clinical Cancer Research 30:1.
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Man Zhang & Huiling Yang. (2009) Negative growth regulators of the cell cycle machinery and cancer. Pathophysiology 16:4, pages 305-309.
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H. Weinmann & E. Ottow. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 221 251 .
Patrick Chène. (2004) Inhibition of the p53-MDM2 Interaction: Targeting a Protein-Protein Interface. Molecular Cancer Research 2:1, pages 20-28.
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R. Pipkorn, W. Waldeck & K. Braun. (2003) Synthesis and application of functional peptides as cell nucleus-directed molecules in the treatment of malignant diseases. Journal of Molecular Recognition 16:5, pages 240-247.
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Patrick Chene & Wolfgang Jahnke. (2002) Oligomerization of p53 upon Cooperative DNA Binding: Towards a Structural Understanding of p53 Function. Angewandte Chemie International Edition 41:10, pages 1702-1704.
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Patrick Chene & Wolfgang Jahnke. (2002) Oligomerisierung von p53 nach kooperativer Bindung an DNA: ein Beitrag zum strukturellen Verständnis der Funktion von p53. Angewandte Chemie 114:10, pages 1778-1780.
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