Citations (51)
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Abeer Obeid, Ali El-Shekeil, Sama Al-Aghbari & Jamal Al-Shabi. (2012) Anticancer, DNA cleavage, and antimicrobial activity studies of some new Schiff-base titanium(IV) complexes. Journal of Coordination Chemistry 65:15, pages 2762-2770.
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Articles from other publishers (50)
Mohammad Taha & Edit Y. Tshuva. (2023)
Phenolato Ti(
iv
) hexacoordinate complexes for anticancer chemotherapy: enhancement of solubility, hydrolytic stability, and cytotoxicity
. Dalton Transactions 52:22, pages 7664-7672.
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Zohar Shpilt & Edit Y. Tshuva. (2023) Stable, cytotoxic, and fluorescent Ti(IV) phenolato complexes – synthesis, characterization, and potential use in live cell imaging. Inorganic Chemistry Communications 152, pages 110660.
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Anastasia Pedko, Eden Rubanovich, Edit Y. Tshuva & Avital Shurki. (2022)
Hydrolytically Stable and Cytotoxic [ONO
N
]
2
Ti(IV)-Type Octahedral Complexes
. Inorganic Chemistry 61:44, pages 17653-17661.
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Zohar Shpilt & Edit Y. Tshuva. (2022) Binding of the anticancer Ti(IV) complex phenolaTi to serum proteins: Thermodynamic and kinetic aspects. Journal of Inorganic Biochemistry 232, pages 111817.
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Mickaël Marloye, Haider Inam, Connor J. Moore, Tyler R. Mertens, Aude Ingels, Marilin Koch, Michal O. Nowicki, Véronique Mathieu, Justin R. Pritchard, Samuel G. Awuah, Sean E. Lawler, Franck Meyer, François Dufrasne & Gilles Berger. (2022) Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity. Inorganic Chemistry Frontiers 9:11, pages 2594-2607.
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Laila Maged Kamal Mohamed, Dina B. E. Farag, Hanan Beherei & Nermeen AbuBakr. (2021) The Anticancer Effect of Magnetic Selenium-Based Nanocomposites on Tongue Carcinoma Stem Cells (In Vitro Study). BioNanoScience 12:1, pages 1-12.
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Gilad Nahari, Roy E. Hoffman & Edit Y. Tshuva. (2021) From medium to endoplasmic reticulum: Tracing anticancer phenolato titanium(IV) complex by 19F NMR detection. Journal of Inorganic Biochemistry 221, pages 111492.
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Gilad Nahari & Edit Y. Tshuva. (2021)
Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their
C
1
-symmetrical mono-ligated titanium(
iv
) complexes as highly stable highly active antitumor compounds
. Dalton Transactions 50:19, pages 6423-6426.
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Gilad Nahari, Ori Braitbard, Liraz Larush, Jacob Hochman & Edit Y. Tshuva. (2020) Effective Oral Administration of an Antitumorigenic Nanoformulated Titanium Complex. ChemMedChem 16:1, pages 108-112.
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Maya Miller, Anna Mellul, Maya Braun, Dana Sherill-Rofe, Emiliano Cohen, Zohar Shpilt, Irene Unterman, Ori Braitbard, Jacob Hochman, Edit Y. Tshuva & Yuval Tabach. (2020) Titanium Tackles the Endoplasmic Reticulum: A First Genomic Study on a Titanium Anticancer Metallodrug. iScience 23:7, pages 101262.
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Rajesh Manne, Maya Miller, Andrew Duthie, M. Fátima C. Guedes da Silva, Edit Y. Tshuva & Tushar S. Basu Baul. (2019)
Cytotoxic homoleptic Ti(
iv
) compounds of ONO-type ligands: synthesis, structures and anti-cancer activity
. Dalton Transactions 48:1, pages 304-314.
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Maya Miller & Edit Y. Tshuva. (2018)
Racemic
vs.
enantiopure inert Ti(
iv
) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
. RSC Advances 8:69, pages 39731-39734.
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Nitzan Ganot, Ori Briaitbard, Asaad Gammal, Joseph Tam, Jacob Hochman & Edit Y. Tshuva. (2018) In Vivo Anticancer Activity of a Nontoxic Inert Phenolato Titanium Complex: High Efficacy on Solid Tumors Alone and Combined with Platinum Drugs. ChemMedChem 13:21, pages 2290-2296.
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Maya Miller & Edit Y. Tshuva. (2018) Synthesis of Pure Enantiomers of Titanium(IV) Complexes with Chiral Diaminobis(phenolato) Ligands and Their Biological Reactivity. Scientific Reports 8:1.
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N. Ganot & E. Y. Tshuva. (2018)
In vitro
combinations of inert phenolato Ti(
iv
) complexes with clinically employed anticancer chemotherapy: synergy with oxaliplatin on colon cells
. RSC Advances 8:11, pages 5822-5827.
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Avia Tzubery, Naomi Melamed-Book & Edit Y. Tshuva. (2018)
Fluorescent antitumor titanium(
iv
) salen complexes for cell imaging
. Dalton Transactions 47:11, pages 3669-3673.
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Avia Tzubery & Edit Y. Tshuva. (2017) Cytotoxic Titanium(IV) Complexes of Salalen‐Based Ligands. European Journal of Inorganic Chemistry 2017:12, pages 1695-1705.
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Maya Miller, Ori Braitbard, Jacob Hochman & Edit Y. Tshuva. (2016) Insights into molecular mechanism of action of salan titanium(IV) complex with in vitro and in vivo anticancer activity. Journal of Inorganic Biochemistry 163, pages 250-257.
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Sigalit Meker, Ori Braitbard, Matthew D. Hall, Jacob Hochman & Edit Y. Tshuva. (2016) Specific Design of Titanium(IV) Phenolato Chelates Yields Stable and Accessible, Effective and Selective Anticancer Agents. Chemistry - A European Journal 22:29, pages 9986-9995.
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Sigalit Meker, Ori Braitbard, Katrin Margulis-Goshen, Shlomo Magdassi, Jacob Hochman & Edit Tshuva. (2015) Highly Stable Tetra-Phenolato Titanium(IV) Agent Formulated into Nanoparticles Demonstrates Anti-Tumoral Activity and Selectivity. Molecules 20:10, pages 18526-18538.
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Hagai Glasner, Sigalit Meker & Edit Y. Tshuva. (2015) Cationic phenolato titanium(IV) complexes of enhanced solubility as active and biologically accessible anti-tumor compounds. Journal of Organometallic Chemistry 788, pages 33-35.
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Hagai Glasner & Edit Y. Tshuva. (2015) Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands. Inorganic Chemistry Communications 53, pages 31-33.
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Nitzan Ganot, Boris Redko, Gary Gellerman & Edit Y. Tshuva. (2015)
Anti-proliferative activity of the combination of salan Ti(
iv
) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: synergism with cisplatin
. RSC Advances 5:11, pages 7874-7879.
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Ali Gumaan El-Shekeil, Abeer Omer Abubakr, Sama Abdalla Al-Aghbari & Mogahid Yahya Nassar. (2014) Anticancer 4: Anticancer and DNA cleavage studies of some new Schiff base titanium (IV) complexes. European Journal of Chemistry 5:3, pages 410-414.
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Sigalit Meker, Katrin Margulis-Goshen, Ester Weiss, Ori Braitbard, Jacob Hochman, Shlomo Magdassi & Edit Y. Tshuva. (2014) Anti-proliferative Activity of Nano-Formulated Phenolato Titanium(IV) Complexes Against Cancer Cells. ChemMedChem 9:6, pages 1294-1298.
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Hagai Glasner & Edit Y. Tshuva. (2014)
C
1
-Symmetrical Titanium(IV) Complexes of Salan Ligands with Differently Substituted Aromatic Rings: Enhanced Cytotoxic Activity
. Inorganic Chemistry 53:6, pages 3170-3176.
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Maya MillerEdit Y. Tshuva. (2014) Cytotoxic Titanium(IV) Complexes of Chiral Diaminobis(phenolato) Ligands: Better Combination of Activity and Stability by the Bipyrrolidine Moiety. European Journal of Inorganic Chemistry 2014:9, pages 1485-1491.
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Sigalit Meker, Katrin Margulis‐Goshen, Ester Weiss, Shlomo Magdassi & Edit Y. Tshuva. (2012) High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species. Angewandte Chemie International Edition 51:42, pages 10515-10517.
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Sigalit Meker, Katrin Margulis‐Goshen, Ester Weiss, Shlomo Magdassi & Edit Y. Tshuva. (2012) High Antitumor Activity of Highly Resistant Salan–Titanium(IV) Complexes in Nanoparticles: An Identified Active Species. Angewandte Chemie 124:42, pages 10667-10669.
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Cesar M. Manna, Ori Braitbard, Esther Weiss, Jacob Hochman & Edit Y. Tshuva. (2012) Cytotoxic Salan-Titanium(IV) Complexes: High Activity Toward a Range of Sensitive and Drug-Resistant Cell Lines, and Mechanistic Insights. ChemMedChem 7:4, pages 703-708.
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Avia Tzubery & Edit Y. Tshuva. (2011)
Cytotoxicity and Hydrolysis of
trans
-Ti(IV) Complexes of Salen Ligands: Structure–Activity Relationship Studies
. Inorganic Chemistry 51:3, pages 1796-1804.
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Cesar M. Manna, Gad Armony & Edit Y. Tshuva. (2011)
Unexpected Influence of Stereochemistry on the Cytotoxicity of Highly Efficient Ti
IV
Salan Complexes: New Mechanistic Insights
. Chemistry – A European Journal 17:50, pages 14094-14103.
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Dani Peri, Cesar M. Manna, Michal Shavit & Edit Y. Tshuva. (2011)
Ti
IV
Complexes of Branched Diamine Bis(phenolato) Ligands: Hydrolysis and Cytotoxicity
. European Journal of Inorganic Chemistry 2011:31, pages 4896-4900.
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Hagai Glasner & Edit Y. Tshuva. (2011) A Marked Synergistic Effect in Antitumor Activity of Salan Titanium(IV) Complexes Bearing Two Differently Substituted Aromatic Rings. Journal of the American Chemical Society 133:42, pages 16812-16814.
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Cesar M. Manna, Gad Armony & Edit Y. Tshuva. (2011) New Insights on the Active Species and Mechanism of Cytotoxicity of Salan-Ti(IV) Complexes: A Stereochemical Study. Inorganic Chemistry 50:20, pages 10284-10291.
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Avia Tzubery & Edit Y. Tshuva. (2011) Trans Titanium(IV) Complexes of Salen Ligands Exhibit High Antitumor Activity. Inorganic Chemistry 50:17, pages 7946-7948.
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Dani Peri, Sigalit Meker, Cesar M. Manna & Edit Y. Tshuva. (2011)
Different
ortho
and
para
Electronic Effects on Hydrolysis and Cytotoxicity of Diamino Bis(Phenolato) “Salan” Ti(IV) Complexes
. Inorganic Chemistry 50:3, pages 1030-1038.
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Sigalit Meker, Cesar M. Manna, Dani Peri & Edit Y. Tshuva. (2011) Major impact of N-methylation on cytotoxicity and hydrolysis of salan Ti(IV) complexes: sterics and electronics are intertwined. Dalton Transactions 40:38, pages 9802.
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Tushar S. Basu Baul & Dick de Vos. (2009) In vitro cytotoxic evaluation of novel dichlorodiorgano[N-(2-pyridylmethylene)arylamine]tin(IV) derivatives in human tumor cell lines. Investigational New Drugs 28:5, pages 609-614.
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Edit Y. Tshuva & Dani Peri. (2009) Modern cytotoxic titanium(IV) complexes; Insights on the enigmatic involvement of hydrolysis. Coordination Chemistry Reviews 253:15-16, pages 2098-2115.
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Edit Y. Tshuva & James A. Ashenhurst. (2009) Cytotoxic Titanium(IV) Complexes: Renaissance. European Journal of Inorganic Chemistry 2009:15, pages 2203-2218.
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Dani Peri, Sigalit Meker, Michal Shavit & Edit Y. Tshuva. (2009)
Synthesis, Characterization, Cytotoxicity, and Hydrolytic Behavior of
C
2
- and
C
1
-Symmetrical Ti
IV
Complexes of Tetradentate Diamine Bis(Phenolato) Ligands: A New Class of Antitumor Agents
. Chemistry - A European Journal 15:10, pages 2403-2415.
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Tal Hermon & Edit Y. Tshuva. (2008) Synthesis and Conformational Analysis of Constrained Ethylene-Bridged Bis(hydroxylamino-1,3,5-triazine) Compounds as Tetradentate Ligands; Structure of Rigid Dinuclear Ti(IV) Complex. The Journal of Organic Chemistry 73:15, pages 5953-5958.
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Michal Shavit & Edit Y. Tshuva. (2008)
Preparation and X‐ray Structures of Ti
IV
Complexes of Bis(carboxylato) Ligands – Formation of Mono‐, Di‐, Tetra‐, and Hexanuclear Complexes with or without OR and μ‐O Ligands
. European Journal of Inorganic Chemistry 2008:9, pages 1467-1474.
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Michal Shavit, Dani Peri, Cesar M. Manna, Jacob S. Alexander & Edit Y. Tshuva. (2007)
Active Cytotoxic Reagents Based on Non-metallocene Non-diketonato Well-Defined
C
2
-Symmetrical Titanium Complexes of Tetradentate Bis(phenolato) Ligands
. Journal of the American Chemical Society 129:40, pages 12098-12099.
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Michal Shavit, Dani Peri, Artem Melman & Edit Y. Tshuva. (2007) Antitumor reactivity of non-metallocene titanium complexes of oxygen-based ligands: is ligand lability essential?. JBIC Journal of Biological Inorganic Chemistry 12:6, pages 825-830.
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Ruili Huang, Anders Wallqvist & David G. Covell. (2005) Anticancer metal compounds in NCI's tumor-screening database: putative mode of action. Biochemical Pharmacology 69:7, pages 1009-1039.
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Jaromír Vinklárek, Hana Paláčková & Jan Honzíček. (2004) Experimental and Theoretical Study of the First Vanadocene(IV) Complexes of α-Amino Acids Prepared from Vanadocene Dichloride. Collection of Czechoslovak Chemical Communications 69:4, pages 811-821.
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Francesco Caruso, Lou Massa, Asta Gindulyte, Claudio Pettinari, Fabio Marchetti, Riccardo Pettinari, Massimo Ricciutelli, Juan Costamagna, Juan Carlos Canales, Joseph Tanski & Miriam Rossi. (2003) (4‐Acyl‐5‐pyrazolonato)titanium Derivatives: Oligomerization, Hydrolysis, Voltammetry, and DFT Study. European Journal of Inorganic Chemistry 2003:17, pages 3221-3232.
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Zohar Shpilt & Edit Y. Tshuva. (2021) Binding of the Anticancer Ti(IV) Complex Phenolati to Serum Proteins: Thermodynamic and Kinetic Aspects. SSRN Electronic Journal.
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