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Miscellaneous

Small molecule antagonists of the LFA-1/ICAM-1 interaction as potential therapeutic agents

Pages 1383-1393 | Published online: 25 Feb 2005

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Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Seyed Ahmad Mohajeri, Milad Iranshahy, Ahmad Yahyazadeh, Maede Hasanpour, Mehrdad Iranshahi & Vahid Reza Askari. (2023) Oral Administration Evaluation of the Hydro-Ethanolic Extract of Ginger (Rhizome of Zingiber officinale) against Postoperative-Induced Peritoneal Adhesion: Investigating the Role of Anti-Inflammatory and Antioxidative Effects. Evidence-Based Complementary and Alternative Medicine 2023, pages 1-15.
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Maryam Abdullahi, Fisayo A. Olotu & Mahmoud E. Soliman. (2018) Allosteric inhibition abrogates dysregulated LFA-1 activation: Structural insight into mechanisms of diminished immunologic disease. Computational Biology and Chemistry 73, pages 49-56.
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Michael D. Wendt. 2012. Protein-Protein Interactions. Protein-Protein Interactions 1 55 .
Seung Woong Lee, Ju-Hwan Lim, Min Seok Kim, Ji-Hak Jeong, Gyu-Yong Song, Woo Song Lee & Mun-Chual Rho. (2011) Phenolic compounds isolated from Zingiber officinale roots inhibit cell adhesion. Food Chemistry 128:3, pages 778-782.
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Min Zhong, Wang Shen, Kenneth J. Barr, Jennifer P. Arbitrario, Michelle R. Arkin, Minna Bui, Teresa Chen, Brian C. Cunningham, Marc J. Evanchik, Emily J. Hanan, Ute Hoch, Karen Huen, Jennifer Hyde, Jeffery L. Kumer, Teresa Lac, Chris E. Lawrence, Jose R. Martell, Johan D. Oslob, Kumar Paulvannan, Saileta Prabhu, Jeffrey A. Silverman, Jasmin Wright, Chul H. Yu, Jiang Zhu & W. Mike Flanagan. (2010) Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorganic & Medicinal Chemistry Letters 20:17, pages 5269-5273.
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Suzanne J. Suchard, Dawn K. Stetsko, Patricia M. Davis, Stacey Skala, Dominique Potin, Michele Launay, T. G. Murali Dhar, Joel C. Barrish, Vojkan Susulic, David J. Shuster, Kim W. McIntyre, Murray McKinnon & Luisa Salter-Cid. (2010) An LFA-1 (αLβ2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in Murine Models of Arthritis. The Journal of Immunology 184:7, pages 3917-3926.
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Seung-Woong Lee, Jong-Sun Chang, Ju-Hwan Lim, Min-Seok Kim, Su-Jin Park, Hyung-Jae Jeong, Min-Soo Kim, Woo-Song Lee & Mun-Chual Rho. (2010) Quinolone Alkaloids from Evodiae fructus Inhibit LFA-1/ICAM-1-mediated Cell Adhesion. Bulletin of the Korean Chemical Society 31:1, pages 64-68.
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Seung Woong Lee, Young Kook Kim, Koanhoi Kim, Hyun Sun Lee, Jung Ho Choi, Woo Song Lee, Chang-Duk Jun, Jee Hun Park, Jeong Min Lee & Mun-Chual Rho. (2008) Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4544-4546.
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R.L. Tiwari, V. Singh & M.K. Barthwal. (2007) Macrophages: An elusive yet emerging therapeutic target of atherosclerosis. Medicinal Research Reviews 28:4, pages 483-544.
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Peter M. Fischer. (2008) Computational chemistry approaches to drug discovery in signal transduction. Biotechnology Journal 3:4, pages 452-470.
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Maret J. Panzenbeck, Deborah D. Jeanfavre, Terence A. Kelly, Rene Lemieux, Gerald Nabozny, Patricia L. Reilly & Sudha Desai. (2006) An orally active, primate selective antagonist of LFA-1 inhibits delayed-type hypersensitivity in a humanized-mouse model. European Journal of Pharmacology 534:1-3, pages 233-240.
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Sompong Wattanasin, Joerg Kallen, Stewart Myers, Qin Guo, Michael Sabio, Claus Ehrhardt, Rainer Albert, Ulrich Hommel, Gisbert Weckbecker, Karl Welzenbach & Gabriele Weitz-Schmidt. (2005) 1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters 15:4, pages 1217-1220.
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Gary T. Wang, Sheldon Wang, Robert Gentles, Thomas Sowin, Sandra Leitza, Edward B. Reilly & Thomas W. von Geldern. (2005) Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding. Bioorganic & Medicinal Chemistry Letters 15:1, pages 195-201.
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Michael J. O’Neill, Peter C. Astles, Stuart M. Allan & Daniel C. Anthony. (2004) Anti-inflammatory modulators in stroke. Drug Discovery Today: Therapeutic Strategies 1:1, pages 59-67.
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Thomas Ullrich, Karl Baumann, Karl Welzenbach, Simone Schmutz, Gian Camenisch, Josef G. Meingassner & Gabriele Weitz-Schmidt. (2004) Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain. Bioorganic & Medicinal Chemistry Letters 14:10, pages 2483-2487.
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Daniel J Burdick, James C MarstersJr.Jr., Ignacio Aliagas-Martin, Mark Stanley, Maureen Beresini, Kevin Clark, Robert S McDowell & Thomas R Gadek. (2004) N -Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure–activity relationship of the benzoyl moiety. Bioorganic & Medicinal Chemistry Letters 14:9, pages 2055-2059.
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Michelle R. Arkin & James A. Wells. (2004) Small-molecule inhibitors of protein–protein interactions: progressing towards the dream. Nature Reviews Drug Discovery 3:4, pages 301-317.
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Thomas R Gadek & Robert S McDowell. (2003) Discovery of small molecule leads in a biotechnology datastream. Drug Discovery Today 8:12, pages 545-550.
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Daniel J. Burdick, Ken Paris, Kenneth Weese, Mark Stanley, Maureen Beresini, Kevin Clark, Robert S. McDowell, James C. MarstersJr.Jr. & Thomas R. Gadek. (2003) N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure–activity relationship. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1015-1018.
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Sompong Wattanasin, Rainer Albert, Claus Ehrhardt, Didier Roche, Michael Sabio, Ulrich Hommel, Karl Welzenbach & Gabriele Weitz-Schmidt. (2003) 1,4-Diazepane-2-ones as novel inhibitors of LFA-1. Bioorganic & Medicinal Chemistry Letters 13:3, pages 499-502.
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Thomas R Gadek & John B Nicholas. (2003) Small molecule antagonists of proteins. Biochemical Pharmacology 65:1, pages 1-8.
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T. R. GadekD. J. BurdickR. S. McDowellM. S. StanleyJ. C. MarstersJr.Jr., K. J. ParisD. A. OareM. E. ReynoldsC. LadnerK. A. ZioncheckW. P. LeeP. GriblingM. S. DennisN. J. SkeltonD. B. TumasK. R. ClarkS. M. KeatingM. H. BeresiniJ. W. TilleyL. G. PrestaS. C. Bodary. (2002) Generation of an LFA-1 Antagonist by the Transfer of the ICAM-1 Immunoregulatory Epitope to a Small Molecule. Science 295:5557, pages 1086-1089.
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