169
Views
105
CrossRef citations to date
0
Altmetric
Review

Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer

&
Pages 1663-1702 | Published online: 25 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Guangcheng Wang, Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li & Zhiyun Peng. (2020) Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 139-144.
Read now
Kunal Nepali, Ritu Ojha, Hsueh-Yun Lee & Jing-Ping Liou. (2016) Early investigational tubulin inhibitors as novel cancer therapeutics. Expert Opinion on Investigational Drugs 25:8, pages 917-936.
Read now
Alex A Philchenkov, Michael P Zavelevich, Volodymyr P Tryndyak, Ludmila M Kuiava, Dmitry Yu Blokhin, Koh Miura, Romano Silvestri & Igor P Pogribny. (2015) Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells. Cancer Biology & Therapy 16:12, pages 1820-1829.
Read now
Jie Zhou, Yi Zhang, Yi-Wen Cui, Zhan-Mei Li, Hong-Rui Song, Jin-Hua Dong, Xiao-Guang Chen & Bai-Ling Xu. (2011) Synthesis and cytotoxic evaluation of N-(4-methoxy-1H-benzo[d]imidazol-7-yl)-arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d]imidazol)-7-sulfonamide analogs of combretastatin A-4. Journal of Asian Natural Products Research 13:4, pages 330-340.
Read now
Neeraj Mahindroo, Jing-Ping Liou, Jang-Yang Chang & Hsing-Pang Hsieh. (2006) Antitubulin agents for the treatment of cancer – a medicinal chemistry update. Expert Opinion on Therapeutic Patents 16:5, pages 647-691.
Read now
Salmaan H Inayat-Hussain & Noel F Thomas. (2004) Recent advances in the discovery and development of stilbenes and lactones in anticancer therapy. Expert Opinion on Therapeutic Patents 14:6, pages 819-835.
Read now

Articles from other publishers (99)

Mohit Agarwal, Obaid Afzal, Salahuddin, Abdulmalik Saleh Alfawaz Altamimi, Mubarak A. Alamri, Manal A. Alossaimi, Vandana Sharma & Mohamed Jawed Ahsan. (2023) Design, Synthesis, ADME, and Anticancer Studies of Newer N -Aryl-5-(3,4,5-Trifluorophenyl)-1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations . ACS Omega 8:30, pages 26837-26849.
Crossref
Yayue Liu, Wencong Yang, Beining Xie, Tao Chen, Senhua Chen, Zhaoming Liu, Bing Sun & Zhigang She. (2023) First discovery of sulfonamides derivatives with acetylcholinesterase inhibitory activity in fungus Pestalotiopsis sp. HNY36-1D. Tetrahedron 142, pages 133524.
Crossref
Sibel Cinar‐Asa, Demet Coskun, Oguzhan Akgun, Halime Akgun, Mehmet Fatih Coskun & Ferda Ari. (2023) Design, Synthesis and Anticancer Activity of New Benzofuran‐Chalcone Hybrids and Their Water Soluble Sodium Salts. ChemistrySelect 8:9.
Crossref
Godshelp O. Egharevba, Ahmed Kamal, Omotayo O. Dosumu, Sunitha Routhu, Olatomide A. Fadare, Stephen O. Oguntoye, Stanislaus N. Njinga & Abimbola P. Oluyori. (2022) Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies. Scientific Reports 12:1.
Crossref
Momen R. Fareed, Mai E. Shoman, Mohammed I. A. Hamed, Mohamed Badr, Hanin A. Bogari, Sameh S. Elhady, Tarek S. Ibrahim, Gamal El-Din A. Abuo-Rahma & Taha F. S. Ali. (2021) New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors. Pharmaceuticals 14:11, pages 1114.
Crossref
Neha V. Bhilare, Pratibha B. Auti, Vinayak S. Marulkar & Vilas J. Pise. (2021) Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review. Mini-Reviews in Medicinal Chemistry 21:2, pages 217-232.
Crossref
Syndla Premalatha & Dittakavi Ramachandran. (2020) Design and synthesis of 1,2,4-Thiadiazole linked combretastatin-A4 derivatives as promising anticancer agents. Chemical Data Collections 28, pages 100481.
Crossref
Shixian Hua, Feihong Chen, Xinyi Wang & Shaohua Gou. (2020) Dual-functional conjugates improving cancer immunochemotherapy by inhibiting tubulin polymerization and indoleamine-2,3-dioxygenase. European Journal of Medicinal Chemistry 189, pages 112041.
Crossref
Vukoti Kiran Kumar, Venkat Swamy Puli, Ala Vasu Babu, Radhakrishnam Raju Ruddarraju & K. R. S. Prasad. (2020) Synthesis, anticancer evaluation, and molecular docking studies of benzoxazole linked combretastatin analogues. Medicinal Chemistry Research 29:3, pages 528-537.
Crossref
Bongkotrat Thanaussavadate, Lukana Ngiwsara, Kriengsak Lirdprapamongkol, Jisnuson Svasti & Pitak Chuawong. (2020) A synthetic 2,3-diarylindole induces microtubule destabilization and G2/M cell cycle arrest in lung cancer cells. Bioorganic & Medicinal Chemistry Letters 30:1, pages 126777.
Crossref
Muhamad Mustafa, Sirajudheen Anwar, Firgani Elgamal, Esam R. Ahmed & Omar M. Aly. (2019) Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study. European Journal of Medicinal Chemistry 183, pages 111697.
Crossref
Irfan Khan, Mohd Adil Shareef & C. Ganesh Kumar. (2019) An overview on the synthetic and medicinal perspectives of indenopyrazoles. European Journal of Medicinal Chemistry 178, pages 1-12.
Crossref
Alba Vicente‐Blázquez, Myriam González, Raquel Álvarez, Sara del Mazo, Manuel Medarde & Rafael Peláez. (2018) Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target. Medicinal Research Reviews 39:3, pages 775-830.
Crossref
V. Ragha Suma, R. Sreenivasulu, M. Subramanyam & K. Ram Mohan Rao. (2019) Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4. Russian Journal of General Chemistry 89:3, pages 499-504.
Crossref
Mei-Jung Lai, Ritu Ojha, Mei-Hsiang Lin, Yi-Min Liu, Hsueh-Yun Lee, Tony Eight Lin, Kai-Cheng Hsu, Chi-Yen Chang, Mei-Chuan Chen, Kunal Nepali, Jang-Yang Chang & Jing-Ping Liou. (2019) 1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase. European Journal of Medicinal Chemistry 162, pages 612-630.
Crossref
Ángel M. Montaña, Julia Lorenzo, Stefano Ponzano & Maria-Filomena Sanasi. (2018) Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound. Bioorganic & Medicinal Chemistry 26:12, pages 3379-3398.
Crossref
Vijay K. Patel, Avineesh Singh, Deepak K. Jain, Preeti Patel, Ravichandran Veerasamy, Prabodh C. Sharma & Harish Rajak. (2017) Combretastatin A-4 based thiophene derivatives as antitumor agent: Development of structure activity correlation model using 3D-QSAR, pharmacophore and docking studies. Future Journal of Pharmaceutical Sciences 3:2, pages 71-78.
Crossref
Muhamad Mustafa, Dalia Abdelhamid, ElShimaa M.N. Abdelhafez, Mahmoud A.A. Ibrahim, Amira M. Gamal-Eldeen & Omar M. Aly. (2017) Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues. European Journal of Medicinal Chemistry 141, pages 293-305.
Crossref
Salwa Elmeligie, Nadia A. Khalil, Eman M. Ahmed & Soha H. Emam. (2017) New 3-Substituted-2-(4-hydroxyanilino)pyridine Derivatives: Synthesis, Antitumor Activity, and Tubulin Polymerization Inhibition. Archiv der Pharmazie 350:2, pages 1600256.
Crossref
Helge Prinz, Ann-Kathrin Ridder, Kirsten Vogel, Konrad J. Böhm, Igor Ivanov, Jahan B. Ghasemi, Elham Aghaee & Klaus Müller. (2017) N -Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization . Journal of Medicinal Chemistry 60:2, pages 749-766.
Crossref
Zhiwei Wang, Huan Qi, Qirong Shen, Guodong Lu, Mingyang Li, Kai Bao, Yingliang Wu & Weige Zhang. (2016) 4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin. European Journal of Medicinal Chemistry 122, pages 520-529.
Crossref
Yong-Tao Duan, Ruo-Jun Man, Dan-Jie Tang, Yong-Fang Yao, Xiang-Xiang Tao, Chen Yu, Xin-Yi Liang, Jigar A. Makawana, Mei-Juan Zou, Zhong-Chang Wang & Hai-Liang Zhu. (2016) Design, Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified Combretastatin A-4 (CA-4) Analogues as Potent Antitubulin Agents. Scientific Reports 6:1.
Crossref
Thanya Rukkijakan, Lukana Ngiwsara, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Nared Phetrak & Pitak Chuawong. (2016) A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells. Bioorganic & Medicinal Chemistry Letters 26:9, pages 2119-2123.
Crossref
Vikas Chaudhary, Jubina B. Venghateri, Hemendra P. S. Dhaked, Anil S. Bhoyar, Sankar K. Guchhait & Dulal Panda. (2016) Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety. Journal of Medicinal Chemistry 59:7, pages 3439-3451.
Crossref
Shanthi Nagarajan, Min Jeong Choi, Yong Seo Cho, Sun-Joon Min, Gyochang Keum, Soo Jin Kim, Chang Sik Lee & Ae Nim Pae. (2015) Tubulin Inhibitor Identification by Bioactive Conformation Alignment Pharmacophore-Guided Virtual Screening. Chemical Biology & Drug Design 86:5, pages 998-1016.
Crossref
Chao Zhang, Bo Zhong, Simin Yang, Liangkun Pan, Siwang Yu, Zhongjun Li, Shuchun Li, Bin Su & Xiangbao Meng. (2015) Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents. Bioorganic & Medicinal Chemistry 23:13, pages 3774-3780.
Crossref
Amedeo Amedei & Elena Niccolai. 2014. Natural Products Analysis. Natural Products Analysis 43 113 .
Samir Mehndiratta, Yi-Fang Chiang, Mei-Jung Lai, Hsueh-Yun Lee, Mei-Chuan Chen, Ching-Chuan Kuo, Chi-Yen Chang, Jang-Yang Chang & Jing-Ping Liou. (2014) Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents. Bioorganic & Medicinal Chemistry 22:17, pages 4917-4923.
Crossref
Yu-Jing Li, Ya-Juan Qin, Jigar A. Makawana, Yan-Ting Wang, Yan-Qing Zhang, Ya-Liang Zhang, Meng-Ru Yang, Ai-Qin Jiang & Hai-Liang Zhu. (2014) Synthesis, biological evaluation and molecular modeling of 1,3,4-thiadiazol-2-amide derivatives as novel antitubulin agents. Bioorganic & Medicinal Chemistry 22:15, pages 4312-4322.
Crossref
Abdul Samad, Moawiah M. Naffaa, Mohammed Afroz Bakht, Manav Malhotra & Majid A. Ganaie. (2014) Target Based Designing of Anthracenone Derivatives as Tubulin Polymerization Inhibiting Agents: 3D QSAR and Docking Approach. International Journal of Medicinal Chemistry 2014, pages 1-15.
Crossref
Florence Bourdon, Marie Lecoeur, Nicolas Lebègue, Bernard Gressier, Michel Luyckx, Pascal Odou, Thierry Dine, Jean-François Goossens & Nicolas Kambia. (2014) Pharmacokinetic Evaluation of a Novel Benzopyridooxathiazepine Derivative as a Potential Anticancer Agent. Pharmacology 94:3-4, pages 170-178.
Crossref
Ahmed KamalAnver Basha Shaik, Sowjanya Polepalli, Vangala Santosh Reddy, G. Bharath Kumar, Soma Gupta, K. V. S. Rama Krishna, Ananthamurthy Nagabhushana, Rakesh K. Mishra & Nishant Jain. (2014) Pyrazole–oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization. Org. Biomol. Chem. 12:40, pages 7993-8007.
Crossref
Nitesh Sanghai, Vaibhav Jain, Ranjan Preet, Somnath Kandekar, Sarita Das, Neha Trivedi, Purusottam Mohapatra, Garima Priyadarshani, Maneesh Kashyap, Dipon Das, Shakti Ranjan Satapathy, Sumit Siddharth, Sankar K. Guchhait, Chanakya N. Kundu & Prasad V. Bharatam. (2014) Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents. Med. Chem. Commun. 5:6, pages 766-782.
Crossref
Zecheng Chen, Andreas Maderna, Sai Chetan K. Sukuru, Melissa Wagenaar, Christopher J. O’Donnell, My-Hanh Lam, Sylvia Musto & Frank Loganzo. (2013) New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation. Bioorganic & Medicinal Chemistry Letters 23:24, pages 6688-6694.
Crossref
Jie Zhou, Jing Jin, Yi Zhang, Yuwen Yin, Xiaoguang Chen & Bailing Xu. (2013) Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4. European Journal of Medicinal Chemistry 68, pages 222-232.
Crossref
N. R. Kuznetsova, E. V. Svirshchevskaya, N. S. Sitnikov, L. Abodo, H. Sutorius, J. Zapke, J. Velder, P. Thomopoulou, H. Oschkinat, A. Prokop, H. -G. Schmalz, A. Yu. Fedorov & E. L. Vodovozova. (2013) Lipophilic prodrugs of a triazole-containing colchicine analogue in liposomes: Biological effects on human tumor cells. Russian Journal of Bioorganic Chemistry 39:5, pages 543-552.
Crossref
Taijie Chen, Yu Luo, Li Sheng, Jia Li, Youhong Hu & Wei Lu. (2013) Synthesis and in vitro cytotoxic evaluation of novel $$N$$ -(3,4,5-trimethoxyphenyl)pyridin-2( $$1H$$ )-one derivatives. Molecular Diversity 17:3, pages 435-444.
Crossref
M. V. Ramana Reddy, Muralidhar R. Mallireddigari, Venkat R. Pallela, Stephen C. Cosenza, Vinay K. Billa, Balaiah Akula, D. R. C. Venkata Subbaiah, E. Vijaya Bharathi, Amol Padgaonkar, Hua Lv, James M. Gallo & E. Premkumar Reddy. (2013) Design, Synthesis, and Biological Evaluation of ( E )- N -Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents . Journal of Medicinal Chemistry 56:13, pages 5562-5586.
Crossref
Francisco Torrens & Gloria Castellano. (2013) Molecular Classification of 5-Amino-2-Aroylquinolines and 4-Aroyl-6,7,8-Trimethoxyquinolines as Highly Potent Tubulin Polymerization Inhibitors. International Journal of Chemoinformatics and Chemical Engineering 3:2, pages 1-26.
Crossref
Elizabeth J. Andrew, Stephanie Merchan, Conor Lawless, A. Peter Banks, Darren J. Wilkinson & David Lydall. (2013) Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4. PLoS ONE 8:6, pages e66242.
Crossref
Branka M. Ivković, Katarina Nikolic, Bojana B. Ilić, Željko S. Žižak, Radmila B. Novaković, Olivera A. Čudina & Sote M. Vladimirov. (2013) Phenylpropiophenone derivatives as potential anticancer agents: Synthesis, biological evaluation and quantitative structure–activity relationship study. European Journal of Medicinal Chemistry 63, pages 239-255.
Crossref
Jahan B. Ghasemi, Elham Aghaee & Ali Jabbari. (2013) Docking, CoMFA and CoMSIA Studies of a Series of N-Benzoylated Phenoxazines and Phenothiazines Derivatives as Antiproliferative Agents. Bulletin of the Korean Chemical Society 34:3, pages 899-906.
Crossref
Deepak K. Lokwani, Aniket P. Sarkate & Devanand B. Shinde. (2012) 3D-QSAR and docking studies of benzoyl urea derivatives as tubulin-binding agents for antiproliferative activity. Medicinal Chemistry Research 22:3, pages 1415-1425.
Crossref
Deng-Gao Zhao, JianJun Chen, Ya-Rong Du, Yan-Yan Ma, Ya-Xiong Chen, Kun Gao & Bu-Rong Hu. (2013) Synthesis and Structure–Activity Relationships of N -Methyl-5,6,7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents . Journal of Medicinal Chemistry 56:4, pages 1467-1477.
Crossref
Jessy Aziz, Etienne Brachet, Abdallah Hamze, Jean-François Peyrat, Guillaume Bernadat, Estelle Morvan, Jérôme Bignon, Joanna Wdzieczak-Bakala, Déborah Desravines, Joelle Dubois, Marie Tueni, Ahmad Yassine, Jean-Daniel Brion & Mouad Alami. (2013) Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors. Org. Biomol. Chem. 11:3, pages 430-442.
Crossref
Valérie Verones, Nathalie Flouquet, Marie Lecoeur, Amelie Lemoine, Amaury Farce, Brigitte Baldeyrou, Christine Mahieu, Nicole Wattez, Amélie Lansiaux, Jean-François Goossens, Pascal Berthelot & Nicolas Lebegue. (2013) Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives. European Journal of Medicinal Chemistry 59, pages 39-47.
Crossref
Yingqian Liu, Dongfeng Wei, Yonglong Zhao, Weidong Cheng, Yan Lu, Yaqiong Ma, Xin Li, Chao Han, Yanxia Wei, Huiming Cao & Chunyan Zhao. (2012) Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents. Bioorganic & Medicinal Chemistry 20:21, pages 6285-6295.
Crossref
M. V. Ramana Reddy, Balaiah Akula, Stephen C. Cosenza, Clement M. Lee, Muralidhar R. Mallireddigari, Venkat R. Pallela, D. R. C. Venkata Subbaiah, Andrew Udofa & E. Premkumar Reddy. (2012) ( Z )-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure–Activity Relationship (SAR), Tubulin Polymerization, and Cell Growth Inhibition Studies . Journal of Medicinal Chemistry 55:11, pages 5174-5187.
Crossref
Clemens Lamberth, Stephan Trah, Sebastian Wendeborn, Raphael Dumeunier, Mikael Courbot, Jeremy Godwin & Peter Schneiter. (2012) Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 2: Pyridazines. Bioorganic & Medicinal Chemistry 20:9, pages 2803-2810.
Crossref
Hsueh-Yun Lee, Lin-Wen Lee, Chih-Ying Nien, Ching-Chuan Kuo, Pen-Yuan Lin, Chi-Yen Chang, Jang-Yang Chang & Jing-Ping Liou. (2012) Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund–von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines. Organic & Biomolecular Chemistry 10:48, pages 9593.
Crossref
Zecheng Chen, Christopher J. O’Donnell & Andreas Maderna. (2012) Synthesis of 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol, a potent antineoplastic benzosuberene derivative for anti-cancer chemotherapy. Tetrahedron Letters 53:1, pages 64-66.
Crossref
John A. Beutler, Gordon M. Cragg & David J. Newman. 2012. Drug Discovery in Africa. Drug Discovery in Africa 29 52 .
Hsueh-Yun Lee, Jang-Yang Chang, Chih-Ying Nien, Ching-Chuan Kuo, Kuang-Hsing Shih, Chun-Hsein Wu, Chi-Yen Chang, Wen-Yang Lai & Jing-Ping Liou. (2011) 5-Amino-2-aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. Part 2. The Impact of Bridging Groups at Position C-2. Journal of Medicinal Chemistry 54:24, pages 8517-8525.
Crossref
Eric C. Bielefeld, David Hangauer & Donald Henderson. (2011) Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neuroscience Research 71:4, pages 348-354.
Crossref
David Cragg, Gordon Kingston & David NewmanKevin Pinney, George Pettit, Mary Trawick, Christopher Jelinek & David Chaplin. 2011. Anticancer Agents from Natural Products, Second Edition. Anticancer Agents from Natural Products, Second Edition 27 64 .
Helge Prinz, Peter Schmidt, Konrad J. Böhm, Silke Baasner, Klaus Müller, Matthias Gerlach, Eckhard G. Günther & Eberhard Unger. (2011) Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents—synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorganic & Medicinal Chemistry 19:14, pages 4183-4191.
Crossref
Helge Prinz, Behfar Chamasmani, Kirsten Vogel, Konrad J. Böhm, Babette Aicher, Matthias Gerlach, Eckhard G. Günther, Peter Amon, Igor Ivanov & Klaus Müller. (2011) N -Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization . Journal of Medicinal Chemistry 54:12, pages 4247-4263.
Crossref
Cheng-Chih Hsieh, Hsueh-Yun Lee, Chih-Ying Nien, Ching-Chuan Kuo, Chi-Yen Chang, Jang-Yang Chang & Jing-Ping Liou. (2011) Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents. Molecules 16:3, pages 2274-2284.
Crossref
Hsueh-Yun Lee, Jang-Yang Chang, Ling-Yin Chang, Wen-Yang Lai, Mei-Jung Lai, Kuang-Hsing Shih, Ching-Chuan Kuo, Chi-Yen Chang & Jing-Ping Liou. (2011) Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation. Organic & Biomolecular Chemistry 9:9, pages 3154.
Crossref
Jason A Segreti, Kristin A Brooks, Kennan C Marsh, Joy L Bauch, Yan Lan, C Thomas Lin, Saul H Rosenberg, Hing L Sham, Glenn A Reinhart, Bryan F Cox & James S Polakowski. (2010) Tumour-selective antivascular effects of the novel anti-mitotic compound A-318315: An in vivo rat regional haemodynamic study . Clinical and Experimental Pharmacology and Physiology 37:5-6, pages 636-640.
Crossref
Patrick J. Crowley, Clemens Lamberth, Urs Müller, Sebastian Wendeborn, Olivia-A. Sageot, John Williams & Alexander Bartovič. (2010) Niementowski-type synthesis of pyrido[3,2-e][1,2,4]triazines: potent aza-analogs of pyrido[2,3-b]pyrazine fungicides. Tetrahedron Letters 51:19, pages 2652-2654.
Crossref
Chih-Ying Nien, Yun-Ching Chen, Ching-Chuan Kuo, Hsing-Pang Hsieh, Chi-Yen Chang, Jian-Sung Wu, Su-Ying Wu, Jing-Ping Liou & Jang-Yang Chang. (2010) 5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. Journal of Medicinal Chemistry 53:5, pages 2309-2313.
Crossref
Vittoria Perri, Christophe Rochais, Jana Sopkova-de Oliveira Santos, Rémi Legay, Thierry Cresteil, Patrick Dallemagne & Sylvain Rault. (2010) Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity. European Journal of Medicinal Chemistry 45:3, pages 1146-1150.
Crossref
Patrick J Crowley, Clemens Lamberth, Urs Müller, Sebastian Wendeborn, Kurt Nebel, John Williams, Olivia-A Sageot, Neil Carter, Tanya Mathie, Hans-Joachim Kempf, Jeremy Godwin, Peter Schneiter & Markus R Dobler. (2010) Synthesis and fungicidal activity of tubulin polymerisation promoters. Part 1: pyrido[2,3- b ]pyrazines . Pest Management Science 66:2, pages 178-185.
Crossref
Gordon M. Cragg, David J. Newman & David G.I. Kingston. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 5 39 .
Zhenglai Fang, Gregory E. Agoston, Gaetan Ladouceur, Anthony M. Treston, LiQuan Wang & Mark Cushman. (2009) Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples. Tetrahedron 65:51, pages 10535-10543.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Olga Cruz-Lopez, Manlio Tolomeo, Stefania Grimaudo, Antonietta Di Cristina, Maria Rosaria Pipitone, Jan Balzarini, Nicola Zonta, Andrea Brancale & Ernest Hamel. (2009) Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry 17:19, pages 6862-6871.
Crossref
G. M. Cragg & D. J. Newman. (2009) Nature: a vital source of leads for anticancer drug development. Phytochemistry Reviews 8:2, pages 313-331.
Crossref
Mei-Jung Lai, Ching-Chuan Kuo, Teng-Kuang Yeh, Hsing-Pang Hsieh, Li-Tzong Chen, Wen-Yu Pan, Kuang-Yang Hsu, Jang-Yang Chang & Jing-Ping Liou. (2009) Synthesis and Structure-Activity Relationships of 1-Benzyl-4,5,6-trimethoxyindoles as a Novel Class of Potent Antimitotic Agents. ChemMedChem 4:4, pages 588-593.
Crossref
Helge Prinz, Peter Schmidt, Konrad J. Böhm, Silke Baasner, Klaus Müller, Eberhard Unger, Matthias Gerlach & Eckhard G. Günther. (2009) 10-(2- oxo -2-Phenylethylidene)-10 H -anthracen-9-ones as Highly Active Antimicrotubule Agents: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization . Journal of Medicinal Chemistry 52:5, pages 1284-1294.
Crossref
Jing Chen, Jianshu Lou, Tao Liu, Ru Wu, Xiaowu Dong, Qiaojun He, Bo Yang & Yongzhou Hu. (2009) Synthesis and In‐Vitro Antitumor Activities of Some Mannich Bases of 9‐Alkyl‐1,2,3,4‐tetrahydrocarbazole‐1‐ones . Archiv der Pharmazie 342:3, pages 165-172.
Crossref
Gadarla Randheer ReddyChing-Chuan KuoUan-Kang TanMohane Selvaraj CoumarChi-Yen ChangYi-Kun ChiangMei-Jung LaiJiann-Yih YehSu-Ying WuJang-Yang ChangJing-Ping LiouHsing-Pang Hsieh. (2008) Synthesis and Structure−Activity Relationships of 2-Amino-1-aroylnaphthalene and 2-Hydroxy-1-aroylnaphthalenes as Potent Antitubulin Agents. Journal of Medicinal Chemistry 51:24, pages 8163-8167.
Crossref
Elena A. Santalova, Vladimir A. Denisenko, Dmitry V. Berdyshev, Dmitry L. Aminin & Karen E. Sanamyan. (2008) 6-Bromo-5-hydroxyindolyl-3-glyoxylate from the Far Eastern Ascidian Syncarpa oviformis . Natural Product Communications 3:10, pages 1934578X0800301.
Crossref
Jing-Ping Liou, Zi-Yi Wu, Ching-Chuan Kuo, Chi-Yen Chang, Pei-Yi Lu, Chi-Ming Chen, Hsing-Pang Hsieh & Jang-Yang Chang. (2008) Discovery of 4-Amino and 4-Hydroxy-1-aroylindoles as Potent Tubulin Polymerization Inhibitors. Journal of Medicinal Chemistry 51:14, pages 4351-4355.
Crossref
Céline Mousset, Anne Giraud, Olivier Provot, Abdallah Hamze, Jérôme Bignon, Jian-Miao Liu, Sylviane Thoret, Joëlle Dubois, Jean-Daniel Brion & Mouâd Alami. (2008) Synthesis and antitumor activity of benzils related to combretastatin A-4. Bioorganic & Medicinal Chemistry Letters 18:11, pages 3266-3271.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Dora Carrion, Carlota Lopez Cara, Olga Cruz-Lopez, Delia Preti, Manlio Tolomeo, Stefania Grimaudo, Antonella Di Cristina, Nicola Zonta, Jan Balzarini, Andrea Brancale, Taradas Sarkar & Ernest Hamel. (2008) Design, synthesis, and biological evaluation of thiophene analogues of chalcones. Bioorganic & Medicinal Chemistry 16:10, pages 5367-5376.
Crossref
Gordon M. Cragg, Guest Editor, Richard G. Powell, Associate Editor & Sheo B. Singh, Guest Editor. (2008) Special Issue in Honor of Professor George Robert Pettit. Journal of Natural Products 71:3, pages 297-299.
Crossref
Susan L. Bane. 2008. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology 259 279 .
Maurizio Botta, Stefano Forli, Matteo Magnani & Fabrizio Manetti. 2009. Tubulin-Binding Agents. Tubulin-Binding Agents 279 328 .
Anne Zuse, Helge Prinz, Klaus Müller, Peter Schmidt, Eckhard G. Günther, Frank Schweizer, Jochen H.M. Prehn & Marek Los. (2007) 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity. European Journal of Pharmacology 575:1-3, pages 34-45.
Crossref
Nastaran Heidari, Bahram Goliaei, Parvaneh Rahimi Moghaddam, Nahid Rahbar-Roshandel & Massoud Mahmoudian. (2007) Apoptotic pathway induced by noscapine in human myelogenous leukemic cells. Anti-Cancer Drugs 18:10, pages 1139-1147.
Crossref
Shuchun Guo, Yanfang Zhao, Xianglin Zhao, Sisi Zhang, Lijun Xie, Weiyong Kong & Ping Gong. (2007) Synthesis and Anti‐tumor Activities of Novel Methylthio‐, Sulfinyl‐, and Sulfonyl‐8 H ‐thieno[2,3‐ b ]pyrrolizin‐8‐oximino Derivatives . Archiv der Pharmazie 340:8, pages 416-423.
Crossref
Daniel J. Kerr, Ernest Hamel, M. Katherine Jung & Bernard L. Flynn. (2007) The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4. Bioorganic & Medicinal Chemistry 15:9, pages 3290-3298.
Crossref
Andrea Brancale & Romano Silvestri. (2006) Indole, a core nucleus for potent inhibitors of tubulin polymerization. Medicinal Research Reviews 27:2, pages 209-238.
Crossref
Michael Wink. 2007. 1 47 .
Nicholas J. Lawrence, Richard P. Patterson, Li-Ling Ooi, Darren Cook & Sylvie Ducki. (2006) Effects of α-substitutions on structure and biological activity of anticancer chalcones. Bioorganic & Medicinal Chemistry Letters 16:22, pages 5844-5848.
Crossref
Jing‐Ping Liou, Neeraj Mahindroo, Chun‐Wei Chang, Fu‐Ming Guo, Sandy Wen‐Hsing Lee, Uan‐Kang Tan, Teng‐Kuang Yeh, Ching‐Chuan Kuo, Yi‐Wei Chang, Ping‐Hsun Lu, Yen‐Shih Tung, Ke‐Ta Lin, Jang‐Yang Chang & Hsing‐Pang Hsieh. (2006) Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents. ChemMedChem 1:10, pages 1106-1118.
Crossref
Akhilesh Kumar Verma, Sandhya Bansal, Jaspal Singh, Rakesh Kumar Tiwari, V. Kasi Sankar, Vibha Tandon & Ramesh Chandra. (2006) Synthesis and in vitro cytotoxicity of haloderivatives of noscapine. Bioorganic & Medicinal Chemistry 14:19, pages 6733-6736.
Crossref
Keith A. Monk, Rogelio Siles, Mallinath B. Hadimani, Benon E. Mugabe, J. Freeland Ackley, Scott W. Studerus, Klaus Edvardsen, Mary Lynn Trawick, Charles M. Garner, Monte R. Rhodes, George R. Pettit & Kevin G. Pinney. (2006) Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorganic & Medicinal Chemistry 14:9, pages 3231-3244.
Crossref
Nicholas J. Lawrence, E. Simon M. Armitage, Benjamin Greedy, Darren Cook, Sylvie Ducki & Alan T. McGown. (2006) The synthesis of indanones related to combretastatin A-4 via microwave-assisted Nazarov cyclization of chalcones. Tetrahedron Letters 47:10, pages 1637-1640.
Crossref
Xiaohu Ouyang, Evgueni L. Piatnitski, Vatee Pattaropong, Xiaoling Chen, Hai-Ying He, Alexander S. Kiselyov, Avdhoot Velankar, Joel Kawakami, Marc Labelle, Leon SmithIIII, Julia Lohman, Sui Ping Lee, Asra Malikzay, James Fleming, Jason Gerlak, Ying Wang, Robin L. Rosler, Kai Zhou, Stan Mitelman, Margarita Camara, David Surguladze, Jacqueline F. Doody & M. Carolina Tuma. (2006) Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines. Bioorganic & Medicinal Chemistry Letters 16:5, pages 1191-1196.
Crossref
Ameenah Gurib-Fakim. (2006) Medicinal plants: Traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 27:1, pages 1-93.
Crossref
Hubert Hédoin, Jane Pearson, John G. Day, Denise Philip, Andrew J. Young & Tony J. Hall. (2006) Porphyridium cruentum A-408 and Planktothrix A-404 retain their capacity to produce biotechnologically exploitable metabolites after cryopreservation. Journal of Applied Phycology 18:1, pages 1-7.
Crossref
Xiaohu Ouyang, Xiaoling Chen, Evgueni L. Piatnitski, Alexander S. Kiselyov, Hai-Ying He, Yunyu Mao, Vatee Pattaropong, Yang Yu, Ki H. Kim, John Kincaid, Leon SmithIIII, Wai C. Wong, Sui Ping Lee, Daniel L. Milligan, Asra Malikzay, James Fleming, Jason Gerlak, Dhanvanthri Deevi, Jacqueline F. Doody, Hui-Hsien Chiang, Sheetal N. Patel, Ying Wang, Robin L. Rolser, Paul Kussie, Marc Labelle & M. Carolina Tuma. (2005) Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry Letters 15:23, pages 5154-5159.
Crossref
Karen W.L. Yee, Anne Hagey, Srdan Verstovsek, Jorge Cortes, Guillermo Garcia-Manero, Susan M. O'Brien, Stefan Faderl, Deborah Thomas, William Wierda, Steven Kornblau, Alessandra Ferrajoli, Maher Albitar, Evelyn McKeegan, David R. Grimm, Toby Mueller, Rhonda R. Holley-Shanks, Leonardo Sahelijo, Gary B. Gordon, Hagop M. Kantarjian & Francis J. Giles. (2005) Phase 1 Study of ABT-751, a Novel Microtubule Inhibitor, in Patients with Refractory Hematologic Malignancies. Clinical Cancer Research 11:18, pages 6615-6624.
Crossref
Gordon M. Cragg & David J. Newman. (2005) Plants as a source of anti-cancer agents. Journal of Ethnopharmacology 100:1-2, pages 72-79.
Crossref
David Chaplin, Christopher Jelinek, George Pettit, Klaus Edvardsen & Kevin Pinney. 2005. Anticancer Agents from Natural Products. Anticancer Agents from Natural Products.
Mark S. Butler. (2005) Natural products to drugs: natural product derived compounds in clinical trials. Natural Product Reports 22:2, pages 162.
Crossref
David J. Newman & Gordon M. Cragg. 2005. Natural Products. Natural Products 129 168 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.