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Expert Opinion on Therapeutic Patents Volume 12, 2002 - Issue 12
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Review

Acetylcholinesterase inhibitors in the context of therapeutic strategies to combat Alzheimer’s disease

Maurizio Recanatini Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, , I-40126 Bologna, Italy
&
Andrea Cavalli Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, , I-40126 Bologna, Italy
Pages 1853-1865 | Published online: 25 Feb 2005

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Bo Feng, Xinpeng Li, Jie Xia & Song Wu. (2017) Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 968-977.
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Vincenzo Tumiatti, Maria Laura Bolognesi, Anna Minarini, Michela Rosini, Andrea Milelli, Riccardo Matera & Carlo Melchiorre. (2008) Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update. Expert Opinion on Therapeutic Patents 18:4, pages 387-401.
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Maria Laura Bolognesi, Anna Minarini, Vincenzo Tumiatti & Carlo Melchiorre. (2006) Progress in acetylcholinesterase inhibitors for Alzheimer’s disease. Expert Opinion on Therapeutic Patents 16:6, pages 811-823.
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Isabel Dorronsoro, Ana Castro & Ana Martinez. (2003) Peripheral and dual binding site inhibitors of acetylcholinesterase as neurodegenerative disease modifying agents. Expert Opinion on Therapeutic Patents 13:11, pages 1725-1732.
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Articles from other publishers (10)

Iratxe Barbolla, Nuria Sotomayor & Esther Lete. (2019) Carbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers: Access to Pyrrolo[1,2- b ]isoquinolines . The Journal of Organic Chemistry 84:16, pages 10183-10196.
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V. Hepnarova, J. Korabecny, L. Matouskova, P. Jost, L. Muckova, M. Hrabinova, N. Vykoukalova, M. Kerhartova, T. Kucera, R. Dolezal, E. Nepovimova, K. Spilovska, E. Mezeiova, N.L. Pham, D. Jun, F. Staud, D. Kaping, K. Kuca & O. Soukup. (2018) The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease. European Journal of Medicinal Chemistry 150, pages 292-306.
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Jing Leng, Hua-Li Qin, Kaicheng Zhu, Ibrahim Jantan, Muhammad Ajaz Hussain, Muhammad Sher, Muhammad Wahab Amjad, Muhammad Naeem-ul-Hassan, Waqas Ahmad & Syed Nasir Abbas Bukhari. (2016) Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chemical Biology & Drug Design 88:6, pages 889-898.
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Ziyad F. Al-Rashid & Richard P. Hsung. (2015) A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4848-4853.
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Oihane García-Calvo, Estíbaliz Coya, Sergio Lage, Iain Coldham, Nuria Sotomayor & Esther Lete. (2013) Intramolecular Carbolithiation Reactions in the Construction of Medium-Sized Rings. Synthesis of Pyrroloisoquinolines, Benzazepines, and Benzazocines. European Journal of Organic Chemistry 2013:8, pages 1460-1470.
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Ziyad F. Al-Rashid & Richard P. Hsung. (2011) (+)-Arisugacin A—Computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 21:9, pages 2687-2691.
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Federica Belluti, Angela Rampa, Lorna Piazzi, Alessandra Bisi, Silvia Gobbi, Manuela Bartolini, Vincenza Andrisano, Andrea Cavalli, Maurizio Recanatini & Piero Valenti. (2005) Cholinesterase Inhibitors:  Xanthostigmine Derivatives Blocking the Acetylcholinesterase-Induced β-Amyloid Aggregation. Journal of Medicinal Chemistry 48:13, pages 4444-4456.
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Lorna Piazzi, Angela Rampa, Alessandra Bisi, Silvia Gobbi, Federica Belluti, Andrea Cavalli, Manuela Bartolini, Vincenza Andrisano, Piero Valenti & Maurizio Recanatini. (2003) 3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2 H -2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation:  A Dual Function Lead for Alzheimer's Disease Therapy . Journal of Medicinal Chemistry 46:12, pages 2279-2282.
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. (2003) Current Awareness in Human Psychopharmacology. Human Psychopharmacology: Clinical and Experimental 18:4, pages 319-328.
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. (2003) Current Awareness in Geriatric Psychiatry. International Journal of Geriatric Psychiatry 18:5, pages 465-472.
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