Advanced search
Publication Cover
Expert Opinion on Therapeutic Patents Volume 12, 2002 - Issue 4
Submit an article Journal homepage
47
Views
32
CrossRef citations to date
0
Altmetric
Miscellaneous

Recent progress in 5-HT6 receptor antagonists for the treatment of CNS diseases

Abdelmalik Slassi Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]
,
Methvin Isaac Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]
&
Anne O’Brien Discovery Chemistry Department, NPS Pharmaceuticals, 6850 Goreway Drive, Mississauga, Ontario, L4V 1V7, Canada, Tel.: +1 905 677 0831; Fax: +1 905 677 9595;, E-mail: [email protected]
Pages 513-527 | Published online: 25 Feb 2005

Citations (32)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

B.K. Sharma, P. Singh, K. Sarbhai & Y.S. Prabhakar. (2010) A quantitative structure-activity relationship study on serotonin 5-HT6 receptor ligands: indolyl and piperidinyl sulphonamides. SAR and QSAR in Environmental Research 21:3-4, pages 369-388.
Read now

Articles from other publishers (31)

V.S. Velingkar, A.K. Chindhe, Mrunal Sanaye & Madhumangiri Gatane. (2016) Design, Synthesis and Evaluation of Substituted 3-(1, 4-Diazepanyl)-Methyl-Phenyl-Sulphonamides as Potent 5-HT6 Antagonists in Cognitive Disorders. Open Pharmaceutical Sciences Journal 3:1, pages 138-148.
Crossref
Bellinda Benhamú, Mar Martín-Fontecha, Henar Vázquez-Villa, Leonardo Pardo & María L. López-Rodríguez. (2014) Serotonin 5-HT 6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease . Journal of Medicinal Chemistry 57:17, pages 7160-7181.
Crossref
Niels Krogsgaard-Larsen, Anders A. Jensen, Tenna J. Schrøder, Claus. T. Christoffersen & Jan Kehler. (2014) Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT 6 and Dopamine D 2 Receptor Ligands. . Journal of Medicinal Chemistry 57:13, pages 5823-5828.
Crossref
A Bakarr Kanu, Simon D. BrandtMike D. Williams, Nancy Zhang & Herbert H. Hill. (2013) Analysis of Psychoactive Cathinones and Tryptamines by Electrospray Ionization Atmospheric Pressure Ion Mobility Time-of-Flight Mass Spectrometry. Analytical Chemistry 85:18, pages 8535-8542.
Crossref
Faisal Hayat, Euna Yoo, Hyewhon Rhim & Hea-Young ParkChoo. (2013) Synthesis and Inhibition Effects on 5-HT 6 Receptor of Benzothiazole Derivatives . Bulletin of the Korean Chemical Society 34:2, pages 495-499.
Crossref
Ruchanok Tearavarich, Viwat Hahnvajanawong, Nicola Dempster, Paul F. Daley, Nicholas V. Cozzi & Simon D. Brandt. (2011) Microwave-accelerated preparation and analytical characterization of 5-ethoxy-N,N-dialkyl-[α,α,β,β-H4]- and [α,α,β,β-D4]-tryptamines. Drug Testing and Analysis 3:9, pages 597-608.
Crossref
Mohammad Goodarzi, Matheus P. Freitas & Nahid Ghasemi. (2010) QSAR studies of bioactivities of 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 receptor ligands using physicochemical descriptors and MLR and ANN-modeling. European Journal of Medicinal Chemistry 45:9, pages 3911-3915.
Crossref
Ramakrishna V.S. Nirogi, Anand V. Daulatabad, G. Parandhama, Shaikh Mohammad, K.R. Sastri, Anil K. Shinde & P.K. Dubey. (2010) Synthesis and pharmacological evaluation of aryl aminosulfonamide derivatives as potent 5-HT6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4440-4443.
Crossref
Simon N. Haydar, Heedong Yun, Patrick M. Andrae, James Mattes, Jean Zhang, Angela Kramer, Deborah L. Smith, Christine Huselton, Radka Graf, Suzan Aschmies, Lee E. Schechter, Thomas A. Comery & Albert J. Robichaud. (2010) 5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT 6 Receptor Antagonists . Journal of Medicinal Chemistry 53:6, pages 2521-2527.
Crossref
Tania de la Fuente, Mar Martín-Fontecha, Jessica Sallander, Bellinda Benhamú, Mercedes Campillo, Rocío A. Medina, Lucie P. Pellissier, Sylvie Claeysen, Aline Dumuis, Leonardo Pardo & María L. López-Rodríguez. (2010) Benzimidazole Derivatives as New Serotonin 5-HT 6 Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation . Journal of Medicinal Chemistry 53:3, pages 1357-1369.
Crossref
Xavier Codony, Javier Burgueño, Maria Javier Ramírez & José Miguel Vela. 2010. Pharmacology of 5-HT6 receptors - Part 1. Pharmacology of 5-HT6 receptors - Part 1 89 110 .
Kevin G. Liu & Albert J. Robichaud. 2010. Pharmacology of 5-HT6 receptors - Part 1. Pharmacology of 5-HT6 receptors - Part 1 1 34 .
Kevin G. Liu & Albert J. Robichaud. (2009) 5-HT 6 antagonists as potential treatment for cognitive dysfunction . Drug Development Research 70:2, pages 145-168.
Crossref
D.J. Heal, S.L. Smith, A. Fisas, X. Codony & H. Buschmann. (2008) Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacology & Therapeutics 117:2, pages 207-231.
Crossref
Churl Min Seong, Woo Kyu Park, Chul Min Park, Jae Yang Kong & No Sang Park. (2008) Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 18:2, pages 738-743.
Crossref
Florence Loiseau, Anne Dekeyne & Mark J. Millan. (2007) Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology 196:1, pages 93-104.
Crossref
Anna Wesołowska, Agnieszka Nikiforuk & Katarzyna Stachowicz. (2007) Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats. Behavioural Pharmacology 18:5-6, pages 439-446.
Crossref
Hassan Elokdah, David Li, Geraldine McFarlane, Ronald C. Bernotas, Albert J. Robichaud, Ronald L. Magolda, Guo Ming Zhang, Deborah Smith & Lee E. Schechter. (2007) Novel 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists. Bioorganic & Medicinal Chemistry 15:18, pages 6208-6226.
Crossref
Gonzalo Romero, Elisabeth Sánchez, Marta Pujol, Pilar Pérez, Xavier Codony, Jörg Holenz, Helmut Buschmann & Petrus J Pauwels. (2006) Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways. British Journal of Pharmacology 148:8, pages 1133-1143.
Crossref
Donald Sikazwe, Mikhail L. Bondarev, Małgorzata Dukat, Jagadeesh B. Rangisetty, Bryan L. Roth & Richard A. Glennon. (2006) Binding of Sulfonyl-Containing Arylalkylamines at Human 5-HT 6 Serotonin Receptors . Journal of Medicinal Chemistry 49:17, pages 5217-5225.
Crossref
Jörg Holenz, Petrus J. Pauwels, José Luis Díaz, Ramon Mercè, Xavier Codony & Helmut Buschmann. (2006) Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents. Drug Discovery Today 11:7-8, pages 283-299.
Crossref
María L. López-Rodríguez, Bellinda Benhamú, Tania de la Fuente, Arantxa Sanz, Leonardo Pardo & Mercedes Campillo. (2005) A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine 6 (5-HT 6 ) Receptor Antagonists . Journal of Medicinal Chemistry 48:13, pages 4216-4219.
Crossref
Renata Kolanos, Uma Siripurapu, Manik Pullagurla, Mohamed Riaz, Vince Setola, Bryan L. Roth, Małgorzata Dukat & Richard A. Glennon. (2005) Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorganic & Medicinal Chemistry Letters 15:8, pages 1987-1991.
Crossref
Jörg Holenz, Ramon Mercè, José Luis Díaz, Xavier Guitart, Xavier Codony, Alberto Dordal, Gonzalo Romero, Antoni Torrens, Josep Mas, Blas Andaluz, Susana Hernández, Xavier Monroy, Elisabeth Sánchez, Enrique Hernández, Raquel Pérez, Roger Cubí, Olga Sanfeliu & Helmut Buschmann. (2004) Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT 6 Receptor Ligands . Journal of Medicinal Chemistry 48:6, pages 1781-1795.
Crossref
Mase Lee, Jagadeesh B. Rangisetty, Manik R. Pullagurla, Małgorzata Dukat, Vince Setola, Bryan L. Roth & Richard A. Glennon. (2005) 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorganic & Medicinal Chemistry Letters 15:6, pages 1707-1711.
Crossref
Manik R Pullagurla, Richard B Westkaemper & Richard A Glennon. (2004) Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. Bioorganic & Medicinal Chemistry Letters 14:17, pages 4569-4573.
Crossref
Manik Pullagurla, Tatiana Bondareva, Richard Young & Richard A Glennon. (2004) Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245. Pharmacology Biochemistry and Behavior 78:2, pages 263-268.
Crossref
Manik R. Pullagurla, Małgorzata Dukat, Vincent Setola, Bryan Roth & Richard A. Glennon. (2003) N1-Benzenesulfonylgramine and N1-benzenesulfonylskatole: novel 5-HT6 receptor ligand templates. Bioorganic & Medicinal Chemistry Letters 13:19, pages 3355-3359.
Crossref
Richard A. Glennon. (2003) Higher-End Serotonin Receptors:  5-HT 5 , 5-HT 6 , and 5-HT 7 . Journal of Medicinal Chemistry 46:14, pages 2795-2812.
Crossref
Mark J. Millan. (2003) The neurobiology and control of anxious states. Progress in Neurobiology 70:2, pages 83-244.
Crossref
Claus Riemer, Edilio Borroni, Bernard Levet-Trafit, James R. Martin, Sonia Poli, Richard H. P. Porter & Michael Bös. (2003) Influence of the 5-HT 6 Receptor on Acetylcholine Release in the Cortex:  Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT 6 Receptor Antagonist . Journal of Medicinal Chemistry 46:7, pages 1273-1276.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.