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Anna F. Mkrtchyan, Ani M. Paloyan, Liana A. Hayriyan, Armen S. Sargsyan, Anna S. Tovmasyan, Ani J. Karapetyan, Artur A. Hambardzumyan, Nelli A. Hovhannisyan, Henrik A. Panosyan, Hamlet N. Khachatryan, Ani S. Dadayan & Ashot S. Saghyan. (2021) Synthesis of enantiomerically enriched non-protein α-amino acids and their study as aldose reductase inhibitors. Synthetic Communications 51:9, pages 1433-1450.
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Mounir Ghamali, Samir Chtita, Rachid Hmamouchi, Azeddine Adad, Mohammed Bouachrine & Tahar Lakhlifi. (2016) The inhibitory activity of aldose reductase of flavonoid compounds: Combining DFT and QSAR calculations. Journal of Taibah University for Science 10:4, pages 534-542.
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Marta Soltesova Prnova, Jana Ballekova, Magdalena Majekova & Milan Stefek. (2015) Antioxidant action of 3-mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid, an efficient aldose reductase inhibitor, in a 1,1′-diphenyl-2-picrylhydrazyl assay and in the cellular system of isolated erythrocytes exposed to tert-butyl hydroperoxide. Redox Report 20:6, pages 282-288.
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Ivana Milackova, Marta Soltesova Prnova, Magdalena Majekova, Ruzena Sotnikova, Michal Stasko, Lucia Kovacikova, Sreeparna Banerjee, Miroslav Veverka & Milan Stefek. (2015) 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. Journal of Enzyme Inhibition and Medicinal Chemistry 30:1, pages 107-113.
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Maria Chatzopoulou, Polyxeni Alexiou, Eleni Kotsampasakou & Vassilis J Demopoulos. (2012) Novel aldose reductase inhibitors: a patent survey (2006 – present). Expert Opinion on Therapeutic Patents 22:11, pages 1303-1323.
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Articles from other publishers (56)
Yuanfan Yang, Junzhu He, Zedong Jiang, Xiping Du, Feng Chen, Jinling Wang & Hui Ni. (2022)
Characterization of the inhibition of aldose reductase with
p
‐coumaric acid ethyl ester
. Journal of Food Biochemistry 46:10.
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Onikepe Deborah Owoseeni, Rajesh B. Patil, Prajakta M. Phage, Ruth Mosunmola Ogboye, Marcus Durojaye Ayoola, Samson Oluwaseyi Famuyiwa, Felix Olusegun Gboyero, Derek Tantoh Ndinteh & Kolade Olatubosun Faloye. (2022) Computational Assessment of Xanthones from African Medicinal Plants as Aldose Reductase Inhibitors. Computation 10:9, pages 146.
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Aqeel Imran, Muhammad Tariq Shehzad, Syed Jawad Ali Shah, Taha al Adhami, Mark Laws, Khondaker Miraz Rahman, Rima D. Alharthy, Imtiaz Ali Khan, Zahid Shafiq & Jamshed Iqbal. (2022) Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study. Scientific Reports 12:1.
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Aqeel Imran, Muhammad Tariq Shehzad, Taha al Adhami, Khondaker Miraz Rahman, Dilawar Hussain, Rima D. Alharthy, Zahid Shafiq & Jamshed Iqbal. (2021) Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation. Bioorganic Chemistry 115, pages 105164.
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Manar G. Salem, Yasmine M. Abdel Aziz, Marwa Elewa, Mohamed S. Nafie, Hosam A. Elshihawy & Mohamed M. Said. (2021) Synthesis, molecular modeling, selective aldose reductase inhibition and hypoglycemic activity of novel meglitinides. Bioorganic Chemistry 111, pages 104909.
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Lucia Kovacikova, Marta Soltesova Prnova, Magdalena Majekova, Andrej Bohac, Cimen Karasu & Milan Stefek. (2021) Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications. Molecules 26:10, pages 2867.
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Muhammad Tariq Shehzad, Aqeel Imran, Abdul Hameed, Mariya al Rashida, Marium Bibi, Maliha Uroos, Asnuzilawati Asari, Shafia Iftikhar, Habsah Mohamad, Muhammad Nawaz Tahir, Zahid Shafiq & Jamshed Iqbal. (2021) Exploring synthetic and therapeutic prospects of new thiazoline derivatives as aldose reductase (ALR2) inhibitors. RSC Advances 11:28, pages 17259-17282.
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Roshan M. Borkar, Shankar Gajji, Soheb A. Mohammed, Mithul Srivastava, Velma Ganga Reddy, Aishwarya Jala, Shailendra Asthana, Ahmed Kamal, Sanjay K. Banerjee & Srinivas Ragampeta. (2021)
Identification and characterization of
in vitro
and
in vivo
fidarestat metabolites: Toxicity and efficacy evaluation of metabolites
. Journal of Mass Spectrometry 56:2.
Crossref
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Belgin Sever, Mehlika Dilek Altıntop, Yeliz Demir, Muhammed Pekdoğan, Gülşen Akalın Çiftçi, Şükrü Beydemir & Ahmet Özdemir. (2021) An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives. Journal of Molecular Structure 1224, pages 129446.
Crossref
Crossref
Matúš Hlaváč, Lucia Kováčiková, Marta Šoltésová Prnová, Peter Šramel, Gabriela Addová, Magdaléna Májeková, Gilles Hanquet, Andrej Boháč & Milan Štefek. (2019) Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. Journal of Medicinal Chemistry 63:1, pages 369-381.
Crossref
Crossref
Manjula Suri. (2019) Dietary approaches toprevent the development of cataract in elderly. MOJ Gerontology & Geriatrics 4:6, pages 247-248.
Crossref
Crossref
Zhaoxi Sun, Xiaohui Wang, Qianqian Zhao & Tong Zhu. (2019) Understanding Aldose Reductase-Inhibitors interactions with free energy simulation. Journal of Molecular Graphics and Modelling 91, pages 10-21.
Crossref
Crossref
Manar G. Salem, Yasmine M. Abdel Aziz, Marwa Elewa, Hosam A. Elshihawy & Mohamed M. Said. (2019) Synthesis and molecular modeling of novel non-sulfonylureas as hypoglycemic agents and selective ALR2 inhibitors. Bioorganic & Medicinal Chemistry 27:15, pages 3383-3389.
Crossref
Crossref
Muhammad Tariq Shehzad, Aqeel Imran, Guy Sedar Singor Njateng, Abdul Hameed, Muhammad Islam, Mariya al-Rashida, Maliha Uroos, Asnuzilawati Asari, Zahid Shafiq & Jamshed Iqbal. (2019) Benzoxazinone-thiosemicarbazones as antidiabetic leads via aldose reductase inhibition: Synthesis, biological screening and molecular docking study. Bioorganic Chemistry 87, pages 857-866.
Crossref
Crossref
Manar G. Salem, Yasmine M. Abdel Aziz, Marwa Elewa, Hosam A. Elshihawy & Mohamed M. Said. (2018) Molecular modelling and synthesis of spiroimidazolidine-2,4-diones with dual activities as hypoglycemic agents and selective inhibitors of aldose reductase. Bioorganic Chemistry 79, pages 131-144.
Crossref
Crossref
Dasharath Kondhare & Harshad Lade. (2017) Phytochemical profile, aldose reductase inhibitory, and antioxidant activities of Indian traditional medicinal Coccinia grandis (L.) fruit extract. 3 Biotech 7:6.
Crossref
Crossref
Jie Wu, Xue Li, Wencheng Wan, Qiaohong Yang, Weifeng Ma, Dan Chen, Jiangmiao Hu, C.-Y.Oliver Chen & Xiaoyong Wei. (2017) Gigantol from Dendrobium chrysotoxum Lindl. binds and inhibits aldose reductase gene to exert its anti-cataract activity: An in vitro mechanistic study. Journal of Ethnopharmacology 198, pages 255-261.
Crossref
Crossref
Amandeep Kaur, Vikas Gupta, Ajay Francis Christopher, Manzoor Ahmad Malik & Parveen Bansal. (2017) Nutraceuticals in prevention of cataract – An evidence based approach. Saudi Journal of Ophthalmology 31:1, pages 30-37.
Crossref
Crossref
Ryota Saito, Maiko Hoshi, Akihiro Kato, Chikako Ishikawa & Toshiya Komatsu. (2017) Green fluorescent protein chromophore derivatives as a new class of aldose reductase inhibitors. European Journal of Medicinal Chemistry 125, pages 965-974.
Crossref
Crossref
Laitao Zhang, Yi-Fang Li, Sheng Yuan, Shijie Zhang, Huanhuan Zheng, Jie Liu, Pinghua Sun, Yijun Gu, Hiroshi Kurihara, Rong-Rong He & Heru Chen. (2016) Bioactivity Focus of α-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors. Scientific Reports 6:1.
Crossref
Crossref
M. SOLTESOVA PRNOVA, J. BALLEKOVA, A. GAJDOSIKOVA, A. GAJDOSIK & M. STEFEK. (2015) A Novel Carboxymethylated Mercaptotriazinoindole Inhibitor of Aldose Reductase Interferes With the Polyol Pathway in Streptozotocin-Induced Diabetic Rats. Physiological Research, pages 587-591.
Crossref
Crossref
Hua Fang, Xiaohong Hu, Meiling Wang, Wencheng Wan, Qiaohong Yang, Xiaosheng Sun, Qiong Gu, Xinxin Gao, Zhengtao Wang, Lianquan Gu, C.-Y. Oliver Chen & Xiaoyong Wei. (2015) Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats. Journal of Ethnopharmacology 172, pages 238-246.
Crossref
Crossref
Milan Stefek, Marta Soltesova Prnova, Magdalena Majekova, Chris Rechlin, Andreas Heine & Gerhard Klebe. (2015) Identification of Novel Aldose Reductase Inhibitors Based on Carboxymethylated Mercaptotriazinoindole Scaffold. Journal of Medicinal Chemistry 58:6, pages 2649-2657.
Crossref
Crossref
Aamer Saeed, Yildiz Tehseen, Hummera Rafique, Norbert Furtmann, Jürgen Bajorath, Ulrich Flörke & Jamshed Iqbal. (2014) Benzothiazolyl substituted iminothiazolidinones and benzamido-oxothiazolidines as potent and partly selective aldose reductase inhibitors. Med. Chem. Commun. 5:9, pages 1371-1380.
Crossref
Crossref
Jian-Hua Huang, Rui-Hua He, Lun-Zhao Yi, Hua-Lin Xie, Dong-sheng Cao & Yi-Zeng Liang. (2013) Exploring the relationship between 5′AMP-activated protein kinase and markers related to type 2 diabetes mellitus. Talanta 110, pages 1-7.
Crossref
Crossref
Jian-Hua Huang, Hua-Lin Xie, Jun Yan, Dong-Sheng Cao, Hong-Mei Lu, Qing-Song Xu & Yi-Zeng Liang. (2013) Interpretation of type 2 diabetes mellitus relevant GC-MS metabolomics fingerprints by using random forests. Anal. Methods 5:18, pages 4883-4889.
Crossref
Crossref
B. Keshavarz Hedayati, R. Parra-Hernandez, E. M. Laxdal, N. J. Dimopoulos, P. Alexiou & V. J. Demopoulos. (2012) An improved neural network ensemble model of Aldose Reductase inhibitory activity. An improved neural network ensemble model of Aldose Reductase inhibitory activity.
Xin Chen, Shuzhen Zhang, Yanchun Yang, Saghir Hussain, Minlan He, Dequan Gui, Bing Ma, Chaojun Jing, Zhixin Qiao, Changjin Zhu & Qun Yu. (2011) 1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase. Bioorganic & Medicinal Chemistry 19:23, pages 7262-7269.
Crossref
Crossref
Milan StefekCimen Karasu. (2011) Eye Lens in Aging and Diabetes: Effect of Quercetin. Rejuvenation Research 14:5, pages 525-534.
Crossref
Crossref
Cornelia Koch, Andreas Heine & Gerhard Klebe. (2011) Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase. Biochimica et Biophysica Acta (BBA) - General Subjects 1810:9, pages 879-887.
Crossref
Crossref
Cornelia Koch, Andreas Heine & Gerhard Klebe. (2011) Tracing the Detail: How Mutations Affect Binding Modes and Thermodynamic Signatures of Closely Related Aldose Reductase Inhibitors. Journal of Molecular Biology 406:5, pages 700-712.
Crossref
Crossref
Milan Stefek. (2011) Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract. Interdisciplinary Toxicology 4:2.
Crossref
Crossref
Julio Caballero. (2010) 3D-QSAR (CoMFA and CoMSIA) and pharmacophore (GALAHAD) studies on the differential inhibition of aldose reductase by flavonoid compounds. Journal of Molecular Graphics and Modelling 29:3, pages 363-371.
Crossref
Crossref
Milan Stefek, Vladimir Snirc, Paul-Omer Djoubissie, Magdalena Majekova, Vassilis Demopoulos, Lucia Rackova, Zelmira Bezakova, Cimen Karasu, Vincenzo Carbone & Ossama El-Kabbani. (2008) Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. Bioorganic & Medicinal Chemistry 16:9, pages 4908-4920.
Crossref
Crossref
Hai-Tao Zhao, Isabelle Hazemann, Andre Mitschler, Vincenzo Carbone, Andrzej Joachimiak, Steve Ginell, Alberto Podjarny & Ossama El-Kabbani. (2008)
Unusual Binding Mode of the 2
S
4
R
Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2
S
4
S
) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 Å Resolution: Implications for the Inhibition Mechanism
. Journal of Medicinal Chemistry 51:5, pages 1478-1481.
Crossref
Crossref
Holger Steuber, Andreas Heine & Gerhard Klebe. (2007) Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution. Journal of Molecular Biology 368:3, pages 618-638.
Crossref
Crossref
Dietmar Rakowitz, Grete Piccolruaz, Cornelia Pirker & Barbara Matuszczak. (2007) Novel Aldose Reductase Inhibitors Derived from 6‐[[(Diphenylmethylene)amino]oxy]hexanoic Acid. Archiv der Pharmazie 340:4, pages 202-208.
Crossref
Crossref
Wei Li, Rong-Ji Dai, Yu-Hong Yu, Liang Li, Chong-Ming Wu, Wei-Wei Luan, Wei-Wei Meng, Xin-Sheng Zhang & Yu-Lin Deng. (2007) Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents. Biological and Pharmaceutical Bulletin 30:6, pages 1123-1129.
Crossref
Crossref
Dietmar Rakowitz, Andreas Gmeiner & Barbara Matuszczak. (2006) Discovery of Novel Aldose Reductase Inhibitors Characterized by an Alkoxy‐Substituted Phenylacetic Acid Core. Archiv der Pharmazie 339:10, pages 559-563.
Crossref
Crossref
Dietmar Rakowitz, Helga Angerer & Barbara Matuszczak. (2006)
Synthesis and Aldose Reductase Inhibitory Activities of Novel
O
‐Substituted Hydroxyphenylacetic Acid Derivatives
. Archiv der Pharmazie 339:10, pages 547-558.
Crossref
Crossref
Catherine Koukoulitsa, Chariklia Zika, George D. Geromichalos, Vassilis J. Demopoulos & Helen Skaltsa. (2006) Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum. Bioorganic & Medicinal Chemistry 14:5, pages 1653-1659.
Crossref
Crossref
Zhi‐Yun Du, Ya‐Dan Bao, Zhong Liu, Wei Qiao, Lin Ma, Zhi‐Shu Huang, Lian‐Quan Gu & Albert S. C. Chan. (2006) Curcumin Analogs as Potent Aldose Reductase Inhibitors. Archiv der Pharmazie 339:3, pages 123-128.
Crossref
Crossref
Holger Steuber, Matthias Zentgraf, Alberto Podjarny, Andreas Heine & Gerhard Klebe. (2006) High-resolution Crystal Structure of Aldose Reductase Complexed with the Novel Sulfonyl-pyridazinone Inhibitor Exhibiting an Alternative Active Site Anchoring Group. Journal of Molecular Biology 356:1, pages 45-56.
Crossref
Crossref
Dietmar Rakowitz, Andreas Gmeiner, Nicole Schröder & Barbara Matuszczak. (2006) Synthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors. European Journal of Pharmaceutical Sciences 27:2-3, pages 188-193.
Crossref
Crossref
Tatiana PetrovaHolger SteuberIsabelle HazemannAlexandra Cousido-SiahAndre MitschlerRoland ChungMitsuru OkaGerhard KlebeOssama El-KabbaniAndrzej JoachimiakAlberto Podjarny. (2005) Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro−Fidarestat Complex. Journal of Medicinal Chemistry 48:18, pages 5659-5665.
Crossref
Crossref
Dietmar Rakowitz, Patric Muigg, Nicole Schröder & Barbara Matuszczak. (2005)
On the Synthesis of Bioisosters of
O
‐Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors
. Archiv der Pharmazie 338:9, pages 419-426.
Crossref
Crossref
Dietmar Rakowitz, Barbara Hennig, Marietta Nagano, Stefan Steger, Luca Costantino & Barbara Matuszczak. (2005) Synthesis of Novel Benzoic Acid Derivatives with Benzothiazolyl Subunit and Evaluation as Aldose Reductase Inhibitors. Archiv der Pharmazie 338:9, pages 411-418.
Crossref
Crossref
Michael C. Van Zandt, Michael L. Jones, David E. Gunn, Leo S. Geraci, J. Howard Jones, Diane R. Sawicki, Janet Sredy, Jorge L. Jacot, A. Thomas DiCioccio, Tatiana Petrova, Andre Mitschler & Alberto D. Podjarny. (2005)
Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-
N
-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications
. Journal of Medicinal Chemistry 48:9, pages 3141-3152.
Crossref
Crossref
R. Parra-Hernandez, E.M. Laxdal, N.J. Dimopoulos & P. Alexiou. (2005) A new neural network ensemble heuristic for a predictor of the aldose reductase inhibitory activity. A new neural network ensemble heuristic for a predictor of the aldose reductase inhibitory activity.
R. Parra-Hernandez, E.M. Laxdal, N.J. Dimopoulos & P. Alexiou. (2005) A neural network-based prediction model of AR inhibitory activity from a sparse set of compounds. A neural network-based prediction model of AR inhibitory activity from a sparse set of compounds.
Ossama El-Kabbani, Connie Darmanin, Mitsuru Oka, Clemens Schulze-Briese, Takashi Tomizaki, Isabelle Hazemann, Andre Mitschler & Alberto Podjarny. (2004) High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor. Journal of Medicinal Chemistry 47:18, pages 4530-4537.
Crossref
Crossref
Connie Darmanin, Guillaume Chevreux, Noelle Potier, Alain Van Dorsselaer, Isabelle Hazemann, Alberto Podjarny & Ossama El-Kabbani. (2004) Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry. Bioorganic & Medicinal Chemistry 12:14, pages 3797-3806.
Crossref
Crossref
Christoph A. Sotriffer, Oliver Krämer & Gerhard Klebe. (2004) Probing flexibility and “induced-fit” phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations. Proteins: Structure, Function, and Bioinformatics 56:1, pages 52-66.
Crossref
Crossref
E.I. Howard, R. Sanishvili, R.E. Cachau, A. Mitschler, B. Chevrier, P. Barth, V. Lamour, M. Van Zandt, E. Sibley, C. Bon, D. Moras, T.R. Schneider, A. Joachimiak & A. Podjarny. (2004) Ultrahigh resolution drug design I: Details of interactions in human aldose reductase-inhibitor complex at 0.66 Å. Proteins: Structure, Function, and Bioinformatics 55:4, pages 792-804.
Crossref
Crossref
Ioannis Nicolaou, Chariklia Zika & Vassilis J. Demopoulos. (2004)
[1-(3,5-Difluoro-4-hydroxyphenyl)-1
H
-pyrrol-3-yl]phenylmethanone as a Bioisostere of a Carboxylic Acid Aldose Reductase Inhibitor
. Journal of Medicinal Chemistry 47:10, pages 2706-2709.
Crossref
Crossref
Shuichi Miyamoto. (2002) Molecular Modeling and Structure-based Drug Discovery Studies of Aldose Reductase Inhibitorsアルドース還元酵素阻害剤の分子モデリングとStructure-based Drug Discovery. Chem-Bio Informatics Journal 2, pages 74-85.
Crossref
Crossref