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Review

Recent advances in histamine H3/H4 receptor ligands

Pages 851-865 | Published online: 02 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Dorota Łażewska & Katarzyna Kieć-Kononowicz. (2018) Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017). Expert Opinion on Therapeutic Patents 28:3, pages 175-196.
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Michael Berlin & Christopher W Boyce. (2007) Recent advances in the development of histamine H3 antagonists. Expert Opinion on Therapeutic Patents 17:6, pages 675-687.
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Mai Zhang, Jennifer D Venable & Robin L Thurmond. (2006) The histamine H4 receptor in autoimmune disease. Expert Opinion on Investigational Drugs 15:11, pages 1443-1452.
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Silvia Fonquerna & Montserrat Miralpeix. (2006) H1 antihistamines: patent highlights 2000 – 2005. Expert Opinion on Therapeutic Patents 16:2, pages 109-117.
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Arthur A Hancock & Michael E Brune. (2005) Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists. Expert Opinion on Investigational Drugs 14:3, pages 223-241.
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Arthur A Hancock & Gerard B Fox. (2004) Perspectives on cognitive domains, H3 receptor ligands and neurological disease. Expert Opinion on Investigational Drugs 13:10, pages 1237-1248.
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Harry R Howard. (2004) Agents for attention-deficit hyperactivity disorder – an update. Expert Opinion on Therapeutic Patents 14:7, pages 983-1008.
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Articles from other publishers (57)

Michelle F. Corrêa, André L. Balico-Silva, Dóra J. Kiss, Gustavo A.B. Fernandes, Jhonatan C. Maraschin, Lucas T. Parreiras-e-Silva, Marina T. Varela, Sarah C. Simões, Michel Bouvier, György M. Keserű, Claudio M. Costa-Neto & João Paulo S. Fernandes. (2021) Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H3 and H4 receptors. Bioorganic & Medicinal Chemistry 30, pages 115924.
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Andressa Soliani, Silvia Megumi Kubota, Michelle Fidelis Corrêa, Suzete Maria Cerutti & João Paulo S. Fernandes. (2020) Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats. Behavioural Brain Research 377, pages 112230.
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Nakisa Ghamari, Omid Zarei, José-Antonio Arias-Montaño, David Reiner, Siavoush Dastmalchi, Holger Stark & Maryam Hamzeh-Mivehroud. (2019) Histamine H3 receptor antagonists/inverse agonists: Where do they go?. Pharmacology & Therapeutics 200, pages 69-84.
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Monika Gaba & Chander Mohan. (2015) Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. Medicinal Chemistry Research 25:2, pages 173-210.
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Hossein Amini-Khoei, Maryam Rahimi-Balaei, Shayan Amiri, Arya Haj-Mirzaian, Mahsa Hassanipour, Armin Shirzadian, Maziar Gooshe, Sakineh Alijanpour, Shahram Ejtemaie Mehr & Ahmad Reza Dehpour. (2015) Morphine modulates the effects of histamine H1 and H3 receptors on seizure susceptibility in pentylenetetrazole-induced seizure model of mice. European Journal of Pharmacology 769, pages 43-47.
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Brad M. Savall, Frank Chavez, Kevin Tays, Paul J. Dunford, Jeffery M. Cowden, Michael D. Hack, Ronald L. Wolin, Robin L. Thurmond & James P. Edwards. (2014) Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H 4 Receptor Antagonists . Journal of Medicinal Chemistry 57:6, pages 2429-2439.
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Kerstin Wingen & Holger Stark. (2013) Scaffold variations in amine warhead of histamine H3 receptor antagonists. Drug Discovery Today: Technologies 10:4, pages e483-e489.
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Ming Tao, Lisa D. Aimone, John A. Gruner, Joanne R. Mathiasen, Zeqi Huang, Jacquelyn Lyons, Rita Raddatz & Robert L. Hudkins. (2012) Synthesis and structure–activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H3 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 22:2, pages 1073-1077.
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Dahui Zhou, Jonathan L. Gross, Jean Y. Sze, Adedayo B. Adedoyin, Mark Bowlby, Li Di, Brian J. Platt, Guoming Zhang, Nicholas Brandon, Thomas A. Comery & Albert J. Robichaud. (2011) Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 21:19, pages 5957-5960.
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Mark Chiu, Brian Estvander, Timothy Esbenshade, Steve Kakavas, Kathy Krueger, Marc Lake & Ana Pereda‐Lopez. 2011. Production of Membrane Proteins. Production of Membrane Proteins 109 138 .
Małgorzata Więcek, Tim Kottke, Xavier Ligneau, Walter Schunack, Roland Seifert, Holger Stark, Jadwiga Handzlik & Katarzyna Kieć-Kononowicz. (2011) N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. Bioorganic & Medicinal Chemistry 19:9, pages 2850-2858.
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Tim Kottke, Kerstin Sander, Lilia Weizel, Erich H. Schneider, Roland Seifert & Holger Stark. (2011) Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands. European Journal of Pharmacology 654:3, pages 200-208.
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Trivendra Tripathi, Mohammed Shahid, Farrukh Sobia, Anuradha Singh, Haris M. Khan, Rahat Ali Khan & Mashiatullah Siddiqui. 2011. Biomedical Aspects of Histamine. Biomedical Aspects of Histamine 133 147 .
Andrew G Foley, Alison Prendergast, Claire Barry, Darren Scully, Neil Upton, Andrew D Medhurst & Ciaran M Regan. (2009) H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms. Neuropsychopharmacology 34:12, pages 2585-2600.
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Giovanni Morini, Mara Comini, Mirko Rivara, Silvia Rivara, Fabrizio Bordi, Pier Vincenzo Plazzi, Lisa Flammini, Francesca Saccani, Simona Bertoni, Vigilio Ballabeni, Elisabetta Barocelli & Marco Mor. (2008) Synthesis and structure–activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorganic & Medicinal Chemistry 16:23, pages 9911-9924.
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Timothy Esbenshade, Michael Brune & Marina Strakhova. 2008. The Third Histamine Receptor. The Third Histamine Receptor 277 304 .
Ewgenij Proschak, Yusuf Tanrikulu & Gisbert Schneider. 2008. Chemoinformatics Approaches to Virtual Screening. Chemoinformatics Approaches to Virtual Screening 217 239 .
Chen Zhao, Minghua Sun, Youssef L. Bennani, Sujatha M. Gopalakrishnan, David G. Witte, Thomas R. Miller, Kathleen M. Krueger, Kaitlin E. Browman, Christine Thiffault, Jill Wetter, Kennan C. Marsh, Arthur A. Hancock, Timothy A. Esbenshade & Marlon D. Cowart. (2008) The Alkaloid Conessine and Analogues as Potent Histamine H 3 Receptor Antagonists . Journal of Medicinal Chemistry 51:17, pages 5423-5430.
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Olivier Roche, Matthias Nettekoven, Walter Vifian & Rosa Maria Rodriguez Sarmiento. (2008) Refinement of histamine H3 ligands pharmacophore model leads to a new class of potent and selective naphthalene inverse agonists. Bioorganic & Medicinal Chemistry Letters 18:15, pages 4377-4379.
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Diana L. Nersesian, Lawrence A. Black, Thomas R. Miller, Timothy A. Vortherms, Timothy A. Esbenshade, Arthur A. Hancock & Marlon D. Cowart. (2008) In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series. Bioorganic & Medicinal Chemistry Letters 18:1, pages 355-359.
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Yu-Ming PuYi-Yin KuTimothy GriemeLawrence A. BlackAshok V. BhatiaMarlon Cowart. (2007) An Expedient and Multikilogram Synthesis of a Naphthalenoid H 3 Antagonist . Organic Process Research & Development 11:6, pages 1004-1009.
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Robert J. Altenbach, Huaqing Liu, Patricia N. Banfor, Kaitlin E. Browman, Gerard B. Fox, Ryan M. Fryer, Victoria A. Komater, Kathleen M. Krueger, Kennan Marsh, Thomas R. Miller, Jia Bao Pan, Liping Pan, Minghua Sun, Christine Thiffault, Jill Wetter, Chen Zhao, Deliang Zhou, Timothy A. Esbenshade, Arthur A. Hancock & Marlon D. Cowart. (2007) Synthesis, Potency, and In Vivo Profiles of Quinoline Containing Histamine H 3 Receptor Inverse Agonists . Journal of Medicinal Chemistry 50:22, pages 5439-5448.
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Yoshihito Funaki, Kimihiko Sato, Motohisa Kato, Yoichi Ishikawa, Ren Iwata & Kazuhiko Yanai. (2007) Evaluation of the binding characteristics of [18F]fluoroproxyfan in the rat brain for in vivo visualization of histamine H3 receptor. Nuclear Medicine and Biology 34:8, pages 981-987.
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Kathleen Isensee, Georg Petroianu & Holger Stark. (2007) Pharmacological aspects of cognitive impairment: past, present and future of drugs in dementia. Journal of Applied Biomedicine 5:2, pages 57-70.
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Olivier Roche & Rosa María Rodríguez Sarmiento. (2007) A new class of histamine H3 receptor antagonists derived from ligand based design. Bioorganic & Medicinal Chemistry Letters 17:13, pages 3670-3675.
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Michael Amon, Xavier Ligneau, Jean‐Claude Camelin, Isabelle Berrebi‐Bertrand, Jean‐Charles Schwartz & Holger Stark. (2007) Highly Potent Fluorescence‐Tagged Nonimidazole Histamine H 3 Receptor Ligands . ChemMedChem 2:5, pages 708-716.
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Marlon Cowart, Gregory A. Gfesser, Kaitlin E. Browman, Ramin Faghih, Thomas R. Miller, Ivan Milicic, John L. Baranowski, Kathleen M. Krueger, David G. Witte, Angela L. Molesky, Victoria A. Komater, Michael J. Buckley, Gilbert J. Diaz, Gerard D. Gagne, Deliang Zhou, Xiaoqing Deng, Liping Pan, Ellen M. Roberts, Marilyn S. Diehl, Jill M. Wetter, Kennan C. Marsh, Gerard B. Fox, Jorge D. Brioni, Timothy A. Esbenshade & Arthur A. Hancock. (2007) Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: In vitro properties, drug-likeness, and behavioral activity. Biochemical Pharmacology 73:8, pages 1243-1255.
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Andrew D. Medhurst, Michael A. Briggs, Gordon Bruton, Andrew R. Calver, Iain Chessell, Barry Crook, John B. Davis, Robert P. Davis, Andrew G. Foley, Teresa Heslop, Warren D. Hirst, Stephen J. Medhurst, Sandrine Ociepka, Alison Ray, Ciaran M. Regan, Becky Sargent, Joanne Schogger, Tania O. Stean, Brenda K. Trail, Neil Upton, Trevor White, Barry Orlek & David M. Wilson. (2007) Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Biochemical Pharmacology 73:8, pages 1182-1194.
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Lawrence A. Black, Diana L. Nersesian, Padam Sharma, Yi-Yin Ku, Youssef L. Bennani, Kennan C. Marsh, Thomas R. Miller, Timothy A. Esbenshade, Arthur A. Hancock & Marlon Cowart. (2007) 4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration. Bioorganic & Medicinal Chemistry Letters 17:5, pages 1443-1446.
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Shinya Harusawa, Makoto Kawamura, Lisa Araki, Ryusuke Taniguchi, Hiroki Yoneyama, Yasuhiko SakamotoNoritsugu KanekoYumi Nakao, Kouta Hatano, Takeshi Fujita, Ryoko Yamamoto, Takushi Kurihara & Atsushi Yamatodani. (2007) Synthesis of Novel 4(5)-(5-Aminotetrahydropyran-2-yl)imidazole Derivatives and Their in Vivo Release of Neuronal Histamine Measured by Brain Microdialysis. Chemical and Pharmaceutical Bulletin 55:8, pages 1245-1253.
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Holger Kubas & Holger Stark. (2006) Medizinische Chemie von Histamin‐H 2 ‐Rezeptorantagonisten: Klassische Wirkstoffentwicklung . Pharmazie in unserer Zeit 36:1, pages 24-32.
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Anu J. Airaksinen, Jill A. Jablonowski, Margreet van der Mey, Ann J. Barbier, Rob P. Klok, Joost Verbeek, Robert Schuit, Jacobus D.M. Herscheid, Josee E. Leysen, Nicholas I. Carruthers, Adriaan A. Lammertsma & Albert D. Windhorst. (2006) Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand. Nuclear Medicine and Biology 33:6, pages 801-810.
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Kjell Malmlöf, Rolf Hohlweg & Karin Rimvall. (2006) Targeting of the central histaminergic system for treatment of obesity and associated metabolic disorders. Drug Development Research 67:8, pages 651-665.
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Yi-Yin Ku, Yu-Ming Pu, Tim Grieme, Padam Sharma, Ashok V. Bhatia & Marlon Cowart. (2006) An efficient and convergent synthesis of the potent and selective H3 antagonist ABT-239. Tetrahedron 62:18, pages 4584-4589.
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Dorota Łażewska, Xavier Ligneau, Jean-Charles Schwartz, Walter Schunack, Holger Stark & Katarzyna Kieć-Kononowicz. (2006) Ether derivatives of 3-piperidinopropan-1-ol as non-imidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry 14:10, pages 3522-3529.
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Michael Amon, Xavier Ligneau, Jean-Charles Schwartz & Holger Stark. (2006) Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities. Bioorganic & Medicinal Chemistry Letters 16:7, pages 1938-1940.
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Mirko Rivara, Valentina Zuliani, Giuseppe Cocconcelli, Giovanni Morini, Mara Comini, Silvia Rivara, Marco Mor, Fabrizio Bordi, Elisabetta Barocelli, Vigilio Ballabeni, Simona Bertoni & Pier Vincenzo Plazzi. (2006) Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series. Bioorganic & Medicinal Chemistry 14:5, pages 1413-1424.
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Wayne D. Vaccaro, Rosy Sher, Michael Berlin, Neng-Yang Shih, Robert Aslanian, John H. Schwerdt, Kevin D. McCormick, John J. Piwinski, Robert E. WestJr.Jr., John C. Anthes, Shirley M. Williams, Ren-Long Wu, H. Susan She, Maria A. Rivelli, Jennifer C. Mutter, Michel R. Corboz, John A. Hey & Leonard Favreau. (2006) Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorganic & Medicinal Chemistry Letters 16:2, pages 395-399.
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Patrizio Blandina & Maria Beatrice Passani. 2006. Neurotransmitter Interactions and Cognitive Function. Neurotransmitter Interactions and Cognitive Function 149 163 .
Simone Lorenzi, Marco Mor, Fabrizio Bordi, Silvia Rivara, Mirko Rivara, Giovanni Morini, Simona Bertoni, Vigilio Ballabeni, Elisabetta Barocelli & Pier Vincenzo Plazzi. (2005) Validation of a histamine H3 receptor model through structure–activity relationships for classical H3 antagonists. Bioorganic & Medicinal Chemistry 13:19, pages 5647-5657.
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Ralf Gutzmer, Carola Diestel, Susanne Mommert, Brigitta Köther, Holger Stark, Miriam Wittmann & Thomas Werfel. (2005) Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells. The Journal of Immunology 174:9, pages 5224-5232.
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Gregory A. Gfesser, Ramin Faghih, Youssef L. Bennani, Michael P. Curtis, Timothy A. Esbenshade, Arthur A. Hancock & Marlon D. Cowart. (2005) Structure–activity relationships of arylbenzofuran H3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 15:10, pages 2559-2563.
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Rob Leurs, Remko A. Bakker, Henk Timmerman & Iwan J. P. de Esch. (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nature Reviews Drug Discovery 4:2, pages 107-120.
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Yu-Ming PuTimothy GriemeAshok GuptaDaniel PlataAshok V. BhatiaMarlon CowartYi-Yin Ku. (2004) A Facile and Scaleable Synthesis of ABT-239, A Benzofuranoid H 3 Antagonist . Organic Process Research & Development 9:1, pages 45-50.
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Marlon Cowart, Ramin Faghih, Michael P. Curtis, Gregory A. Gfesser, Youssef L. Bennani, Lawrence A. Black, Liping Pan, Kennan C. Marsh, James P. Sullivan, Timothy A. Esbenshade, Gerard B. Fox & Arthur A. Hancock. (2004) 4-(2-[2-(2( R )-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H 3 Receptor Antagonists Potently Enhance Cognition and Attention . Journal of Medicinal Chemistry 48:1, pages 38-55.
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Hargita Hegyesi, Zsuzsa Darvas, Robin L. Thurmond & András Falus. 2005. Biophysical Aspects of Transmembrane Signaling. Biophysical Aspects of Transmembrane Signaling 265 291 .
Maria Beatrice Passani, Jian-Sheng Lin, Arthur Hancock, Sylvain Crochet & Patrizio Blandina. (2004) The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Trends in Pharmacological Sciences 25:12, pages 618-625.
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Sven Graßmann, Joachim Apelt, Xavier Ligneau, Heinz H. Pertz, Jean‐Michel Arrang, C. Robin Ganellin, Jean‐Charles Schwartz, Walter Schunack & Holger Stark. (2004) Search for Histamine H 3 Receptor Ligands with Combined Inhibitory Potency at Histamine N ‐Methyltransferase: ω‐Piperidinoalkanamine Derivatives . Archiv der Pharmazie 337:10, pages 533-545.
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Nadia Pelloux-LéonAbdellatif FkyeratAntonia PiripitsiWasyl TertiukWalter SchunackHolger StarkMonique GarbargXavier LigneauJean-Michel ArrangJean-Charles SchwartzC. Robin Ganellin. (2004) Meta-Substituted Aryl(thio)ethers as Potent Partial Agonists (or Antagonists) for the Histamine H 3 Receptor Lacking a Nitrogen Atom in the Side Chain . Journal of Medicinal Chemistry 47:12, pages 3264-3274.
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Konrad H Bleicher, Luke G Green, Rainer E Martin & Mark Rogers-Evans. (2004) Ligand identification for G-protein-coupled receptors: a lead generation perspective. Current Opinion in Chemical Biology 8:3, pages 287-296.
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Galina MeierMichael KrauseAnnette HülsXavier LigneauHeinz H. PertzJean-Michel ArrangC. Robin GanellinJean-Charles SchwartzWalter SchunackHolger Stark. (2004) 4-( ω -(Alkyloxy)alkyl)-1 H -imidazole Derivatives as Histamine H 3 Receptor Antagonists/Agonists . Journal of Medicinal Chemistry 47:10, pages 2678-2687.
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Tibor Mikó, Xavier Ligneau, Heinz H Pertz, Jean-Michel Arrang, C Robin Ganellin, Jean-Charles Schwartz, Walter Schunack & Holger Stark. (2004) Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry 12:10, pages 2727-2736.
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Michael P. Curtis, Wesley Dwight, John Pratt, Marlon Cowart, Timothy A. Esbenshade, Kathy M. Krueger, Gerard B. Fox, Jia Bao Pan, Thomas G. Pagano, Arthur A. Hancock, Ramin Faghih & Youssef L. Bennani. (2004) D‐Amino Acid Homopiperazine Amides: Discovery of A‐320436, a Potent and Selective Non‐Imidazole Histamine H 3 ‐Receptor Antagonist . Archiv der Pharmazie 337:4, pages 219-229.
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Holger Stark & Manfred Schubert‐Zsilavecz. (2004) H 1 ‐Antihistaminika: Entwicklungen, Strukturen und neue Tendenzen . Pharmazie in unserer Zeit 33:2, pages 92-98.
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Gregory A. Gfesser, Henry Zhang, Jurgen Dinges, Gerard B. Fox, Jia Bao Pan, Timothy A. Esbenshade, Betty B. Yao, David Witte, Thomas R. Miller, Chae-Hee Kang, Kathy M. Krueger, Youssef L. Bennani, Arthur A. Hancock & Ramin Faghih. (2004) Structure–activity relationships of non-imidazole H3 receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists. Bioorganic & Medicinal Chemistry Letters 14:3, pages 673-676.
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Marlon Cowart, John K. Pratt, Andrew O. Stewart, Youssef L. Bennani, Timothy A. Esbenshade & Arthur A. Hancock. (2004) A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans. Bioorganic & Medicinal Chemistry Letters 14:3, pages 689-693.
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Shelly A. Glase & David J. Dooley. 2004. 1 12 .

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