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Review

Protein tyrosine kinase inhibitors as anticancer agents

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Pages 35-53 | Published online: 02 Mar 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Fabrizio Carta, Andrea Scozzafava & Claudiu T Supuran. (2012) Sulfonamides: a patent review (2008 – 2012). Expert Opinion on Therapeutic Patents 22:7, pages 747-758.
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Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero & Claudiu T Supuran. (2006) The sulfamide motif in the design of enzyme inhibitors. Expert Opinion on Therapeutic Patents 16:1, pages 27-47.
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Articles from other publishers (29)

AbdulAziz A. Alotaibi, Hanadi H. Asiri, A.F.M. Motiur Rahman & Mohammed M. Alanazi. (2023) Novel pyrrolo[2,3-d]pyrimidine derivatives as multi-kinase inhibitors with VEGFR-2 selectivity. Journal of Saudi Chemical Society 27:5, pages 101712.
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Keshav Taruneshwar Jha, Abhimannu Shome, Chahat & Pooja A Chawla. (2023) Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural activity relationship. Bioorganic Chemistry 138, pages 106680.
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Ahmed Elkamhawy, Seohyun Son, Hwa Young Lee, Mahmoud H. El-Maghrabey, Mohamed A. El Hamd, Saud O. Alshammari, Abeer A. Abdelhameed, Qamar A. Alshammari, Ahmed Abdeen, Samah F. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Radwan Alnajjar, Won Jun Choi, Ahmed A. Al-Karmalawy & Kyeong Lee. (2022) Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives. Pharmaceuticals 16:1, pages 43.
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Vishal Unadkat, Shishir Rohit, Paranjay Parikh, Vinod Sanna & Sanjay Singh. (2021) Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors. Bioorganic Chemistry 114, pages 105124.
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Sevinc Ilkar Erdagi & Ufuk Yildiz. (2019) Diosgenin-conjugated PCL–MPEG polymeric nanoparticles for the co-delivery of anticancer drugs: design, optimization, in vitro drug release and evaluation of anticancer activity . New Journal of Chemistry 43:17, pages 6622-6635.
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Vinod G. Ugale, Harun M. Patel & Sanjay J. Surana. (2017) Molecular modeling studies of quinoline derivatives as VEGFR-2 tyrosine kinase inhibitors using pharmacophore based 3D QSAR and docking approach. Arabian Journal of Chemistry 10, pages S1980-S2003.
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R. N. Jadeja, K. M. Vyas, K. K. Upadhyay & R. V. Devkar. (2017) In vitro apoptosis-inducing effect and gene expression profiles of mixed ligand Cu( ii ) complexes derived from 4-acyl pyrazolones on human lung cancer cells . RSC Advances 7:28, pages 17107-17116.
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Nagwa M. Abdel Gawad, Noha H. Amin, Mohammed T. Elsaadi, Fatma M.M. Mohamed, Andrea Angeli, Viviana De Luca, Clemente Capasso & Claudiu T. Supuran. (2016) Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines. Bioorganic & Medicinal Chemistry 24:13, pages 3043-3051.
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Ahmed Elkamhawy, Ahmed Karam Farag, Ambily Nath Indu Viswanath, Tarek M. Bedair, Dong Gyu Leem, Kyung-Tae Lee, Ae Nim Pae & Eun Joo Roh. (2015) Targeting EGFR/HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking. Bioorganic & Medicinal Chemistry Letters 25:22, pages 5147-5154.
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Mohanad Yakdhan Saleh & Ala Ismael Ayoub. (2014) Synthesis of new derivatives of 2-chloro-3-formyl-1,8-naphthyridine. European Journal of Chemistry 5:3, pages 475-480.
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Yongjun Mao, Wenxiu Zhu, Xiaoguang Kong, Zhen Wang, Hua Xie, Jian Ding, Nicholas Kenneth Terrett, Jingkang Shen & Jingshan Shen. (2013) Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry 21:11, pages 3090-3104.
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Enrico Perspicace, Valérie Jouan-Hureaux, Rino Ragno, Flavio Ballante, Stefania Sartini, Concettina La Motta, Federico Da Settimo, Binbin Chen, Gilbert Kirsch, Serge Schneider, Béatrice Faivre & Stéphanie Hesse. (2013) Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). European Journal of Medicinal Chemistry 63, pages 765-781.
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Ning Ding, Wei Zhang, Hua Ling Xiao, Peng Wang & Ying Xia Li. (2012) Synthesis and biological evaluation of a series of novel salicylanilides as inhibitors of EGFR protein tyrosine kinases. Chinese Chemical Letters 23:5, pages 529-532.
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Xiaoyun Wu, Shuguang Wu & Wen-Hua Chen. (2011) Molecular docking and 3D-QSAR study on 4-(1H-indazol-4-yl) phenylamino and aminopyrazolopyridine urea derivatives as kinase insert domain receptor (KDR) inhibitors. Journal of Molecular Modeling 18:3, pages 1207-1218.
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Claudiu T. Supuran. 2012. Polypharmacology in Drug Discovery. Polypharmacology in Drug Discovery 459 491 .
Jean-Yves Winum, Alfonso Maresca, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2012) Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases. Chemical Communications 48:66, pages 8177.
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Naoyuki Suzuki, Takeshi Shiota, Fumihiko Watanabe, Norihiro Haga, Takami Murashi, Takafumi Ohara, Kenji Matsuo, Naoki Oomori, Hiroshi Yari, Keiji Dohi, Makiko Inoue, Motofumi Iguchi, Jyunko Sentou & Tooru Wada. (2011) Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1601-1606.
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Ahmad Shaabani, Mozhdeh Seyyedhamzeh, Ali Maleki & Maryam Behnam. (2009) A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides. Tetrahedron Letters 50:46, pages 6355-6357.
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Seppo Parkkila, Alessio Innocenti, Heini Kallio, Mika Hilvo, Andrea Scozzafava & Claudiu T. Supuran. (2009) The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian α-carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry Letters 19:15, pages 4102-4106.
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Tara R. Rheault, Thomas R. Caferro, Scott H. Dickerson, Kelly H. Donaldson, Michael D. Gaul, Aaron S. Goetz, Robert J. Mullin, Octerloney B. McDonald, Kimberly G. Petrov, David W. Rusnak, Lisa M. Shewchuk, Glenn M. Spehar, Anne T. Truesdale, Dana E. Vanderwall, Edgar R. Wood & David E. Uehling. (2009) Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 19:3, pages 817-820.
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Juan Du, Beilei Lei, Jin Qin, Huanxiang Liu & Xiaojun Yao. (2009) Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking. Journal of Molecular Graphics and Modelling 27:5, pages 642-654.
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Zhen-wei Cai, Yongzheng Zhang, Robert M. Borzilleri, Ligang Qian, Stephanie Barbosa, Donna Wei, Xiaoping Zheng, Lawrence Wu, Junying Fan, Zhongping Shi, Barri S. Wautlet, Steve Mortillo, Robert JeyaseelanSr.Sr., Daniel W. Kukral, Amrita Kamath, Punit Marathe, Celia D’Arienzo, George Derbin, Joel C. Barrish, Jeffrey A. Robl, John T. Hunt, Louis J. Lombardo, Joseph Fargnoli & Rajeev S. Bhide. (2008) Discovery of Brivanib Alaninate (( S )-(( R )-1-(4-(4-Fluoro-2-methyl-1 H -indol-5-yloxy)-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215) . Journal of Medicinal Chemistry 51:6, pages 1976-1980.
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Julio Caballero, Michael Fernández, Mario Saavedra & Fernando D. González-Nilo. (2008) 2D Autocorrelation, CoMFA, and CoMSIA modeling of protein tyrosine kinases’ inhibition by substituted pyrido[2,3-d]pyrimidine derivatives. Bioorganic & Medicinal Chemistry 16:2, pages 810-821.
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Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero & Claudiu T. Supuran. (2006) Therapeutic potential of sulfamides as enzyme inhibitors. Medicinal Research Reviews 26:6, pages 767-792.
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Jian LI, Jin-zhi TAN, Li-li CHEN, Jian ZHANG, Xu SHEN, Chang-lin MEI, Li-li FU, Li-ping LIN, Jian DING, Bing XIONG, Xi-shan XIONG, Hong LIU, Xiao-min LUO & Hua-liang JIANG. (2006) Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives. Acta Pharmacologica Sinica 27:9, pages 1259-1271.
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Alex G. Waterson, Kirk L. Stevens, Michael J. Reno, Yue-Mei Zhang, Eric E. Boros, Frederic Bouvier, Abdullah Rastagar, David E. Uehling, Scott H. Dickerson, Bryan Reep, Octerloney B. McDonald, Edgar R. Wood, David W. Rusnak, Krystal J. Alligood & Sharon K. Rudolph. (2006) Alkynyl pyrimidines as dual EGFR/ErbB2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 16:9, pages 2419-2422.
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Daniel H. Albert, Paul Tapang, Terrance J. Magoc, Lori J. Pease, David R. Reuter, Ru-Qi Wei, Junling Li, Jun Guo, Peter F. Bousquet, Nayereh S. Ghoreishi-Haack, Baole Wang, Gail T. Bukofzer, Yi-Chun Wang, Jason A. Stavropoulos, Kresna Hartandi, Amanda L. Niquette, Nirupama Soni, Eric F. Johnson, J. Owen McCall, Jennifer J. Bouska, Yanping Luo, Cherrie K. Donawho, Yujia Dai, Patrick A. Marcotte, Keith B. Glaser, Michael R. Michaelides & Steven K. Davidsen. (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Molecular Cancer Therapeutics 5:4, pages 995-1006.
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Yi Jin, Hui-Yuan Li, Li-Ping Lin, Jinzhi Tan, Jian Ding, Xiaomin Luo & Ya-Qiu Long. (2005) Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors. Bioorganic & Medicinal Chemistry 13:19, pages 5613-5622.
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Hwei-Ru Tsou, Elsebe G. Overbeek-Klumpers, William A. Hallett, Marvin F. Reich, M. Brawner Floyd, Bernard D. Johnson, Ronald S. Michalak, Ramaswamy Nilakantan, Carolyn Discafani, Jonathan Golas, Sridhar K. Rabindran, Ru Shen, Xiaoqing Shi, Yu-Fen Wang, Janis Upeslacis & Allan Wissner. (2005) Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity. Journal of Medicinal Chemistry 48:4, pages 1107-1131.
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