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Review

Recent advances in the cannabinoids

Pages 1435-1452 | Published online: 25 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Mayank Kumar Sharma, Prashant R Murumkar, Mahesh A Barmade, Rajani Giridhar & Mange Ram Yadav. (2015) A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opinion on Therapeutic Patents 25:10, pages 1093-1116.
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Benjamin J Ragen, Jordan Seidel, Christine Chollak, Robert H Pietrzak & Alexander Neumeister. (2015) Investigational drugs under development for the treatment of PTSD. Expert Opinion on Investigational Drugs 24:5, pages 659-672.
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Doris Riether. (2012) Selective cannabinoid receptor 2 modulators: a patent review 2009 – present. Expert Opinion on Therapeutic Patents 22:5, pages 495-510.
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E Kate Högenauer. (2007) Latest advances in the cannabinoids. Expert Opinion on Therapeutic Patents 17:12, pages 1457-1476.
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Giulio G Muccioli & Didier M Lambert. (2006) Latest advances in cannabinoid receptor antagonists and inverse agonists. Expert Opinion on Therapeutic Patents 16:10, pages 1405-1423.
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Alyson Fox & Stuart Bevan. (2005) Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opinion on Investigational Drugs 14:6, pages 695-703.
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Larry Yet. 2018. Privileged Structures in Drug Discovery. Privileged Structures in Drug Discovery 414 434 .
Mayank Kumar Sharma, Prashant R. Murumkar, Ashish M. Kanhed, Rajani Giridhar & Mange Ram Yadav. (2014) Prospective therapeutic agents for obesity: Molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists. European Journal of Medicinal Chemistry 79, pages 298-339.
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Andrew G. Horti, Vanessa Raymont & Garth E. Terry. 2014. PET and SPECT of Neurobiological Systems. PET and SPECT of Neurobiological Systems 249 319 .
Sonia Gattinoni, Chiara De Simone, Sabrina Dallavalle, Filomena Fezza, Raffaella Nannei, Natalia Battista, Patrizia Minetti, Gianandrea Quattrociocchi, Antonio Caprioli, Franco Borsini, Walter Cabri, Sergio Penco, Lucio Merlini & Mauro Maccarrone. (2010) A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4406-4411.
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David Burdick, Russell DeOrazio, Peter Guzzo, Alicia Habershaw, Mark Helle, Bernard Paul & Mark Wolf. (2010) Synthesis and structure–activity relationship of substitutions at the C-1 position of Δ9-tetrahydrocannabinol. Bioorganic & Medicinal Chemistry Letters 20:4, pages 1424-1426.
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Herbert H. Seltzman. (2009) Recent CB1 cannabinoid receptor antagonists and inverse agonists. Drug Development Research 70:8, pages 601-615.
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Lumír Ondřej Hanuš. (2008) Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Medicinal Research Reviews 29:2, pages 213-271.
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Marco Mor, Alessio Lodola, Silvia Rivara, Federica Vacondio, Andrea Duranti, Andrea Tontini, Silvano Sanchini, Giovanni Piersanti, Jason R. Clapper, Alvin R. King, Giorgio Tarzia & Daniele Piomelli. (2008) Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates. Journal of Medicinal Chemistry 51:12, pages 3487-3498.
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Hirofumi Omura, Makoto Kawai, Akiko Shima, Yasuhiro Iwata, Fumitaka Ito, Tsutomu Masuda, Atsuko Ohta, Naoya Makita, Kiyoyuki Omoto, Hiromi Sugimoto, Akira Kikuchi, Hiroshi Iwata & Kazuo Ando. (2008) The SAR studies of novel CB2 selective agonists, benzimidazolone derivatives. Bioorganic & Medicinal Chemistry Letters 18:11, pages 3310-3314.
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Brijesh Kumar Srivastava, Rina Soni, Amit Joharapurkar, Kalapatapu V.V.M. Sairam, Jayendra Z. Patel, Amitgiri Goswami, Sandeep A. Shedage, Sidhartha S. Kar, Rahul P. Salunke, Shivaji B. Gugale, Amol Dhawas, Pravin Kadam, Bhupendra Mishra, Nisha Sadhwani, Vishal B. Unadkat, Prasenjit Mitra, Mukul R. Jain & Pankaj R. Patel. (2008) Bioisosteric replacement of dihydropyrazole of 4S-(−)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole. Bioorganic & Medicinal Chemistry Letters 18:3, pages 963-968.
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Brijesh Kumar Srivastava,*, Amit Joharapurkar, Saurin Raval, Jayendra Z. Patel, Rina Soni, Preeti Raval, Archana Gite, Amitgiri Goswami, Nisha Sadhwani, Neha Gandhi, Harilal Patel, Bhupendra Mishra, Manish Solanki, Bipin Pandey, Mukul R. Jain & Pankaj R. Patel. (2007) Diaryl Dihydropyrazole-3-carboxamides with Significant In Vivo Antiobesity Activity Related to CB1 Receptor Antagonism:  Synthesis, Biological Evaluation, and Molecular Modeling in the Homology Model. Journal of Medicinal Chemistry 50:24, pages 5951-5966.
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Edward K. Dziadulewicz, Stuart J. Bevan, Christopher T. Brain, Paul R. Coote, Andrew J. Culshaw, Andrew J. Davis, Lee J. Edwards, Adrian J. Fisher, Alyson J. Fox, Clive Gentry, Alex Groarke, Terance W. Hart, Werner Huber, Iain F. James, Adam Kesingland, Luigi La Vecchia, Yvonne Loong, Isabelle Lyothier, Kara McNair, Cathal O'Farrell, Marcus Peacock, Robert Portmann, Ulrich Schopfer, Mohammed Yaqoob & Jiri Zadrobilek. (2007) Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone:  A Potent, Orally Bioavailable Human CB 1 /CB 2 Dual Agonist with Antihyperalgesic Properties and Restricted Central Nervous System Penetration . Journal of Medicinal Chemistry 50:16, pages 3851-3856.
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Brian J. Lavey, Joseph A. Kozlowski, Bandarpalle B. Shankar, James M. Spitler, Guowei Zhou, De-Yi Yang, Youheng Shu, Michael K.C. Wong, Shing-Chun Wong, Neng-Yang Shih, Jie Wu, Stuart W. McCombie, Razia Rizvi, Ronald L. Wolin & Charles A. Lunn. (2007) Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands. Bioorganic & Medicinal Chemistry Letters 17:13, pages 3760-3764.
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Roger A. Smith, Zahra Fathi, Furahi Achebe, Christiana Akuche, Su-Ellen Brown, Soongyu Choi, Jianmei Fan, Susan Jenkins, Harold C.E. Kluender, Anish Konkar, Rico Lavoie, Ronald Mays, Jennifer Natoli, Stephen J. O’Connor, Astrid A. Ortiz, Ning Su, Christy Taing, Susan Tomlinson, Theresa Tritto, Gan Wang, Stephan-Nicholas Wirtz, Wai Wong, Xiao-Fan Yang, Shihong Ying & Zhonghua Zhang. (2007) Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity. Bioorganic & Medicinal Chemistry Letters 17:10, pages 2706-2711.
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Christina B. Madsen-Duggan, John S. Debenham, Thomas F. Walsh, Richard B. Toupence, Song X. Huang, Junying Wang, Xinchun Tong, Julie Lao, Tung M. Fong, Marie-Therese Schaeffer, Jing Chen Xiao, Cathy R.-R.C. Huang, Chun-Pyn Shen, D. Sloan Stribling, Lauren P. Shearman, Alison M. Strack, D. Euan MacIntyre, Lex H.T. Van der Ploeg & Mark T. Goulet. (2007) Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 17:7, pages 2031-2035.
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Roger A. Smith, Zahra Fathi, Su-Ellen Brown, Soongyu Choi, Jianmei Fan, Susan Jenkins, Harold C.E. Kluender, Anish Konkar, Rico Lavoie, Ronald Mays, Jennifer Natoli, Stephen J. O’Connor, Astrid A. Ortiz, Brent Podlogar, Christy Taing, Susan Tomlinson, Theresa Tritto & Zhonghua Zhang. (2007) Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives. Bioorganic & Medicinal Chemistry Letters 17:3, pages 673-678.
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Hong Fan, Hayden T. Ravert, Daniel P. Holt, Robert F. Dannals & Andrew G. Horti. (2006) Synthesis of 1‐(2,4‐dichlorophenyl)‐4‐cyano‐5‐(4‐[ 11 C]methoxyphenyl)‐ N ‐(piperidin‐1‐yl)‐1 H ‐pyrazole‐3‐carboxamide ([ 11 C]JHU75528) and 1‐(2‐bromophenyl)‐4‐cyano‐5‐(4‐[ 11 C]methoxyphenyl)‐ N ‐(piperidin‐1‐yl)‐1 H ‐pyrazole‐3‐carboxamide ([ 11 C]JHU75575) as potential radioligands for PET imaging of cerebral cannabinoid receptor . Journal of Labelled Compounds and Radiopharmaceuticals 49:12, pages 1021-1036.
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Jochen Antel, Peter C. Gregory & Ulrich Nordheim. (2006) CB 1 Cannabinoid Receptor Antagonists for Treatment of Obesity and Prevention of Comorbid Metabolic Disorders . Journal of Medicinal Chemistry 49:14, pages 4008-4016.
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John S. Debenham, Christina B. Madsen-Duggan, Thomas F. Walsh, Junying Wang, Xinchun Tong, George A. Doss, Julie Lao, Tung M. Fong, Marie-Therese Schaeffer, Jing Chen Xiao, Cathy R.-R.C. Huang, Chun-Pyn Shen, Yue Feng, Donald J. Marsh, D. Sloan Stribling, Lauren P. Shearman, Alison M. Strack, D. Euan MacIntyre, Lex H.T. Van der Ploeg & Mark T. Goulet. (2006) Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters 16:3, pages 681-685.
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Julia Adam, Phillip M. Cowley, Takao Kiyoi, Angus J. Morrison & Christopher J.W. Mort. 2006. Progress in Medicinal Chemistry Volume 44. Progress in Medicinal Chemistry Volume 44 207 329 .
Jos H.M. Lange, Herman H. van Stuivenberg, Willem Veerman, Henri C. Wals, Bob Stork, Hein K.A.C. Coolen, Andrew C. McCreary, Tiny J.P. Adolfs & Chris G. Kruse. (2005) Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorganic & Medicinal Chemistry Letters 15:21, pages 4794-4798.
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Jos H.M. Lange & Chris G. Kruse. (2005) Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists. Drug Discovery Today 10:10, pages 693-702.
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Francis Barth. 2005. Annual Reports in Medicinal Chemistry Volume 40. Annual Reports in Medicinal Chemistry Volume 40 103 118 .
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