Citations (32)
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Alice Lee-Dutra, Danielle K Wiener & Siquan Sun. (2011) Cathepsin S inhibitors: 2004 – 2010. Expert Opinion on Therapeutic Patents 21:3, pages 311-337.
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Dong Wang & Dieter Brömme. (2005) Drug delivery strategies for cathepsin inhibitors in joint diseases. Expert Opinion on Drug Delivery 2:6, pages 1015-1028.
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Joon-Yong Chung, Young-An Bae, Byoung-Kuk Na & Yoon Kong. (2005) Cysteine protease inhibitors as potential antiparasitic agents. Expert Opinion on Therapeutic Patents 15:8, pages 995-1007.
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Articles from other publishers (29)
Natalie Fuchs, Mergim Meta, Bellinda Lantzberg, Matthias Bros, Seah Ling Kuan, Tanja Weil & Tanja Schirmeister. (2023) Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer. ChemMedChem 18:15.
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Natalie Fuchs, Mergim Meta, Detlef Schuppan, Lutz Nuhn & Tanja Schirmeister. (2020) Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery. Cells 9:9, pages 2021.
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Mira Kim, Jiyoung Jeon, Jiyeon Song, Kwee Hyun Suh, Young Hoon Kim, Kyung Hoon Min & Kwang-Ok Lee. (2013) Synthesis of proline analogues as potent and selective cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 23:11, pages 3140-3144.
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Neil Moss, Zhaoming Xiong, Mike Burke, Derek Cogan, Donghong A. Gao, Kathleen Haverty, Alexander Heim-Riether, Eugene R. Hickey, Raj Nagaraja, Matthew Netherton, Kathy O’Shea, Philip Ramsden, Racheline Schwartz, Daw-Tsun Shih, Yancey Ward, Erick Young & Qing Zhang. (2012) Exploration of cathepsin S inhibitors characterized by a triazole P1–P2 amide replacement. Bioorganic & Medicinal Chemistry Letters 22:23, pages 7189-7193.
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Mariana Kasabova, Ahlame Saidi, Clément Naudin, Juliette Sage, Fabien Lecaille & Gilles Lalmanach. (2011) Cysteine Cathepsins: Markers and Therapy Targets in Lung Disorders. Clinical Reviews in Bone and Mineral Metabolism 9:2, pages 148-161.
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Dimitris K. Agrafiotis, John J. M. Wiener, Andrew Skalkin & Jeremy Kolpak. (2011) Single R-Group Polymorphisms (SRPs) and R-Cliffs: An Intuitive Framework for Analyzing and Visualizing Activity Cliffs in a Single Analog Series. Journal of Chemical Information and Modeling 51:5, pages 1122-1131.
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Wullie Arbuckle, Mark Baugh, Simone Belshaw, D. Jonathan Bennett, John Bruin, Jiaqiang Cai, Kenneth S. Cameron, Chris Claxton, Maureen Dempster, Kathryn Everett, Xavier Fradera, William Hamilton, Philip S. Jones, Emma Kinghorn, Clive Long, Iain Martin, John Robinson & Paul Westwood. (2011) 1H-Imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: Separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka. Bioorganic & Medicinal Chemistry Letters 21:3, pages 932-935.
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Jiaqiang Cai, John Robinson, Simone Belshaw, Kathryn Everett, Xavier Fradera, Mario van Zeeland, Leon van Berkom, Peter van Rijnsbergen, Lucy Popplestone, Mark Baugh, Maureen Dempster, John Bruin, William Hamilton, Emma Kinghorn, Paul Westwood, Jennifer Kerr, Zoran Rankovic, Wullie Arbuckle, D. Jonathan Bennett, Philip S. Jones, Clive Long, Iain Martin, Joost C.M. Uitdehaag & Tommi Meulemans. (2010) Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 20:23, pages 6890-6894.
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Jiaqiang Cai, Mark Baugh, Darcey Black, Clive Long, D. Jonathan Bennett, Maureen Dempster, Xavier Fradera, Jonathan Gillespie, Fiona Andrews, Sylviane Boucharens, John Bruin, Kenneth S. Cameron, Iain Cumming, William Hamilton, Philip S. Jones, Allard Kaptein, Emma Kinghorn, Maurice Maidment, Iain Martin, Ann Mitchell, Zoran Rankovic, John Robinson, Paul Scullion, Joost C.M. Uitdehaag, Paul Vink, Paul Westwood, Mario van Zeeland, Leon van Berkom, Martijn Bastiani & Tommi Meulemans. (2010) 6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4350-4354.
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Jiaqiang Cai, D. Jonathan Bennett, Zoran Rankovic, Maureen Dempster, Xavier Fradera, Jonathan Gillespie, Iain Cumming, William Finlay, Mark Baugh, Sylviane Boucharens, John Bruin, Kenneth S. Cameron, William Hamilton, Jennifer Kerr, Emma Kinghorn, George McGarry, John Robinson, Paul Scullion, Joost C.M. Uitdehaag, Mario van Zeeland, Dominique Potin, Laurent Saniere, Andre Fouquet, Francois Chevallier, Hortense Deronzier, Cecile Dorleans & Eric Nicolai. (2010) 2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4447-4450.
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Jiaqiang Cai, Xavier Fradera, Mario van Zeeland, Maureen Dempster, Kenneth S. Cameron, D. Jonathan Bennett, John Robinson, Lucy Popplestone, Mark Baugh, Paul Westwood, John Bruin, William Hamilton, Emma Kinghorn, Clive Long & Joost C.M. Uitdehaag. (2010) 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important. Bioorganic & Medicinal Chemistry Letters 20:15, pages 4507-4510.
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Dimitris K. Agrafiotis & John J. M. Wiener. (2010) Scaffold Explorer: An Interactive Tool for Organizing and Mining Structure−Activity Data Spanning Multiple Chemotypes. Journal of Medicinal Chemistry 53:13, pages 5002-5011.
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Xiaohu Deng, Jimmy T. Liang, Matthew Peterson, Raymond Rynberg, Eugene Cheung & Neelakandha S. Mani. (2010) Practical Synthesis of a Cathepsin S Inhibitor: Route Identification, Purification Strategies, and Serendipitous Discovery of a Crystalline Salt Form. The Journal of Organic Chemistry 75:6, pages 1940-1947.
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Michael K. Ameriks, Frank U. Axe, Scott D. Bembenek, James P. Edwards, Yin Gu, Lars Karlsson, Mike Randal, Siquan Sun, Robin L. Thurmond & Jian Zhu. (2009) Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements. Bioorganic & Medicinal Chemistry Letters 19:21, pages 6131-6134.
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Michael K. Ameriks, Hui Cai, James P. Edwards, Damara Gebauer, Elizabeth Gleason, Yin Gu, Lars Karlsson, Steven Nguyen, Siquan Sun, Robin L. Thurmond & Jian Zhu. (2009) Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency. Bioorganic & Medicinal Chemistry Letters 19:21, pages 6135-6139.
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Susana Ayesa, Charlotta Lindquist, Tatiana Agback, Kurt Benkestock, Björn Classon, Ian Henderson, Ellen Hewitt, Katarina Jansson, Anders Kallin, Dave Sheppard & Bertil Samuelsson. (2009) Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity. Bioorganic & Medicinal Chemistry 17:3, pages 1307-1324.
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Jianmei Wei, Barbara A. Pio, Hui Cai, Steven P. Meduna, Siquan Sun, Yin Gu, Wen Jiang, Robin L. Thurmond, Lars Karlsson & James P. Edwards. (2007) Pyrazole-based cathepsin S inhibitors with improved cellular potency. Bioorganic & Medicinal Chemistry Letters 17:20, pages 5525-5528.
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Jacques Yves Gauthier, W. Cameron Black, Isabelle Courchesne, Wanda Cromlish, Sylvie Desmarais, Robert Houle, Sonia Lamontagne, Chun Sing Li, Frédéric Massé, Daniel J. McKay, Marc Ouellet, Joël Robichaud, Jean-François Truchon, Vouy-Linh Truong, Qingping Wang & M. David Percival. (2007) The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 17:17, pages 4929-4933.
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Hiroaki Inagaki, Hiroyuki Tsuruoka, Michael Hornsby, Scott A. Lesley, Glen Spraggon & Jonathan A. Ellman. (2007) Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode. Journal of Medicinal Chemistry 50:11, pages 2693-2699.
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Arnab K. Chatterjee, Hong Liu, David C. Tully, Jianhua Guo, Robert Epple, Ross Russo, Jennifer Williams, Michael Roberts, Tove Tuntland, Jonathan Chang, Perry Gordon, Thomas Hollenbeck, Christine Tumanut, Jun Li & Jennifer L. Harris. (2007) Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorganic & Medicinal Chemistry Letters 17:10, pages 2899-2903.
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Andrew W. Patterson, Warren J. L. Wood, Michael Hornsby, Scott Lesley, Glen Spraggon & Jonathan A. Ellman. (2006) Identification of Selective, Nonpeptidic Nitrile Inhibitors of Cathepsin S Using the Substrate Activity Screening Method. Journal of Medicinal Chemistry 49:21, pages 6298-6307.
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David C. Tully, Hong Liu, Arnab K. Chatterjee, Phil B. Alper, Robert Epple, Jennifer A. Williams, Michael J. Roberts, David H. Woodmansee, Brian T. Masick, Christine Tumanut, Jun Li, Glen Spraggon, Michael Hornsby, Jonathan Chang, Tove Tuntland, Thomas Hollenbeck, Perry Gordon, Jennifer L. Harris & Donald S. Karanewsky. (2006) Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorganic & Medicinal Chemistry Letters 16:19, pages 5112-5117.
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David C. Tully, Hong Liu, Arnab K. Chatterjee, Phil B. Alper, Jennifer A. Williams, Michael J. Roberts, Daniel Mutnick, David H. Woodmansee, Thomas Hollenbeck, Perry Gordon, Jonathan Chang, Tove Tuntland, Christine Tumanut, Jun Li, Jennifer L. Harris & Donald S. Karanewsky. (2006) Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 16:19, pages 5107-5111.
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David C. Tully, Hong Liu, Phil B. Alper, Arnab K. Chatterjee, Robert Epple, Michael J. Roberts, Jennifer A. Williams, KhanhLinh T. Nguyen, David H. Woodmansee, Christine Tumanut, Jun Li, Glen Spraggon, Jonathan Chang, Tove Tuntland, Jennifer L. Harris & Donald S. Karanewsky. (2006) Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorganic & Medicinal Chemistry Letters 16:7, pages 1975-1980.
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Phillip B. Alper, Hong Liu, Arnab K. Chatterjee, KhanhLinh T. Nguyen, David C. Tully, Christine Tumanut, Jun Li, Jennifer L. Harris, Tove Tuntland, Jonathan Chang, Perry Gordon, Thomas Hollenbeck & Donald S. Karanewsky. (2006) Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorganic & Medicinal Chemistry Letters 16:6, pages 1486-1490.
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Warren J. L. Wood, Andrew W. Patterson, Hiroyuki Tsuruoka, Rishi K. Jain & Jonathan A. Ellman. (2005) Substrate Activity Screening: A Fragment-Based Method for the Rapid Identification of Nonpeptidic Protease Inhibitors. Journal of the American Chemical Society 127:44, pages 15521-15527.
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Hong Liu, David C. Tully, Robert Epple, Badry Bursulaya, Jun Li, Jennifer L. Harris, Jennifer A. Williams, Ross Russo, Christine Tumanut, Michael J. Roberts, Phil B. Alper, Yun He & Donald S. Karanewsky. (2005) Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorganic & Medicinal Chemistry Letters 15:22, pages 4979-4984.
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Darin J. Gustin, Clark A. Sehon, Jianmei Wei, Hui Cai, Steven P. Meduna, Haripada Khatuya, Siquan Sun, Yin Gu, Wen Jiang, Robin L. Thurmond, Lars Karlsson & James P. Edwards. (2005) Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters 15:6, pages 1687-1691.
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