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Review

Patent status of histone deacetylase inhibitors

Pages 791-804 | Published online: 25 Feb 2005

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MarianaS. Gerova & OgnyanI. Petrov. (2014) A Convenient Synthesis of the New Histone Deacetylase Inhibitor Scriptaid. Organic Preparations and Procedures International 46:1, pages 76-79.
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Steve Price & Hazel J Dyke. (2007) Histone deacetylase inhibitors. Expert Opinion on Therapeutic Patents 17:7, pages 745-765.
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Hilmar Weinmann & Eckhard Ottow. (2005) Histone deacetylase inhibitors: a survey of recent patents. Expert Opinion on Therapeutic Patents 15:12, pages 1677-1690.
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Articles from other publishers (14)

Hajar Sirous, Giuseppe Campiani, Simone Brogi, Vincenzo Calderone & Giulia Chemi. (2020) Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors. Molecules 25:8, pages 1952.
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Vijayalekshmi Sarojini, Alan J. Cameron, Kyriakos G. Varnava, William A. Denny & Gangadhar Sanjayan. (2019) Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function. Chemical Reviews 119:17, pages 10318-10359.
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Kiichi Niitsu, Osamu Kobayashi, Takahiro J. Yamaguchi & Haruo Kobayashi. (2019) Design and theoretical analysis of a clock jitter reduction circuit using gated phase blending between self-delayed clock edges. IEICE Electronics Express 16:13, pages 20190218-20190218.
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Florian Thaler. (2012) Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications. Pharmaceutical Patent Analyst 1:1, pages 75-90.
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Isabelle Paquin, Stéphane Raeppel, Silvana Leit, Frédéric Gaudette, Nancy Zhou, Oscar Moradei, Oscar Saavedra, Naomy Bernstein, Franck Raeppel, Giliane Bouchain, Sylvie Fréchette, Soon H. Woo, Arkadii Vaisburg, Marielle Fournel, Ann Kalita, Marie-France Robert, Aihua Lu, Marie-Claude Trachy-Bourget, Pu Theresa Yan, Jianhong Liu, Jubrail Rahil, A. Robert MacLeod, Jeffrey M. Besterman, Zuomei Li & Daniel Delorme. (2008) Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters 18:3, pages 1067-1071.
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Matthias Körner & Ulrich Tibes. 2008. Progress in Medicinal Chemistry Volume 46. Progress in Medicinal Chemistry Volume 46 205 280 .
Yukihiro Itoh, Takayoshi Suzuki, Akiyasu Kouketsu, Nobuaki Suzuki, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa & Naoki Miyata. (2007) Design, Synthesis, Structure−Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors. Journal of Medicinal Chemistry 50:22, pages 5425-5438.
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Christopher L. Hamblett, Joey L. Methot, Dawn M. Mampreian, David L. Sloman, Matthew G. Stanton, Astrid M. Kral, Judith C. Fleming, Jonathan C. Cruz, Melissa Chenard, Nicole Ozerova, Anna M. Hitz, Hongmei Wang, Sujal V. Deshmukh, Naim Nazef, Andreas Harsch, Bethany Hughes, William K. Dahlberg, Alex A. Szewczak, Richard E. Middleton, Ralph T. Mosley, J. Paul Secrist & Thomas A. Miller. (2007) The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters 17:19, pages 5300-5309.
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Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa & Naoki Miyata. (2007) Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters 17:15, pages 4208-4212.
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Steve Price, Walter Bordogna, Richard J. Bull, David E. Clark, Peter H. Crackett, Hazel J. Dyke, Matthew Gill, Neil V. Harris, Julia Gorski, Julia Lloyd, Peter M. Lockey, Julia Mullett, Alan G. Roach, Fabien Roussel & Anne B. White. (2007) Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry Letters 17:2, pages 370-375.
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Steve Price, Walter Bordogna, Ruth Braganza, Richard J. Bull, Hazel J. Dyke, Sophie Gardan, Matthew Gill, Neil V. Harris, Robert A. Heald, Marco van den Heuvel, Peter M. Lockey, Julia Lloyd, Aranzazu G. Molina, Alan G. Roach, Fabien Roussel, Jonathan M. Sutton & Anne B. White. (2007) Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. Bioorganic & Medicinal Chemistry Letters 17:2, pages 363-369.
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Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa & Naoki Miyata. (2006) Highly Potent and Selective Histone Deacetylase 6 Inhibitors Designed Based on a Small-Molecular Substrate. Journal of Medicinal Chemistry 49:16, pages 4809-4812.
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Takayoshi Suzuki, Azusa Matsuura, Akiyasu Kouketsu, Shinya Hisakawa, Hidehiko Nakagawa & Naoki Miyata. (2005) Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent. Bioorganic & Medicinal Chemistry 13:13, pages 4332-4342.
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J. S. Ungerstedt, Y. Sowa, W.-S. Xu, Y. Shao, M. Dokmanovic, G. Perez, L. Ngo, A. Holmgren, X. Jiang & P. A. Marks. (2005) Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. Proceedings of the National Academy of Sciences 102:3, pages 673-678.
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