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Review

GSK-3 inhibitors and their potential in the treatment of Alzheimer’s disease

Pages 1315-1331 | Published online: 30 Sep 2005

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Deepa S. Mandlik, Satish K. Mandlik & Arulmozhi S.. (2022) Therapeutic implications of glycogen synthase kinase-3β in Alzheimer’s disease: a novel therapeutic target. International Journal of Neuroscience 0:0, pages 1-17.
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Valle Palomo & Ana Martinez. (2017) Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015). Expert Opinion on Therapeutic Patents 27:6, pages 657-666.
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Eeda Koti Reddy, Remya C., Ayyiliath M. Sajith, Dileep K. V., Sadasivan C. & Shaik Anwar. (2016) Functionalised dihydroazo pyrimidine derivatives from Morita–Baylis–Hillman acetates: synthesis and studies against acetylcholinesterase as its inhibitors. RSC Advances 6:81, pages 77431-77439.
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Peng Zhang, Shufen Li, Yang Gao, Wenbo Lu, Ke Huang, Deyong Ye, Xi Li & Yong Chu. (2014) Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3β (GSK-3β) with cellular activity of promoting glucose uptake. Bioorganic & Medicinal Chemistry Letters 24:24, pages 5639-5643.
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Koteswara Rao Valasani, Jhansi Rani Vangavaragu, Victor W. Day & Shirley ShiDu Yan. (2014) Structure Based Design, Synthesis, Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Identification of Novel Cyclophilin D Inhibitors. Journal of Chemical Information and Modeling 54:3, pages 902-912.
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Stefan Berg, Margareta Bergh, Sven Hellberg, Katharina Högdin, Yvonne Lo-Alfredsson, Peter Söderman, Stefan von Berg, Tatjana Weigelt, Mats Ormö, Yafeng Xue, Julie TuckerJan Neelissen, Eva Jerning, Yvonne Nilsson & Ratan Bhat. (2012) Discovery of Novel Potent and Highly Selective Glycogen Synthase Kinase-3β (GSK3β) Inhibitors for Alzheimer’s Disease: Design, Synthesis, and Characterization of Pyrazines. Journal of Medicinal Chemistry 55:21, pages 9107-9119.
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Alan P. Kozikowski, Hendra Gunosewoyo, Songpo Guo, Irina N. Gaisina, Richard L. Walter, Ariel Ketcherside, Colleen A. McClung, Andrew D. Mesecar & Barbara Caldarone. (2011) Identification of a Glycogen Synthase Kinase-3β Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice. ChemMedChem 6:9, pages 1593-1602.
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Wei Mai, Kazuyuki Kawakami, Abbas Shakoori, Satoru Kyo, Katsuyoshi Miyashita, Kenji Yokoi, Mingji Jin, Takeo Shimasaki, Yoshiharu Motoo & Toshinari Minamoto. (2009) Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase. Clinical Cancer Research 15:22, pages 6810-6819.
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Ana Martinez. (2008) Preclinical efficacy on GSK‐3 inhibitors: Towards a future generation of powerful drugs. Medicinal Research Reviews 28:5, pages 773-796.
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Arantxa Encinas, Ana Castro, Nuria E. Campillo & Juan A. Páez. (2007) The Tautomerism of 5-Amino-3-oxo-1,2,4-thiadiazole: An Experimental and Theoretical Study. European Journal of Organic Chemistry 2007:33, pages 5603-5608.
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Abbas Shakoori, Wei Mai, Katsuyoshi Miyashita, Kazuo Yasumoto, Yutaka Takahashi, Akishi Ooi, Kazuyuki Kawakami & Toshinari Minamoto. (2007) Inhibition of GSK-3β activity attenuates proliferation of human colon cancer cells in rodents. Cancer Science 98:9, pages 1388-1393.
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Rainer Mussmann, Marcus Geese, Friedrich Harder, Simone Kegel, Uwe Andag, Alexander Lomow, Ulrike Burk, Daria Onichtchouk, Cord Dohrmann & Matthias Austen. (2007) Inhibition of GSK3 Promotes Replication and Survival of Pancreatic Beta Cells. Journal of Biological Chemistry 282:16, pages 12030-12037.
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