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Expert Opinion on Therapeutic Patents Volume 15, 2005 - Issue 3
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Review

Recent progress in the discovery of antagonists acting at P2X7 receptor

Romeo Romagnoli Interdisciplinary Center for the Study of Inflammation (ICSI), Università di Ferrara, Italy. [email protected]
,
Pier Giovanni Baraldi Interdisciplinary Center for the Study of Inflammation (ICSI), Università di Ferrara, Italy. [email protected]
&
Francesco Di Virgilio Interdisciplinary Center for the Study of Inflammation (ICSI), Università di Ferrara, Italy. [email protected]
Pages 271-287 | Published online: 22 Apr 2005

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Char-Chang Shieh, Michael F Jarvis, Chih-Hung Lee & Richard J Perner. (2006) P2X receptor ligands and pain. Expert Opinion on Therapeutic Patents 16:8, pages 1113-1127.
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Articles from other publishers (14)

Jin-Hee Park, Ga-Eun Lee, So-Deok Lee, Tran Thi Hien, Sujin Kim, Jin Won Yang, Joong-Heui Cho, Hyojin Ko, Sung-Chul Lim, Yoon-Gyoon Kim, Keon-Wook Kang & Yong-Chul Kim. (2015) Discovery of Novel 2,5-Dioxoimidazolidine-Based P2X 7 Receptor Antagonists as Constrained Analogues of KN62 . Journal of Medicinal Chemistry 58:5, pages 2114-2134.
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A. Pupovac, L. Stokes & R. Sluyter. (2013) CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation. Purinergic Signalling 9:4, pages 609-619.
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Lukas Wanka, Khalid Iqbal & Peter R. Schreiner. (2013) The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives. Chemical Reviews 113:5, pages 3516-3604.
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Marek Cieślak & Michał Komoszyński. (2011) Rola ektopuryn w procesie od zapalenia do demielinizacji – perspektywy powstania nowych metod leczenia stwardnienia rozsianego. Neurologia i Neurochirurgia Polska 45:5, pages 489-499.
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Anton D Michel, Sin-Wei Ng, Shilina Roman, William C Clay, David K Dean & Daryl S Walter. (2009) Mechanism of action of species-selective P2X7 receptor antagonists. British Journal of Pharmacology 156:8, pages 1312-1325.
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William A. Carroll, Diana Donnelly-Roberts & Michael F. Jarvis. (2008) Selective P2X7 receptor antagonists for chronic inflammation and pain. Purinergic Signalling 5:1.
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Patrick Betschmann, Brian Bettencourt, Diana Donnelly-Roberts, Michael Friedman, Jonathan George, Gavin Hirst, Nathan Josephsohn, Donald Konopacki, Biqin Li, John Maull, Michael J. Morytko, Nigel StJohn Moore, Marian Namovic, Paul Rafferty, Jose-Andres Salmeron-Garcia, Edit Tarcsa, Lu Wang & Kevin Woller. (2008) Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters 18:14, pages 3848-3851.
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Alan S. Florjancic, Sridhar Peddi, Arturo Perez-Medrano, Biqin Li, Marian T. Namovic, George Grayson, Diana L. Donnelly-Roberts, Michael F. Jarvis & William A. Carroll. (2008) Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters 18:6, pages 2089-2092.
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Michael J. Morytko, Patrick Betschmann, Kevin Woller, Anna Ericsson, Haipeng Chen, Diana L. Donnelly-Roberts, Marian T. Namovic, Michael F. Jarvis, William A. Carroll & Paul Rafferty. (2008) Synthesis and in vitro activity of N′-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists. Bioorganic & Medicinal Chemistry Letters 18:6, pages 2093-2096.
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A D Michel, L J Chambers & D S Walter. (2008) Negative and positive allosteric modulators of the P2X 7 receptor . British Journal of Pharmacology 153:4, pages 737-750.
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A D Michel, L J Chambers, W C Clay, J P Condreay, D S Walter & I P Chessell. (2007) Direct labelling of the human P2X 7 receptor and identification of positive and negative cooperativity of binding . British Journal of Pharmacology 151:1, pages 84-95.
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Malcolm S. Buchanan, Anthony R. Carroll, Rama Addepalli, Vicky M. Avery, John N. A. Hooper & Ronald J. Quinn. (2007) Natural Products, Stylissadines A and B, Specific Antagonists of the P2X 7 Receptor, an Important Inflammatory Target 1 . The Journal of Organic Chemistry 72:7, pages 2309-2317.
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Christopher A. Gabel. (2007) P2 purinergic receptor modulation of cytokine production. Purinergic Signalling 3:1-2.
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Varvara P. Grichko & Olga A. Shenderova. 2006. Ultrananocrystalline Diamond. Ultrananocrystalline Diamond 529 557 .

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