66
Views
41
CrossRef citations to date
0
Altmetric
Review

11β-Hydroxysteroid dehydrogenase-1 as a therapeutic target for metabolic diseases

, &
Pages 289-303 | Published online: 22 Apr 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Alex Odermatt. (2009) Diazepane–acetamide derivatives as selective 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Expert Opinion on Therapeutic Patents 19:10, pages 1477-1483.
Read now
Craig D Boyle & Timothy J Kowalski. (2009) 11β-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents. Expert Opinion on Therapeutic Patents 19:6, pages 801-825.
Read now
Katherine A Hughes, Scott P Webster & Brian R Walker. (2008) 11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity. Expert Opinion on Investigational Drugs 17:4, pages 481-496.
Read now
Scott Peter Webster & Thomas David Pallin. (2007) 11β-Hydroxysteroid dehydrogenase type 1 inhibitors as therapeutic agents. Expert Opinion on Therapeutic Patents 17:12, pages 1407-1422.
Read now
Rolf Thieringer & Anne Hermanowski-Vosatka. (2005) Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?. Expert Review of Cardiovascular Therapy 3:5, pages 911-924.
Read now

Articles from other publishers (36)

Gabriel Navarrete-Vázquez, Maria Guadalupe Morales-Vilchis, Samuel Estrada-Soto, Juan José Ramírez-Espinosa, Sergio Hidalgo-Figueroa, Carlos Nava-Zuazo, Hugo Tlahuext, Ismael Leon-Rivera, José L. Medina-Franco, Fabian López-Vallejo, Scott P. Webster, Margaret Binnie, Rolffy Ortiz-Andrade & Hermenegilda Moreno-Diaz. (2014) Synthesis of 2-{2-[(α/β-naphthalen-1-ylsulfonyl)amino]-1,3-thiazol-4-yl} acetamides with 11β-hydroxysteroid dehydrogenase inhibition and in combo antidiabetic activities. European Journal of Medicinal Chemistry 74, pages 179-186.
Crossref
Xu Deng, Yu Shen, Jing Yang, Juan He, Yu Zhao, Li-Yan Peng, Ying Leng & Qin-Shi Zhao. (2013) Discovery and structure–activity relationships of ent-Kaurene diterpenoids as potent and selective 11β-HSD1 inhibitors: Potential impact in diabetes. European Journal of Medicinal Chemistry 65, pages 403-414.
Crossref
Takashi Sawada & Masahisa Nakada. (2013) Enantioselective Total Synthesis of (+)-Colletoic Acid via Catalytic Asymmetric Intramolecular Cyclopropanation of an α-Diazo-β-keto Diphenylphosphine Oxide. Organic Letters 15:5, pages 1004-1007.
Crossref
Eric Valeur, Serge Christmann-Franck, Franck Lepifre, Denis Carniato, Daniel Cravo, Christine Charon, Sophie Bozec, Djordje Musil, Per Hillertz, Liliane Doare, Fabien Schmidlin, Marc Lecomte, Melanie Schultz & Didier Roche. (2012) Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I. Bioorganic & Medicinal Chemistry Letters 22:18, pages 5909-5914.
Crossref
Rawindra Gaware, Rupesh Khunt, Laszlo Czollner, Christian Stanetty, Thierry Da Cunha, Denise V. Kratschmar, Alex Odermatt, Paul Kosma, Ulrich Jordis & Dirk Claßen-Houben. (2011) Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & Medicinal Chemistry 19:6, pages 1866-1880.
Crossref
Christian Stanetty, Laszlo Czollner, Iris Koller, Priti Shah, Rawindra Gaware, Thierry Da Cunha, Alex Odermatt, Ulrich Jordis, Paul Kosma & Dirk Claßen-Houben. (2010) Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors. Bioorganic & Medicinal Chemistry 18:21, pages 7522-7541.
Crossref
Scott P. Webster, Margaret Binnie, Kirsty M.M. McConnell, Karen Sooy, Peter Ward, Michael F. Greaney, Andy Vinter, T. David Pallin, Hazel J. Dyke, Matthew I.A. Gill, Ines Warner, Jonathan R. Seckl & Brian R. Walker. (2010) Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorganic & Medicinal Chemistry Letters 20:11, pages 3265-3271.
Crossref
Michael Siu, Theodore O. Johnson, Yong Wang, Sajiv K. Nair, Wendy D. Taylor, Stephan J. Cripps, Jean J. Matthews, Martin P. Edwards, Thomas A. Pauly, Jacques Ermolieff, Arturo Castro, Natilie A. Hosea, Amy LaPaglia, Andrea N. Fanjul & Jennifer E. Vogel. (2009) N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorganic & Medicinal Chemistry Letters 19:13, pages 3493-3497.
Crossref
Dirk Classen-Houben, Daniela Schuster, Thierry Da Cunha, Alex Odermatt, Gerhard Wolber, Ulrich Jordis & Bernhard Kueenburg. (2009) Selective inhibition of 11β-hydroxysteroid dehydrogenase 1 by 18α-glycyrrhetinic acid but not 18β-glycyrrhetinic acid. The Journal of Steroid Biochemistry and Molecular Biology 113:3-5, pages 248-252.
Crossref
Christopher Fotsch, Michael D. Bartberger, Eric A. Bercot, Michelle Chen, Rod Cupples, Maury Emery, Jenne Fretland, Anil Guram, Clarence Hale, Nianhe Han, Dean Hickman, Randall W. Hungate, Michael Hayashi, Renee Komorowski, Qingyian Liu, Guy Matsumoto, David J. St. JeanJr.Jr., Stefania Ursu, Murielle Véniant, Guifen Xu, Qiuping Ye, Chester Yuan, Jiandong Zhang, Xiping Zhang, Hua Tu & Minghan Wang. (2008) Further Studies with the 2-Amino-1,3-thiazol-4(5 H )-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey Pharmacodynamic Model . Journal of Medicinal Chemistry 51:24, pages 7953-7967.
Crossref
Maj Sundbom, Christina Kaiser, Eva Björkstrand, Victor M Castro, Catarina Larsson, Göran Selén, Charlotte Söderberg Nyhem & Stephen R James. (2008) Inhibition of 11βHSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice. BMC Pharmacology 8:1.
Crossref
Yuping Zhu, Steven H. Olson, Donald Graham, Gool Patel, Anne Hermanowski-Vosatka, Steven Mundt, Kashmira Shah, Marty Springer, Rolf Thieringer, Samuel Wright, Jianying Xiao, Hratch Zokian, Jasminka Dragovic & James M. Balkovec. (2008) Phenylcyclobutyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I. Bioorganic & Medicinal Chemistry Letters 18:11, pages 3412-3416.
Crossref
Yuping Zhu, Steven H. Olson, Anne Hermanowski-Vosatka, Steven Mundt, Kashmira Shah, Marty Springer, Rolf Thieringer, Samuel Wright, Jianying Xiao, Hratch Zokian & James M. Balkovec. (2008) 4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I. Bioorganic & Medicinal Chemistry Letters 18:11, pages 3405-3411.
Crossref
Da-Yuan Wang, Quinn Lu, Stacey L. Walsh, Lisa Payne, Sundip S. Modha, Martin J. Scott, Thomas D. Sweitzer, Robert S. Ames, Daniel J. Krosky & Hu Li. (2008) Development of a High-Throughput Cell-Based Assay for 11β-Hydroxysteroid Dehydrogenase Type 1 Using BacMam Technology. Molecular Biotechnology 39:2, pages 127-134.
Crossref
Lars Johansson, Christopher Fotsch, Michael D. Bartberger, Victor M. Castro, Michelle Chen, Maurice Emery, Sonja Gustafsson, Clarence Hale, Dean Hickman, Evert Homan, Steven R. Jordan, Renee Komorowski, Aiwen Li, Kenneth McRae, George Moniz, Guy Matsumoto, Carlos Orihuela, Gunnar Palm, Murielle Veniant, Minghan Wang, Meredith Williams & Jiandong Zhang. (2008) 2-Amino-1,3-thiazol-4(5 H )-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice . Journal of Medicinal Chemistry 51:10, pages 2933-2943.
Crossref
Hermenegilda Moreno-Díaz, Rafael Villalobos-Molina, Rolffy Ortiz-Andrade, Daniel Díaz-Coutiño, Jose Luis Medina-Franco, Scott P. Webster, Margaret Binnie, Samuel Estrada-Soto, Maximiliano Ibarra-Barajas, Ismael León-Rivera & Gabriel Navarrete-Vázquez. (2008) Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides. Bioorganic & Medicinal Chemistry Letters 18:9, pages 2871-2877.
Crossref
Jin Hee Lee, Nam Sook Kang & Sung-Eun Yoo. (2008) Docking-based 3D-QSAR study for 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 18:7, pages 2479-2490.
Crossref
Tsuyoshi Shinozuka, Yuko Yamamoto, Toru Hasegawa, Keiji Saito & Satoru Naito. (2008) First total synthesis of sterenins A, C and D. Tetrahedron Letters 49:10, pages 1619-1622.
Crossref
Xiangdong Su, Nigel Vicker & Barry V.L. Potter. 2008. Progress in Medicinal Chemistry Volume 46. Progress in Medicinal Chemistry Volume 46 29 130 .
Chester Yuan, David J. St. JeanJr.Jr., Qingyian Liu, Lynn Cai, Aiwen Li, Nianhe Han, George Moniz, Ben Askew, Randall W. Hungate, Lars Johansson, Lars Tedenborg, David Pyring, Meredith Williams, Clarence Hale, Michelle Chen, Rod Cupples, Jiandong Zhang, Steven Jordan, Michael D. Bartberger, Yaxiong Sun, Maurice Emery, Minghan Wang & Christopher Fotsch. (2007) The discovery of 2-anilinothiazolones as 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 17:22, pages 6056-6061.
Crossref
Lori Sutin, Sören Andersson, Lars Bergquist, Victor M. Castro, Eva Danielsson, Stephen James, Martin Henriksson, Lars Johansson, Christina Kaiser, Katarina Flyrén & Meredith Williams. (2007) Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Bioorganic & Medicinal Chemistry Letters 17:17, pages 4837-4840.
Crossref
Katarina Flyrén, Lars O. Bergquist, Victor M. Castro, Christopher Fotsch, Lars Johansson, David J. St. JeanJr.Jr., Lori Sutin & Meredith Williams. (2007) Piperidine amides as 11β-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorganic & Medicinal Chemistry Letters 17:12, pages 3421-3425.
Crossref
Nigel Vicker, Xiangdong Su, Dharshini Ganeshapillai, Andrew Smith, Atul Purohit, Michael J. Reed & Barry V.L. Potter. (2007) Novel non-steroidal inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. The Journal of Steroid Biochemistry and Molecular Biology 104:3-5, pages 123-129.
Crossref
Xiangdong Su, Nigel Vicker, Harshani Lawrence, Andrew Smith, Atul Purohit, Michael J. Reed & Barry V.L. Potter. (2007) Inhibition of human and rat 11β-hydroxysteroid dehydrogenase type 1 by 18β-glycyrrhetinic acid derivatives. The Journal of Steroid Biochemistry and Molecular Biology 104:3-5, pages 312-320.
Crossref
Scott P. Webster, Peter Ward, Margaret Binnie, Eilidh Craigie, Kirsty M.M. McConnell, Karen Sooy, Andy Vinter, Jonathan R. Seckl & Brian R. Walker. (2007) Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 17:10, pages 2838-2843.
Crossref
Bryan Sorensen, Martin Winn, Jeff Rohde, Qi Shuai, Jiahong Wang, Steven Fung, Katina Monzon, William Chiou, DeAnne Stolarik, Hovis Imade, Liping Pan, Xiaoqing Deng, Linda Chovan, Kenton Longenecker, Russell Judge, Wenying Qin, Michael Brune, Heidi Camp, Ernst U. Frevert, Peer Jacobson & J.T. Link. (2007) Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors. Bioorganic & Medicinal Chemistry Letters 17:2, pages 527-532.
Crossref
Bryan Sorensen, Jeff Rohde, Jiahong Wang, Steven Fung, Katina Monzon, William Chiou, Liping Pan, Xiaoqing Deng, DeAnne Stolarik, Ernst U. Frevert, Peer Jacobson & J.T. Link. (2006) Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction. Bioorganic & Medicinal Chemistry Letters 16:23, pages 5958-5962.
Crossref
Vince S.C. Yeh, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, Robin Shapiro, Victoria Knourek-Segel, Eugene Bush, Denise Wilcox, Phong T. Nguyen, Michael Brune, Peer Jacobson & J.T. Link. (2006) Discovery of orally active butyrolactam 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 16:21, pages 5555-5560.
Crossref
Vince S.C. Yeh, Ravi Kurukulasuriya, David Madar, Jyoti R. Patel, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Peer Jacobson, Hing L. Sham & J.T. Link. (2006) Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements. Bioorganic & Medicinal Chemistry Letters 16:20, pages 5408-5413.
Crossref
Vince S.C. Yeh, Jyoti R. Patel, Hong Yong, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, David Beno, Michael Brune, Peer Jacobson, Hing Sham & J.T. Link. (2006) Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors. Bioorganic & Medicinal Chemistry Letters 16:20, pages 5414-5419.
Crossref
Daniela Schuster, Evelyne M. Maurer, Christian Laggner, Lyubomir G. Nashev, Thomas Wilckens, Thierry Langer & Alex Odermatt. (2006) The Discovery of New 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors by Common Feature Pharmacophore Modeling and Virtual Screening. Journal of Medicinal Chemistry 49:12, pages 3454-3466.
Crossref
Xiangdong Su, Nigel Vicker, Dharshini Ganeshapillai, Andrew Smith, Atul Purohit, Michael J. Reed & Barry V.L. Potter. (2006) Benzothiazole derivatives as novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology 248:1-2, pages 214-217.
Crossref
Craig D. Boyle, Timothy J. Kowalski & Lili Zhang. 2006. Annual Reports in Medicinal Chemistry Volume 41. Annual Reports in Medicinal Chemistry Volume 41 127 140 .
Xin Gu, Jasminka Dragovic, Gloria C. Koo, Sam L. Koprak, Cheryl LeGrand, Steven S. Mundt, Kashmira Shah, Marty S. Springer, Eugene Y. Tan, Rolf Thieringer, Anne Hermanowski-Vosatka, Hratch J. Zokian, James M. Balkovec & Sherman T. Waddell. (2005) Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome. Bioorganic & Medicinal Chemistry Letters 15:23, pages 5266-5269.
Crossref
Gary M. Coppola, Paivi J. Kukkola, James L. Stanton, Alan D. Neubert, Nicholas Marcopulos, Natalie A. Bilci, Hua Wang, Hollis C. Tomaselli, Jenny Tan, Thomas D. Aicher, Douglas C. Knorr, Arco Y. Jeng, Beatriz Dardik & Ricardo E. Chatelain. (2005) Perhydroquinolylbenzamides as Novel Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1. Journal of Medicinal Chemistry 48:21, pages 6696-6712.
Crossref
Steven Olson, Susan D. Aster, Kai Brown, Linda Carbin, Donald W. Graham, Anne Hermanowski-Vosatka, Cheryl B. LeGrand, Steven S. Mundt, Michael A. Robbins, James M. Schaeffer, Llnon H. Slossberg, Michael J. Szymonifka, Rolf Thieringer, Samuel D. Wright & James M. Balkovec. (2005) Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1. Bioorganic & Medicinal Chemistry Letters 15:19, pages 4359-4362.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.