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Review

Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds

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Pages 505-519 | Published online: 10 May 2005

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Read on this site (2)

SanjayR. Chemburkar, DavidG. Anderson & RajarathnamE. Reddy. (2010) Efficient Method for Synthesis of 2-Acetylbenzo(b)thiophene and Its Derivatives, the Key Synthons for 5-Lipoxygenase Inhibitors. Synthetic Communications 40:13, pages 1887-1894.
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Carlo Pergola & Oliver Werz. (2010) 5-Lipoxygenase inhibitors: a review of recent developments and patents. Expert Opinion on Therapeutic Patents 20:3, pages 355-375.
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Articles from other publishers (20)

Ala Orafaie, Mina Mousavian, Hossein Orafai & Hamid Sadeghian. (2020) An overview of lipoxygenase inhibitors with approach of in vivo studies. Prostaglandins & Other Lipid Mediators 148, pages 106411.
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Subramani Muthuraman, Shweta Sinha, C.S. Vasavi, Kamran Manzoor Waidha, Biswarup Basu, Punnagai Munussami, M.M. Balamurali, Mukesh Doble & Rajendran Saravana Kumar. (2019) Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies. Bioorganic & Medicinal Chemistry 27:4, pages 604-619.
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Mohamed Touaibia, Martin J. G. Hébert, Natalie A. Levesque, Jérémie A. Doiron, Marco S. Doucet, Jacques Jean-François, Marc Cormier, Luc H. Boudreau & Marc E. Surette. (2018) Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship. Chemical Biology & Drug Design 92:5, pages 1876-1887.
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Pier Morin, Patrick-Denis St-Coeur, Jérémie Doiron, Marc Cormier, Julie Poitras, Marc Surette & Mohamed Touaibia. (2017) Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity. Molecules 22:7, pages 1124.
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Jérémie A. Doiron, Luc M. Leblanc, Martin J. G. Hébert, Natalie A. Levesque, Aurélie F. Paré, Jacques Jean-François, Marc Cormier, Marc E. Surette & Mohamed Touaibia. (2017) Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors. Chemical Biology & Drug Design 89:4, pages 514-528.
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Rosalina Wisastra & Frank Dekker. (2014) Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked. Cancers 6:3, pages 1500-1521.
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Marcia E Newcomer, Nathaniel C Gilbert & Max O Funk. 2011. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry.
Yiran Wu, Chong He, Yang Gao, Shan He, Ying Liu & Luhua Lai. (2012) Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors. Journal of Medicinal Chemistry 55:6, pages 2597-2605.
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Chong He, Yiran Wu, Yongquan Lai, Zongwei Cai, Ying Liu & Luhua Lai. (2012) Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network. Molecular BioSystems 8:5, pages 1585.
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Andrea Huwiler & Josef Pfeilschifter. (2009) Lipids as targets for novel anti-inflammatory therapies. Pharmacology & Therapeutics 124:1, pages 96-112.
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Christian Feißt, Carlo Pergola, Marija Rakonjac, Antonietta Rossi, Andreas Koeberle, Gabriele Dodt, Marika Hoffmann, Christina Hoernig, Lutz Fischer, Dieter Steinhilber, Lutz Franke, Gisbert Schneider, Olof Rådmark, Lidia Sautebin & Oliver Werz. (2009) Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. Cellular and Molecular Life Sciences 66:16, pages 2759-2771.
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R.L. Tiwari, V. Singh & M.K. Barthwal. (2007) Macrophages: An elusive yet emerging therapeutic target of atherosclerosis. Medicinal Research Reviews 28:4, pages 483-544.
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Oliver Schwarz, Sven Jakupovic, Horst-Dieter Ambrosi, Lars Ole Haustedt, Christian Mang & Lutz Müller-Kuhrt. (2007) Natural Products in Parallel Chemistry––Novel 5-Lipoxygenase Inhibitors from BIOS-Based Libraries Starting from α-Santonin. Journal of Combinatorial Chemistry 9:6, pages 1104-1113.
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Brian J. O’Connor, Claes-Göran Löfdahl, Meyer Balter, Andrew Szczeklik, Louis-Philippe Boulet & Charles B. Cairns. (2007) Zileuton added to low-dose inhaled beclomethasone for the treatment of moderate to severe persistent asthma. Respiratory Medicine 101:6, pages 1088-1096.
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Mingfang Zheng, Mingyue Zheng, Deju Ye, Yangmei Deng, Shuifeng Qiu, Xiaomin Luo, Kaixian Chen, Hong Liu & Hualiang Jiang. (2007) Indole derivatives as potent inhibitors of 5-lipoxygenase: Design, synthesis, biological evaluation, and molecular modeling. Bioorganic & Medicinal Chemistry Letters 17:9, pages 2414-2420.
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Robert A. Pufahl, Thomas P. Kasten, Rob Hills, James K. Gierse, Beverly A. Reitz, Robin A. Weinberg & Jaime L. Masferrer. (2007) Development of a fluorescence-based enzyme assay of human 5-lipoxygenase. Analytical Biochemistry 364:2, pages 204-212.
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G.P. Roth & D.W. Green. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 873 916 .
Oliver Werz & Dieter Steinhilber. (2006) Therapeutic options for 5-lipoxygenase inhibitors. Pharmacology & Therapeutics 112:3, pages 701-718.
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Erich L. Grimm, Christine Brideau, Nathalie Chauret, Chi-Chung Chan, Daniel Delorme, Yves Ducharme, Diane Ethier, Jean-Pierre Falgueyret, Richard W. Friesen, Jocelyne Guay, Pierre Hamel, Denis Riendeau, Chantal Soucy-Breau, Philip Tagari & Yves Girard. (2006) Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters 16:9, pages 2528-2531.
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Christian Feißt, Lutz Franke, Giovanni Appendino & Oliver Werz. (2005) Identification of Molecular Targets of the Oligomeric Nonprenylated Acylphloroglucinols from Myrtus communis and Their Implication as Anti-Inflammatory Compounds . Journal of Pharmacology and Experimental Therapeutics 315:1, pages 389-396.
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