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Review

Targeting the vitamin D receptor: advances in drug discovery

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Pages 1133-1145 | Published online: 02 Dec 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ichiro Takada & Makoto Makishima. (2015) Therapeutic application of vitamin D receptor ligands: an updated patent review. Expert Opinion on Therapeutic Patents 25:12, pages 1373-1383.
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Mihwa Choi & Makoto Makishima. (2009) Therapeutic applications for novel non-hypercalcemic vitamin D receptor ligands. Expert Opinion on Therapeutic Patents 19:5, pages 593-606.
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Articles from other publishers (20)

Badamasi M. Ibrahim, John C. Oyem & Sirajo M. Umar. (2023) Supplementation with Vitamins D3 and A Mitigates Parkinsonism in a Haloperidol Mice Model. Journal of Chemical Neuroanatomy, pages 102366.
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Michiyasu Ishizawa, Daisuke Akagi & Makoto Makishima. (2018) Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum. International Journal of Molecular Sciences 19:7, pages 1975.
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Amanda J Unsworth, Gagan D Flora & Jonathan M Gibbins. (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research 114:5, pages 645-655.
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Masaru Nakagawa, Shigeyuki Uno, Noriyoshi Iriyama, Manabu Matsunawa, Makoto Makishima, Jin Takeuchi, Isao Tsuboi, Yoshihiro Hatta & Masami Takei. (2018) Combined treatment with benzo[a]pyrene and 1α,25-dihydroxyvitamin D3 induces expression of plasminogen activator inhibitor 1 in monocyte/macrophage-derived cells. Toxicology and Applied Pharmacology 345, pages 48-56.
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Makoto Makishima & Sachiko Yamada. 2018. Vitamin D. Vitamin D 629 646 .
Makoto Makishima. 2014. Fifty Years of Cytochrome P450 Research. Fifty Years of Cytochrome P450 Research 277 290 .
Jun Ozeki, Mihwa Choi, Kaori Endo-Umeda, Kenichi Sakurai, Sadao Amano & Makoto Makishima. (2013) Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice. Neuropeptides 47:5, pages 329-332.
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Michiyasu Ishizawa, Michitaka Ogura, Shigeaki Kato & Makoto Makishima. (2012) Impairment of Bilirubin Clearance and Intestinal Interleukin-6 Expression in Bile Duct-Ligated Vitamin D Receptor Null Mice. PLoS ONE 7:12, pages e51664.
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Mihwa Choi, Jun Ozeki, Masami Hashizume, Shigeaki Kato, Hisamitsu Ishihara & Makoto Makishima. (2012) Vitamin D Receptor Activation Induces Peptide YY Transcription in Pancreatic Islets. Endocrinology 153:11, pages 5188-5199.
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Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, Kaori Endo-Umeda, Sachiko Yamada, Kazumasa Ikeda & Makoto Makishima. (2012) Vitamin D Receptor Activation Enhances Benzo[ a ]pyrene Metabolism via CYP1A1 Expression in Macrophages . Drug Metabolism and Disposition 40:11, pages 2059-2066.
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Masayuki Chuma, Kaori Endo-Umeda, Shigeki Shimba, Sachiko Yamada & Makoto Makishima. (2012) Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer. Biological and Pharmaceutical Bulletin 35:4, pages 582-587.
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Mihwa Choi, Sachiko Yamada & Makoto Makishima. (2011) Dynamic and Ligand-Selective Interactions of Vitamin D Receptor with Retinoid X Receptor and Cofactors in Living Cells. Molecular Pharmacology 80:6, pages 1147-1155.
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Makoto Makishima & Sachiko Yamada. 2011. Vitamin D. Vitamin D 1509 1524 .
Michiyasu Ishizawa, Ken-ichi Iwasaki, Shigeaki Kato & Makoto Makishima. (2009) Hypergravity modulates vitamin D receptor target gene mRNA expression in mice. American Journal of Physiology-Endocrinology and Metabolism 297:3, pages E728-E734.
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Manabu Matsunawa, Yusuke Amano, Kaori Endo, Shigeyuki Uno, Toshiyuki Sakaki, Sachiko Yamada & Makoto Makishima. (2009) The Aryl Hydrocarbon Receptor Activator Benzo[a]pyrene Enhances Vitamin D3 Catabolism in Macrophages. Toxicological Sciences 109:1, pages 50-58.
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Yusuke Amano, Yoshitake Cho, Manabu Matsunawa, Kazuo Komiyama & Makoto Makishima. (2009) Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells. The Journal of Steroid Biochemistry and Molecular Biology 114:3-5, pages 144-151.
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Yusuke Amano, Kazuo Komiyama & Makoto Makishima. (2009) Vitamin D and periodontal disease. Journal of Oral Science 51:1, pages 11-20.
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Makoto Nakabayashi, Sachiko Yamada, Nobuko Yoshimoto, Takashi Tanaka, Miharu Igarashi, Teikichi Ikura, Nobutoshi Ito, Makoto Makishima, Hiroaki Tokiwa, Hector F. DeLuca & Masato Shimizu. (2008) Crystal Structures of Rat Vitamin D Receptor Bound to Adamantyl Vitamin D Analogs: Structural Basis for Vitamin D Receptor Antagonism and Partial Agonism. Journal of Medicinal Chemistry 51:17, pages 5320-5329.
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Michiyasu Ishizawa, Manabu Matsunawa, Ryutaro Adachi, Shigeyuki Uno, Kazumasa Ikeda, Hiroyuki Masuno, Masato Shimizu, Ken-ichi Iwasaki, Sachiko Yamada & Makoto Makishima. (2008) Lithocholic acid derivatives act as selective vitamin D receptor modulators without inducing hypercalcemia. Journal of Lipid Research 49:4, pages 763-772.
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Yuka Inaba, Keiko Yamamoto, Nobuko Yoshimoto, Manabu Matsunawa, Shigeyuki Uno, Sachiko Yamada & Makoto Makishima. (2007) Vitamin D 3 Derivatives with Adamantane or Lactone Ring Side Chains are Cell Type-Selective Vitamin D Receptor Modulators . Molecular Pharmacology 71:5, pages 1298-1311.
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