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Review

Nicotinic acetylcholine receptor ligands as potential therapeutics

Pages 1221-1239 | Published online: 02 Dec 2005

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Alberto Leoni, Alessandra Locatelli, Rita Morigi & Mirella Rambaldi. (2014) Novel thiazole derivatives: a patent review (2008 – 2012. Part 2). Expert Opinion on Therapeutic Patents 24:7, pages 759-777.
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Jeffrey Paul. 2019. Translational Medicine in CNS Drug Development. Translational Medicine in CNS Drug Development 63 80 .
K.V. Niessen, T. Seeger, S. Rappenglück, T. Wein, G. Höfner, K.T. Wanner, H. Thiermann & F. Worek. (2018) In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers. Toxicology Letters 293, pages 190-197.
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François Crestey, Anders A. Jensen, Christian Soerensen, Charlotte Busk Magnus, Jesper T. Andreasen, Günther H. J. Peters & Jesper L. Kristensen. (2018) Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts. Journal of Medicinal Chemistry 61:4, pages 1719-1729.
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K.V. Niessen, S. Muschik, F. Langguth, S. Rappenglück, T. Seeger, H. Thiermann & F. Worek. (2016) Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology. Toxicology Letters 247, pages 1-10.
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Antoni R. Blaazer & Iwan J. P. de Esch. 2015. Thermodynamics and Kinetics of Drug Binding. Thermodynamics and Kinetics of Drug Binding 81 105 .
Ann J. Barbier, Martijn Hilhorst, André Van Vliet, Peter Snyder, Michael G. Palfreyman, Maria Gawryl, Nancy Dgetluck, Monica Massaro, Renger Tiessen, Wia Timmerman & Dana C. Hilt. (2015) Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Encenicline, a Selective α7 Nicotinic Receptor Partial Agonist, in Single Ascending-dose and Bioavailability Studies. Clinical Therapeutics 37:2, pages 311-324.
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SHELDON H. PRESKORN, MARIA GAWRYL, NANCY DGETLUCK, MICHAEL PALFREYMAN, LANCE O. BAUER & DANA C. HILT. (2014) Normalizing Effects of EVP-6124, an Alpha-7 Nicotinic Partial Agonist, on Event-Related Potentials and Cognition. Journal of Psychiatric Practice 20:1, pages 12-24.
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K.V. Niessen, T. Seeger, J.E.H. Tattersall, C.M. Timperley, M. Bird, C. Green, H. Thiermann & F. Worek. (2013) Affinities of bispyridinium non-oxime compounds to [3H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. Chemico-Biological Interactions 206:3, pages 545-554.
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Christoph Eibl, Isabelle Tomassoli, Lenka Munoz, Clare Stokes, Roger L. Papke & Daniela Gündisch. (2013) The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: The influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents. Bioorganic & Medicinal Chemistry 21:23, pages 7283-7308.
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Richard W. Fitch, Gordon D. Sturgeon, Shaun R. Patel, Thomas F. Spande, H. Martin Garraffo, John W. Daly & Richard H. Blaauw. (2009) Epiquinamide: A Poison That Wasn’t from a Frog That Was. Journal of Natural Products 72:2, pages 243-247.
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Ruin Moaddel, Krzysztof Jozwiak & Irving W. Wainer. (2007) Allosteric modifiers of neuronal nicotinic acetylcholine receptors: New methods, new opportunities. Medicinal Research Reviews 27:5, pages 723-753.
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C.A. Briggs & M. Gopalakrishnan. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 877 918 .

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