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Expert Opinion on Therapeutic Patents Volume 16, 2006 - Issue 12
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Review

An update on non-steroidal liver X receptor agonists and their potential use in the treatment of atherosclerosis

D Jonathan Bennett Department of Chemistry, Organon Laboratories Ltd, Newhouse ML1 5SH, Scotland, UK
,
Lindsay D Brown Department of Chemistry, Organon Laboratories Ltd, Newhouse ML1 5SH, Scotland, UK
,
Andrew J Cooke Department of Chemistry, Organon Laboratories Ltd, Newhouse ML1 5SH, Scotland, UK
&
Andrew S Edwards Department of Chemistry, Organon Laboratories Ltd, Newhouse ML1 5SH, Scotland, UK
Pages 1673-1699 | Published online: 22 Nov 2006

Citations (10)

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Read on this site (2)

Xiaolin Li, Vince Yeh & Valentina Molteni. (2010) Liver X receptor modulators: a review of recently patented compounds (2007 – 2009). Expert Opinion on Therapeutic Patents 20:4, pages 535-562.
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Pier G Baraldi, Francesca Fruttarolo, Mojgan A Tabrizi, Romeo Romagnoli & Delia Preti. (2007) Novel 8-heterocyclyl xanthine derivatives in drug development – an update. Expert Opinion on Drug Discovery 2:9, pages 1161-1183.
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Articles from other publishers (8)

Jeremy M. Travins, Ronald C. Bernotas, David H. Kaufman, Elaine Quinet, Ponnal Nambi, Irene Feingold, Christine Huselton, Anna Wilhelmsson, Annika Goos-Nilsson & Jay Wrobel. (2010) 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists. Bioorganic & Medicinal Chemistry Letters 20:2, pages 526-530.
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Ronald C. Bernotas, David H. Kaufman, Robert R. Singhaus, John Ullrich, Rayomand Unwalla, Elaine Quinet, Ponnal Nambi, Anna Wilhelmsson, Annika Goos-Nilsson & Jay Wrobel. (2009) 4-(3-Aryloxyaryl)quinoline alcohols are liver X receptor agonists. Bioorganic & Medicinal Chemistry 17:23, pages 8086-8092.
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Britt-Marie Swahn, Istvan Macsari, Jenny Viklund, Liselotte Öhberg, Johanna Sjödin, Jan Neelissen & Johanna Lindquist. (2009) Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides. Bioorganic & Medicinal Chemistry Letters 19:7, pages 2009-2012.
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Ronald C. Bernotas, Robert R. Singhaus, David H. Kaufman, John Ullrich, Horace FletcherIIIIII, Elaine Quinet, Ponnal Nambi, Rayomand Unwalla, Anna Wilhelmsson, Annika Goos-Nilsson, Mathias Farnegardh & Jay Wrobel. (2009) Biarylether amide quinolines as liver X receptor agonists. Bioorganic & Medicinal Chemistry 17:4, pages 1663-1670.
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R.L. Tiwari, V. Singh & M.K. Barthwal. (2007) Macrophages: An elusive yet emerging therapeutic target of atherosclerosis. Medicinal Research Reviews 28:4, pages 483-544.
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Baihua Hu, Elaine Quinet, Rayomand Unwalla, Mike Collini, James Jetter, Rebecca Dooley, Diane Andraka, Lisa Nogle, Dawn Savio, Anita Halpern, Annika Goos-Nilsson, Anna Wilhelmsson, Ponnal Nambi & Jay Wrobel. (2008) Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity. Bioorganic & Medicinal Chemistry Letters 18:1, pages 54-59.
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Jonathan Bennett, Andrew Cooke, Heather J. McKinnon & Olaf Nimz. 2008. 103 119e .
Baihua Hu, James Jetter, David Kaufman, Robert Singhaus, Ronald Bernotas, Rayomand Unwalla, Elaine Quinet, Dawn Savio, Anita Halpern, Michael Basso, James Keith, Valerie Clerin, Liang Chen, Qiang-Yuan Liu, Irene Feingold, Christine Huselton, Farooq Azam, Annika Goos-Nilsson, Anna Wilhelmsson, Ponnal Nambi & Jay Wrobel. (2007) Further modification on phenyl acetic acid based quinolines as liver X receptor modulators. Bioorganic & Medicinal Chemistry 15:10, pages 3321-3333.
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