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Expert Opinion on Therapeutic Patents Volume 16, 2006 - Issue 4
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Review

Recent developments in C5/C5a inhibitors

Lavinia M Proctor Senior Development Officer, Promics Ltd, PO Box 4578, Eight Mile Plains, QLD, 4113, Australia
,
Trent M Woodruff Senior Development Officer, Promics Ltd, PO Box 4578, Eight Mile Plains, QLD, 4113, Australia
&
Stephen M Taylor Professor of Pharmacology, School of Biomedical Sciences, University of Queensland, St Lucia, QLD, 4072, Australia. [email protected]
Pages 445-458 | Published online: 24 Mar 2006

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Alexandre Fisette & Katherine Cianflone. (2010) The ASP and C5L2 pathway: another bridge between inflammation and metabolic homeostasis. Clinical Lipidology 5:3, pages 367-377.
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Weizhi Xu, Vinod Kumar, Cedric S. Cui, Xaria X. Li, Andrew K. Whittaker, Zhi Ping Xu, Maree T. Smith, Trent M. Woodruff & Felicity Y. Han. (2022) Success in Navigating Hurdles to Oral Delivery of a Bioactive Peptide Complement Antagonist through Use of Nanoparticles to Increase Bioavailability and In Vivo Efficacy. Advanced Therapeutics 5:12, pages 2200109.
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Muhammad Akhtar, Aftab Shaukat, Arshad Zahoor, Yu Chen, Ying Wang, Mei Yang, Talha Umar, Mengyao Guo & Ganzhen Deng. (2019) Anti-inflammatory effects of Hederacoside-C on Staphylococcus aureus induced inflammation via TLRs and their downstream signal pathway in vivo and in vitro. Microbial Pathogenesis 137, pages 103767.
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Trent M. Woodruff, Kutty S. Nandakumar & Francesco Tedesco. (2011) Inhibiting the C5–C5a receptor axis. Molecular Immunology 48:14, pages 1631-1642.
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Anton Bunschoten, Johannes H. Ippel, John A. W. Kruijtzer, Louris Feitsma, Carla J. C. de Haas, Rob M. J. Liskamp & Johan Kemmink. (2010) A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds. Amino Acids 40:2, pages 731-740.
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Jay P. Powers, Daniel J. Dairaghi & Juan C. Jaen. 2011. 171 186 .
Hitesh J. Sanganee, Andrew Baxter, Simon Barber, Alastair J.H. Brown, Denise Grice, Fraser Hunt, Sarah King, David Laughton, Garry Pairaudeau, Bob Thong, Richard Weaver & John Unitt. (2009) Discovery of small molecule human C5a receptor antagonists. Bioorganic & Medicinal Chemistry Letters 19:4, pages 1143-1147.
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Yong Gong, J. Kent Barbay, Mieke Buntinx, Jian Li, Jean Van Wauwe, Concha Claes, Guy Van Lommen, Pamela J. Hornby & Wei He. (2008) Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists. Bioorganic & Medicinal Chemistry Letters 18:14, pages 3852-3855.
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J. Kent Barbay, Yong Gong, Mieke Buntinx, Jian Li, Concha Claes, Pamela J. Hornby, Guy Van Lommen, Jean Van Wauwe & Wei He. (2008) Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists. Bioorganic & Medicinal Chemistry Letters 18:8, pages 2544-2548.
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Daniel Ricklin & John D Lambris. (2007) Complement-targeted therapeutics. Nature Biotechnology 25:11, pages 1265-1275.
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