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Expert Opinion on Therapeutic Patents Volume 16, 2006 - Issue 9
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Patent Evaluation

Long-acting muscarinic M3 receptor antagonists

GlaxoSmithKline: WO2005086873 and WO2005087236

Peter Norman Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK
Pages 1315-1320 | Published online: 31 Aug 2006

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Subhabrata Moitra, Arvind B Bhome & Bill B Brashier. (2015) Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date. Drug Design, Development and Therapy 9, pages 1989-1999.
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Articles from other publishers (5)

Norbert Pauk. (2016) Current view of the pharmacotherapy of COPD. Interní medicína pro praxi 18:3, pages 114-119.
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Bart C Moulton & Allison D Fryer. (2011) Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD. British Journal of Pharmacology 163:1, pages 44-52.
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Ilaria Peretto, Paola Petrillo & Bruno P. Imbimbo. (2009) Medicinal chemistry and therapeutic potential of muscarinic M3 antagonists. Medicinal Research Reviews 29:6, pages 867-902.
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María Prat, Dolors Fernández, M. Antonia Buil, María I. Crespo, Gaspar Casals, Manuel Ferrer, Laia Tort, Jordi Castro, Juan M. Monleón, Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Teresa Doménech, Dolors Vilella, Francisca Antón, Josep M. Huerta, Sonia Espinosa, Manuel López, Sonia Sentellas, Marisa González, Joan Albertí, Victor Segarra, Alvaro Cárdenas, Jorge Beleta & Hamish Ryder. (2009) Discovery of Novel Quaternary Ammonium Derivatives of (3 R )-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3 R )-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide) . Journal of Medicinal Chemistry 52:16, pages 5076-5092.
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Jean-Philippe Starck, Laurent Provins, Bernard Christophe, Michel Gillard, Sophie Jadot, Patrick Lo Brutto, Luc Quéré, Patrice Talaga & Michel Guyaux. (2008) Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD. Bioorganic & Medicinal Chemistry Letters 18:8, pages 2675-2678.
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