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Expert Opinion on Therapeutic Patents Volume 17, 2007 - Issue 1
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Review

Non-steroidal glucocorticoid receptor antagonists: the race to replace RU-486 for anti-glucocorticoid therapy

Michael L Mohler Medicinal Chemist, GTx, Inc. – The Men’s Health Biotech, 3 North Dunlap Street, Memphis, TN 38163, USA
,
Yali He Medicinal Chemist, GTx, Inc. – The Men’s Health Biotech, 3 North Dunlap Street, Memphis, TN 38163, USA
,
Zhongzhi Wu Medicinal Chemist, GTx, Inc. – The Men’s Health Biotech, 3 North Dunlap Street, Memphis, TN 38163, USA
,
Seoung-Soo Hong Medicinal Chemist, GTx, Inc. – The Men’s Health Biotech, 3 North Dunlap Street, Memphis, TN 38163, USA
&
Duane D Miller Director of Medicinal Chemistry, GTx, Inc. – The Men’s Health Biotech, 3 North Dunlap Street, Memphis, TN 38163, USA. [email protected]
Pages 59-81 | Published online: 03 Jan 2007

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S. A. Usanov, A. V. Kliuchenovich & N. V. Strushkevich. (2019) Drug design strategies for Cushing’s syndrome. Expert Opinion on Drug Discovery 14:2, pages 143-151.
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Michael Berlin. (2010) Recent advances in the development of novel glucocorticoid receptor modulators. Expert Opinion on Therapeutic Patents 20:7, pages 855-873.
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Articles from other publishers (15)

洪美 侯. (2023) Research Status of Glucocorticoid Inducing Steroid Myopathy. Advances in Clinical Medicine 13:06, pages 9860-9870.
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Markus Berger, Ekkehard May, Hartmut Rehwinkel, Heike Schäcke, Roland Neuhaus, Antje Rottmann, Thomas M. Zollner & Stefan Jaroch. (2020) Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate. Bioorganic & Medicinal Chemistry Letters 30:16, pages 127298.
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Markus Berger, Hartmut Rehwinkel, Norbert Schmees, Heike Schäcke, Karl Edman, Lisa Wissler, Andreas Reichel & Stefan Jaroch. (2017) Discovery of new selective glucocorticoid receptor agonist leads. Bioorganic & Medicinal Chemistry Letters 27:3, pages 437-442.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 459 493 .
Jacqueline L. Beaudry, Emily C. Dunford, Trevor Teich, Dessi Zaharieva, Hazel Hunt, Joseph K. Belanoff & Michael C. Riddell. (2014) Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats. PLoS ONE 9:3, pages e91248.
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Raj Mitra. (2011) Adverse Effects of Corticosteroids on Bone Metabolism: A Review. PM&R 3:5, pages 466-471.
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Vitomir Sunjic & Michael J. ParnhamVitomir Šunjić & Michael J. Parnham. 2011. Signposts to Chiral Drugs. Signposts to Chiral Drugs 103 116 .
Christopher M. Yates, Peter J. Brown, Eugene L. Stewart, Christopher PattenRobert J. H. AustinJason A. Holt, Jodi M. Maglich, Davina C. AngellRosemary Z. Sasse, Simon J. TaylorIain J. UingsRyan P. Trump. (2010) Structure Guided Design of 5-Arylindazole Glucocorticoid Receptor Agonists and Antagonists. Journal of Medicinal Chemistry 53:11, pages 4531-4544.
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Guillaume A. Schoch, Brigitte D'Arcy, Martine Stihle, Dominique Burger, Dominik Bär, Jörg Benz, Ralf Thoma & Armin Ruf. (2010) Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations. Journal of Molecular Biology 395:3, pages 568-577.
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Steven M. Sparks, Pierette Banker, David M. Bickett, Daphne C. Clancy, Scott H. Dickerson, Dulce M. Garrido, Pamela L. Golden, Andrew J. Peat, Lauren R. Sheckler, Francis X. Tavares, Stephen A. Thomson & James E. Weiel. (2009) Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues. Bioorganic & Medicinal Chemistry Letters 19:3, pages 981-985.
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Michael L. Mohler, Yali He, Zhongzhi Wu, Dong Jin Hwang & Duane D. Miller. (2008) Recent and emerging anti‐diabetes targets. Medicinal Research Reviews 29:1, pages 125-195.
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Robin D. Clark, Nicholas C. Ray, Karen Williams, Paul Blaney, Stuart Ward, Peter H. Crackett, Christopher Hurley, Hazel J. Dyke, David E. Clark, Peter Lockey, Rene Devos, Melanie Wong, Soraya S. Porres, Colin P. Bright, Robert E. Jenkins & Joseph Belanoff. (2008) 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorganic & Medicinal Chemistry Letters 18:4, pages 1312-1317.
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Ramesh Narayanan, Michael L. Mohler, Casey E. Bohl, Duane D. Miller & James T. Dalton. (2008) Selective androgen receptor modulators in preclinical and clinical development. Nuclear Receptor Signaling 6:1, pages nrs.06010.
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Robin D. Clark, Nicholas C. Ray, Paul Blaney, Peter H. Crackett, Christopher Hurley, Karen Williams, Hazel J. Dyke, David E. Clark, Peter M. Lockey, Rene Devos, Melanie Wong, Anne White & Joseph K. Belanoff. (2007) 2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists. Bioorganic & Medicinal Chemistry Letters 17:20, pages 5704-5708.
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Nicholas C. Ray, Robin D. Clark, David E. Clark, Karen Williams, H.G. Hickin, Peter H. Crackett, Hazel J. Dyke, Peter M. Lockey, Melanie Wong, René Devos, Anne White & Joseph K. Belanoff. (2007) Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators. Bioorganic & Medicinal Chemistry Letters 17:17, pages 4901-4905.
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