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Expert Opinion on Therapeutic Patents Volume 17, 2007 - Issue 12
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Review

Strategies for atrial fibrillation therapy: focusing on IKur potassium channel

Qian Yang China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu, 210009, China +86 25 8327 1351; +86 25 8327 1351; [email protected]
,
Xiaojian Wang China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu, 210009, China +86 25 8327 1351; +86 25 8327 1351; [email protected]
,
Lupei Du China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu, 210009, China +86 25 8327 1351; +86 25 8327 1351; [email protected]
,
Minyong Li China Pharmaceutical University, School of Pharmacy, Nanjing, Jiangsu, 210009, China +86 25 8327 1351; +86 25 8327 1351; [email protected]
&
Qidong You China Pharmaceutical University, School of Pharmacy,Nanjing, Jiangsu, 210009, China +86 25 8327 1351; +86 25 8327 1351; [email protected]
Pages 1443-1456 | Published online: 06 Dec 2007

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Juan Tamargo, Ricardo Caballero, Ricardo Gómez & Eva Delpón. (2009) IKur/Kv1.5 channel blockers for the treatment of atrial fibrillation. Expert Opinion on Investigational Drugs 18:4, pages 399-416.
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Articles from other publishers (12)

Aya M. Emam, Steve Peigneur, Anne-Sophie Depuydt, Samy M. Ibrahim, Ernesto Lopes Pinheiro-Junior, Mohamed El-Sadek, Louise Hendrickx, Jan Tytgat & Hend Kothayer. (2021) Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities. Bioorganic Chemistry 115, pages 105264.
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Roine I. Olsson, Ingemar Jacobson, Tommy Iliefski, Jonas Boström, Öjvind Davidsson, Ola Fjellström, Annika Björe, Christina Olsson, Johan Sundell, Ulrik Gran, Jonna Gyll, Jesper Malmberg, Olle Hidestål, Hans Emtenäs, Tor Svensson, Zhong-Qing Yuan, Gert Strandlund, Annika Åstrand, Emma Lindhardt, Gunilla Linhardt, Elin Forsström, Ågot Högberg, Frida Persson, Birgit Andersson, Anna Rönnborg & Boel Löfberg. (2014) Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel. Bioorganic & Medicinal Chemistry Letters 24:5, pages 1269-1273.
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Xiaoke Guo, Qian Yang, Jing Xu, Li Zhang, Hongxi Chu, Peng Yu, Yingying Zhu, Jinglian Wei, Weilin Chen, Yaozhong Zhang, Xiaojin Zhang, Haopeng Sun, Yiqun Tang & Qidong You. (2013) Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors. Bioorganic & Medicinal Chemistry 21:21, pages 6466-6476.
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Roine I. Olsson, Ingemar Jacobson, Jonas Boström, Tomas Fex, Annika Björe, Christina Olsson, Johan Sundell, Ulrik Gran, Anna Öhrn, Andreas Nordin, Jonna Gyll, Maria Thorstensson, Ahlke Hayen, Karolina Aplander, Olle Hidestål, Fanyi Jiang, Gunilla Linhardt, Elin Forsström, Teresa Collins, Monika Sundqvist, Emma Lindhardt, Annika Åstrand & Boel Löfberg. (2013) Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5. Bioorganic & Medicinal Chemistry Letters 23:3, pages 706-710.
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Qidong You, Qian Yang & Xiaojian Wang. 2011. Ion Channels and Their Inhibitors. Ion Channels and Their Inhibitors 117 147 .
Qian Yang, David Fedida, Hongjian Xu, Binghe Wang, Lupei Du, Xiaojian Wang, Minyong Li & Qidong You. (2010) Structure-Based Virtual Screening and Electrophysiological Evaluation of New Chemotypes of Kv1.5 Channel Blockers. ChemMedChem 5:8, pages 1353-1358.
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Douglas C. Beshore, Nigel J. Liverton, Charles J. McIntyre, Christopher F. Claiborne, Brian Libby, J. Christopher Culberson, Joseph J. Salata, Christopher P. Regan, Joseph J. Lynch, Laszlo Kiss, Robert H. Spencer, Stephanie A. Kane, Rebecca B. White, Suzie Yeh, George D. Hartman & Christopher J. Dinsmore. (2010) Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorganic & Medicinal Chemistry Letters 20:8, pages 2493-2496.
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Yiqing Yang, Jun Li, Xiaoping Lin, Yanzong Yang, Kui Hong, Lei Wang, Jinqiu Liu, Li Li, Dinghong Yan, Dandan Liang, Junjie Xiao, Hongmei Jin, Jie Wu, Yangyang Zhang & Yi-Han Chen. (2009) Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation. Journal of Human Genetics 54:5, pages 277-283.
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Lupei Du, Minyong Li, Qian Yang, Yiqun Tang, Qidong You & Lin Xia. (2009) Molecular hybridization, synthesis, and biological evaluation of novel chroman IKr and IKs dual blockers. Bioorganic & Medicinal Chemistry Letters 19:5, pages 1477-1480.
Crossref
Qian Yang, Lupei Du, Keng-Chang Tsai, Xiaojian Wang, Minyong Li & Qidong You. (2009) Pharmacophore Mapping for Kv1.5 Potassium Channel Blockers. QSAR & Combinatorial Science 28:1, pages 59-71.
Crossref
Qian Yang, Lupei Du, Xiaojian Wang, Minyong Li & Qidong You. (2008) Modeling the binding modes of Kv1.5 potassium channel and blockers. Journal of Molecular Graphics and Modelling 27:2, pages 178-187.
Crossref
John W Ford & James T Milnes. (2008) New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value. Journal of Cardiovascular Pharmacology 52:2, pages 105-120.
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