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Review

Latest advances in the cannabinoids

Pages 1457-1476 | Published online: 06 Dec 2007

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Alberto Leoni, Alessandra Locatelli, Rita Morigi & Mirella Rambaldi. (2014) Novel thiazole derivatives: a patent review (2008 – 2012. Part 2). Expert Opinion on Therapeutic Patents 24:7, pages 759-777.
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Doris Riether. (2012) Selective cannabinoid receptor 2 modulators: a patent review 2009 – present. Expert Opinion on Therapeutic Patents 22:5, pages 495-510.
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Wayne E Childers, Adam M Gilbert, Jeffrey D Kennedy & Garth T Whiteside. (2008) Advances in the development of novel analgesics. Expert Opinion on Therapeutic Patents 18:9, pages 1027-1067.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 15 64 .
Jos H.M. Lange, Stefan Verhoog, Hans J. Sanders, Arnold van Loevezijn & Chris G. Kruse. (2011) A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines. Tetrahedron Letters 52:25, pages 3198-3200.
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Jos H.M. Lange, Hans J. Sanders & Jeroen van Rheenen. (2011) An expedient atom-efficient synthesis of the cannabinoid CB1 receptor inverse agonist ibipinabant. Tetrahedron Letters 52:12, pages 1303-1305.
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Serena Pasquini, Alessia Ligresti, Claudia Mugnaini, Teresa Semeraro, Lavinia Cicione, Maria De Rosa, Francesca Guida, Livio Luongo, Maria De Chiaro, Maria Grazia CascioDaniele BologniniPietro MariniRoger PertweeSabatino Maione, Vincenzo Di Marzo & Federico Corelli. (2010) Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure−Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands. Journal of Medicinal Chemistry 53:16, pages 5915-5928.
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Jos H.M. Lange, Martina A.W. van der Neut, Arnold P. den Hartog, Henri C. Wals, Jan Hoogendoorn, Herman H. van Stuivenberg, Bernard J. van Vliet & Chris G. Kruse. (2010) Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1752-1757.
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Jos H.M. Lange, Martina A.W. van der Neut, Henri C. Wals, Gijs D. Kuil, Alice J.M. Borst, Arie Mulder, Arnold P. den Hartog, Hicham Zilaout, Wouter Goutier, Herman H. van Stuivenberg & Bernard J. van Vliet. (2010) Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies. Bioorganic & Medicinal Chemistry Letters 20:3, pages 1084-1089.
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Eric J. Gilbert, Guowei Zhou, Michael K.C. Wong, Ling Tong, Bandarpalle B. Shankar, Chunli Huang, Joseph Kelly, Brian J. Lavey, Stuart W. McCombie, Lei Chen, Razia Rizvi, Youhao Dong, Youheng Shu, Joseph A. Kozlowski, Neng-Yang Shih, R. William Hipkin, Waldemar Gonsiorek, Asra Malikzay, Charles A. Lunn, Len Favreau & Daniel J. Lundell. (2010) Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors. Bioorganic & Medicinal Chemistry Letters 20:2, pages 608-611.
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Herbert H. Seltzman. (2009) Recent CB1 cannabinoid receptor antagonists and inverse agonists. Drug Development Research 70:8, pages 601-615.
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Jos H.M. Lange, Arnold P. den Hartog, Martina A.W. van der Neut, Bernard J. van Vliet & Chris G. Kruse. (2009) Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 19:19, pages 5675-5678.
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Karin Worm, Damian G. Weaver, Rosalyn C. Green, Christopher T. Saeui, Doreen-Marie S. Dulay, William M. Barker, Joel A. Cassel, Gabriel J. Stabley, Robert N. DeHaven, Christopher J. LaBuda, Michael Koblish, Bernice L. Brogdon, Steven A. Smith & Roland E. Dolle. (2009) Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists. Bioorganic & Medicinal Chemistry Letters 19:17, pages 5004-5008.
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Duen-Ren Hou, Safiul Alam, Ting-Chun Kuan, Mani Ramanathan, Tsung-Pang Lin & Ming-Shiu Hung. (2009) 1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 19:3, pages 1022-1025.
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Sangdon Han, Jayant Thatte & Robert M. Jones. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 227 246 .
Shi-Liang Tseng, Ming-Shiu Hung, Chun-Ping Chang, Jen-Shin Song, Chia-Liang Tai, Hua-Hao Chiu, Wan-Ping Hsieh, Yinchiu Lin, Wan-Ling Chung, Chun-Wei Kuo, Chien-Huang Wu, Cheng-Ming Chu, Yen-Shih Tung, Yu-Sheng Chao & Kak-Shan Shia. (2008) Bioisosteric Replacement of the Pyrazole 5-Aryl Moiety of N -(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1 H -pyrazole-3-carboxamide (SR141716A). A Novel Series of Alkynylthiophenes as Potent and Selective Cannabinoid-1 Receptor Antagonists . Journal of Medicinal Chemistry 51:17, pages 5397-5412.
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Erin F. DiMauro, John L. Buchanan, Alan Cheng, Renee Emkey, Stephen A. Hitchcock, Liyue Huang, Ming Y. Huang, Brett Janosky, Josie H. Lee, Xingwen Li, Matthew W. Martin, Susan A. Tomlinson, Ryan D. White, Xiao Mei Zheng, Vinod F. Patel & Robert T. FremeauJr.Jr.. (2008) Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorganic & Medicinal Chemistry Letters 18:15, pages 4267-4274.
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Cheng-Ming Chu, Ming-Shiu Hung, Min-Tsang Hsieh, Chun-Wei Kuo, Suja T. D.Jen-Shin Song, Hua-Hao Chiu, Yu-Sheng Chao & Kak-Shan Shia. (2008) Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists. Organic & Biomolecular Chemistry 6:18, pages 3399.
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