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Expert Opinion on Therapeutic Patents Volume 17, 2007 - Issue 3
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Patent Evaluation

Pyrazole trk kinase inhibitors for the treatment of cancer

AstraZeneca: WO06087538 and WO06087530

Robert L Hudkins Distinguished Scientist, Medicinal Chemistry Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA
&
Kurt A Josef Research Scientist, Medicinal Chemistry Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA
Pages 351-356 | Published online: 20 Feb 2007

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Tao Wang, Dingwei Yu & Michelle L Lamb. (2009) Trk kinase inhibitors as new treatments for cancer and pain. Expert Opinion on Therapeutic Patents 19:3, pages 305-319.
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John U. Chukwu, Concepción López, Asensio González, Mercè Font-Bardía, M. Teresa Calvet, Ramon Messeguer & Carme Calvis. (2014) Pd(II) complexes with N-substituted pyrazoles as ligands. The influence of the R group [OMe versus NMe2] of [1-{R–(CH2)2–}-3,5-Ph2–(C3HN2)] on their cytotoxic activity on breast cancer cell lines. Journal of Organometallic Chemistry 766, pages 13-21.
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Stéphane L. Raeppel, Frédéric Gaudette, Hannah Nguyen, Normand Beaulieu, James Wang, Christiane Maroun, Jeffrey M. Besterman & Arkadii Vaisburg. (2012) Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors. International Journal of Medicinal Chemistry 2012, pages 1-6.
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Sudipta Roy, Sujata Roy & Gordon W. Gribble. 2012. Metalation of Azoles and Related Five-Membered Ring Heterocycles. Metalation of Azoles and Related Five-Membered Ring Heterocycles 155 260 .
Ramsay E. Beveridge, Dilinie Fernando & Brian S. Gerstenberger. (2010) One-pot copper-catalyzed synthesis of N-functionalized pyrazoles from boronic acids. Tetrahedron Letters 51:38, pages 5005-5008.
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Rabindranath Tripathy, Thelma S. Angeles, Shi X. Yang & John P. Mallamo. (2008) TrkA kinase inhibitors from a library of modified and isosteric Staurosporine aglycone. Bioorganic & Medicinal Chemistry Letters 18:12, pages 3551-3555.
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