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Expert Opinion on Therapeutic Patents Volume 17, 2007 - Issue 4
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Review

Pleuromutilin antibacterial agents: patent review 2001 – 2006

Oludotun A Phillips Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. [email protected]
&
Leyla H Sharaf Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait
Pages 429-435 | Published online: 19 Apr 2007

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Herbert A Kirst. (2012) Recent derivatives from smaller classes of fermentation-derived antibacterials. Expert Opinion on Therapeutic Patents 22:1, pages 15-35.
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Fei Chai, Jun Wang, Ke-Xin Zhou, Shou-Kai Wang, Ya-Hong Liu, Zhen Jin & You-Zhi Tang. (2022) Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents. Bioorganic Chemistry 126, pages 105859.
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Han-Qing Fang, Jie Zeng, Shou-Kai Wang, Xiao Wang, Fang Chen, Bo Li, Jie Liu, Zhen Jin, Ya-Hong Liu & You-Zhi Tang. (2022) Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection. Molecules 27:3, pages 931.
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Mehdi Goudarzi, Amin Khoshbayan & Fateme Taheri. (2021) Retapamulin: Current Status and Future Perspectives. Archives of Clinical Infectious Diseases 16:4.
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Yun‐Ge Li, Ju‐Xian Wang, Guo‐Ning Zhang, Mei Zhu, Xue‐Fu You, Xin‐Xin Hu, Fan Zhang & Yu‐Cheng Wang. (2019) Antibacterial Activity and Structure−Activity Relationship of a Series of Newly Synthesized Pleuromutilin Derivatives. Chemistry & Biodiversity 16:2.
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Olivia Goethe, Abigail Heuer, Xiaoshen Ma, Zhixun Wang & Seth B. Herzon. (2019) Antibacterial properties and clinical potential of pleuromutilins. Natural Product Reports 36:1, pages 220-247.
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Xiaoshen Ma, Roman Kucera, Olivia F. Goethe, Stephen K. Murphy & Seth B. Herzon. (2018) Directed C–H Bond Oxidation of (+)-Pleuromutilin. The Journal of Organic Chemistry 83:13, pages 6843-6892.
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Junjia Liu, T. Aaron Bedell, Julian G. West & Erik J. Sorensen. (2016) Design and synthesis of molecular scaffolds with anti-infective activity. Tetrahedron 72:25, pages 3579-3592.
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Hui Li, Yingyu Wang, Xiaowei Li, Qin Fu, Yawen Shan, Tianhe Liu & Xi Xia. (2016) Determination of valnemulin in swine and bovine tissues by ultra-high performance liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 1014, pages 102-106.
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Jinbo Ouyang, Jingkang Wang, Yongli Wang, Qiuxiang Yin & Hongxun Hao. (2016) Thermodynamic study on dynamic water and organic vapor sorption on amorphous valnemulin hydrochloride. Frontiers of Chemical Science and Engineering 9:1, pages 94-104.
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Neal J. Fazakerley & David J. Procter. (2014) Synthesis and synthetic chemistry of pleuromutilin. Tetrahedron 70:39, pages 6911-6930.
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Chenyu Ling, Liqiang Fu, Suo Gao, Wenjing Chu, Hui Wang, Yanqin Huang, Xiaoyan Chen & Yushe Yang. (2014) Design, Synthesis, and Structure–Activity Relationship Studies of Novel Thioether Pleuromutilin Derivatives as Potent Antibacterial Agents. Journal of Medicinal Chemistry 57:11, pages 4772-4795.
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Xinyang Wang, Yong Ling, Hui Wang, Jianghe Yu, Junming Tang, Heng Zheng, Xi Zhao, Donggeng Wang, Guangtong Chen, Wenqian Qiu & Jinhua Tao. (2012) Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies. Bioorganic & Medicinal Chemistry Letters 22:19, pages 6166-6172.
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Liqiang Fu, Xin Liu, Chenyu Ling, Jianjun Cheng, Xingsheng Guo, Huili He, Shi Ding & Yushe Yang. (2012) Design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates. Bioorganic & Medicinal Chemistry Letters 22:2, pages 814-819.
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Daniel P. Uccello, Shawn M. Miller, Noah A. Dieterich, Antonia F. Stepan, SeungWon Chung, Kathleen A. Farley, Brian Samas, Jinshan Chen & Justin I. Montgomery. (2011) The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product. Tetrahedron Letters 52:33, pages 4247-4251.
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Stephen D. Lotesta, Junjia Liu, Emma V. Yates, Inna Krieger, James C. Sacchettini, Joel S. Freundlich & Erik J. Sorensen. (2011) Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis. Chemical Science 2:7, pages 1258.
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Junjia Liu, Stephen D. Lotesta & Erik J. Sorensen. (2011) A concise synthesis of the molecular framework of pleuromutilin. Chem. Commun. 47:5, pages 1500-1502.
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Hongbin Guo, Kaiyong Liu, Yahong Liu, Binghu Fang, Min Liu, Limin He & Zhenling Zeng. (2011) Molecularly imprinted solid-phase extraction for the selective determination of valnemulin in feeds with high performance liquid chromatography. Journal of Chromatography B 879:2, pages 181-185.
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Sergio Sánchez, Adán Chávez, Angela Forero, Yolanda García-Huante, Alba Romero, Mauricio Sánchez, Diana Rocha, Brenda Sánchez, Mariana Ávalos, Silvia Guzmán-Trampe, Romina Rodríguez-Sanoja, Elizabeth Langley & Beatriz Ruiz. (2010) Carbon source regulation of antibiotic production. The Journal of Antibiotics 63:8, pages 442-459.
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Liqiang Fu, Xin Liu, Jianjun Cheng, Huili He, Zhan Cai, Xingsheng Guo, Shi Ding & Yushe Yang. (2010) First Scale-Up Synthesis of FU-23, a Novel Water-Soluble Pleuromutilin-Derived Antibiotic. Organic Process Research & Development 14:4, pages 815-819.
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Qiushi Huang, Jiancheng Li, Lijun Xia, Xi Xia, Peng Duan, Jianzhong Shen & Shuangyang Ding. (2010) Residue depletion of valnemulin in swine tissues after oral administration. Analytica Chimica Acta 664:1, pages 62-67.
Crossref
Changhua Hu, Yi Zou & Wenting Zhao. (2009) Effect of soybean oil on the production of mycelial biomass and pleuromutilin in the shake-flask culture of Pleurotus mutilis. World Journal of Microbiology and Biotechnology 25:10, pages 1705-1711.
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Line Lolk, Jacob Pøhlsgaard, Anne Sofie Jepsen, Lykke H. Hansen, Henrik Nielsen, Signe I. Steffansen, Laura Sparving, Annette B. Nielsen, Birte Vester & Poul Nielsen. (2008) A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome. Journal of Medicinal Chemistry 51:16, pages 4957-4967.
Crossref
Shridhar Hegde & Michelle Schmidt. 2008. 455 497 .

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