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Review

Dry powder inhalation systems for pulmonary delivery of therapeutic peptides and proteins

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Pages 429-442 | Published online: 07 Apr 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Larissa Gomes dos Reis & Daniela Traini. (2020) Advances in the use of cell penetrating peptides for respiratory drug delivery. Expert Opinion on Drug Delivery 17:5, pages 647-664.
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Meng Wai Woo, Shahnaz Mansouri & Xiao Dong Chen. (2014) Antisolvent vapor precipitation: the future of pulmonary drug delivery particle production?. Expert Opinion on Drug Delivery 11:3, pages 307-311.
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Satomi Onoue, Shingen Misaka, Yohei Kawabata & Shizuo Yamada. (2009) New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy. Expert Opinion on Drug Delivery 6:8, pages 793-811.
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Articles from other publishers (21)

Sachin S. Gaikwad, Snehal R. Pathare, Mayur A. More, Nikita A. Waykhinde, Umesh D. Laddha, Kishor S. Salunkhe, Sanjay J. Kshirsagar, Sakshi S. Patil & Kuldeep H. Ramteke. (2023) Dry Powder Inhaler with the technical and practical obstacles, and forthcoming platform strategies. Journal of Controlled Release 355, pages 292-311.
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Malihe Karimi, Hossein Kamali, Marzieh Mohammadi & Mohsen Tafaghodi. (2022) Evaluation of various techniques for production of inhalable dry powders for pulmonary delivery of peptide and protein. Journal of Drug Delivery Science and Technology 69, pages 103186.
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Hong-Goo Lee, Dong-Wook Kim & Chung-Woong Park. (2017) Dry powder inhaler for pulmonary drug delivery: human respiratory system, approved products and therapeutic equivalence guideline. Journal of Pharmaceutical Investigation 48:6, pages 603-616.
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Jovana Milenkovic, Aleck H. Alexopoulos & Costas Kiparissides. (2017) Optimization of a DPI Inhaler: A Computational Approach. Journal of Pharmaceutical Sciences 106:3, pages 850-858.
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Hiroki Suzuki, Yoshiki Kojo, Keisuke Yakushiji, Kayo Yuminoki, Naofumi Hashimoto & Satomi Onoue. (2016) Strategic application of self-micellizing solid dispersion technology to respirable powder formulation of tranilast for improved therapeutic potential. International Journal of Pharmaceutics 499:1-2, pages 255-262.
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Nitesh K. Kunda, Iman M. Alfagih, Imran Y. Saleem & Gillian A. Hutcheon. 2015. Pulmonary Drug Delivery. Pulmonary Drug Delivery 301 320 .
Hesham M. Tawfeek. (2013) Evaluation of PEG and mPEG-co-(PGA-co-PDL) microparticles loaded with sodium diclofenac. Saudi Pharmaceutical Journal 21:4, pages 387-397.
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Satomi Onoue, Takuya Matsui, Masashi Kato, Takahiro Mizumoto, Baosheng Liu, Liang Liu, Shin-ichiro Karaki, Atsukazu Kuwahara & Shizuo Yamada. (2013) Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability. European Journal of Pharmaceutical Sciences 49:3, pages 382-389.
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Satomi Onoue, Yoshiki Seto, Masashi Kato, Yosuke Aoki, Yoshiki Kojo & Shizuo Yamada. (2013) Inhalable Powder Formulation of Pirfenidone with Reduced Phototoxic Risk for Treatment of Pulmonary Fibrosis. Pharmaceutical Research 30:6, pages 1586-1596.
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Flore Depreter, Gabrielle Pilcer & Karim Amighi. (2013) Inhaled proteins: Challenges and perspectives. International Journal of Pharmaceutics 447:1-2, pages 251-280.
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Nitesh K. Kunda, Satyanarayana Somavarapu, Stephen B. Gordon, Gillian A. Hutcheon & Imran Y. Saleem. (2012) Nanocarriers Targeting Dendritic Cells for Pulmonary Vaccine Delivery. Pharmaceutical Research 30:2, pages 325-341.
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Satomi Onoue, Takuya Matsui, Kazuki Kuriyama, Kumiko Ogawa, Yoshiki Kojo, Takahiro Mizumoto, Shin-ichiro Karaki, Atsukazu Kuwahara & Shizuo Yamada. (2012) Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation. Peptides 35:2, pages 182-189.
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Satomi Onoue, Hideyuki Sato, Kumiko Ogawa, Yoshiki Kojo, Yosuke Aoki, Yohei Kawabata, Koichi Wada, Takahiro Mizumoto & Shizuo Yamada. (2012) Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats. European Journal of Pharmaceutics and Biopharmaceutics 80:1, pages 54-60.
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Satomi Onoue, Yosuke Aoki, Yohei Kawabata, Takuya Matsui, Kiyoshi Yamamoto, Hideyuki Sato, Yukinori Yamauchi & Shizuo Yamada. (2011) Development of Inhalable Nanocrystalline Solid Dispersion of Tranilast for Airway Inflammatory Diseases. Journal of Pharmaceutical Sciences 100:2, pages 622-633.
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Philip Chi Lip Kwok & Hak-Kim Chan. 2011. Peptide and Protein Delivery. Peptide and Protein Delivery 23 46 .
R.I. Henkin. (2010) Intranasal insulin: From nose to brain. Nutrition 26:6, pages 624-633.
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Shingen Misaka, Yosuke Aoki, Shin-ichiro Karaki, Atsukazu Kuwahara, Takahiro Mizumoto, Satomi Onoue & Shizuo Yamada. (2010) Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: Anti-inflammatory effect in experimental asthmatic rats. Peptides 31:1, pages 72-78.
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R.I. Henkin. (2010) Inhaled insulin—Intrapulmonary, intranasal, and other routes of administration: Mechanisms of action. Nutrition 26:1, pages 33-39.
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Satomi Onoue, Kiyoshi Yamamoto, Yohei Kawabata, Mariko Hirose, Takahiro Mizumoto & Shizuo Yamada. (2009) Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery. International Journal of Pharmaceutics 382:1-2, pages 144-150.
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Satomi Onoue, Hideyuki Sato, Yohei Kawabata, Takahiro Mizumoto, Naofumi Hashimoto & Shizuo Yamada. (2009) In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy. Journal of Controlled Release 138:1, pages 16-23.
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Shingen Misaka, Hideyuki Sato, Yukinori Yamauchi, Satomi Onoue & Shizuo Yamada. (2009) Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats. European Journal of Pharmaceutical Sciences 37:3-4, pages 469-476.
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