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Expert Opinion on Therapeutic Patents Volume 18, 2008 - Issue 4
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Patent Evaluation

Inhibition of stearoyl-CoA desaturase by cyclic amine derivatives

Merck Frosst Canada: WO2007134457

Agnieszka Dobrzyn Nencki Institute of Experimental Biology, Laboratory of Cell Signaling and Metabolic Disorders, Pasteura 3, 02-093 Warsaw, Poland +48 22 5892459; +48 22 8225342; [email protected]
&
Pawel Dobrzyn Nencki Institute of Experimental Biology, Laboratory of Cell Signaling and Metabolic Disorders, Pasteura 3, 02-093 Warsaw, Poland +48 22 5892459; +48 22 8225342; [email protected]
Pages 457-460 | Published online: 07 Apr 2008

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Pawel Dobrzyn & Agnieszka Dobrzyn. (2010) Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase. Expert Opinion on Therapeutic Patents 20:6, pages 849-853.
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Articles from other publishers (2)

Yoshikazu Uto, Tsuneaki Ogata, Yohei Kiyotsuka, Yuko Ueno, Yuriko Miyazawa, Hitoshi Kurata, Tsuneo Deguchi, Nobuaki Watanabe, Masahiro Konishi, Ryo Okuyama, Nobuya Kurikawa, Toshiyuki Takagi, Satoko Wakimoto & Jun Ohsumi. (2010) Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorganic & Medicinal Chemistry Letters 20:1, pages 341-345.
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Marc Issandou, Anne Bouillot, Jean-Marie Brusq, Marie-Claire Forest, Didier Grillot, Raphaelle Guillard, Sandrine Martin, Christelle Michiels, Thierry Sulpice & Alain Daugan. (2009) Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models. European Journal of Pharmacology 618:1-3, pages 28-36.
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