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Review

EGFR-targeting agents in oncology

, , , MD PhD & , MD PhD
Pages 889-901 | Published online: 04 Aug 2008

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C. Thirumurugan, P. Vadivel, A. Lalitha & S. Lakshmanan. (2020) Synthesis, characterization of novel quinoline-2-carboxamide based chalcone derivatives and their molecular docking, photochemical studies. Synthetic Communications 50:6, pages 831-839.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Hazem A. Ghabbour & Manal A. Al-Gendy. (2017) Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1229-1239.
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Rafat M. Mohareb, Rehab A. Ibrahim & Eman M. Samir. (2023) Synthesis and docking studies of pyran, pyridine and thiophene derivatives and their antitumor evaluations against cancer, hepatocellular carcinoma and cervical carcinoma cell lines. Journal of the Iranian Chemical Society 20:9, pages 2163-2187.
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Karam A. El-Sharkawy, Abeer A. Mohamed, Fatma O. Al Farouk & Rafat M. Mohareb. (2023) New Approaches for the Synthesis N-alkylated Benzo[b]thiophene Derivatives together with their Antiproliferative and Molecular Docking Studies. Anti-Cancer Agents in Medicinal Chemistry 23:12, pages 1429-1446.
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Leila Emami, Soghra Khabnadideh, Zahra Faghih, Farnoosh Farahvasi, Fatemeh Zonobi, Saman Zare Gheshlaghi, Shadi Daili, Ali Ebrahimi & Zeinab Faghih. (2022) Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents. BMC Chemistry 16:1.
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Rafat Milad Mohareb, Noha M. Asaad Bagato & Ibrahim Taha Radwan. (2022) Design, Synthesis, Molecular Docking, and Biological Studies of New Heterocyclic Compounds Derived from β-Diketones as Novel EGFR and Pim-1 Inhibitors Endowed with Antitumor Activity. Anti-Cancer Agents in Medicinal Chemistry 22:14, pages 2558-2576.
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Leila Emami, Zeinab Faghih, Soghra Khabnadideh, Zahra Rezaei, Razieh Sabet, Ebrahim Harigh & Zahra Faghih. (2021) 2-(Chloromethyl)-3-phenylquinazolin-4(3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies. Journal of the Iranian Chemical Society 18:8, pages 1877-1889.
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Wafaa A. Ewes, Mohammad A. Elmorsy, Shahenda M. El-Messery & Magda N.A. Nasr. (2020) Synthesis, biological evaluation and molecular modeling study of [1,2,4]-Triazolo[4,3-c]quinazolines: New class of EGFR-TK inhibitors. Bioorganic & Medicinal Chemistry 28:7, pages 115373.
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K. Thirumurugan, Sivalingam Lakshmanan, Dharman Govindaraj, D. Sam Daniel Prabu, N. Ramalakshmi & S. Arul Antony. (2018) Design, synthesis and anti-inflammatory activity of pyrimidine scaffold benzamide derivatives as epidermal growth factor receptor tyrosine kinase inhibitors. Journal of Molecular Structure 1171, pages 541-550.
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Hatem A. Abuelizz, Mohamed Marzouk, Hazem Ghabbour & Rashad Al-Salahi. (2017) Synthesis and anticancer activity of new quinazoline derivatives. Saudi Pharmaceutical Journal 25:7, pages 1047-1054.
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Hua-Li Qin, Jing Leng, Bahaa G. M. Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi & Syed Nasir Abbas Bukhari. (2017) Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents. Chemical Biology & Drug Design 90:3, pages 443-449.
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Gao-Feng Zha, Hua-Li Qin, Bahaa G.M. Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Ahmed H. Abdelazeem & Syed Nasir Abbas Bukhari. (2017) Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance. European Journal of Medicinal Chemistry 135, pages 34-48.
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Hua-Li Qin, Jing Leng, Cheng-Pan Zhang, Ibrahim Jantan, Muhammad Wahab Amjad, Muhammad Sher, Muhammad Naeem-ul-Hassan, Muhammad Ajaz Hussain & Syed Nasir Abbas Bukhari. (2016) Synthesis of α,β-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells. Journal of Medicinal Chemistry 59:7, pages 3549-3561.
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Maher A. El‐Hashash, Mohamed E. Azab & Jehan M. Morsy. (2015) One‐Pot Synthesis of Some Dynamic 2‐Substituted Benzoxazinones and Their Corresponding Qinazolinones of Anticipated Biological Activity. Journal of Heterocyclic Chemistry 53:1, pages 95-101.
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Ibrahim A. Al-Suwaidan, Amer M. Alanazi, Alaa A.-M. Abdel-Aziz, Menshawy A. Mohamed & Adel S. El-Azab. (2013) Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: Molecular docking study. Bioorganic & Medicinal Chemistry Letters 23:13, pages 3935-3941.
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Shaojing Hu, Guojian Xie, Don X. Zhang, Charles Davis, Wei Long, Yunyan Hu, Fei Wang, Xinshan Kang, Fenlai Tan, Lieming Ding & Yinxiang Wang. (2012) Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors. Bioorganic & Medicinal Chemistry Letters 22:19, pages 6301-6305.
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Ning Ding, Wei Zhang, Hua Ling Xiao, Peng Wang & Ying Xia Li. (2012) Synthesis and biological evaluation of a series of novel salicylanilides as inhibitors of EGFR protein tyrosine kinases. Chinese Chemical Letters 23:5, pages 529-532.
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Malleshappa N. Noolvi, Harun M. Patel, Varun Bhardwaj & Ankit Chauhan. (2011) Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: Search for anticancer agent. European Journal of Medicinal Chemistry 46:6, pages 2327-2346.
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Ri-Dong Li, Xin Zhang, Qiao-Yan Li, Ze-Mei Ge & Run-Tao Li. (2011) Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. Bioorganic & Medicinal Chemistry Letters 21:12, pages 3637-3640.
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Ronghui Lin, Sigmond G. Johnson, Peter J. Connolly, Steven K. Wetter, Eva Binnun, Terry V. Hughes, William V. Murray, Niranjan B. Pandey, Sandra J. Moreno-Mazza, Mary Adams, Angel R. Fuentes-Pesquera & Steven A. Middleton. (2009) Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 19:8, pages 2333-2337.
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