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Current Opinion on Therapeutic Patents Volume 2, 1992 - Issue 4
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Cardiovascular Agents (Including Blood Products)

Overview: ACAT Inhibitors: A Potential New Approach to the Treatment of Hypercholesterolaemia and Atherosclerosis

Patrick M O'Brien Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105 USA
&
Drago R Sliskovic Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105 USA
Pages 507-526 | Published online: 02 Mar 2011

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Helen T Lee & Joseph A Picard. (1995) Review: Cardiovascular & Renal Recent developments in hypocholesterolaemic agents. Expert Opinion on Therapeutic Patents 5:5, pages 397-415.
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Joseph A Picard. (1993) Patent Update: ACAT Inhibitors. Current Opinion on Therapeutic Patents 3:1, pages 151-160.
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Articles from other publishers (16)

Pinaki Bhattacharjee, Nicholas Rutland & Malliga R. Iyer. (2022) Targeting Sterol O -Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential . Journal of Medicinal Chemistry 65:24, pages 16062-16098.
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Philippe Boucher & Hans Gerhard Vogel. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 2273 2281 .
Philippe Boucher & Hans Gerhard Vogel. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 11 .
Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 1661 1717 .
H.T Lee, W.H Roark, J.A Picard, D.R Sliskovic, B.D Roth, R.L Stanfield, K.L Hamelehle, R.F Bousley & B.R Krause. (1998) Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorganic & Medicinal Chemistry Letters 8:3, pages 289-294.
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Hui-Yin Li, Indawati DeLucca, George A. Boswell, Jeffrey T. Billheimer, Spencer Drummond, Peter J. Gillies & Candy Robinson. (1997) Design, synthesis and structure-activity relationship studies of novel 4,4-bis(trifluoromethyl)imidazolines as acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents. Bioorganic & Medicinal Chemistry 5:7, pages 1345-1361.
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Hui-Yin Li, Indawati DeLucca, Spencer Drummond & George A. Boswell. (1997) Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors. Tetrahedron 53:15, pages 5359-5372.
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Claude F PurchaseIIII, Andrew D White, Maureen K Anderson, Thomas M.A Bocan, Richard F Bousley, Katherine L Hamelehle, Reynold Homan, Brian R Krause, Peter Lee, Sandra Bak Mueller, Cecilia Speyer, Richard L Stanfield & James F Reindel. (1996) Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines. Bioorganic & Medicinal Chemistry Letters 6:15, pages 1753-1758.
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George A Boswell, Hui-Yin Li, Indawati Delucca, Jeffrey T. Billheimer, Spencer Drummond, Peter J. Gillies & Candy Robinson. (1996) Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl coa: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents. Bioorganic & Medicinal Chemistry Letters 6:7, pages 885-888.
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Bharat K. Trivedi, Ann Holmes, Terri S. Purchase, Arnold D. Essenburg, Katherine L. Hamelehle, Brian R. Krause, MaryKay Shaw Hes & Richard L. Stanfield. (1995) A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylurea ACAT inhibitors. Bioorganic & Medicinal Chemistry Letters 5:19, pages 2229-2234.
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A. Chiari, D. Fancelli, P.P. Lovisolo, A. Radice, L. Savoia, D. Severino & G. Ghiselli. (1995) Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters 5:15, pages 1581-1586.
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Yasufumi Nagata, Mari Yonemoto, Yoshikazu Iwasawa, Akiko Shimizu-Nagumo, Hiromi Hattori, Yoshio Sawazaki & Toshio Kamei. (1995) N-[2-[N′-pentyl-(6,6-dimethyl-2,4-heptadiynyl) amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). Biochemical Pharmacology 49:5, pages 643-651.
Crossref
H.T. Lee, D.R. Sliskovic, R.L. Stanfield, K.L. Hamelehle, R.F. Bousley & B.R. Krause. (1995) Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents 14. synthesis and structure-activity relationships of a novel series of sulfonamide tetrazoles. Bioorganic & Medicinal Chemistry Letters 5:3, pages 301-306.
Crossref
Patrick M. O'Brien, Drago R. Sliskovic, Maureen K. Anderson, Richard F. Bousley, Brian R. Krause & Richard L. Stanfield. (1995) Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 12. Syntheses and biological activity of structurally novel tetrazole amides. Bioorganic & Medicinal Chemistry Letters 5:3, pages 289-294.
Crossref
W. Howard Roark, Janak Padia, Gary L. Bolton, C. John Blankley, Arnold D. Essenburg, Richard L. Stanfield, Richard F. Bousley, Brian R. Krause & Bruce D. Roth. (1995) Bioisosterism in drug design: Identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors. Bioorganic & Medicinal Chemistry 3:1, pages 29-39.
Crossref
Scott D. Larsen & Charles H. Spilman. 1993. 217 226 .

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