358
Views
20
CrossRef citations to date
0
Altmetric
Reviews

Farnesoid X receptor modulators: a patent review

, PhD
Pages 1047-1057 | Published online: 23 Jun 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Hong Wang, Qingxian He, Guangji Wang, Xiaowei Xu & Haiping Hao. (2018) FXR modulators for enterohepatic and metabolic diseases. Expert Opinion on Therapeutic Patents 28:11, pages 765-782.
Read now
Valentina Sepe, Eleonora Distrutti, Stefano Fiorucci & Angela Zampella. (2018) Farnesoid X receptor modulators 2014-present: a patent review. Expert Opinion on Therapeutic Patents 28:5, pages 351-364.
Read now
Valentina Sepe, Eleonora Distrutti, Stefano Fiorucci & Angela Zampella. (2015) Farnesoid X receptor modulators (2011 – 2014): a patent review. Expert Opinion on Therapeutic Patents 25:8, pages 885-896.
Read now

Articles from other publishers (17)

Qiang Ren, Ya Chen, Zongtao Zhou, Zongyu Cai, Shixuan Jiao, Wanqiu Huang, Bin Wang, Siliang Chen, Wenxin Wang, Zhijun Cao, Zhongcheng Yang, Liming Deng, Lijun Hu, Luyong Zhang & Zheng Li. (2023) Discovery of the First-in-Class Intestinal Restricted FXR and FABP1 Dual Modulator ZLY28 for the Treatment of Nonalcoholic Fatty Liver Disease. Journal of Medicinal Chemistry 66:9, pages 6082-6104.
Crossref
Mohammad Rudiansyah, Saade Abdalkareem Jasim, Bakhadir S. Azizov, Vadim Samusenkov, Walid Kamal Abdelbasset, Ghulam Yasin, Hawraa Jabbar Mohammad, Mohammed Abed Jawad, Trias Mahmudiono, Seyed Reza Hosseini‐Fard, Rasoul Mirzaei & Sajad Karampoor. (2022) The emerging microbiome‐based approaches to IBD therapy: From SCFAs to urolithin A . Journal of Digestive Diseases 23:8-9, pages 412-434.
Crossref
Ruicong Sun, Chunjin Xu, Baisui Feng, Xiang Gao & Zhanju Liu. (2021) Critical roles of bile acids in regulating intestinal mucosal immune responses. Therapeutic Advances in Gastroenterology 14, pages 175628482110180.
Crossref
Simona De Marino, Carmen Festa, Valentina Sepe & Angela Zampella. 2019. Bile Acids and Their Receptors. Bile Acids and Their Receptors 137 165 .
Edithe Selwa, Eddy Elisée, Agustin Zavala & Bogdan I. Iorga. (2017) Blinded evaluation of farnesoid X receptor (FXR) ligands binding using molecular docking and free energy calculations. Journal of Computer-Aided Molecular Design 32:1, pages 273-286.
Crossref
Liping Yang, David Broderick, Yan Campbell, Adrian F. Gombart, Jan F. Stevens, Yuan Jiang, Victor L. Hsu, William H. Bisson & Claudia S. Maier. (2016) Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:12, pages 1667-1677.
Crossref
Wei Wang, Ming Zhan, Qi Li, Wei Chen, Huiling Chu, Qihong Huang, Zhaoyuan Hou, Mohan Man & Jian Wang. (2016) FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression . Oncotarget 7:23, pages 34617-34629.
Crossref
Christel A.S. Bergström, William N. Charman & Christopher J.H. Porter. (2016) Computational prediction of formulation strategies for beyond-rule-of-5 compounds. Advanced Drug Delivery Reviews 101, pages 6-21.
Crossref
Vinod S. Hegade, R. Alexander Speight, Rachel E. Etherington & David E. J. Jones. (2016) Novel bile acid therapeutics for the treatment of chronic liver diseases. Therapeutic Advances in Gastroenterology 9:3, pages 376-391.
Crossref
Shufeng Zhou. 2016. Cytochrome P450 2D6. Cytochrome P450 2D6 315 340 .
Eva Hambruch, Shinobu Miyazaki-Anzai, Ulrike Hahn, Silke Matysik, Alfred Boettcher, Sanja Perović-Ottstadt, Thomas Schlüter, Olaf Kinzel, Helen Desiree Krol, Ulrich Deuschle, Michael Burnet, Moshe Levi, Gerd Schmitz, Makoto Miyazaki & Claus Kremoser. (2012) Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice. Journal of Pharmacology and Experimental Therapeutics 343:3, pages 556-567.
Crossref
Weihua Li, Jing Fu, Feixiong Cheng, Mingyue Zheng, Jian Zhang, Guixia Liu & Yun Tang. (2012) Unbinding Pathways of GW4064 from Human Farnesoid X Receptor As Revealed by Molecular Dynamics Simulations. Journal of Chemical Information and Modeling 52:11, pages 3043-3052.
Crossref
Brent A. Neuschwander-Tetri. (2011) Farnesoid X Receptor Agonists: What They Are and How They Might Be Used in Treating Liver Disease. Current Gastroenterology Reports 14:1, pages 55-62.
Crossref
Yan Zhu, Fei Li & Grace L. Guo. (2011) Tissue-specific function of farnesoid X receptor in liver and intestine. Pharmacological Research 63:4, pages 259-265.
Crossref
Antimo Gioiello, Antonio Macchiarulo, Andrea Carotti, Paolo Filipponi, Gabriele Costantino, Giovanni Rizzo, Luciano Adorini & Roberto Pellicciari. (2011) Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3α,7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-amine. Bioorganic & Medicinal Chemistry 19:8, pages 2650-2658.
Crossref
Patrice André, Christophe Ramière, Caroline Scholtes, Claire Curtil & Vincent Lotteau. (2011) Role of nuclear receptors in hepatitis B and C infections. Clinics and Research in Hepatology and Gastroenterology 35:3, pages 169-175.
Crossref
Hans G.F. Richter, Gregory M. Benson, Denise Blum, Evelyne Chaput, Song Feng, Christophe Gardes, Uwe Grether, Peter Hartman, Bernd Kuhn, Rainer E. Martin, Jean-Marc Plancher, Markus G. Rudolph, Franz Schuler, Sven Taylor & Konrad H. Bleicher. (2011) Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes. Bioorganic & Medicinal Chemistry Letters 21:1, pages 191-194.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.