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Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity

, MD PhD &
Pages 1457-1470 | Published online: 10 Sep 2010

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Roozbeh Sanaei, Nima Rezaei, Asghar Aghamohammadi, Ali-Akbar Delbandi, Parsova Tavasolian & Nader Tajik. (2019) Disturbed Transcription of TLRs’ Negative Regulators and Cytokines Secretion among TLR4- and 9-Activated PBMCs of Agammaglobulinemic Patients. Immunological Investigations 48:8, pages 860-874.
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Tadeusz Robak & Ewa Robak. (2012) Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders. Expert Opinion on Investigational Drugs 21:7, pages 921-947.
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Articles from other publishers (18)

Keshav Taruneshwar Jha, Abhimannu Shome, Chahat, Viney Chawla & Pooja A. Chawla. (2023) Medicinal perspectives and structure-activity relationship studies of pyrimidine based Bruton’s tyrosine kinase inhibitors as potential anticancer agents. Process Biochemistry 132, pages 308-322.
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Fatih M. Uckun & Taracad Venkatachalam. (2021) Targeting Solid Tumors With BTK Inhibitors. Frontiers in Cell and Developmental Biology 9.
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Fatih M. Uckun & Sanjive Qazi. 2020. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 343 360 .
Magdalena Krajewska-Włodarczyk, Agnieszka Owczarczyk-Saczonek, Zbigniew Żuber, Maja Wojtkiewicz & Joanna Wojtkiewicz. (2019) Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases. International Journal of Molecular Sciences 20:21, pages 5453.
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Fatih M. Uckun & Sanjive Qazi. 2018. Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Drug Discovery and Evaluation: Methods in Clinical Pharmacology 1 18 .
Wendy B. Young, James Barbosa, Peter Blomgren, Meire C. Bremer, James J. Crawford, Donna Dambach, Steve Gallion, Sarah G. Hymowitz, Jeffrey E. Kropf, Seung H. Lee, Lichuan Liu, Joseph W. Lubach, Jen Macaluso, Pat Maciejewski, Brigitte Maurer, Scott A. Mitchell, Daniel F. Ortwine, Julie Di Paolo, Karin Reif, Heleen Scheerens, Aaron Schmitt, C. Gregory Sowell, Xiaojing Wang, Harvey Wong, Jin-Ming Xiong, Jianjun Xu, Zhongdong Zhao & Kevin S. Currie. (2015) Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834. Bioorganic & Medicinal Chemistry Letters 25:6, pages 1333-1337.
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G. Lopez-Herrera, J. L. Maravillas-Montero, J. C. Rodríguez-Alba & L. Santos-Argumedo. 2015. Agammaglobulinemia. Agammaglobulinemia 99 115 .
Li Xing & Adrian Huang. (2014) Bruton's TK inhibitors: structural insights and evolution of clinical candidates. Future Medicinal Chemistry 6:6, pages 675-695.
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Dramane Lainé, Matthew Lucas, Francisco Lopez-Tapia & Stephen Lynch. 2013. Medicinal Chemistry Approaches to Personalized Medicine. Medicinal Chemistry Approaches to Personalized Medicine 255 288 .
Jonathan Hsu, Jun Zhang, Chris Kitson, Seng-Lai Tan, Satwant Narula, Julie A. DeMartino & Cheng Liao. (2013) Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling. SLAS Discovery 18:8, pages 890-898.
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J. R. Dye, A. J. Ullal & D. S. Pisetsky. (2013) The Role of Microparticles in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus. Scandinavian Journal of Immunology 78:2, pages 140-148.
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Rakesh Bam, Wen Ling, Sharmin Khan, Angela Pennisi, Sathisha Upparahalli Venkateshaiah, Xin Li, Frits van Rhee, Saad Usmani, Bart Barlogie, John Shaughnessy, Joshua Epstein & Shmuel Yaccoby. (2013) Role of Bruton's tyrosine kinase in myeloma cell migration and induction of bone disease. American Journal of Hematology 88:6, pages 463-471.
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Seng-Lai Tan, Cheng Liao, Matthew C. Lucas, Christopher Stevenson & Julie A. DeMartino. (2013) Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders. Pharmacology & Therapeutics 138:2, pages 294-309.
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Jonathan Hsu, Yajuan Gu, Seng-Lai Tan, Satwant Narula, Julie A. DeMartino & Cheng Liao. (2013) Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints. Immunology Letters 150:1-2, pages 97-104.
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Qian Qi, Weishan Huang, Yuting Bai, Gabriel Balmus, Robert S. Weiss & Avery August. (2012) A Unique Role for ITK in Survival of Invariant NKT Cells Associated with the p53-Dependent Pathway in Mice. The Journal of Immunology 188:8, pages 3611-3619.
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Thomas U. Marron, Monica Martinez-Gallo, Joyce E. Yu & Charlotte Cunningham-Rundles. (2012) Toll-like receptor 4–, 7–, and 8–activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines. Journal of Allergy and Clinical Immunology 129:1, pages 184-190.e4.
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Fatih M. Uckun, Sanjive Qazi, Zahide Ozer, Amanda L. Garner, Jason Pitt, Hong Ma & Kim D. Janda. (2011) Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. British Journal of Haematology 153:6, pages 741-752.
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Andreas Kuglstatter, April Wong, Stan Tsing, Simon W. Lee, Yan Lou, Armando G. Villaseñor, J. Michael Bradshaw, David Shaw, Jim W. Barnett & Michelle F. Browner. (2011) Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Science 20:2, pages 428-436.
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