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Inhibitors of anaplastic lymphoma kinase: a patent review

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Pages 1653-1681 | Published online: 20 Oct 2010

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Eugen F Mesaros, Gregory R Ott & Bruce D Dorsey. (2014) Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review. Expert Opinion on Therapeutic Patents 24:4, pages 417-442.
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Anna Kruczynski, Georges Delsol, Camille Laurent, Pierre Brousset & Laurence Lamant. (2012) Anaplastic lymphoma kinase as a therapeutic target. Expert Opinion on Therapeutic Targets 16:11, pages 1127-1138.
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Articles from other publishers (15)

Xiaoxia Liang, Pan Wu, Qian Yang, Yunyu Xie, Changliang He, Lizi Yin, Zhongqiong Yin, Guizhou Yue, Yuanfeng Zou, Lixia Li, Xu Song, Cheng Lv, Wei Zhang & Bo Jing. (2021) An update of new small-molecule anticancer drugs approved from 2015 to 2020. European Journal of Medicinal Chemistry 220, pages 113473.
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Xiaoxia Liang, Qian Yang, Pan Wu, Changliang He, Lizi Yin, Funeng Xu, Zhongqiong Yin, Guizhou Yue, Yuanfeng Zou, Lixia Li, Xu Song, Cheng Lv, Wei Zhang & Bo Jing. (2021) The synthesis review of the approved tyrosine kinase inhibitors for anticancer therapy in 2015–2020. Bioorganic Chemistry 113, pages 105011.
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Christel A.S. Bergström, William N. Charman & Christopher J.H. Porter. (2016) Computational prediction of formulation strategies for beyond-rule-of-5 compounds. Advanced Drug Delivery Reviews 101, pages 6-21.
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M.C. Boutterin, P. Mazot, C. Faure, S. Doly, N. Gervasi, M.L. Tremblay & M. Vigny. (2013) Control of ALK (wild type and mutated forms) phosphorylation: Specific role of the phosphatase PTP1B. Cellular Signalling 25:6, pages 1505-1513.
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Cindy L O'Bryant, Sarah D Wenger, Miryoung Kim & Lisa A Thompson. (2013) Crizotinib: A New Treatment Option for ALK -Positive Non-Small Cell Lung Cancer . Annals of Pharmacotherapy 47:2, pages 189-197.
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Simon Giroux. (2013) Overcoming acquired resistance to kinase inhibition: The cases of EGFR, ALK and BRAF. Bioorganic & Medicinal Chemistry Letters 23:2, pages 394-401.
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Sandrine Vendeville & Maxwell D. Cummings. 2013. 371 386 .
Luca Mologni & Carlo Gambacorti-Passerini. (2012) New developments in the treatment of ALK-driven malignancies. Clinical Investigation 2:8, pages 835-852.
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Diane E. Gingrich, Joseph G. Lisko, Matthew A. Curry, Mangeng Cheng, Matthew Quail, Lihui Lu, Weihua Wan, Mark S. Albom, Thelma S. Angeles, Lisa D. Aimone, R. Curtis Haltiwanger, Kevin Wells-Knecht, Gregory R. Ott, Arup K. Ghose, Mark A. Ator, Bruce Ruggeri & Bruce D. Dorsey. (2012) Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase. Journal of Medicinal Chemistry 55:10, pages 4580-4593.
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Floor A.M. Duijkers, José Gaal, Jules P.P. Meijerink, Pieter Admiraal, Rob Pieters, Ronald R. de Krijger & Max M. van Noesel. (2012) High Anaplastic Lymphoma Kinase Immunohistochemical Staining in Neuroblastoma and Ganglioneuroblastoma Is an Independent Predictor of Poor Outcome. The American Journal of Pathology 180:3, pages 1223-1231.
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Henry J. Breslin, Brandon M. Lane, Gregory R. Ott, Arup K. Ghose, Thelma S. Angeles, Mark S. Albom, Mangeng Cheng, Weihua Wan, R. Curtis Haltiwanger, Kevin J. Wells-Knecht & Bruce D. Dorsey. (2011) Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.1 3,7 .1 9,13 ]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles . Journal of Medicinal Chemistry 55:1, pages 449-464.
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Eugen F. Mesaros, Tho V. Thieu, Gregory J. Wells, Craig A. Zificsak, Jason C. Wagner, Henry J. Breslin, Rabindranath Tripathy, James L. Diebold, Robert J. McHugh, Ashley T. Wohler, Matthew R. Quail, Weihua Wan, Lihui Lu, Zeqi Huang, Mark S. Albom, Thelma S. Angeles, Kevin J. Wells-Knecht, Lisa D. Aimone, Mangeng Cheng, Mark A. Ator, Gregory R. Ott & Bruce D. Dorsey. (2011) Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1- f ][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors . Journal of Medicinal Chemistry 55:1, pages 115-125.
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Veena R. Ganeshan & Nina F. Schor. (2011) Pharmacologic Management of High-Risk Neuroblastoma in Children. Pediatric Drugs 13:4, pages 245-255.
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P. Jake Slavish, Jeanine E. Price, Qin Jiang, Xiaoli Cui, Stephan W. Morris & Thomas R. Webb. (2011) Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition. Bioorganic & Medicinal Chemistry Letters 21:15, pages 4592-4596.
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Craig A. Zificsak, Jay P. Theroff, Lisa D. Aimone, Thelma S. Angeles, Mark S. Albom, Mangeng Cheng, Eugen F. Mesaros, Gregory R. Ott, Matthew R. Quail, Ted L. Underiner, Weihua Wan & Bruce D. Dorsey. (2011) Methanesulfonamido-cyclohexylamine derivatives of 2,4-diaminopyrimidine as potent ALK inhibitors. Bioorganic & Medicinal Chemistry Letters 21:13, pages 3877-3880.
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