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Expert Opinion on Therapeutic Patents Volume 20, 2010 - Issue 12
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Targeting the embryonic gene Cripto-1 in cancer and beyond

Caterina Bianco National Cancer Institute, National Institutes of Health, Mammary Biology & Tumorigenesis Laboratory, 37 Convent Drive, Building 37, Room 1112, Bethesda, MD 20892, USA +1 301 451 3761; +1 301 402 8656; [email protected]
&
David S Salomon National Cancer Institute, National Institutes of Health, Mammary Biology & Tumorigenesis Laboratory, 37 Convent Drive, Building 37, Room 1112, Bethesda, MD 20892, USA +1 301 451 3761; +1 301 402 8656; [email protected]
Pages 1739-1749 | Published online: 13 Nov 2010

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João Matheus Bremm, Juliano André Boquett, Marcus Silva Michels, Thayne Woycinck Kowalski, Flávia Gobetti Gomes, Fernanda Sales Luiz Vianna, Maria Teresa Vieira Sanseverino & Lucas Rosa Fraga. (2021) Investigating the role of EGF-CFC gene family in recurrent pregnancy loss through bioinformatics and molecular approaches. Systems Biology in Reproductive Medicine 67:6, pages 450-462.
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M. A. Ligtenberg, K. Witt, F. Galvez-Cancino, A. Sette, A. Lundqvist, A. Lladser & R. Kiessling. (2016) Cripto-1 vaccination elicits protective immunity against metastatic melanoma. OncoImmunology 5:5.
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Malgorzata Klauzinska, Daniel Bertolette, Sudhamsh Tippireddy, Luigi Strizzi, Peter C. Gray, Monica Gonzales, Meg Duroux, Menotti Ruvo, Christian Wechselberger, Nadia P. Castro, Maria Cristina Rangel, Annalia Focà, Annamaria Sandomenico, Mary J. C. Hendrix, David Salomon & Frank Cuttitta. (2015) Cripto-1: an extracellular protein – connecting the sequestered biological dots. Connective Tissue Research 56:5, pages 364-380.
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Tadahiro Nagaoka, Hideaki Karasawa, Nadia Pereira Castro, Maria Cristina Rangel, David S. Salomon & Caterina Bianco. (2012) An evolving web of signaling networks regulated by Cripto-1. Growth Factors 30:1, pages 13-21.
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Articles from other publishers (24)

Rachel Lev, Orit Bar-Am, Yoni Lati, Ombretta Guardiola, Gabriella Minchiotti & Dror Seliktar. (2023) Biomanufacturing Recombinantly Expressed Cripto-1 Protein in Anchorage-Dependent Mammalian Cells Growing in Suspension Bioreactors within a Three-Dimensional Hydrogel Microcarrier. Gels 9:3, pages 243.
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John Maher & David M. Davies. (2023) CAR-Based Immunotherapy of Solid Tumours—A Survey of the Emerging Targets. Cancers 15:4, pages 1171.
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Beverly A. Teicher & Joel Morris. (2022) Antibody-drug Conjugate Targets, Drugs, and Linkers. Current Cancer Drug Targets 22:6, pages 463-529.
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John B. Pawlak & Gerard C. Blobe. (2021) TGF ‐β superfamily co‐receptors in cancer . Developmental Dynamics 251:1, pages 117-143.
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Annamaria Sandomenico & Menotti Ruvo. (2019) Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers. Current Medicinal Chemistry 26:11, pages 1994-2050.
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Faisal Alowaidi, Saeed M Hashimi, Maria Nguyen, Mallika Meshram, Naif Alqurashi, Brenton L Cavanagh, Bernadette Bellette, Saso Ivanovski, Adrian Meedenyia & Stephen A Wood. (2018) Investigating the role of CRIPTO‐1 (TDGF‐1) in glioblastoma multiforme U87 cell line. Journal of Cellular Biochemistry 120:5, pages 7412-7427.
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Roberto Ruiu, Lidia Tarone, Valeria Rolih, Giuseppina Barutello, Elisabetta Bolli, Federica Riccardo, Federica Cavallo & Laura Conti. 2019. Cancer Immunotherapy. Cancer Immunotherapy 119 188 .
Adouda Adjiri. (2018) Tracing the path of cancer initiation: the AA protein-based model for cancer genesis. BMC Cancer 18:1.
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YingYu Zhang, XuGuang Mi, ZhenBo Song, YuXin Li, YingShi & JunQi Niu. (2018) Cripto-1 promotes resistance to drug-induced apoptosis by activating the TAK-1/NF-κB/survivin signaling pathway. Biomedicine & Pharmacotherapy 104, pages 729-737.
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Kang-Seo Park, Yong Wha Moon, Mark Raffeld, Dae Ho Lee, Yisong Wang & Giuseppe Giaccone. (2018) High cripto-1 and low miR-205 expression levels as prognostic markers in early stage non-small cell lung cancer. Lung Cancer 116, pages 38-45.
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Alice Agliano, Alfonso Calvo & Carol Box. (2017) The challenge of targeting cancer stem cells to halt metastasis. Seminars in Cancer Biology 44, pages 25-42.
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Yania Yáñez, Elena Grau, Virginia C Rodríguez-Cortez, David Hervás, Enrique Vidal, Rosa Noguera, Miguel Hernández, Vanessa Segura, Adela Cañete, Ana Conesa, Jaime Font de Mora & Victoria Castel. (2015) Two independent epigenetic biomarkers predict survival in neuroblastoma. Clinical Epigenetics 7:1.
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C. Oneyama & M. Okada. (2015) MicroRNAs as the fine-tuners of Src oncogenic signalling. Journal of Biochemistry 157:6, pages 431-438.
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Bingbing Wei, Wei Jin, Jun Ruan, Zhuoqun Xu, You Zhou, Jiabei Liang, Huan Cheng, Ke Jin, Xing Huang, Peng Lu & Qiang Hu. (2014) Cripto-1 expression and its prognostic value in human bladder cancer patients. Tumor Biology 36:2, pages 1105-1113.
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Daniela Ruggiero, Stefania Nappo, Teresa Nutile, Rossella Sorice, Francesco Talotta, Emilia Giorgio, Celine Bellenguez, Anne-Louise Leutenegger, Giovanna L. Liguori & Marina Ciullo. (2015) Genetic Variants Modulating CRIPTO Serum Levels Identified by Genome-Wide Association Study in Cilento Isolates. PLOS Genetics 11:1, pages e1004976.
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Chun Huang, Wangsheng Chen, Xiaowen Wang, Jinqiu Zhao, Qian Li & Zhongxue Fu. (2015) Cripto-1 Promotes the Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-13.
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Malgorzata Klauzinska, Nadia P. Castro, Maria Cristina Rangel, Benjamin T. Spike, Peter C. Gray, Daniel Bertolette, Frank Cuttitta & David Salomon. (2014) The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition. Seminars in Cancer Biology 29, pages 51-58.
Crossref
Kang-Seo Park, Mark Raffeld, Yong Wha Moon, Liqiang Xi, Caterina Bianco, Trung Pham, Liam C. Lee, Tetsuya Mitsudomi, Yasushi Yatabe, Isamu Okamoto, Deepa Subramaniam, Tony Mok, Rafael Rosell, Ji Luo, David S. Salomon, Yisong Wang & Giuseppe Giaccone. (2014) CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance. Journal of Clinical Investigation 124:7, pages 3003-3015.
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Berit B. Tysnes, Hege A. Sætran, Sverre J. Mørk, Naira V. Margaryan, Geir E. Eide, Kjell Petersen, Luigi Strizzi & Mary J.C. Hendrix. (2013) Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients. Translational Oncology 6:6, pages 732-IN33.
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Lalage M. Wakefield & Caroline S. Hill. (2013) Beyond TGFβ: roles of other TGFβ superfamily members in cancer. Nature Reviews Cancer 13:5, pages 328-341.
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Frank Cuttitta & David S. Salomon. 2013. Handbook of Biologically Active Peptides. Handbook of Biologically Active Peptides 502 505 .
Maria C. Rangel, Hideaki Karasawa, Nadia P. Castro, Tadahiro Nagaoka, David S. Salomon & Caterina Bianco. (2012) Role of Cripto-1 during Epithelial-to-Mesenchymal Transition in Development and Cancer. The American Journal of Pathology 180:6, pages 2188-2200.
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Dwi U. Kemaladewi, David J. J. Gorter, Annemieke Aartsma‐Rus, Gert‐Jan Ommen, Peter ten Dijke, Peter A. C. 't Hoen & Willem M. Hoogaars. (2011) Cell‐type specific regulation of myostatin signaling. The FASEB Journal 26:4, pages 1462-1472.
Crossref
Maria Cristina Rangel, Nadia P. Castro, Hideaki Karasawa, Tadahiro Nagaoka, David S. Salomon & Caterina Bianco. 2012. Stem Cells and Cancer Stem Cells, Volume 2. Stem Cells and Cancer Stem Cells, Volume 2 155 166 .

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