475
Views
31
CrossRef citations to date
0
Altmetric
Reviews

Novel N-methyl-d-aspartate receptor antagonists: a review of compounds patented since 2006

&
Pages 1683-1702 | Published online: 08 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Rose M Santangelo, Timothy M Acker, Sommer S Zimmerman, Brooke M Katzman, Katie L Strong, Stephen F Traynelis & Dennis C Liotta. (2012) Novel NMDA receptor modulators: an update. Expert Opinion on Therapeutic Patents 22:11, pages 1337-1352.
Read now

Articles from other publishers (29)

Lishou Yang, Huadan Liu, Enhua Wang, Huanhuan Liu, Hongshi Liu, Lang Zhou, Tingfei Deng, Xiong Pan, Zhanxing Hu & Xiaosheng Yang. (2023) Design, synthesis and evaluation of novel 1-phenyl-pyrrolo[1,2-b]isoquinolin-3-one derivatives as antagonists for the glycine binding site of the NMDA receptor. European Journal of Medicinal Chemistry 258, pages 115624.
Crossref
Jishun Quan, Huali Yang, Fengyun Qin, Yeli He, Jiao Liu, Ying Zhao, Chao Ma & Maosheng Cheng. (2023) Discovery of novel tryptamine derivatives as GluN2B subunit-containing NMDA receptor antagonists via pharmacophore-merging strategy with orally available therapeutic effect of cerebral ischemia. European Journal of Medicinal Chemistry 253, pages 115318.
Crossref
Lishou Yang, Qian Yang, Enhua Wang, Juan Yang, Qiji Li, Jiafu Cao, Li Wang, Xiu Liao, Yan Yang & Xiaosheng Yang. (2022) Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells. Bioorganic & Medicinal Chemistry 59, pages 116675.
Crossref
Scott J. Myers, Kamalesh P. Ruppa, Lawrence J. Wilson, Yesim A. Tahirovic, Polina Lyuboslavsky, David S. Menaldino, Zackery W. Dentmon, George W. Koszalka, Robert Zaczek, Raymond J. Dingledine, Stephen F. Traynelis & Dennis C. Liotta. (2021) A Glutamate N -Methyl-d-Aspartate (NMDA) Receptor Subunit 2B–Selective Inhibitor of NMDA Receptor Function with Enhanced Potency at Acidic pH and Oral Bioavailability for Clinical Use . Journal of Pharmacology and Experimental Therapeutics 379:1, pages 41-52.
Crossref
Rita Turnaturi, Lucia Montenegro, Agostino Marrazzo, Rosalba Parenti, Lorella Pasquinucci & Carmela Parenti. (2018) Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review. European Journal of Medicinal Chemistry 155, pages 492-502.
Crossref
Linkui Zhang, Ying Zhao, Jian Wang, Donglin Yang, Chenwen Zhao, Changli Wang, Chao Ma & Maosheng Cheng. (2018) Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. European Journal of Medicinal Chemistry 151, pages 27-38.
Crossref
Margarida Espadinha, Jorge Dourado, Rocio Lajarin-Cuesta, Clara Herrera-Arozamena, Lidia M. D. Gonçalves, María Isabel Rodríguez-Franco, Cristobal de los Rios & Maria M. M. Santos. (2017) Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists. ChemMedChem 12:7, pages 537-545.
Crossref
Asya Makhro, Qinghai Tian, Lars Kaestner, Dmitry Kosenkov, Giuseppe Faggian, Max Gassmann, Colin Schwarzwald & Anna Bogdanova. (2016) Cardiac N-methyl d-aspartate Receptors as a Pharmacological Target. Journal of Cardiovascular Pharmacology 68:5, pages 356-373.
Crossref
Matthias P. Quick & Bernhard Wünsch. (2016) Heck Reaction as Key Step in the Synthesis of Hydrogenated 2-benzazepin-1-ones. Journal of Heterocyclic Chemistry 53:5, pages 1488-1493.
Crossref
Gaurav Kumar & Ranjana Patnaik. (2016) Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study. Medical Hypotheses 92, pages 35-43.
Crossref
Brooke M. Katzman, Riley E. Perszyk, Hongjie Yuan, Yesim Altas Tahirovic, Ayodeji E. Sotimehin, Stephen F. Traynelis & Dennis C. Liotta. (2015) A novel class of negative allosteric modulators of NMDA receptor function. Bioorganic & Medicinal Chemistry Letters 25:23, pages 5583-5588.
Crossref
David S. Chang, Rahul Raghavan, Sandy Christiansen & Steven P. Cohen. (2015) Emerging targets in treating pain. Current Opinion in Anaesthesiology 28:4, pages 379-397.
Crossref
Anil Kumar, Dinesh K. Dhull & Pooja S. Mishra. (2015) Therapeutic potential of mGluR5 targeting in Alzheimer's disease. Frontiers in Neuroscience 9.
Crossref
Vishal P. Zambre, Varsha A. Hambarde, Nilesh N. Petkar, Chinmay N. Patel & Sanjay D. Sawant. (2015) Structural investigations by in silico modeling for designing NR2B subunit selective NMDA receptor antagonists. RSC Advances 5:30, pages 23922-23940.
Crossref
Nuno A.L. Pereira, Francesc X. Sureda, Roser Esplugas, Maria Pérez, Mercedes Amat & Maria M.M. Santos. (2014) Tryptophanol-derived oxazolopiperidone lactams: Identification of a hit compound as NMDA receptor antagonist. Bioorganic & Medicinal Chemistry Letters 24:15, pages 3333-3336.
Crossref
Jana Sawynok. (2014) Topical and Peripheral Ketamine as an Analgesic. Anesthesia & Analgesia 119:1, pages 170-178.
Crossref
Tanya Chotibut, Richard W. Davis, Jennifer C. Arnold, Zachary Frenchek, Shawn Gurwara, Vimala Bondada, James W. Geddes & Michael F. Salvatore. (2013) Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model. Molecular Neurobiology 49:3, pages 1282-1292.
Crossref
Martine Dhilly, Javier Becerril-Ortega, Nathalie Colloc'h, Eric T. MacKenzie, Louisa Barré, Alain Buisson, Olivier Nicole & Cécile Perrio. (2013) Synthesis and in Vitro Characterisation of Ifenprodil-Based Fluorescein Conjugates as GluN1/GluN2B N -Methyl- D -aspartate Receptor Antagonists . ChemBioChem 14:6, pages 759-769.
Crossref
Damien Lemoine, Ruotian Jiang, Antoine Taly, Thierry Chataigneau, Alexandre Specht & Thomas Grutter. (2012) Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition. Chemical Reviews 112:12, pages 6285-6318.
Crossref
Rebeca Martínez-Turrillas, Elena Puerta, Dhrubajyoti Chowdhury, Sonia Marco, Masahiko Watanabe, Norberto Aguirre & Isabel Pérez-Otaño. (2012) The NMDA receptor subunit GluN3A protects against 3-nitroproprionic-induced striatal lesions via inhibition of calpain activation. Neurobiology of Disease 48:3, pages 290-298.
Crossref
Filippo Caraci, Giuseppe Battaglia, Maria Angela Sortino, Simona Spampinato, Gemma Molinaro, Agata Copani, Ferdinando Nicoletti & Valeria Bruno. (2012) Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic?. Neurochemistry International 61:4, pages 559-565.
Crossref
Maiken Hedegaard, Kasper B. Hansen, Karen T. Andersen, Hans Bräuner-Osborne & Stephen F. Traynelis. (2012) Molecular pharmacology of human NMDA receptors. Neurochemistry International 61:4, pages 601-609.
Crossref
P. B. Burger, H. Yuan, E. Karakas, M. Geballe, H. Furukawa, D. C. Liotta, J. P. Snyder & S. F. Traynelis. (2012) Mapping the Binding of GluN2B-Selective N-Methyl-D-aspartate Receptor Negative Allosteric Modulators. Molecular Pharmacology 82:2, pages 344-359.
Crossref
Radouane Koudih, Gwénaëlle Gilbert, Martine Dhilly, Ahmed Abbas, Louisa Barré, Danièle Debruyne & Franck Sobrio. (2012) Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor. European Journal of Medicinal Chemistry 53, pages 408-415.
Crossref
Hiro Furukawa. (2012) Structure and function of glutamate receptor amino terminal domains. The Journal of Physiology 590:1, pages 63-72.
Crossref
Xiaohua Li, Mark A Frye & Richard C Shelton. (2011) Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development. Neuropsychopharmacology 37:1, pages 77-101.
Crossref
Kamalesh B. Ruppa, Dalton King & Richard E. Olson. 2012. Annual Reports in Medicinal Chemistry Volume 47. Annual Reports in Medicinal Chemistry Volume 47 89 103 .
Erkan Karakas, Noriko Simorowski & Hiro Furukawa. (2011) Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature 475:7355, pages 249-253.
Crossref
Adak Nasiripourdori, Valérie Taly, Thomas Grutter & Antoine Taly. (2011) From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules. Toxins 3:3, pages 260-293.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.