220
Views
15
CrossRef citations to date
0
Altmetric
Perspective

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts

, PhD & , PhD
Pages 1619-1625 | Published online: 04 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Zehui Tan, Hongrui Lei, Ming Guo, Yuxiang Chen & Xin Zhai. (2021) An updated patent review of autotaxin inhibitors (2017–present). Expert Opinion on Therapeutic Patents 31:5, pages 421-434.
Read now
Aikaterini Nikolaou, Maroula G. Kokotou, Dimitris Limnios, Anastasia Psarra & George Kokotos. (2017) Autotaxin inhibitors: a patent review (2012-2016). Expert Opinion on Therapeutic Patents 27:7, pages 815-829.
Read now
Efrosini Barbayianni, Victoria Magrioti, Panagiota Moutevelis-Minakakis & George Kokotos. (2013) Autotaxin inhibitors: a patent review. Expert Opinion on Therapeutic Patents 23:9, pages 1123-1132.
Read now

Articles from other publishers (11)

Rajkumar Patle, Shital Shinde, Sagarkumar Patel, Rahul Maheshwari, Heena Jariyal, Akshay Srivastava, Neelam Chauhan, Christoph Globisch, Alok Jain, Rakesh K. Tekade & Amit Shard. (2021) Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing. Bioorganic & Medicinal Chemistry Letters 42, pages 128062.
Crossref
Christiana Magkrioti, Eleanna Kaffe, Elli-Anna Stylianaki, Camelia Sidahmet, Georgia Melagraki, Antreas Afantitis, Alexios N. Matralis & Vassilis Aidinis. (2020) Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors. International Journal of Molecular Sciences 21:19, pages 7002.
Crossref
Wenming Wang, Fengmei Zhao, Yarui Zhao, Weiwei Pan, Pengcheng Cao, Lintao Wu, Zhijun Wang, Xuan Zhao, Yi Zhao & Hongfei Wang. (2019) Design, Synthesis, and Preliminary Bioactivity Evaluation of 2,7-Substituted Carbazole Derivatives as Potent Autotaxin Inhibitors and Antitumor Agents†. Anti-Cancer Agents in Medicinal Chemistry 19:2, pages 256-264.
Crossref
Yi-Min Liu, Kunal Nepali & Jing-Ping Liou. (2016) Idiopathic Pulmonary Fibrosis: Current Status, Recent Progress, and Emerging Targets. Journal of Medicinal Chemistry 60:2, pages 527-553.
Crossref
Mandi M. Murph, Guowei W. Jiang, Molly K. Altman, Wei Jia, Duy T. Nguyen, Jada M. Fambrough, William J. Hardman, Ha T. Nguyen, Sterling K. Tran, Ali A. Alshamrani, Damian Madan, Jianxing Zhang & Glenn D. Prestwich. (2015) Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma. Bioorganic & Medicinal Chemistry 23:17, pages 5999-6013.
Crossref
Efrosini Barbayianni, Eleanna Kaffe, Vassilis Aidinis & George Kokotos. (2015) Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer. Progress in Lipid Research 58, pages 76-96.
Crossref
Khalid Mohammed Khan, Salman Siddiqui, Muhammad Saleem, Muhammad Taha, Syed Muhammad Saad, Shahnaz Perveen & M. Iqbal Choudhary. (2014) Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1. Bioorganic & Medicinal Chemistry 22:22, pages 6509-6514.
Crossref
Achyutharao Sidduri, David C. Budd, Maria E. Fuentes, Ted Lambros, Yonglin Ren, Vikram Roongta, Ryan C. Schoenfeld, Paul Gillespie, Christopher S. Stevenson, Theresa Truitt & Yimin Qian. (2014) Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4450-4454.
Crossref
David C Budd & Yimin Qian. (2013) Development of lysophosphatidic acid pathway modulators as therapies for fibrosis. Future Medicinal Chemistry 5:16, pages 1935-1952.
Crossref
Yimin Qian, Matthew Hamilton, Achyutharao Sidduri, Stephen Gabriel, Yonglin Ren, Ruoqi Peng, Rama Kondru, Arjun Narayanan, Terry Truitt, Rachid Hamid, Yun Chen, Lin Zhang, Adrian J. Fretland, Ruben Alvarez Sanchez, Kung-Ching Chang, Matthew Lucas, Ryan C. Schoenfeld, Dramane Laine, Maria E. Fuentes, Christopher S. Stevenson & David C. Budd. (2012) Discovery of Highly Selective and Orally Active Lysophosphatidic Acid Receptor-1 Antagonists with Potent Activity on Human Lung Fibroblasts. Journal of Medicinal Chemistry 55:17, pages 7920-7939.
Crossref
Catrina D. Mize, Ashley M. Abbott, Samantha B. Gacasan, Abby L. Parrill & Daniel L. Baker. (2011) Ligand-based autotaxin pharmacophore models reflect structure-based docking results. Journal of Molecular Graphics and Modelling 31, pages 76-86.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.