446
Views
33
CrossRef citations to date
0
Altmetric
Reviews

Microtubules as antifungal and antiparasitic drug targets

, MTech, , MSc, , PhD & , PhD
Pages 167-186 | Published online: 05 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira & Hovakim Zakaryan. (2021) A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity. Emerging Microbes & Infections 10:1, pages 783-796.
Read now

Articles from other publishers (31)

Qiao Su, Louise Baker, Samantha Emery, Balu Balan, Brendan Ansell, Swapnil Tichkule, Ivo Mueller, Staffan G. Svärd & Aaron Jex. (2023) Transcriptomic analysis of albendazole resistance in human diarrheal parasite Giardia duodenalis. International Journal for Parasitology: Drugs and Drug Resistance 22, pages 9-19.
Crossref
Diana G. Ríos-Valencia, Javier Ambrosio, Rocío Tirado-Mendoza, Julio César Carrero & Juan Pedro Laclette. (2023) What about the Cytoskeletal and Related Proteins of Tapeworms in the Host’s Immune Response? An Integrative Overview. Pathogens 12:6, pages 840.
Crossref
Shuo Li, Mattia Mori, Mingyan Yang, Soumia Elfazazi, Rafael Hortigüela, Peter Chan, Xinyue Feng, April Risinger, Zhiyou Yang, María Ángela Oliva, J. Fernando Díaz & Wei-Shuo Fang. (2023) Targeting the tubulin C-terminal tail by charged small molecules. Organic & Biomolecular Chemistry 21:1, pages 153-162.
Crossref
Ezra J. Marker & Stefan L. Debbert. 2022. Parasitic Helminths and Zoonoses - From Basic to Applied Research. Parasitic Helminths and Zoonoses - From Basic to Applied Research.
Tassanee Ongtanasup, Anisha Mazumder, Anupma Dwivedi & Komgrit Eawsakul. (2022) Homology Modeling, Molecular Docking, Molecular Dynamic Simulation, and Drug-Likeness of the Modified Alpha-Mangostin against the β-Tubulin Protein of Acanthamoeba Keratitis. Molecules 27:19, pages 6338.
Crossref
Tobias Mühlethaler, Lampros Milanos, Jose Antonio Ortega, Thorsten B. Blum, Dario Gioia, Bibhas Roy, Andrea E. Prota, Andrea Cavalli & Michel O. Steinmetz. (2022) Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angewandte Chemie International Edition 61:25.
Crossref
Tobias Mühlethaler, Lampros Milanos, Jose Antonio Ortega, Thorsten B. Blum, Dario Gioia, Bibhas Roy, Andrea E. Prota, Andrea Cavalli & Michel O. Steinmetz. (2022) Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angewandte Chemie 134:25.
Crossref
Mohammad Akbarzadeh, Ilka Deipenwisch, Beate Schoelermann, Axel Pahl, Sonja Sievers, Slava Ziegler & Herbert Waldmann. (2022) Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology 29:6, pages 1053-1064.e3.
Crossref
Gabrielle dos Santos da Silva e Miranda, Joseane Lima Prado Godinho, Sara Teixeira de Macedo-Silva, Brunno Renato Farias Verçoza, Alisson Amaral da Rocha, Milena Barenco Pires de Abreu Sodré, Victor Feliciano dos Santos Ramos & Juliany Cola Fernandes Rodrigues. 2022. Leishmaniasis - General Aspects of a Stigmatized Disease. Leishmaniasis - General Aspects of a Stigmatized Disease.
Zahoor Ahmad, Rana Muhammad Sabir Tariq, Musarrat Ramzan, Muhammad Adnan Bukhari, Ali Raza, Muhammad Aamir Iqbal, Ram Swaroop Meena, Mohammad Sohidul Islam, Oksana Sytar, Ntsomboh-Ntsefong Godswill, Allah Wasaya, Kulvir Singh, Akbar Hossain, Muhammad Ali Raza, Mirza Hasanuzzaman, Sipan Soysal, Murat Erman, Fatih Cig, Mustafa Ceritoğlu, Semih Açıkbaş, Özge Uçar, Aynur Bilmez Özçinar, Rukiye Kılıç & Ayman EL Sabagh. 2022. Managing Plant Production Under Changing Environment. Managing Plant Production Under Changing Environment 351 374 .
Linda Wordeman & Juan Jesus Vicente. (2021) Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles. Cancers 13:22, pages 5650.
Crossref
Samantha J. Emery-Corbin, Qiao Su, Swapnil Tichkule, Louise Baker, Ernest Lacey & Aaron R. Jex. (2021) In vitro selection of Giardia duodenalis for Albendazole resistance identifies a β-tubulin mutation at amino acid E198K. International Journal for Parasitology: Drugs and Drug Resistance 16, pages 162-173.
Crossref
Paola Borrego-Muñoz, Felipe Ospina & Diego Quiroga. (2021) A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives. Molecules 26:13, pages 3997.
Crossref
Ludovica Monti, Anne-Sophie Cornec, Killian Oukoloff, Jane Kovalevich, Kristen Prijs, Thibault Alle, Kurt R. Brunden, Amos B. SmithIIIIII, Nelly El-Sakkary, Lawrence J. Liu, Ali Syed, Danielle E. Skinner, Carlo Ballatore & Conor R. Caffrey. (2020) Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro . ACS Infectious Diseases 7:5, pages 1089-1103.
Crossref
Donald J. AbrahamConor R. Caffrey, Dietmar Steverding, Rafaela S. Ferreira, Renata B. de Oliveira, Anthony J. O'Donoghue, Ludovica Monti, Carlo Ballatore, Kelly A. Bachovchin, Lori Ferrins, Michael P. Pollastri, Kimberley M. Zorn, Daniel H. Foil, Alex M. Clark, Melina Mottin, Carolina H. Andrade, Jair L. de Siqueira‐Neto & Sean Ekins. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 79 .
Frida S. Herrera‐Vázquez, Félix Matadamas‐Martínez, Rodrigo Aguayo‐Ortiz, Laura Dominguez, Teresa Ramírez‐Apan, Lilián Yépez‐Mulia & Francisco Hernández‐Luis. (2020) Design, Synthesis and Evaluation of 2,4‐Diaminoquinazoline Derivatives as Potential Tubulin Polymerization Inhibitors. ChemMedChem 15:19, pages 1802-1812.
Crossref
Vladimír Čermák, Vojtěch Dostál, Michael Jelínek, Lenka Libusová, Jan Kovář, Daniel Rösel & Jan Brábek. (2020) Microtubule-targeting agents and their impact on cancer treatment. European Journal of Cell Biology 99:4, pages 151075.
Crossref
Suélen Andreia Rossi, Haroldo Cesar de Oliveira, Daniel Agreda-Mellon, José Lucio, Maria José Soares Mendes-Giannini, Jesús Pablo García-Cambero & Oscar Zaragoza. (2020) Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp . Antimicrobial Agents and Chemotherapy 64:4.
Crossref
Hassan Mirzaei, Mahdi Abastabar & Saeed Emami. (2020) Indole-derived chalcones as anti-dermatophyte agents: In vitro evaluation and in silico study. Computational Biology and Chemistry 84, pages 107189.
Crossref
M. LevkutJr.Jr., V. Revajová, M. Levkutová, E. Selecká, Z. Ševčíková, V. Karaffová & M. LevkutSr.Sr.. (2019) The influence of chestnut wood and flubendazole on morphology of small intestine and lymphocytes of peripheral blood, spleen and jejunum in broiler chickens. Helminthologia 56:4, pages 273-281.
Crossref
Nubia Noemi Cob-Calan, Luz America Chi-Uluac, Filiberto Ortiz-Chi, Daniel Cerqueda-García, Gabriel Navarrete-Vázquez, Esaú Ruiz-Sánchez & Emanuel Hernández-Núñez. (2019) Molecular Docking and Dynamics Simulation of Protein β-Tubulin and Antifungal Cyclic Lipopeptides. Molecules 24:18, pages 3387.
Crossref
Sang-Choon Lee, Sang-Heon Kim, Rachel A. Hoffmeister, Moon-Young Yoon & Sung-Kun Kim. (2019) Novel Peptide-Based Inhibitors for Microtubule Polymerization in Phytophthora capsici. International Journal of Molecular Sciences 20:11, pages 2641.
Crossref
Alessio del Casino, Valentina Lukinović, Rakesh Bhatt, Laura E. Randle, Michael J. Dascombe, Dr Brian J. Fennell, Michael G. B. Drew, Angus Bell, Alistair J. Fielding & Fyaz M. D. Ismail. (2018) Synthesis, Structural Determination, and Pharmacology of Putative Dinitroaniline Antimalarials. ChemistrySelect 3:26, pages 7572-7580.
Crossref
Megan Truong, Leigh G. Monahan, Dee A. Carter & Ian G. Charles. (2018) Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis. PeerJ 6, pages e4761.
Crossref
Ryan Young & Eva-­Rachele Pesce. 2015. Marine Biomedicine. Marine Biomedicine 183 246 .
Linh H. Mai, Guy G. Chabot, Philippe Grellier, Lionel Quentin, Vincent Dumontet, Cyril Poulain, Laila S. Espindola, Sylvie Michel, Hue T.B. Vo, Brigitte Deguin & Raphaël Grougnet. (2015) Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). European Journal of Medicinal Chemistry 93, pages 93-100.
Crossref
Dinesh Shetty, Yong Kim, Hyunsuk Shim & James Snyder. (2014) Eliminating the Heart from the Curcumin Molecule: Monocarbonyl Curcumin Mimics (MACs). Molecules 20:1, pages 249-292.
Crossref
Madhu Aeluri, Srinivas Chamakuri, Bhanudas Dasari, Shiva Krishna Reddy Guduru, Ravikumar Jimmidi, Srinivas Jogula & Prabhat Arya. (2014) Small Molecule Modulators of Protein–Protein Interactions: Selected Case Studies. Chemical Reviews 114:9, pages 4640-4694.
Crossref
Yan-Ting Wang, Ya-Juan Qin, Ya-Liang Zhang, Yu-Jing Li, Bing Rao, Yan-Qing Zhang, Meng-Ru Yang, Ai-Qin Jiang, Jin-Liang Qi & Hai-Liang Zhu. (2014) Synthesis, biological evaluation, and molecular docking studies of novel chalcone oxime derivatives as potential tubulin polymerization inhibitors. RSC Adv. 4:61, pages 32263-32275.
Crossref
Christine Mara, Enda Dempsey, Angus Bell & James W. Barlow. (2013) Synthesis and evaluation of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane, and benzodioxaphosphininamine sulfides and related compounds as potential anti-malarial agents. Bioorganic & Medicinal Chemistry Letters 23:12, pages 3580-3583.
Crossref
Enda Dempsey, Miguel Prudêncio, Brian J. Fennell, Carina S. Gomes-Santos, James W. Barlow & Angus Bell. (2013) Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites. Molecular and Biochemical Parasitology 188:2, pages 116-127.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.