691
Views
39
CrossRef citations to date
0
Altmetric
Reviews

Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 – 2010)

, PhD, , PhD & , PhD
Pages 131-146 | Published online: 06 Jan 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Jae-Jun Ban, Robin J Ruthenborg, Kevin W Cho & Jung-whan Kim. (2014) Regulation of obesity and insulin resistance by hypoxia-inducible factors. Hypoxia 2, pages 171-183.
Read now

Articles from other publishers (38)

Yan‐Xia Zhang, Mi‐Rong Jing, Chun‐Bo Cai, Shuai‐Gang Zhu, Chao‐Jing Zhang, Qi‐Meng Wang, Yuan‐Kun Zhai, Xin‐Ying Ji & Dong‐Dong Wu. (2022) Role of hydrogen sulphide in physiological and pathological angiogenesis. Cell Proliferation 56:3.
Crossref
Shicheng Sun, Changfa Guo, Taihong Gao, Dengzhen Ma, Xiangsheng Su, Qi Pang & Rui Zhang. (2022) Hypoxia Enhances Glioma Resistance to Sulfasalazine-Induced Ferroptosis by Upregulating SLC7A11 via PI3K/AKT/HIF-1α Axis. Oxidative Medicine and Cellular Longevity 2022, pages 1-22.
Crossref
Fan-Fan Shang, Jing Ying Wang, Qian Xu, Hao Deng, Hong-Yan Guo, Xuejun Jin, Xiaoting Li, Qing-Kun Shen & Zhe-Shan Quan. (2021) Design, synthesis of novel celastrol derivatives and study on their antitumor growth through HIF-1α pathway. European Journal of Medicinal Chemistry 220, pages 113474.
Crossref
Oleg Vetrovoy, Kseniia Sarieva, Ekaterina Lomert, Peter Nimiritsky, Natalia Eschenko, Olga Galkina, Andrey Lyanguzov, Ekaterina Tyulkova & Elena Rybnikova. (2019) Pharmacological HIF1 Inhibition Eliminates Downregulation of the Pentose Phosphate Pathway and Prevents Neuronal Apoptosis in Rat Hippocampus Caused by Severe Hypoxia. Journal of Molecular Neuroscience 70:5, pages 635-646.
Crossref
Shinichiro Fuse, Kensuke Suzuki, Takahiro Kuchimaru, Tetsuya Kadonosono, Hiroki Ueda, Shinichi Sato, Shinae Kizaka-Kondoh & Hiroyuki Nakamura. (2020) Design, synthesis, and evaluation of indeno[2,1-c]pyrazolones for use as inhibitors against hypoxia-inducible factor (HIF)-1 transcriptional activity. Bioorganic & Medicinal Chemistry 28:1, pages 115207.
Crossref
D. A. Fedorov, M. Yu. Frolova, I. E. Krasovskaya & N. V. Kuleva. (2019) The Effects of Severe Hypobaric Hypoxia and Inhibition of Hypoxia-Inducible Factor-1 (HIF-1) on Biomarkers of Cardiac and Skeletal Muscle Injury in Rats. Biophysics 64:5, pages 808-811.
Crossref
Jie Wu, Zhi-Hong Zhang, Lin-Hao Zhang, Xue-Jun Jin, Juan Ma & Hu-Ri Piao. (2019) Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1α pathway. Bioorganic & Medicinal Chemistry Letters 29:6, pages 853-858.
Crossref
Hui Wang, Heng Jiang, Melissa Van De Gucht & Mark De Ridder. (2019) Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?. Cancers 11:1, pages 112.
Crossref
Wenji Xie, Lihui Liu, Haixia He & Kaixuan Yang. (2018) Prognostic value of hypoxia-inducible factor-1 alpha in nasopharyngeal carcinoma: a meta-analysis. The International Journal of Biological Markers 33:4, pages 447-454.
Crossref
Deepak Bhattarai, Xuezhen Xu & Kyeong Lee. (2018) Hypoxia-inducible factor-1 (HIF-1) inhibitors from the last decade (2007 to 2016): A “structure-activity relationship” perspective. Medicinal Research Reviews 38:4, pages 1404-1442.
Crossref
Davinder Singh, Rohit Arora, Pardeep Kaur, Balbir Singh, Rahul Mannan & Saroj Arora. (2017) Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer. Cell & Bioscience 7:1.
Crossref
Xiaobo Zhou, Ming Chen, Zhiyuan Zheng, Guo-Yuan Zhu, Zhi-Hong Jiang & Li-Ping Bai. (2017) Synthesis and evaluation of novel 12-aryl berberine analogues with hypoxia-inducible factor-1 inhibitory activity. RSC Advances 7:43, pages 26921-26929.
Crossref
Shinichiro Fuse, Toshiaki Ohuchi, Yasunobu Asawa, Shinichi Sato & Hiroyuki Nakamura. (2016) Development of 1-aryl-3-furanyl/thienyl-imidazopyridine templates for inhibitors against hypoxia inducible factor (HIF)-1 transcriptional activity. Bioorganic & Medicinal Chemistry Letters 26:24, pages 5887-5890.
Crossref
Caroline Wigerup, Sven Påhlman & Daniel Bexell. (2016) Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer. Pharmacology & Therapeutics 164, pages 152-169.
Crossref
Peter Vaupel & Gabriele Multhoff. (2016) Adenosine can thwart antitumor immune responses elicited by radiotherapyAdenosine kann Strahlentherapie-vermittelte Immunantworten gegen Tumore konterkarieren. Strahlentherapie und Onkologie 192:5, pages 279-287.
Crossref
Guangzhe Li, Soyoko Azuma, Hidemitsu Minegishi & Hiroyuki Nakamura. (2015) Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity. Journal of Organometallic Chemistry 798, pages 189-195.
Crossref
Fares Nigim, Jill Cavanaugh, Anoop P. Patel, William T. CurryJrJr, Shin-ichi Esaki, Ekkehard M. Kasper, Andrew S. Chi, David N. Louis, Robert L. Martuza, Samuel D. Rabkin & Hiroaki Wakimoto. (2015) Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. Journal of Neuropathology & Experimental Neurology 74:7, pages 710-722.
Crossref
Guangzhe Li, Soyoko Azuma, Shinichi Sato, Hidemitsu Minegishi & Hiroyuki Nakamura. (2015) ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity. Bioorganic & Medicinal Chemistry Letters 25:13, pages 2624-2628.
Crossref
Hyun Seung Ban & Hiroyuki Nakamura. (2015) Boron-Based Drug Design. The Chemical Record 15:3, pages 616-635.
Crossref
Yorinobu Yasuda, Takeaki Arakawa, Yumi Nawata, Sayaka Shimada, Shinya Oishi, Nobutaka Fujii, Shinichi Nishimura, Akira Hattori & Hideaki Kakeya. (2015) Design, synthesis, and structure–activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorganic & Medicinal Chemistry 23:8, pages 1776-1787.
Crossref
Takeshi Nakajima, Norihiko Takeda, Tomoyo Taguchi & Mitsuyoshi Azuma. (2015) Design, Synthesis, and Biological Activity Evaluation of Thiazolidinones Containing Alkynyl and Alkenyl Furans for Disrupting Protein–Protein Interactions between HIF-1α and p300. HETEROCYCLES 91:2, pages 351.
Crossref
Khaled Ghattass, Sally El-Sitt, Kazem Zibara, Saide Rayes, Makhluf J Haddadin, Marwan El-Sabban & Hala Gali-Muhtasib. (2014) The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway. Molecular Cancer 13:1.
Crossref
S Engelhardt, S Patkar & O O Ogunshola. (2014) Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia. British Journal of Pharmacology 171:5, pages 1210-1230.
Crossref
Markus Mandl & Reinhard Depping. (2014) Hypoxia-Inducible Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (HIF-1β): Is It a Rare Exception?. Molecular Medicine 20:1, pages 215-220.
Crossref
Michael Härter, Karl‐Heinz Thierauch, Stephen Boyer, Ajay Bhargava, Peter Ellinghaus, Hartmut Beck, Susanne Greschat‐Schade, Holger Hess‐Stumpp & Kerstin Unterschemmann. (2013) Inhibition of Hypoxia‐Induced Gene Transcription by Substituted Pyrazolyl Oxadiazoles: Initial Lead Generation and Structure–Activity Relationships. ChemMedChem 9:1, pages 61-66.
Crossref
Hiroyuki Nakamura, Yuka Yasui & Hyun Seung Ban. (2013) Synthesis and biological evaluation of ortho-carborane containing benzoxazole as an inhibitor of hypoxia inducible factor (HIF)-1 transcriptional activity. Journal of Organometallic Chemistry 747, pages 189-194.
Crossref
Dler Faieeq Darweesh MahmoodAmna AbderrazakKhadija El HadriThomas SimmetMustapha Rouis. (2013) The Thioredoxin System as a Therapeutic Target in Human Health and Disease. Antioxidants & Redox Signaling 19:11, pages 1266-1303.
Crossref
Divya Teja Vavilala, Bliss E. O’Bryhim, V.K. Chaithanya Ponnaluri, R. Sid White, Jeff Radel, R.C. Andrew Symons & Mridul Mukherji. (2013) Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model. Biochemical and Biophysical Research Communications 438:4, pages 697-702.
Crossref
Hidemitsu Minegishi, Shinji Fukashiro, Hyun Seung Ban & Hiroyuki Nakamura. (2013) Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Medicinal Chemistry Letters 4:2, pages 297-301.
Crossref
Birgitte Mayland Havelund, Flemming Brandt Sørensen, John Pløen, Jan Lindebjerg, Karen‐Lise Garm Spindler & Anders Jakobsen. (2012) Immunohistological expression of HIF ‐1α, GLUT ‐1, B cl‐2 and K i‐67 in consecutive biopsies during chemoradiotherapy in patients with rectal cancer . APMIS 121:2, pages 127-138.
Crossref
Hidemitsu Minegishi, Takuya Matsukawa & Hiroyuki Nakamura. (2012) Synthesis and Biological Evaluation of Diaryl‐Substituted Carboranes as Inhibitors of Hypoxia Inducible Factor (HIF)‐1 Transcriptional Activity. ChemMedChem 8:2, pages 265-271.
Crossref
Alexander V. Zhdanov, Ruslan I. Dmitriev & Dmitri B. Papkovsky. (2012) Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. Bioscience Reports 32:6, pages 587-595.
Crossref
Bin Bao, Asfar S. Azmi, Shadan Ali, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong & Fazlul H. Sarkar. (2012) The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:2, pages 272-296.
Crossref
Josiah V Dungwa, Linda P Hunt & Pramila Ramani. (2012) HIF‐1α up‐regulation is associated with adverse clinicopathological and biological factors in neuroblastomas. Histopathology 61:3, pages 417-427.
Crossref
Yan Xia, Hyun-Kyung Choi & Kyeong Lee. (2012) Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors. European Journal of Medicinal Chemistry 49, pages 24-40.
Crossref
Lee Anna Cunningham, Kate Candelario & Lu Li. (2012) Roles for HIF-1α in neural stem cell function and the regenerative response to stroke. Behavioural Brain Research 227:2, pages 410-417.
Crossref
Ayano Takeuchi, Makihito Hori, Shinichi Sato, Hyun Seung Ban, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Takao Yamori & Hiroyuki Nakamura. (2012) Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity. MedChemComm 3:11, pages 1455.
Crossref
Wenwei Huang, Ruili Huang, Matias S. Attene-Ramos, Srilatha Sakamuru, Erika E. Englund, James Inglese, Christopher P. Austin & Menghang Xia. (2011) Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorganic & Medicinal Chemistry Letters 21:18, pages 5239-5243.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.