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Editorial

Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

, , MD PhD &
Pages 1285-1292 | Published online: 16 Aug 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Evan Q. Comeaux & Robert C. A. M. van Waardenburg. (2014) Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target. Drug Metabolism Reviews 46:4, pages 494-507.
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Articles from other publishers (65)

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Alina A. Okhina, Artem D. Rogachev, Kseniya S. Kovaleva, Olga I. Yarovaya, Anna S. Khotskina, Evgeniy L. Zavyalov, Sergey Z. Vatsadze, Andrey G. Pokrovsky & Nariman F. Salakhutdinov. (2023) Development of an LC-MS/MS-based method for quantification and pharmacokinetics study on SCID mice of a dehydroabietylamine-adamantylamine conjugate, a promising inhibitor of the DNA repair enzyme. Journal of Pharmaceutical and Biomedical Analysis, pages 115507.
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Swati Lamba & Amit Roy. (2023) Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites. Drug Discovery Today 28:6, pages 103574.
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Xue Zhi Zhao, Wenjie Wang, George T. Lountos, Joseph E. Tropea, Danielle Needle, Yves Pommier & Terrence R. BurkeJrJr. (2022) Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1. Frontiers in Chemistry 10.
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Huimin Zhang, Yun Xiong, Dan Su, Chao Wang, Mrinal Srivastava, Mengfan Tang, Xu Feng, Min Huang, Zhen Chen & Junjie Chen. (2022) TDP1-independent pathways in the process and repair of TOP1-induced DNA damage. Nature Communications 13:1.
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Oksana V. Salomatina, Nadezhda S. Dyrkheeva, Irina I. Popadyuk, Alexandra L. Zakharenko, Ekaterina S. Ilina, Nina I. Komarova, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik & Konstantin P. Volcho. (2021) New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2. Molecules 27:1, pages 72.
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Guoqiang Sun, Dawei Rong, Zhouxiao Li, Guangshun Sun, Fan Wu, Xiao Li, Hongyong Cao, Ye Cheng, Weiwei Tang & Yangbai Sun. (2021) Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges. Frontiers in Cell and Developmental Biology 9.
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De-Xuan Hu, Wen-Lin Tang, Yu Zhang, Hao Yang, Wenjie Wang, Keli Agama, Yves Pommier & Lin-Kun An. (2021) Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer. Journal of Medicinal Chemistry 64:11, pages 7617-7629.
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Elizaveta D. Gladkova, Arina A. Chepanova, Ekaterina S. Ilina, Alexandra L. Zakharenko, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Olga I. Lavrik & Nariman F. Salakhutdinov. (2021) Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. Molecules 26:7, pages 1945.
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Emma Baglini, Silvia Salerno, Elisabetta Barresi, Marco Robello, Federico Da Settimo, Sabrina Taliani & Anna Maria Marini. (2021) Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs. European Journal of Pharmaceutical Sciences 156, pages 105594.
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Lauren R. H. Krumpe, Brice A. P. Wilson, Christophe Marchand, Suthananda N. Sunassee, Alun Bermingham, Wenjie Wang, Edmund Price, Tad Guszczynski, James A. Kelley, Kirk R. Gustafson, Yves Pommier, K. Johan Rosengren, Christina I. Schroeder & Barry R. O’Keefe. (2020) Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. Journal of the American Chemical Society 142:50, pages 21178-21188.
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Elizaveta D. Gladkova, Ivan V. Nechepurenko, Roman A. Bredikhin, Arina A. Chepanova, Alexandra L. Zakharenko, Olga A. Luzina, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Evgeniya M. Mamontova, Rashid O. Anarbaev, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2020) The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme. International Journal of Molecular Sciences 21:19, pages 7162.
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Irina V. Il’ina, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Alexander Yu. Sidorenko, Nikolay S. Li-Zhulanov, Dina V. Korchagina, Raina Chand, Daniel M. Ayine-Tora, Arina A. Chepanova, Olga D. Zakharova, Ekaterina S. Ilina, Jóhannes Reynisson, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Konstantin P. Volcho, Nariman F. Salakhutdinov & Olga I. Lavrik. (2020) Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. Molecules 25:15, pages 3496.
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Masataka Tsuda, Kaito Kitamasu, Chiho Kumagai, Kazuya Sugiyama, Toshiaki Nakano & Hiroshi Ide. (2020) Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1). DNA Repair 91-92, pages 102849.
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Hong-Li Zhang, Yu Zhang, Xue-Long Yan, Long-Gao Xiao, De-Xuan Hu, Qian Yu & Lin-Kun An. (2020) Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors. Bioorganic & Medicinal Chemistry 28:11, pages 115527.
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