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New antibacterials for the treatment of toxoplasmosis; a patent review

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Pages 311-333 | Published online: 10 Mar 2012

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Iman Fathy Abou-El-Naga, Maha Mohamed Gomaa & Samar Nabil ElAchy. (2022) Effect of HIV aspartyl protease inhibitors on experimental infection with a cystogenic Me49 strain of Toxoplasma gondii. Pathogens and Global Health 116:2, pages 107-118.
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Sara Ayazian Mavi, Mohammad Hossein Modarressi, Mehdi Mohebali, Saeedeh Shojaee, Hojjat Zeraati, Aref Teimouri & Hossein Keshavarz. (2019) Assessment of the immunogenicity and protective efficiency of a novel dual-promoter DNA vaccine, harboring SAG1 and GRA7 genes, from RH strain of Toxoplasma gondii in BALB/c mice. Infection and Drug Resistance 12, pages 2519-2530.
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Céline Dard, Pierre Marty, Marie-Pierre Brenier-Pinchart, Cécile Garnaud, Hélène Fricker-Hidalgo, Hervé Pelloux & Christelle Pomares. (2018) Management of toxoplasmosis in transplant recipients: an update. Expert Review of Anti-infective Therapy 16:6, pages 447-460.
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Simone Carradori, Daniela Secci, Bruna Bizzarri, Paola Chimenti, Celeste De Monte, Paolo Guglielmi, Cristina Campestre, Daniela Rivanera, Claudia Bordón & Lorraine Jones-Brando. (2017) Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 746-758.
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Juan B. Rodriguez, Bruno N. Falcone & Sergio H. Szajnman. (2016) Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase. Expert Opinion on Drug Discovery 11:3, pages 307-320.
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Laura Vanagas, Victoria Jeffers, Silvina S Bogado, Maria C Dalmasso, William J Sullivan$suffix/text()$suffix/text() & Sergio O Angel. (2012) Toxoplasma histone acetylation remodelers as novel drug targets. Expert Review of Anti-infective Therapy 10:10, pages 1189-1201.
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Articles from other publishers (43)

Juan B. Rodriguez & Sergio H. Szajnman. (2023) An updated review of chemical compounds with anti-Toxoplasma gondii activity. European Journal of Medicinal Chemistry 262, pages 115885.
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Zhuo-Er Qiu, Lei Chen, Xiao-Chun Hou, Jie Sheng, Jian-Bang Xu, Jia-Wen Xu, Dong-Dong Gao, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Lei Peng, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Wei-Jie Guan, Zhao-Rong Lun, Wen-Liang Zhou & Yi-Lin Zhang. (2023) Toxoplasma gondii infection triggers ongoing inflammation mediated by increased intracellular Cl− concentration in airway epithelium. Journal of Infection 86:1, pages 47-59.
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Asmaa M. El-kady, Wafa Abdullah I. Al-Megrin, Iman A. M. Abdel-Rahman, Eman Sayed, Eman Abdullah Alshehri, Majed H. Wakid, Fadi M. Baakdah, Khalil Mohamed, Hayam Elshazly, Hussah M. Alobaid, Safa H. Qahl, Hatem A. Elshabrawy & Salwa S. Younis. (2022) Ginger Is a Potential Therapeutic for Chronic Toxoplasmosis. Pathogens 11:7, pages 798.
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Aishah E. Albalawi, Abdullah D. Alanazi, Mohamed S. Alyousif, Azadeh Sepahvand, Katrin Ebrahimi, Massumeh Niazi & Hossein Mahmoudvand. (2021) The High Potency of Green Synthesized Copper Nanoparticles to Prevent the Toxoplasma gondii Infection in Mice. Acta Parasitologica 66:4, pages 1472-1479.
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Enas F. Abdel Hamed, Nahed E. Mostafa, Eman M. Fawzy, Mohamed N. Ibrahim, Rasha Attia & Marwa A. Salama. (2021) The delayed death-causing nature of Rosmarinus officinalis leaf extracts and their mixture within experimental chronic toxoplasmosis: Therapeutic and prophylactic implications. Acta Tropica 221, pages 105992.
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Mahbobeh Montazeri, Fatemeh Mirzaee, Ahmad Daryani, Raheleh Naeimayi, ShohreMoradi Karimabad, HadisehKhalilzadeh Arjmandi, Niusha Esmaealzadeh & Somayeh Shahani. (2020) Anti-Toxoplasma activities of the hydroalcoholic extract of some brassicaceae species. Advanced Biomedical Research 9:1, pages 5.
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Ehsan Ahmadpour, Mohammad Ali Ebrahimzadeh, Mehdi Sharif, Sara Edalatian, Shahabeddin Sarvi, Mahbobeh Montazeri, Saeed Mehrzadi, Mohammad Akbari, Mohammad Taghi Rahimi & Ahmad Daryani. (2019) Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo. Journal of Pharmacopuncture 22:3, pages 154-159.
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Tamila Galaka, Bruno N. Falcone, Catherine Li, Sergio H. Szajnman, Silvia N.J. Moreno, Roberto Docampo & Juan B. Rodriguez. (2019) Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii. Bioorganic & Medicinal Chemistry 27:16, pages 3663-3673.
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Safoura Hariri, Jahan B. Ghasemi, Farhad Shirini & Behnam Rasti. (2019) Probing the origin of dihydrofolate reductase inhibition via proteochemometric modeling. Journal of Chemometrics 33:2, pages e3090.
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Valeria Sander, Sergio O. Angel & Marina Clemente. 2018. Prospects of Plant-Based Vaccines in Veterinary Medicine. Prospects of Plant-Based Vaccines in Veterinary Medicine 89 120 .
Wen-Bin Yang, Dong-Hui Zhou, Yang Zou, Kai Chen, Qing Liu, Jin-Lei Wang, Xing-Quan Zhu & Guang-Hui Zhao. (2017) Vaccination with a DNA vaccine encoding Toxoplasma gondii ROP54 induces protective immunity against toxoplasmosis in mice. Acta Tropica 176, pages 427-432.
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Ahmad Daryani, Mohammad Ali Ebrahimzadeh, Mohammad Mohammad Taheri, Ehsan Ahmadpour, Mahbobeh Montazeri, Shahabeddin Sarvi & Mohammad Akbari. (2017) Anti-Toxoplasma Effects of Methanol Extracts of Feijoa sellowiana, Quercus castaneifolia, and Allium paradoxum. Journal of Pharmacopuncture 20:3, pages 220-226.
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Zhu-Hong Li, Catherine Li, Sergio H. Szajnman, Juan B. Rodriguez & Silvia N. J. Moreno. (2017) Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis. Antimicrobial Agents and Chemotherapy 61:8.
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Wei-Ning Zhu, Jin-Lei Wang, Kai Chen, Dong-Mei Yue, Xiao-Xuan Zhang, Si-Yang Huang & Xing-Quan Zhu. (2017) Evaluation of protective immunity induced by DNA vaccination with genes encoding Toxoplasma gondii GRA17 and GRA23 against acute toxoplasmosis in mice. Experimental Parasitology 179, pages 20-27.
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Ragab M. Fereig, Yasuhiro Kuroda, Mohamad Alaa Terkawi, Motamed Elsayed Mahmoud & Yoshifumi Nishikawa. (2017) Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice. PLOS ONE 12:4, pages e0176324.
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Sergio H. Szajnman, Tamila Galaka, Zhu-Hong Li, Catherine Li, Nathan M. Howell, María N. Chao, Boris Striepen, Vasant Muralidharan, Silvia N. J. Moreno & Juan B. Rodriguez. (2017) In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites . Antimicrobial Agents and Chemotherapy 61:2.
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Lina Zheng, Yue Hu, Qianqian Hua, Fangjun Luo, Guizhen Xie, Xiangzhi Li, Jiaxin Lin, Yujing Wan, Shoufeng Ren, Changwang Pan & Feng Tan. (2017) Protective immune response in mice induced by a suicidal DNA vaccine encoding NTPase-II gene of Toxoplasma gondii. Acta Tropica 166, pages 336-342.
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Mahbobeh Montazeri, Mehdi Sharif, Shahabeddin Sarvi, Saeed Mehrzadi, Ehsan Ahmadpour & Ahmad Daryani. (2017) A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006–2016). Frontiers in Microbiology 8.
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Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María Chao, Sergio Szajnman, Roberto Docampo, Silvia Moreno & Juan Rodriguez. (2017) Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites. Molecules 22:1, pages 82.
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María N. Chao, Catherine Li, Melissa Storey, Bruno N. Falcone, Sergio H. Szajnman, Sergio M. Bonesi, Roberto Docampo, Silvia N. J. Moreno & Juan B. Rodriguez. (2016) Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii . ChemMedChem 11:24, pages 2690-2702.
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Ragab M. Fereig & Yoshifumi Nishikawa. (2016) Peroxiredoxin 3 promotes IL-12 production from macrophages and partially protects mice against infection with Toxoplasma gondii. Parasitology International 65:6, pages 741-748.
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Dong-Hun Lee, Ah-Ra Kim, Su-Hwa Lee & Fu-Shi Quan. (2016) Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge. Acta Tropica 164, pages 77-83.
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Eliézer L. P. Ramos, Silas S. Santana, Murilo V. Silva, Fernanda M. Santiago, Tiago W. P. Mineo & José R. Mineo. (2016) Lectins from Synadenium carinatum (ScLL) and Artocarpus heterophyllus (ArtinM) Are Able to Induce Beneficial Immunomodulatory Effects in a Murine Model for Treatment of Toxoplasma gondii Infection. Frontiers in Cellular and Infection Microbiology 6.
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Dong Hun Lee, Su Hwa Lee, Ah Ra Kim & Fu Shi Quan. (2016) Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii. PLOS ONE 11:8, pages e0161231.
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Jia Chen, Zhong-Yuan Li, Eskild Petersen, Wen-Ge Liu & Xing-Quan Zhu. (2016) Co-administration of interleukins 7 and 15 with DNA vaccine improves protective immunity against Toxoplasma gondii. Experimental Parasitology 162, pages 18-23.
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Ragab M. Fereig & Yoshifumi Nishikawa. 2016. Vaccine Design. Vaccine Design 153 164 .
Shuai Wang, YuJian Wang, XiaoNi Sun, ZhenChao Zhang, TingQi Liu, Javaid Ali Gadahi, Ibrahim Adam Hassan, LiXin Xu, RuoFeng Yan, XiaoKai Song & XiangRui Li. (2015) Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1-alpha. BMC Infectious Diseases 15:1.
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Shuai Wang, Ibrahim A. Hassan, XinChao Liu, LiXin Xu, RuoFeng Yan, XiaoKai Song & XiangRui Li. (2015) Immunological changes induced by Toxoplasma gondii Glutathione-S-Transferase (TgGST) delivered as a DNA vaccine. Research in Veterinary Science 99, pages 157-164.
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Mojgan Allahyari, Reyhaneh Mohabati, Jalal Babaie, Samira Amiri, Zahra Jafari Siavashani, Mehrak Zare, Ghazaleh Sadeghiani & Majid Golkar. (2015) Production of in-vitro refolded and highly antigenic SAG1 for development of a sensitive and specific Toxoplasma IgG ELISA. Journal of Immunological Methods 416, pages 157-166.
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Lobna A. El-Zawawy, Doaa El-Said, Shereen F. Mossallam, Heba S. Ramadan & Salwa S. Younis. (2015) Preventive prospective of triclosan and triclosan-liposomal nanoparticles against experimental infection with a cystogenic ME49 strain of Toxoplasma gondii. Acta Tropica 141, pages 103-111.
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Ibrahim A Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song & Xiangrui Li. (2014) DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice. Parasites & Vectors 7:1.
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Ibrahim A. Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song & XiangRui Li. (2014) Immunoglobulin and cytokine changes induced following immunization with a DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase protein. Experimental Parasitology 146, pages 1-10.
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Melissa D'Ascenzio, Bruna Bizzarri, Celeste De Monte, Simone Carradori, Adriana Bolasco, Daniela Secci, Daniela Rivanera, Nathan Faulhaber, Claudia Bordón & Lorraine Jones-Brando. (2014) Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii. European Journal of Medicinal Chemistry 86, pages 17-30.
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James S. Pham, Karen L. Dawson, Katherine E. Jackson, Erin E. Lim, Charisse Flerida A. Pasaje, Kelsey E.C. Turner & Stuart A. Ralph. (2014) Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites. International Journal for Parasitology: Drugs and Drug Resistance 4:1, pages 1-13.
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Mariana Ferrer-Casal, Catherine Li, Melina Galizzi, Carlos A. Stortz, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno & Juan B. Rodriguez. (2014) New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase. Bioorganic & Medicinal Chemistry 22:1, pages 398-405.
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Maria L Alomar, Federico AO Rasse-Suriani, Agustina Ganuza, Verónica M Cóceres, Franco M Cabrerizo & Sergio O Angel. (2013) In vitro evaluation of β-carboline alkaloids as potential anti-Toxoplasma agents. BMC Research Notes 6:1.
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Pablo D. Elicio, María N. Chao, Melina Galizzi, Catherine Li, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno & Juan B. Rodriguez. (2013) Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. European Journal of Medicinal Chemistry 69, pages 480-489.
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Hai-Long Wang, Ya-Qing Li, Li-Tian Yin, Xiao-Li Meng, Min Guo, Jian-Hong Zhang, Hong-Li Liu, Juan-Juan Liu & Guo-Rong Yin. (2013) Toxoplasma gondii Protein Disulfide Isomerase (TgPDI) Is a Novel Vaccine Candidate against Toxoplasmosis. PLoS ONE 8:8, pages e70884.
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M. J. XU, D. H. ZHOU, S. Y. HUANG, F. R. ZHAO, A. J. NISBET, R. Q. LIN, H. Q. SONG & X. Q. ZHU. (2013) Comparative characterization of microRNA profiles of different genotypes of Toxoplasma gondii . Parasitology 140:9, pages 1111-1118.
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Marion Recher, Alejandro P. Barboza, Zhu-Hong Li, Melina Galizzi, Mariana Ferrer-Casal, Sergio H. Szajnman, Roberto Docampo, Silvia N.J. Moreno & Juan B. Rodriguez. (2013) Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. European Journal of Medicinal Chemistry 60, pages 431-440.
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Carl Song, Melissa A Chiasson, Nirvana Nursimulu, Stacy S Hung, James Wasmuth, Michael E Grigg & John Parkinson. (2013) Metabolic reconstruction identifies strain‐specific regulation of virulence in Toxoplasma gondii . Molecular Systems Biology 9:1.
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Min Meng, Shenyi He, Guanghui Zhao, Yang Bai, Huaiyu Zhou, Hua Cong, Gang Lu, Qunli Zhao & Xing-Quan Zhu. (2012) Evaluation of protective immune responses induced by DNA vaccines encoding Toxoplasma gondii surface antigen 1 (SAG1) and 14-3-3 protein in BALB/c mice. Parasites & Vectors 5:1.
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Ronize Andréia Ferreira, Alaide Braga de Oliveira, Simone Andrade Gualberto, José M. Miguel Del Corral, Ricardo Toshio Fujiwara, Pedro Henrique Gazzinelli Guimarães & Ricardo Wagner de Almeida Vitor. (2012) New naphthoquinones and an alkaloid with in vitro activity against Toxoplasma gondii RH and EGS strains. Experimental Parasitology 132:4, pages 450-457.
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